Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo.

abstract：:Low passage Fischer rat embryo cultures, which are normally very resistant to transformation by 3-methylcholanthrene but are highly susceptible when chronically infected with the Rauscher murine leukemia virus, were completely protected from transformation by methylcholanthrene when treated with neutralizing antibody ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price PJ,Bellew TM,King MP,Freeman AE,Gilden RV,Huebner RJ

更新日期：1976-01-01 00:00:00

abstract：:Mosquitoes transmit devastating human diseases because they need vertebrate blood for egg development. Metabolism in female mosquitoes is tightly coupled with blood meal-mediated reproduction, which requires an extremely high level of energy consumption. Functional analysis has shown that major genes encoding for enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Hou Y,Saha TT,Pei G,Raikhel AS,Zou Z

更新日期：2017-03-28 00:00:00

abstract：:Glucocorticoids play a critical role in control of the cytokine response after immune challenge. Conversely, cytokines modulate glucocorticoid production by the hypothalamic-pituitary-adrenal axis. To define the potency and mechanism of interleukin-6 (IL-6) for augmentation of adrenal function, we exploited mice defic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bethin KE,Vogt SK,Muglia LJ

更新日期：2000-08-01 00:00:00

abstract：:The mid-winter development of refractoriness to melatonin (Mel) triggers recrudescence of the atrophied reproductive apparatus of rodents. As a consequence, over-wintering animals become reproductively competent just before the onset of spring conditions favorable for breeding. The neural target tissues that cease to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman DA,Zucker I

更新日期：2001-05-22 00:00:00

abstract：:The reduction in levels of the potentially toxic amyloid-beta peptide (Abeta) has emerged as one of the most important therapeutic goals in Alzheimer's disease. Key targets for this goal are factors that affect the expression and processing of the Abeta precursor protein (betaAPP). Earlier reports from our laboratory ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaw KT,Utsuki T,Rogers J,Yu QS,Sambamurti K,Brossi A,Ge YW,Lahiri DK,Greig NH

更新日期：2001-06-19 00:00:00

abstract：:Understanding the mechanisms of nanoparticle interaction with cell membranes is essential for designing materials for applications such as bioimaging and drug delivery, as well as for assessing engineered nanomaterial safety. Much attention has focused on nanoparticles that bind strongly to biological membranes or ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foreman-Ortiz IU,Liang D,Laudadio ED,Calderin JD,Wu M,Keshri P,Zhang X,Schwartz MP,Hamers RJ,Rotello VM,Murphy CJ,Cui Q,Pedersen JA

更新日期：2020-11-10 00:00:00

abstract：:Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. While attempting to isolate full-length TRPM6, we found that the human TRPM6 gene encodes multiple mRNA isoforms. Full-length TRPM6 varian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chubanov V,Waldegger S,Mederos y Schnitzler M,Vitzthum H,Sassen MC,Seyberth HW,Konrad M,Gudermann T

更新日期：2004-03-02 00:00:00

abstract：:Pyruvate ferredoxin oxidoreductase (POR) has been previously purified from the hyperthermophilic archaeon, Pyrococcus furiosus, an organism that grows optimally at 100 degrees C by fermenting carbohydrates and peptides. The enzyme contains thiamine pyrophosphate and catalyzes the oxidative decarboxylation of pyruvate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma K,Hutchins A,Sung SJ,Adams MW

更新日期：1997-09-02 00:00:00

abstract：:Physiological and evolutionary adaptations operate at very different time scales. Nevertheless, there are reasons to believe there should be a strong relationship between the two, as together they modify the phenotype. Physiological adaptations change phenotype by altering certain microscopic parameters; evolutionary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milo R,Hou JH,Springer M,Brenner MP,Kirschner MW

更新日期：2007-10-23 00:00:00

abstract：:Diphtheria toxin ( DTx ) is an extremely potent inhibitor of protein synthesis. It is secreted as a linear polypeptide, which is cleaved to produce disulfide-linked A and B fragments. Fragment A, the inhibitor of protein synthesis, requires fragment B, the recognition subunit, for entry into intact cells. Fragment B h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalman LS,Wisnieski BJ

