Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

abstract：:Conformational aspects of the acetylcholine receptor (AcChoR) of Electrophorus electricus have been examined by studies of its interaction with structurally related, constrained aromatic bis quaternary compounds. Among the compounds synthesized was 3,3'-bis[alpha-(trimethylammonium)-methyl]azobenzene dibromide (3,3'-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wassermann NH,Bartels E,Erlanger BF

更新日期：1979-01-01 00:00:00

abstract：:Molybdate- and ATP-dependent in vitro synthesis of the iron-molybdenum cofactor (FeMo-co) of nitrogenase requires the protein products of at least the nifB, nifN, and nifE genes. Extracts of FeMo-co-negative mutants of Klebsiella pneumoniae and Azotobacter vinelandii with lesions in different genes can be complemented...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah VK,Imperial J,Ugalde RA,Ludden PW,Brill WJ

更新日期：1986-03-01 00:00:00

abstract：:Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by rapid infiltration of leukocytes, mostly of innate immunity, in both primary and repeated challenges. Formation of rose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hicks AM,Riedlinger G,Willingham MC,Alexander-Miller MA,Von Kap-Herr C,Pettenati MJ,Sanders AM,Weir HM,Du W,Kim J,Simpson AJ,Old LJ,Cui Z

更新日期：2006-05-16 00:00:00

abstract：:Ras CAAX (C = cysteine, A = aliphatic amino acid, and X = any amino acid) peptidomimetic inhibitors of farnesyl protein transferase suppress Ras-dependent cell transformation by preventing farnesylation of the Ras oncoprotein. These compounds are potential anticancer agents for tumors associated with Ras mutations. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kauffmann RC,Qian Y,Vogt A,Sebti SM,Hamilton AD,Carthew RW

更新日期：1995-11-21 00:00:00

abstract：:Inhomogeneous ab initio molecular dynamics simulations show that vaporization of MgSiO3 is incongruent and that the vapor phase is dominated by SiO and O2 molecules. The vapor is strongly depleted in Mg at low temperature and approaches the composition of the liquid near the critical point. We find that the liquid-vap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao B,Stixrude L

更新日期：2018-05-22 00:00:00

abstract：:Continuous intravenous infusion of heparin suppresses smooth muscle cell proliferation in rats after endothelial injury but may lead to hemorrhage and other complications. The anticoagulant property has been removed from chemically modified heparin without loss of antiproliferative effect but use of such compounds is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman ER,Adams DH,Karnovsky MJ

更新日期：1990-05-01 00:00:00

abstract：:The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of gamma-aminobutyric acid type A (GABAA) receptors in the brain during pregnancy and after delivery was investigated in rats. In contrast with plasma, where all steroids increased in parallel, the kinetics ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Concas A,Mostallino MC,Porcu P,Follesa P,Barbaccia ML,Trabucchi M,Purdy RH,Grisenti P,Biggio G

更新日期：1998-10-27 00:00:00

abstract：:The substrate specificity of the catalytic subunit of rabbit skeletal muscle 3': 5'-cyclic AMP-dependent protein kinase (EC 2.7.1.37; ATP: protein phosphotransferase) has been studied using the synthetic peptide Arg-Gly-Tyr-Ser-Leu-Gly corresponding to the sequence around serine 24, a phosphorylation site in reduced, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kemp BE,Benjamini E,Krebs EG

更新日期：1976-04-01 00:00:00

abstract：:Transmission electron microscope images were obtained of fractions of poly(1-tetradecene sulfone) and poly(cyclohexene sulfone) cast from very dilute solutions (0.007%, wt/vol) and rapidly freeze-dried on a mica surface. The samples were then vertically platinum-carbon (Pt-C) replicated with 9 +/- 0.3-A Pt-C and held ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruben GC,Stockmayer WH

更新日期：1992-09-01 00:00:00

abstract：:The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weaver-Feldhaus J,Gruis NA,Neuhausen S,Le Paslier D,Stockert E,Skolnick MH,Kamb A

