Critical vaporization of MgSiO3.

abstract：:The accuracy of computer predictions of RNA secondary structure from sequence data and free energy parameters has been increased to roughly 70%. Performance is judged by comparison with structures known from phylogenetic analysis. The algorithm also generates suboptimal structures. On average, the best structure withi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaeger JA,Turner DH,Zuker M

更新日期：1989-10-01 00:00:00

abstract：:Congenital malformations now represent the largest single cause of mortality in the infant of the diabetic mother. The mechanism by which diabetes exerts its teratogenic effects is not known. This study evaluated whether arachidonic acid might be involved, a possibility raised by the role of arachidonic acid in palata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldman AS,Baker L,Piddington R,Marx B,Herold R,Egler J

更新日期：1985-12-01 00:00:00

abstract：:Much discussion has occurred in recent years on whether observed patterns of structure in island bird communities are the result of competitive interactions among species or independent rates of colonization and extinction. Here two patterns of structure are presented for birds on 12 West Indian islands. Each of four ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faaborg J

更新日期：1982-03-01 00:00:00

abstract：:One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with relatively larger lesions generally did not display a CR. To investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welters MJ,Kenter GG,de Vos van Steenwijk PJ,Löwik MJ,Berends-van der Meer DM,Essahsah F,Stynenbosch LF,Vloon AP,Ramwadhdoebe TH,Piersma SJ,van der Hulst JM,Valentijn AR,Fathers LM,Drijfhout JW,Franken KL,Oostendorp J,Fle

更新日期：2010-06-29 00:00:00

abstract：:Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have studied two host factors, the spleen and antibody, that influence sequest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： David PH,Hommel M,Miller LH,Udeinya IJ,Oligino LD

更新日期：1983-08-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus 2 originated in Wuhan, China at the end of 2019 and rapidly spread in more than 100 countries. Researchers in different fields have been working on finding explanations for the unequal impact of the virus and deaths from the associated coronavirus disease 2019 (COVID-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arpino B,Bordone V,Pasqualini M

更新日期：2020-08-11 00:00:00

abstract：:Retroviral gene expression is inhibited in embryonal carcinoma (EC) cells. We have constructed a recombinant retroviral vector that is capable of expressing the neomycin-resistance (neo) gene in EC cells. The critical modification that permits expression of the neo gene is the insertion of a composite simian virus 40 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubenstein JL,Nicolas JF,Jacob F

更新日期：1984-11-01 00:00:00

abstract：:Interfacial zones between tissues provide specialized, transitional junctions central to normal tissue function. Regenerative medicine strategies focused on multiple cell types and/or bi/tri-layered scaffolds do not provide continuously graded interfaces, severely limiting the integration and biological performance of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips JE,Burns KL,Le Doux JM,Guldberg RE,García AJ

更新日期：2008-08-26 00:00:00

abstract：:The mammalian retina contains an autonomous circadian clock system that controls many physiological functions within this tissue. Previous studies on young mice have reported that removal of the key circadian clock gene Bmal1 from the retina affects the circadian regulation of visual function, but does not affect phot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baba K,Piano I,Lyuboslavsky P,Chrenek MA,Sellers JT,Zhang S,Gargini C,He L,Tosini G,Iuvone PM

更新日期：2018-12-18 00:00:00

abstract：:Liddle syndrome is a mendelian form of hypertension characterized by constitutively elevated renal Na reabsorption that can result from activating mutations in the beta or gamma subunit of the epithelial Na channel. All reported mutations have deleted the last 45-76 normal amino acids from the cytoplasmic C terminus o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansson JH,Schild L,Lu Y,Wilson TA,Gautschi I,Shimkets R,Nelson-Williams C,Rossier BC,Lifton RP

更新日期：1995-12-05 00:00:00

abstract：:Shiverer (shi) is an autosomal recessive mutation in the mouse characterized by an almost total lack of central nervous system myelin. While small amounts of other myelin components are present in the brain of the shi mouse, the four forms of myelin basic protein (MBP) are not detectable. Previous investigations by us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molineaux SM,Engh H,de Ferra F,Hudson L,Lazzarini RA