更新日期：1984-06-01 00:00:00

abstract：:Antigen-induced activation of T cells can be specifically inhibited by antigen analogs that have been termed T-cell receptor peptide antagonists. These antagonists appear to act by inducing the formation of nonstimulatory or partially stimulatory complexes between T-cell receptors and the major histocompatibility comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Page DM,Alexander J,Snoke K,Appella E,Sette A,Hedrick SM,Grey HM

更新日期：1994-04-26 00:00:00

abstract：:Plasma membrane insulin receptors, affinity labeled by covalent crosslinking to receptor-bound 125I-labeled insulin, are shown to appear as a heterogeneous population of three major disulfide-linked complexes (Mr 350,000, 320,000, and 290,000) upon electrophoresis in highly porous dodecyl sulfate/polyacrylamide gels i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Massague J,Pilch PF,Czech MP

更新日期：1980-12-01 00:00:00

abstract：:CCR5 (R5)-tropic, but not CXCR4 (X4)-tropic, HIV-1 is associated with primary HIV-1 infection and transmission. Recent studies have shown that IFN-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, restrict a broad range of viruses. Here, we demonstrate that an IFITM2 isoform (Δ20 IFITM2) la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu WL,Grotefend CR,Tsai MT,Wang YL,Radic V,Eoh H,Huang IC

更新日期：2017-07-03 00:00:00

abstract：:For over a century neuroscientists have debated the dynamics by which human cortical language networks allow words to be spoken. Although it is widely accepted that Broca's area in the left inferior frontal gyrus plays an important role in this process, it was not possible, until recently, to detail the timing of its ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flinker A,Korzeniewska A,Shestyuk AY,Franaszczuk PJ,Dronkers NF,Knight RT,Crone NE

更新日期：2015-03-03 00:00:00

abstract：:An array of photoreceptors including cryptochromes, phototropin, and phytochromes regulates various light responses in plants. Among these photoreceptors, phytochromes perceive red and far-red light by switching between two interconvertible spectral forms (Pr and Pfr). The Pfr form promotes light responses partly by d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paik I,Yang S,Choi G

更新日期：2012-01-24 00:00:00

abstract：:Total cellular poly(A)-enriched RNA from a variety of fresh human leukemic blood cells and hematopoietic cell lines was analyzed for homology with molecularly cloned DNA probes containing the onc sequence of Abelson murine leukemia virus (Ab-MuLV), Harvey murine sarcoma virus (Ha-MuSV), simian sarcoma virus (SSV), and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westin EH,Wong-Staal F,Gelmann EP,Dalla-Favera R,Papas TS,Lautenberger JA,Eva A,Reddy EP,Tronick SR,Aaronson SA,Gallo RC

更新日期：1982-04-01 00:00:00

abstract：:Rapid North Atlantic cooling events during the last deglaciation caused atmospheric reorganizations on global and regional scales. Their impact on Asian climate has been investigated for monsoonal domains, but remains largely unknown in westerly wind-dominated semiarid regions. Here we generate a dust record from sout...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Safaierad R,Mohtadi M,Zolitschka B,Yokoyama Y,Vogt C,Schefuß E

更新日期：2020-08-04 00:00:00

abstract：:The pleiotropic activities of interferons (IFNs) are mediated primarily through the transcriptional regulation of many downstream effector genes. The mRNA profiles from IFN-alpha, -beta, or -gamma treatments of the human fibrosarcoma cell line, HT1080, were determined by using oligonucleotide arrays with probe sets co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Der SD,Zhou A,Williams BR,Silverman RH

更新日期：1998-12-22 00:00:00

abstract：:The high-potential iron-sulfur center associated with the g = 1.89-1.90 electron paramagnetic resonance signal in spinach chloroplasts is fully reduced in the dark. It is photooxidized in the presence of 3-(3,4-dichlorophenyl)-1,1-dimethylurea and reduced after illumination with red actinic light in the absence of inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitmarsh J,Cramer WA

更新日期：1979-09-01 00:00:00

abstract：:Endothelin, originally purified from porcine aortic endothelial cells, is widely distributed in tissues and is recognized as a product of epithelial cells, glial cells, and neurons in addition to endothelial cells. We found evidence by mRNA content and immunoreactivity that this peptide is synthesized in rat parathyro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujii Y,Moreira JE,Orlando C,Maggi M,Aurbach GD,Brandi ML,Sakaguchi K

