Sequencing newly replicated DNA reveals widespread plasticity in human replication timing.

abstract：:Recently, surface-sensitive spectroscopy data and molecular dynamics simulations have generated intense interest in the distribution of electrolyte ions between bulk water and the air/water interface. A partitioning model for cations and anions developed for biopolymer surface is extended here to interpret the effects...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pegram LM,Record MT Jr

更新日期：2006-09-26 00:00:00

abstract：:A major virulence factor of Plasmodium falciparum is the adherence of parasitized erythrocytes to the wall of postcapillary venules via a specific interaction between parasite-derived erythrocyte surface ligands and receptors on endothelial cells. To study this phenomenon in vitro, we selected a parasite population th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaiyaroj SC,Coppel RL,Novakovic S,Brown GV

更新日期：1994-11-08 00:00:00

abstract：:Benzophenones are among the most useful photocrosslinking agents in biology. We have evolved an orthogonal aminoacyl-tRNA synthetase/tRNA pair that makes possible the in vivo incorporation of p-benzoyl-l-phenylalanine into proteins in Escherichia coli in response to the amber codon, TAG. This unnatural amino acid was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin JW,Martin AB,King DS,Wang L,Schultz PG

更新日期：2002-08-20 00:00:00

abstract：:Regulatory mechanisms for tissue repair and regeneration within damaged tissue have been extensively studied. However, the systemic regulation of tissue repair remains poorly understood. To elucidate tissue nonautonomous control of repair process, it is essential to induce local damage, independent of genetic manipula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kashio S,Obata F,Zhang L,Katsuyama T,Chihara T,Miura M

更新日期：2016-02-16 00:00:00

abstract：:Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan polysaccharide (SCW), which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) rats do not develop arthritis in response to the same SCW stimulus. To evaluate this difference in inflammat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternberg EM,Hill JM,Chrousos GP,Kamilaris T,Listwak SJ,Gold PW,Wilder RL

更新日期：1989-04-01 00:00:00

abstract：:Direct reciprocity and conditional cooperation are important mechanisms to prevent free riding in social dilemmas. However, in large groups, these mechanisms may become ineffective because they require single individuals to have a substantial influence on their peers. However, the recent discovery of zero-determinant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Wu B,Traulsen A,Nowak MA

更新日期：2014-11-18 00:00:00

abstract：:Epithelia are planar tissues that undergo major morphogenetic movements during development. These movements must work in the context of the mechanical properties of epithelia. Surprisingly little is known about these mechanical properties at the time and length scales of morphogenetic processes. We show that at a time...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luu O,David R,Ninomiya H,Winklbauer R

更新日期：2011-03-08 00:00:00

abstract：:In many plant species only a small proportion of buds yield branches. Both the timing and extent of bud activation are tightly regulated to produce specific branching architectures. For example, the primary shoot apex can inhibit the activation of lateral buds. This process is termed apical dominance and is dependent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prusinkiewicz P,Crawford S,Smith RS,Ljung K,Bennett T,Ongaro V,Leyser O

更新日期：2009-10-13 00:00:00

abstract：:There is considerable evidence that links the activation of cellular genes to oncogenesis. We previously reported that structural rearrangements in the cellular oncogene c-erbB correlate with the development of erythroblastosis induced by avian leukosis virus (ALV). c-erbB recently has been shown to be related to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raines MA,Lewis WG,Crittenden LB,Kung HJ

更新日期：1985-04-01 00:00:00

abstract：:Aortic endothelial cells from normal pigs and pigs with von Willebrand disease have been established in long-term cultures. Both cultures appeared similar in terms of general growth characteristics, morphologic features and ultrastructure. Immunofluorescent staining of these cultures with chicken (or rabbit) antiporci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Booyse FM,Quarfoot AJ,Bell S,Fass DN,Lewis JC,Mann KG,Bowie EJ