更新日期：1986-10-01 00:00:00

abstract：:The fifth exons of major histocompatibility complex (MHC) class I genes encode a transmembrane domain (TM) that is largely responsible for class I antigen cell-surface expression usually through conventional hydrophobic amino acid-membrane interactions or, less often, through phosphatidylinositol linkage. In this repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crew MD,Filipowsky ME,Neshat MS,Smith GS,Walford RL

更新日期：1991-06-01 00:00:00

abstract：:Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due to their unique structural and biophysical features. We here present the development of a binding scaffold based on variable lymphocyte receptors, which are nonimmunoglobulin antibodies composed of Leucine-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SC,Park K,Han J,Lee JJ,Kim HJ,Hong S,Heu W,Kim YJ,Ha JS,Lee SG,Cheong HK,Jeon YH,Kim D,Kim HS

更新日期：2012-02-28 00:00:00

abstract：:In signal-recognition particle (SRP)-dependent protein targeting to the bacterial plasma membrane, two GTPases, Ffh (a subunit of the bacterial SRP) and FtsY (the bacterial SRP receptor), act as GTPase activating proteins for one another. The molecular mechanism of this reciprocal GTPase activation is poorly understoo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shan SO,Walter P

更新日期：2003-04-15 00:00:00

abstract：:Osteogenin was recently purified and the amino acid sequences of tryptic peptides were determined. Osteogenin in conjunction with insoluble collagenous bone matrix induces cartilage and bone formation in vivo. To understand the mechanism of action of osteogenin, we examined its influence on periosteal cells, osteoblas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vukicevic S,Luyten FP,Reddi AH

更新日期：1989-11-01 00:00:00

abstract：:Polyploidy, which results from whole genome duplication (WGD), has shaped the long-term evolution of eukaryotic genomes in all kingdoms. Polyploidy is also implicated in adaptation, domestication, and speciation. Yet when WGD newly occurs, the resulting neopolyploids face numerous challenges. A particularly pernicious...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan C,Zhang H,Henry CE,Franklin FCH,Bomblies K

更新日期：2020-04-21 00:00:00

abstract：:Two 1,4-benzoquinone derivatives, found in the venom of the scorpion Diplocentrus melici following exposure to air, have been isolated, characterized, synthesized, and assessed for antimicrobial activities. Initially a white, viscous liquid, the extracted venom colors within minutes under ambient conditions. From this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo-Noriega EN,Sathyamoorthi S,Banerjee S,Gnanamani E,Mendoza-Trujillo M,Mata-Espinosa D,Hernández-Pando R,Veytia-Bucheli JI,Possani LD,Zare RN

更新日期：2019-06-25 00:00:00

abstract：:The Cdc28 protein kinase functions in the G1 to S phase transition of the cell cycle of the budding yeast Saccharomyces cerevisiae. This is in contrast with observations of the homologous protein kinase from a variety of metazoans, where activity and function are associated with the G2 to M phase transition. We presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed SI,Wittenberg C

更新日期：1990-08-01 00:00:00

abstract：:Absorbance changes in untreated intact leaf discs, produced upon excitation with high-intensity red light, were shown to be due to the photooxidation of cytochrome b-559. At low intensities (<100 W/m2), photooxidation was almost undetectable. Photooxidation occurred with a half-time of 4.3 sec and an extent of 0.64 mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canaani O,Havaux M

更新日期：1990-12-01 00:00:00

abstract：:Treatment of a human breast cancer cell line (MDA-MB-435) in nude mice with a recombinant adenovirus containing the human interferon (IFN) consensus gene, IFN-con1 (ad5/IFN), resulted in tumor regression in 100% of the animals. Tumor regression occurred when virus was injected either within 24 hr of tumor cell implant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang JF,Hu C,Geng Y,Selm J,Klein SB,Orazi A,Taylor MW

更新日期：1996-04-30 00:00:00

abstract：:An integral mitochondrial membrane protein (p32) of yeast has previously been molecularly cloned and sequenced and suggested to function as a mitochondrial import receptor. However, this protein has also been proposed to function as phosphate translocator [Guérin, B., Bukusoglu, C., Rakotomanana, F. & Wohlrab, H. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami H,Blobel G,Pain D