更新日期：1994-08-02 00:00:00

abstract：:We have measured high-resolution x-ray absorption spectra of lanthanide (Ln) and heavy transition metal complexes that display prominent narrow absorption peaks near the L2 and L3 absorption edges. The anomalous scattering factors (f' and f"), which are mathematically related to the absorption cross section, have corr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lye RC,Phillips JC,Kaplan D,Doniach S,Hodgson KO

更新日期：1980-10-01 00:00:00

abstract：:A peptide containing 31 amino acids with inhibin-like activity has been synthesized by the solid-phase method. The synthetic product was shown to be homogeneous in high-performance liquid chromatography and paper electrophoresis. In the mouse pituitary incubation system, the follitropin-suppressing activity of the syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamashiro D,Li CH,Ramasharma K,Sairam MR

更新日期：1984-09-01 00:00:00

abstract：:Spider-like forms of purified reovirus RNA have been characterized by electron microscopy. These structures contained 11.3 +/- 0.8 mum of double-stranded RNA and up to 20 arms, each of distinct length. Length measurements of 64 "spiders" suggest that in these structures the viral genome is folded fairly specifically. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavenoff R,Talcove D,Mudd JA

更新日期：1975-11-01 00:00:00

abstract：:Type VI secretion systems (T6SSs) are multiprotein complexes best studied in Gram-negative pathogens where they have been shown to inhibit or kill prokaryotic or eukaryotic cells and are often important for virulence. We recently showed that T6SS loci are also widespread in symbiotic human gut bacteria of the order Ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatzidaki-Livanis M,Geva-Zatorsky N,Comstock LE

更新日期：2016-03-29 00:00:00

abstract：:Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of proinflammatory leuko...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fredman G,Ozcan L,Spolitu S,Hellmann J,Spite M,Backs J,Tabas I

更新日期：2014-10-07 00:00:00

abstract：:Mouse teratocarcinoma cells induced to differentiate in vitro undergo a massive (30%) demethylation of DNA. A similar undermethylation is also observed in the mouse extraembryonic membranes, the yolk sac and placenta. In both cases, the decrease in methyl moieties occurs at a large number of CpG sites spread out over ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin A,Webb C,Szyf M,Yisraeli J,Rosenthal A,Naveh-Many T,Sciaky-Gallili N,Cedar H

更新日期：1984-04-01 00:00:00

abstract：:Endogenous circadian rhythms have been described in a wide range of organisms from prokaryotes to man. Although basic circadian mechanisms at the molecular level are genetically fixed, certain properties of circadian rhythms at the organismic level can be modified by environmental conditions and subsequently retained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandstätter R,Kumar V,Abraham U,Gwinner E

更新日期：2000-10-24 00:00:00

abstract：:Endothelial cells (ECs) line the mammalian vascular system and respond to the hemodynamic stimulus of fluid shear stress, the frictional force produced by blood flow. When ECs are exposed to shear stress, one of the fastest responses is an increase of K(+) conductance, which suggests that ion channels are involved in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoger JH,Ilyin VI,Forsyth S,Hoger A

更新日期：2002-05-28 00:00:00

abstract：:Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong JW,Hendrix DA,Papatsenko D,Levine MS

更新日期：2008-12-23 00:00:00

abstract：:Regional cerebral blood flow was measured with positron-emission tomography during two encoding and two retrieval tasks that were designed to compare memory for object features with memory for object locations. Bilateral increases in regional cerebral blood flow were observed in both anterior and posterior regions of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen AM,Milner B,Petrides M,Evans AC

更新日期：1996-08-20 00:00:00

abstract：:The identity of cells that mediate positive selection of CD8(+) T cells was investigated in two T cell receptor (TCR) transgenic systems. Irradiated beta(2)-microglobulin mutant mice or mice with mutations in both the K(b) and D(b) genes were repopulated with fetal liver cells from class I(+) TCR transgenic mice. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zerrahn J,Volkmann A,Coles MC,Held W,Lemonnier FA,Raulet DH