更新日期：1977-12-01 00:00:00

abstract：:Loss or reduction in function of tumor suppressor genes contributes to tumorigenesis. Here, by allelic DNA copy number analysis using single-nucleotide polymorphism genotyping array and mass spectrometry, we report homozygous deletion in glioblastoma multiformes at chromosome 13q21, where DACH1 gene is located. We fou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe A,Ogiwara H,Ehata S,Mukasa A,Ishikawa S,Maeda D,Ueki K,Ino Y,Todo T,Yamada Y,Fukayama M,Saito N,Miyazono K,Aburatani H

更新日期：2011-07-26 00:00:00

abstract：:During heat shock, structural changes in proteins and membranes may lead to cell death. While GroE and other chaperone proteins are involved in the prevention of stress-induced protein aggregation and in the recovery of protein structures, a mechanism for short-term membrane stabilization during stress remains to be e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Török Z,Horváth I,Goloubinoff P,Kovács E,Glatz A,Balogh G,Vígh L

更新日期：1997-03-18 00:00:00

abstract：:Although current demands for therapeutic mAbs are growing quickly, production methods to date, including in vitro mammalian tissue culture and transgenic animals, provide only limited quantities at high cost. Several tumor-associated antigens in tumor cells have been identified as targets for therapeutic mAbs. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodzik R,Glogowska M,Bandurska K,Okulicz M,Deka D,Ko K,van der Linden J,Leusen JH,Pogrebnyak N,Golovkin M,Steplewski Z,Koprowski H

更新日期：2006-06-06 00:00:00

abstract：:A mutant strain deficient in RNase T was isolated and used to study the role of this enzyme in Escherichia coli. Strains lacking as much as 70% of RNase T activity, alone or in combination with the absence of other RNases, display normal growth properties. However, in cca strains, which lack tRNA nucleotidyltransferas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deutscher MP,Marlor CW,Zaniewski R

更新日期：1985-10-01 00:00:00

abstract：:Intracellular transport is based on molecular motors that pull cargos along cytoskeletal filaments. One motor species always moves in one direction, e.g., conventional kinesin moves to the microtubule plus end, whereas cytoplasmic dynein moves to the microtubule minus end. However, many cellular cargoes are observed t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller MJ,Klumpp S,Lipowsky R

更新日期：2008-03-25 00:00:00

abstract：:Developmental and physiological responses are regulated by light throughout the entire life cycle of higher plants. To sense changes in the light environment, plants have developed various photoreceptors, including the red/far-red light-absorbing phytochromes and blue light-absorbing cryptochromes. A wide variety of p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bognár LK,Hall A,Adám E,Thain SC,Nagy F,Millar AJ

更新日期：1999-12-07 00:00:00

abstract：:Thrombin induces platelet aggregation and formation of a fibrin clot in platelet-rich plasma; leupeptin, a protease inhibitor, partially inhibits platelet aggregation, but it does not inhibit fibrin clot formation. Indomethacin does not inhibit either thrombin-induced platelet aggregation or fibrin clot formation. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruggiero M,Lapetina EG

更新日期：1986-05-01 00:00:00

abstract：:Teratocarcinoma is a germ-line carcinoma giving rise to an embryoid tumor with structures derived from the three embryonic layers: mesoderm, endoderm, and ectoderm. Teratocarcinoma is widely used as an in vitro model system to study regulation of cell determination and differentiation during mammalian embryogenesis. M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trojan J,Johnson TR,Rudin SD,Blossey BK,Kelley KM,Shevelev A,Abdul-Karim FW,Anthony DD,Tykocinski ML,Ilan J

更新日期：1994-06-21 00:00:00

abstract：:Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in the lung. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alder JK,Chen JJ,Lancaster L,Danoff S,Su SC,Cogan JD,Vulto I,Xie M,Qi X,Tuder RM,Phillips JA 3rd,Lansdorp PM,Loyd JE,Armanios MY

更新日期：2008-09-02 00:00:00

abstract：:Since 1930, areas of state-managed forest in the central Himalayas of India have increasingly been devolved to management by local communities. This article studies the long-run effects of the devolution on the cost of forest management and on forest conservation. Village council-management costs an order of magnitude...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Somanathan E,Prabhakar R,Mehta BS

