Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics.

abstract：:The suggested role of adenosine 3':5'-cyclic monophosphate as the "second messenger" in the neurite outgrowth from chick embryonic sensory ganglia mediated by nerve growth factor was examined. Although N(6),O(2)-dibutyryl adenosine 3':5'-cyclic monophosphate induces fiber outgrowth at concentrations of 1-5 mM, this re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frazier WA,Ohlendorf CE,Boyd LF,Aloe L,Johnson EM,Ferrendelli JA,Bradshaw RA

更新日期：1973-08-01 00:00:00

abstract：:DNA fragments encoding the mouse steroid 21-hydroxylase (C21 or Cyp21A1) gene are de novo methylated when introduced into the mouse adrenocortical tumor cell line Y1 by DNA-mediated gene transfer. Although CCGG sequences within the C21 gene are de novo methylated, CCGG sites within flanking vector sequences, other mam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szyf M,Schimmer BP,Seidman JG

更新日期：1989-09-01 00:00:00

abstract：:Overlapping cDNAs derived from the chicken alpha-fibrinogen mRNA have been sequenced, beginning from within the coding region for the signal peptide of this subunit and terminating within the poly(A) extension. The predicted size of chicken alpha-fibrinogen is 54,187 daltons, which is the smallest of any alpha chain r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissbach L,Grieninger G

更新日期：1990-07-01 00:00:00

abstract：:Artificially aminoacylated suppressor tRNAs were used to introduce photoreactive amino acids into model mitochondrial precursor proteins to probe the environment along the protein import pathway. Amino acids with benzophenone side chains of various lengths [DL-2-amino-3-(p-benzoylphenyl)propanoic acid (1) and DL-2-ami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanamori T,Nishikawa S,Shin I,Schultz PG,Endo T

更新日期：1997-01-21 00:00:00

abstract：:This study presents, to our knowledge, the first on-line measurement of acetylcholinesterase (AcChoEase) release from brain tissue. It is now well established that a soluble form of the enzyme is released from central nervous system neurons, and it has been proposed on indirect grounds that such release may occur not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llinás RR,Greenfield SA

更新日期：1987-05-01 00:00:00

abstract：:Insects, as a group, have been remarkably successful in adapting to a great range of physical and biological environments, in large part because of their ability to fly. The evolution of flight in small insects was accompanied by striking adaptations of the thoracic musculature that enabled very high wing beat frequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swank DM,Vishnudas VK,Maughan DW

更新日期：2006-11-14 00:00:00

abstract：:Are judicial rulings based solely on laws and facts? Legal formalism holds that judges apply legal reasons to the facts of a case in a rational, mechanical, and deliberative manner. In contrast, legal realists argue that the rational application of legal reasons does not sufficiently explain the decisions of judges an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danziger S,Levav J,Avnaim-Pesso L

更新日期：2011-04-26 00:00:00

abstract：:Microinjection of plasmids encoding human tau (htau) protein into identified lamprey reticulospinal neurons (anterior bulbar cells, or ABCs) in situ induces chronic htau expression. htau protein is transported to both the axon and dendrites of expressing ABCs by mechanisms that require the C-terminal domain of htau pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hall GF,Yao J,Lee G

更新日期：1997-04-29 00:00:00

abstract：:Tunas are migratory fishes in offshore habitats and top predators with unique features. Despite their ecological importance and high market values, the open-ocean lifestyle of tuna, in which effective sensing systems such as color vision are required for capture of prey, has been poorly understood. To elucidate the ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,Mori K,Saitoh K,Oshima K,Mekuchi M,Sugaya T,Shigenobu Y,Ojima N,Muta S,Fujiwara A,Yasuike M,Oohara I,Hirakawa H,Chowdhury VS,Kobayashi T,Nakajima K,Sano M,Wada T,Tashiro K,Ikeo K,Hattori M,Kuhara S,

更新日期：2013-07-02 00:00:00

abstract：:A single anterior-animal blastomere, which includes the presumptive neural region in the eight-cell embryo of the Halocynthia, a protochordate, when dissociated, cleavage-arrested with cytochalasin B, and cultured in isolation, differentiated exclusively to epidermal type judging from membrane excitability and immunor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okado H,Takahashi K