更新日期：1999-09-28 00:00:00

abstract：:Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same period...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-Emmenegger C,Xiao Q,Kostina NY,Sherman SE,Rahimi K,Partridge BE,Li S,Sahoo D,Reveron Perez AM,Buzzacchera I,Han H,Kerzner M,Malhotra I,Möller M,Wilson CJ,Good MC,Goulian M,Baumgart T,Klein ML,Percec V

更新日期：2019-03-19 00:00:00

abstract：:Understanding the relationship between the structural and functional organization of the human brain is one of the most important goals of neuroscience. Individual variability in brain structure means that it is essential to obtain this information from the same subject. To date, this has been almost impossible. Even ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walters NB,Egan GF,Kril JJ,Kean M,Waley P,Jenkinson M,Watson JD

更新日期：2003-03-04 00:00:00

abstract：:The gene IL-3 encodes interleukin 3, a hematopoietic colony-stimulating factor (CSF) that is capable of supporting the proliferation of a broad range of hematopoietic cell types. By using somatic cell hybrids and in situ chromosomal hybridization, we localized this gene to human chromosome 5 at bands q23-31, a chromos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Beau MM,Epstein ND,O'Brien SJ,Nienhuis AW,Yang YC,Clark SC,Rowley JD

更新日期：1987-08-01 00:00:00

abstract：:Murine Ly-6-encoded molecules play an important role in the antigen-independent activation of lymphocytes. We have described the cloning of a cDNA encoding the protein component of an Ly-6 molecule. Hybridization studies indicated that this cDNA identified multiple DNA fragments on Southern blots. The banding pattern ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LeClair KP,Rabin M,Nesbitt MN,Pravtcheva D,Ruddle FH,Palfree RG,Bothwell A

更新日期：1987-03-01 00:00:00

abstract：:Vibrio cholerae serogroup O139 emerged on the Indian subcontinent in October 1992 to become the first non-O1 V. cholerae serogroup documented to cause epidemic cholera. Although related to V. cholerae El Tor O1 strains, O139 strains have unique surface structures that include a capsular surface layer and lipopolysacch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waldor MK,Colwell R,Mekalanos JJ

更新日期：1994-11-22 00:00:00

abstract：:The gaseous phytohormone ethylene C(2)H(4) mediates numerous aspects of growth and development. Genetic analysis has identified a number of critical elements in ethylene signaling, but how these elements interact biochemically to transduce the signal from the ethylene receptor complex at the endoplasmic reticulum (ER)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ju C,Yoon GM,Shemansky JM,Lin DY,Ying ZI,Chang J,Garrett WM,Kessenbrock M,Groth G,Tucker ML,Cooper B,Kieber JJ,Chang C

更新日期：2012-11-20 00:00:00

abstract：:In the usual Darwinian case in which struggle for existence leads to density limitations on the environment's carrying capacity, R. A. Fisher's reproductive-value concept reduces to zero for every initial age group. To salvage some meaning for Fisher's notion, two variant reproductive-value concepts are defined here: ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelson PA

更新日期：1978-12-01 00:00:00

abstract：:The photoaffinity labeling agent 5-azidoindole-3-acetic acid, an analog of the endogenous plant hormone indole-3-acetic acid (an auxin), was used to identify indole-3-acetic acid-binding proteins in maize. Two peptides with subunit molecular masses of 24 and 22 kilodaltons are specifically labeled in a saturable manne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones AM,Venis MA

更新日期：1989-08-01 00:00:00

abstract：:Rapamycin is an immunosuppressive immunophilin ligand reported as having neurotrophic activity. We show that modification of rapamycin at the mammalian target of rapamycin (mTOR) binding region yields immunophilin ligands, WYE-592 and ILS-920, with potent neurotrophic activities in cortical neuronal cultures, efficacy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruan B,Pong K,Jow F,Bowlby M,Crozier RA,Liu D,Liang S,Chen Y,Mercado ML,Feng X,Bennett F,von Schack D,McDonald L,Zaleska MM,Wood A,Reinhart PH,Magolda RL,Skotnicki J,Pangalos MN,Koehn FE,Carter GT,Abou-Gharbia M

更新日期：2008-01-08 00:00:00