更新日期：2009-03-17 00:00:00

abstract：:Nuclear RNA of high molecular weight, approximately 15 to 30 x 10(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were inters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes DS,Bonner J

更新日期：1974-04-01 00:00:00

abstract：:In most Gram-positive bacteria, serine-46-phosphorylated HPr (P-Ser-HPr) controls the expression of numerous catabolic genes ( approximately 10% of their genome) by acting as catabolite corepressor. HPr kinase/phosphorylase (HprK/P), the bifunctional sensor enzyme for catabolite repression, phosphorylates HPr, a phosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mijakovic I,Poncet S,Galinier A,Monedero V,Fieulaine S,Janin J,Nessler S,Marquez JA,Scheffzek K,Hasenbein S,Hengstenberg W,Deutscher J

更新日期：2002-10-15 00:00:00

abstract：:Carbon fixation is the process by which CO(2) is incorporated into organic compounds. In modern agriculture in which water, light, and nutrients can be abundant, carbon fixation could become a significant growth-limiting factor. Hence, increasing the fixation rate is of major importance in the road toward sustainabili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-Even A,Noor E,Lewis NE,Milo R

更新日期：2010-05-11 00:00:00

abstract：:We demonstrate that single interneurons can toggle the output neurons of the cerebellar cortex (the Purkinje cells) between their two states. The firing of Purkinje cells has previously been shown to alternate between an "up" state in which the cell fires spontaneous action potentials and a silent "down" state. We sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldfield CS,Marty A,Stell BM

更新日期：2010-07-20 00:00:00

abstract：:The qualities of perception depend not only on the sensory inputs but also on the brain state before stimulus presentation. Although the collective evidence from neuroimaging studies for a relation between prestimulus state and perception is strong, the interpretation in the context of sensory computations or decision...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kayser SJ,McNair SW,Kayser C

更新日期：2016-04-26 00:00:00

abstract：:Tyrosine hydroxylase (EC 1.14.16.2), the enzyme catalyzing the rate-limiting step in catecholamine biosynthesis, was localized by electron microscopy within noradrenergic neurons of the nucleus locus coeruleus of the rat brain with a specific antibody to tyrosine hydroxylase labeled by the peroxidase-antiperoxidase im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pickel VM,Joh TH,Reis DJ

更新日期：1975-02-01 00:00:00

abstract：:Cellular wound healing or the repair of plasma membrane/cell wall damage (plasma membrane damage) occurs frequently in nature. Although various cellular perturbations, such as DNA damage, spindle misalignment, and impaired daughter cell formation, are monitored by cell cycle checkpoint mechanisms in budding yeast, whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kono K,Al-Zain A,Schroeder L,Nakanishi M,Ikui AE

更新日期：2016-06-21 00:00:00

abstract：:Voltage-gated channels maintain cellular resting potentials and generate neuronal action potentials by regulating ion flux. Here, we show that Ether-à-go-go (EAG) K+ channels also regulate intracellular signaling pathways by a mechanism that is independent of ion flux and depends on the position of the voltage sensor....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hegle AP,Marble DD,Wilson GF

更新日期：2006-02-21 00:00:00

abstract：:Direct measurements of the intracellular level of lambda repressor have been made by a DNA-filter assay and a radioimmune assay. Transcription of cI, the structural gene for repressor, appears to initiate at two different promoters, prm and pre. Promoter pre is activated during the establishment of lysogeny by the act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reichardt L,Kaiser AD

更新日期：1971-09-01 00:00:00

abstract：:Statistically significant declines in chronic disability prevalence rates were observed in the elderly United States population between the 1982 and 1989 National Long Term Care Surveys (NLTCS). The 1994 NLTCS was used to investigate whether disability rate declines continued to 1994. The 1982, 1984, 1989, and 1994 NL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manton KG,Corder L,Stallard E

更新日期：1997-03-18 00:00:00