更新日期：1988-08-01 00:00:00

abstract：:A 6.2-kb full-length clone encoding a distinct protein-tyrosine phosphatase (PTP; EC 3.1.3.48), PTPD1, was isolated from a human skeletal muscle cDNA library. The cDNA encodes a protein of 1174 amino acids with N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family, which also includes the tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Møller NP,Møller KB,Lammers R,Kharitonenkov A,Sures I,Ullrich A

更新日期：1994-08-02 00:00:00

abstract：:Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain. Differences between the two strains include changes in the light-harvesting capacity, which is lower in OTH95, and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardol P,Bailleul B,Rappaport F,Derelle E,Béal D,Breyton C,Bailey S,Wollman FA,Grossman A,Moreau H,Finazzi G

更新日期：2008-06-03 00:00:00

abstract：:Retinoblastoma is a childhood tumor that can arise because of mutant alleles acquired as somatic or germinal mutations. The mutant allele can be carried in the germ line. The mutations creating these alleles act by inactivating copies of a recessive oncogene located within band q14 of chromosome 13 and termed the RB1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friend SH,Horowitz JM,Gerber MR,Wang XF,Bogenmann E,Li FP,Weinberg RA

更新日期：1987-12-01 00:00:00

abstract：:We investigate the role of networks of alliances in preventing (multilateral) interstate wars. We first show that, in the absence of international trade, no network of alliances is peaceful and stable. We then show that international trade induces peaceful and stable networks: Trade increases the density of alliances ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson MO,Nei S

更新日期：2015-12-15 00:00:00

abstract：:The temporal and spatial patterns of floral determination in cultured internode segments of Nicotiana tabacum L. cv. Wisconsin 38 were investigated. Segments from internodes, when cultured on hormone-free medium, either produced some de novo floral shoots or produced only vegetative shoots. Segments that produced some...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singer SR,McDaniel CN

更新日期：1987-05-01 00:00:00

abstract：:Despite the increasing number of regulatory proteins identified in clathrin-independent endocytic (CIE) pathways, our understanding of the exact functions of these proteins and the sequential manner in which they function remains limited. In this study, using the Caenorhabditis elegans intestine as a model, we observe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen S,Li L,Li J,Liu B,Zhu X,Zheng L,Zhang R,Xu T

更新日期：2014-10-28 00:00:00

abstract：:H-2(q) mice (DBA/1) do not make an antibody response to a synthetic aminoacid polymer, (Glu, Ala,Tyr(10)), after an immunizing regimen that produces a good antibody response in mouse strains with other H-2 alleles. Their thymocytes, however, show evidence of recognizing this antigen since they synthesize DNA when they...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gershon RK,Maurer PH,Merryman CF

更新日期：1973-01-01 00:00:00

abstract：:Archaeochemistry as the application of the most recent analytical techniques to ancient samples now provides an unprecedented understanding of human culture throughout history. In this paper, we report on a multiplatform analytical investigation of 170-y-old champagne bottles found in a shipwreck at the bottom of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeandet P,Heinzmann SS,Roullier-Gall C,Cilindre C,Aron A,Deville MA,Moritz F,Karbowiak T,Demarville D,Brun C,Moreau F,Michalke B,Liger-Belair G,Witting M,Lucio M,Steyer D,Gougeon RD,Schmitt-Kopplin P

更新日期：2015-05-12 00:00:00

abstract：:Radioimmunoassay revealed increased dynorphin A(1-8)-like immunoreactivity [dynA(1-8)LI] in the aged rat brain. Among a number of brain regions examined, an age-related dynA(1-8)LI elevation was found only in the hippocampal formation and frontal cortex. Moreover, the increase in dynA(1-8)LI in the aged hippocampus wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang HK,Owyang VV,Hong JS,Gallagher M

更新日期：1989-04-01 00:00:00

abstract：:The development of the luminescence system in Beneckea harveyi is controlled by cyclic nucleotides at the level of transcription. In the wild type, it is repressed by exogenously added guanosine 3':5'-cyclic monophosphate and this repression is overcome by the addition of adenosine 3':5'-cyclic monophosphate. These ob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulitzur S,Yashphe J,Hastings JW