更新日期：1991-05-15 00:00:00

abstract：:The absorption spectrum of an activesite specific chromophoric acyl enzyme, sturgeon beta-(2-furyl)-acryloyl-glyceraldehyde-3-phosphate dehydrogenase, is reported. This acyl enzyme undergoes all of the catalyzed reactions characteristic of the intermediate of the physiological acyl enzyme, 3-phospho-D-glyceroyl-glycer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malhotra OP,Bernhard SA

更新日期：1973-07-01 00:00:00

abstract：:The phytohormone cytokinin influences many aspects of plant growth and development, several of which also involve the cellular process of autophagy, including leaf senescence, nutrient remobilization, and developmental transitions. The Arabidopsis type-A response regulators (type-A ARR) are negative regulators of cyto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acheampong AK,Shanks C,Cheng CY,Schaller GE,Dagdas Y,Kieber JJ

更新日期：2020-10-27 00:00:00

abstract：:An 125I-labeled synthetic analog of bovine parathyroid hormone, [8-norleucine,18-norleucine,34-tyrosine]PTH-(1-34) amide ([Nle]PTH-(1-34)-NH2), purified by high-pressure liquid chromatography (HPLC), was employed to label the parathyroid hormone (PTH) receptor in cell lines derived from PTH target tissues: the ROS 17/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright BS,Tyler GA,O'Brien R,Caporale LH,Rosenblatt M

更新日期：1987-01-01 00:00:00

abstract：:The myocardin family proteins (myocardin, MRTF-A, and MRTF-B) are serum response factor (SRF) cofactors and potent transcription activators. Gene-ablation studies have indicated important developmental functions for myocardin family proteins primarily in regulation of cardiac and smooth muscle development. Using Xenop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meadows SM,Warkman AS,Salanga MC,Small EM,Krieg PA

更新日期：2008-02-05 00:00:00

abstract：:Attention to a stimulus enhances both neuronal responses and gamma frequency synchrony in visual area V4, both of which should increase the impact of attended information on downstream neurons. To determine whether gamma synchrony is common throughout the ventral stream, we recorded from neurons in the superficial and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buffalo EA,Fries P,Landman R,Buschman TJ,Desimone R

更新日期：2011-07-05 00:00:00

abstract：:Calcicludine (CaC) is a 60-amino acid polypeptide from the venom of Dendroaspis angusticeps. It is structurally homologous to the Kunitz-type protease inhibitor, to dendrotoxins, which block K+ channels, and to the protease inhibitor domain of the amyloid beta protein that accumulates in Alzheimer disease. Voltage-cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweitz H,Heurteaux C,Bois P,Moinier D,Romey G,Lazdunski M

更新日期：1994-02-01 00:00:00

abstract：:There is currently no consensus on the importance of climate change in Mesoamerican prehistory. Some invoke drought as a causal factor in major cultural transitions, including the abandonment of many sites at 900 CE, while others conclude that cultural factors were more important. This lack of agreement reflects the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharya T,Byrne R,Böhnel H,Wogau K,Kienel U,Ingram BL,Zimmerman S

更新日期：2015-02-10 00:00:00

abstract：:The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

更新日期：2017-01-10 00:00:00

abstract：:delta-Aminolevulinic acid (ALA) synthase [succinyl-CoA:glycine C-succinyltransferase (decarboxylating), EC 2.3.1.37] activity was detected in cell extracts of the unicellular green flagellate alga Euglena gracilis. The enzyme was identified by substrate and cofactor requirements, and activity was proportional to numbe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beale SI,Foley T,Dzelzkalns V

更新日期：1981-03-01 00:00:00

abstract：:Spectrin is an important structural component of the plasma membrane skeleton. Heretofore-unidentified isoforms of spectrin also associate with Golgi and other organelles. We have discovered another member of the beta-spectrin gene family by homology searches of the GenBank databases and by 5' rapid amplification of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stankewich MC,Tse WT,Peters LL,Ch'ng Y,John KM,Stabach PR,Devarajan P,Morrow JS,Lux SE

更新日期：1998-11-24 00:00:00