更新日期：1993-04-15 00:00:00

abstract：:Faithful transmission of genetic material to daughter cells involves a characteristic temporal order of DNA replication, which may play a significant role in the inheritance of epigenetic states. We developed a genome-scale approach--Repli Seq--to map temporally ordered replicating DNA using massively parallel sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen RS,Thomas S,Sandstrom R,Canfield TK,Thurman RE,Weaver M,Dorschner MO,Gartler SM,Stamatoyannopoulos JA

更新日期：2010-01-05 00:00:00

abstract：:Recent advances in electrodes for noninvasive recording of electroencephalograms expand opportunities collecting such data for diagnosis of neurological disorders and brain-computer interfaces. Existing technologies, however, cannot be used effectively in continuous, uninterrupted modes for more than a few days due to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Norton JJ,Lee DS,Lee JW,Lee W,Kwon O,Won P,Jung SY,Cheng H,Jeong JW,Akce A,Umunna S,Na I,Kwon YH,Wang XQ,Liu Z,Paik U,Huang Y,Bretl T,Yeo WH,Rogers JA

更新日期：2015-03-31 00:00:00

abstract：:We have developed a color complementation assay that allows rapid screening of specific genomic DNA sequences. It is based on the simultaneous amplification of two or more DNA segments with fluorescent oligonucleotide primers such that the generation of a color, or combination of colors, can be visualized and used for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chehab FF,Kan YW

更新日期：1989-12-01 00:00:00

abstract：:In polyandrous species, fathers benefit from attracting greater maternal investment toward their offspring at the expense of the offspring of other males, while mothers should usually allocate resources equally among offspring. This conflict can lead to an evolutionary arms race between the sexes, manifested through a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raunsgard A,Opedal ØH,Ekrem RK,Wright J,Bolstad GH,Armbruster WS,Pélabon C

更新日期：2018-11-06 00:00:00

abstract：:B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG/ Transducer of ErbB2 gene family and is induced by genotoxic stress in a p53- and Checkpoint kinase 1 (CHK1)-dependent manner. Down-regulation of BTG3 has been observed in human cancers, suggesting that it plays an important role in tumor supp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng YC,Lin TY,Shieh SY

更新日期：2013-04-09 00:00:00

abstract：:Local changes in conformation between the calcium-saturated and calcium-free forms of calmodulin were monitored using antisera to four peptides corresponding to three helical regions of the calcium-saturated protein. The N-terminal helix was monitored using antiserum to residues 9-19, calmodulin-(9-19); the C-terminal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gariépy J,Mietzner TA,Schoolnik GK

更新日期：1986-12-01 00:00:00

abstract：:The ATM (ataxia telangiectasia mutated) protein plays a central role in sensing and responding to DNA double-strand breaks. Lymphoid cells are unique in undergoing physiologic double-strand breaks in the processes of Ig class switch recombination and T or B cell receptor V(D)J recombination, and a role for ATM in thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vacchio MS,Olaru A,Livak F,Hodes RJ

更新日期：2007-04-10 00:00:00

abstract：:Presynaptic and postsynaptic differentiation occurs at axodendritic contacts between CNS neurons. Synaptic adhesion mediated by synaptic cell adhesion molecule (SynCAM) and beta-neurexins/neuroligins triggers presynaptic differentiation. The signals that trigger postsynaptic differentiation are, however, unknown. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nam CI,Chen L

更新日期：2005-04-26 00:00:00

abstract：:We have made direct, quantitative measurements of the lateral motion and age-dependent distribution of acetylcholine receptors (AChR) on the surface of rat myotubes in primary culture. AChR were fluorescently marked with tetramethylrhodamine-labeled alpha-bungarotoxin and AChR lateral motion was measured by the fluore...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axelrod D,Ravdin P,Koppel DE,Schlessinger J,Webb WW,Elson EL,Podleski TR

更新日期：1976-12-01 00:00:00