更新日期：1976-12-01 00:00:00

abstract：:Opioid drugs produce their pharmacological effects by activating inhibitory guanine nucleotide-binding regulatory protein-linked mu, delta, and kappa opioid receptors. One major effector for these receptors is adenylyl cyclase, which is inhibited upon receptor activation. However, little is known about which of the te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KS,Lee KW,Lee KW,Im JY,Yoo JY,Kim SW,Lee JK,Nestler EJ,Han PL

更新日期：2006-03-07 00:00:00

abstract：:Two affinity species of the interleukin 2 (IL-2) receptor are different states of a single receptor molecule. We assumed that a binary complex between the IL-2 receptor and another lymphocyte-specific protein would constitute the high-affinity receptor. To test this assumption, we counted the numbers of IL-2 receptors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo S,Shimizu A,Saito Y,Kinoshita M,Honjo T

更新日期：1986-12-01 00:00:00

abstract：:The Hawaiian honeycreepers (Drepanidae) represent a superb illustration of evolutionary radiation, with a single colonization event giving rise to 19 extant and at least 10 extinct species [Curnutt, J. & Pimm, S. (2001) Stud. Avian Biol. 22, 15-30]. They also represent a dramatic example of anthropogenic extinction. C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benning TL,LaPointe D,Atkinson CT,Vitousek PM

更新日期：2002-10-29 00:00:00

abstract：:Diffuse large B cell lymphomas (DLBCLs) often express BCL6, a transcriptional repressor required for the formation of normal germinal centers. In a subset of DLBCLs, BCL6 is deregulated by chromosomal translocations or aberrant somatic hypermutation; in other tumors, BCL6 expression may simply reflect germinal center ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polo JM,Juszczynski P,Monti S,Cerchietti L,Ye K,Greally JM,Shipp M,Melnick A

更新日期：2007-02-27 00:00:00

abstract：:Most current gene transfer methods function satisfactorily in specialized systems involving established cell lines but are often not applicable with nonadherent, primary hematopoietic cells, which are notoriously difficult to transfect. To approach this problem, we have investigated an alternative method of gene trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zenke M,Steinlein P,Wagner E,Cotten M,Beug H,Birnstiel ML

更新日期：1990-05-01 00:00:00

abstract：:In this report we analyzed genetically informative data to investigate within-person change and between-person differences in late-life cognitive abilities as a function of childhood social class. We used data from nine testing occasions spanning 28 y in the Swedish Adoption/Twin Study of Aging and parental social cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ericsson M,Lundholm C,Fors S,Dahl Aslan AK,Zavala C,Reynolds CA,Pedersen NL

更新日期：2017-07-03 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine that has been implicated in various inflammatory diseases. Chronic inflammation is a mainstay of liver fibrosis, a leading cause of morbidity worldwide, but the role of MIF in liver scarring has not yet been elucidated. Here we have un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heinrichs D,Knauel M,Offermanns C,Berres ML,Nellen A,Leng L,Schmitz P,Bucala R,Trautwein C,Weber C,Bernhagen J,Wasmuth HE

更新日期：2011-10-18 00:00:00

abstract：:The high resolution 1H and 31P NMR spectra of the (dG-dC)8 duplex have been recorded in low- and high-salt solutions in order to evaluate the structural aspects of the salt-induced transition of oligo(dG-dC) in solution [Pohl, F. M. & Jovin, T. M. (1972) J. Mol. Biol. 67, 375-396]. The NMR data require that the (dG-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Canuel LL,Pohl FM

更新日期：1979-06-01 00:00:00

abstract：:Locus content maps are derived from monosomic or disomic chromosomes broken by radiation, shearing, or other clastogen, the fragments being distributed among clones by dilution or incorporation into the cells of another species and scored for segregation of markers. Locus content maps provide evidence about radiosensi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teague JW,Collins A,Morton NE

更新日期：1996-10-15 00:00:00

abstract：:The identity of cells that mediate positive selection of CD8(+) T cells was investigated in two T cell receptor (TCR) transgenic systems. Irradiated beta(2)-microglobulin mutant mice or mice with mutations in both the K(b) and D(b) genes were repopulated with fetal liver cells from class I(+) TCR transgenic mice. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zerrahn J,Volkmann A,Coles MC,Held W,Lemonnier FA,Raulet DH

更新日期：1999-09-28 00:00:00