Shear stress regulates the endothelial Kir2.1 ion channel.

Abstract:

:Endothelial cells (ECs) line the mammalian vascular system and respond to the hemodynamic stimulus of fluid shear stress, the frictional force produced by blood flow. When ECs are exposed to shear stress, one of the fastest responses is an increase of K(+) conductance, which suggests that ion channels are involved in the early shear stress response. Here we show that an applied shear stress induces a K(+) ion current in cells expressing the endothelial Kir2.1 channel. This ion current shares the properties of the shear-induced current found in ECs. In addition, the shear current induction can be specifically prevented by tyrosine kinase inhibition. Our findings identify the Kir2.1 channel as an early component of the endothelial shear response mechanism.

authors

Hoger JH,Ilyin VI,Forsyth S,Hoger A

doi

10.1073/pnas.102184999

keywords:

subject

Has Abstract

pub_date

2002-05-28 00:00:00

pages

7780-5

issue

11

eissn

0027-8424

issn

1091-6490

journal_volume

99

pub_type

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