Control of bud activation by an auxin transport switch.

abstract：:The forebrain cholinergic system promotes higher brain function in part by signaling through the M(1) muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic neurons degenerate, therefore selectively activating M(1) receptors could improve cognitive function in these patients whil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma L,Seager MA,Wittmann M,Jacobson M,Bickel D,Burno M,Jones K,Graufelds VK,Xu G,Pearson M,McCampbell A,Gaspar R,Shughrue P,Danziger A,Regan C,Flick R,Pascarella D,Garson S,Doran S,Kreatsoulas C,Veng L,Lindsley C

更新日期：2009-09-15 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system postulated to be a cell-mediated autoimmune disease in which interferon gamma (IFN-gamma) plays an important role. There is increased IFN-gamma secretion in MS, and IFN-gamma administration induces exacerbations of disease. We foun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balashov KE,Smith DR,Khoury SJ,Hafler DA,Weiner HL

更新日期：1997-01-21 00:00:00

abstract：:Antidiuretic hormone (ADH) increases the water permeability of the toad urinary bladder. The increase occurs in the apical plasma membrane of granular cells that line the urinary surface of the bladder and is produced by the insertion of water permeability units that have been identified by freeze-fracture electron mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris HW Jr,Wade JB,Handler JS

更新日期：1988-03-01 00:00:00

abstract：:C factor, an intercellular signaling protein, is required for aggregation and sporulation of the social bacterium, Myxococcus xanthus. We report that C factor, which normally is associated with the cell surface, provides input to the Frz signal transduction cascade. Elements of this cascade have sequence homology to b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Søgaard-Andersen L,Kaiser D

更新日期：1996-04-02 00:00:00

abstract：:The great mass extinctions of the fossil record were a major creative force that provided entirely new kinds of opportunities for the subsequent explosive evolution and diversification of surviving clades. Today, the synergistic effects of human impacts are laying the groundwork for a comparably great Anthropocene mas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson JB

更新日期：2008-08-12 00:00:00

abstract：:Climate models show that particles formed by nucleation can affect cloud cover and, therefore, the earth's radiation budget. Measurements worldwide show that nucleation rates in the atmospheric boundary layer are positively correlated with concentrations of sulfuric acid vapor. However, current nucleation theories do ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen M,Titcombe M,Jiang J,Jen C,Kuang C,Fischer ML,Eisele FL,Siepmann JI,Hanson DR,Zhao J,McMurry PH

更新日期：2012-11-13 00:00:00

abstract：:The translocation from chromosome 8 to chromosome 21, t(8;21), associated with acute myeloid leukemia results in production of an AML1/MTG8(ETO) fusion transcript. The product of the AML1 gene contains an evolutionarily conserved 128-amino acid region referred to as the "Runt domain," which is necessary for binding to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakakura C,Yamaguchi-Iwai Y,Satake M,Bae SC,Takahashi A,Ogawa E,Hagiwara A,Takahashi T,Murakami A,Makino K

更新日期：1994-11-22 00:00:00

abstract：:A 16-amino acid residue peptide derived from a consensus motif of natural ferredoxins incorporates a tetranuclear iron sulfur cluster under physiological conditions. Successful assembly of the [4Fe-4S]2+/1+ cluster within a monomeric peptide was demonstrated using size exclusion chromatography, UV-visible, visible CD,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibney BR,Mulholland SE,Rabanal F,Dutton PL

更新日期：1996-12-24 00:00:00

abstract：:In many eukaryotic systems during immune responses, mitogen-activated protein kinases (MAPKs) link cytoplasmic signaling to chromatin events by targeting transcription factors, chromatin remodeling complexes, and the RNA polymerase machinery. So far, knowledge on these events is scarce in plants and no attempts have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayapuram N,Jarad M,Alhoraibi HM,Bigeard J,Abulfaraj AA,Völz R,Mariappan KG,Almeida-Trapp M,Schlöffel M,Lastrucci E,Bonhomme L,Gust AA,Mithöfer A,Arold ST,Pflieger D,Hirt H

更新日期：2021-01-19 00:00:00

abstract：:Interleukin 3 (IL-3) stimulates the proliferation and differentiation of various haematopoietic progenitor cells. Recently, IL-3 and other cytokines were reported to exert a neurotrophic activity and to be associated with neurological disorders, suggesting their complex role in the central nervous system. We now show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chavany C,Vicario-Abejón C,Miller G,Jendoubi M

更新日期：1998-09-15 00:00:00

abstract：:The recent observation of superconductivity in [Formula: see text] has raised fundamental questions about the hierarchy of the underlying electronic structure. Calculations suggest that this system falls in the Mott-Hubbard regime, rather than the charge-transfer configuration of other nickel oxides and the supercondu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodge BH,Li D,Lee K,Osada M,Wang BY,Sawatzky GA,Hwang HY,Kourkoutis LF

更新日期：2021-01-12 00:00:00

abstract：:Magnetic interactions between dissolved oxygen and nitroxide radical spin probes lead to broadening of the ESR lines. We have used a closed-chamber method based on this property to determine the maximum rate of O2 uptake per cell (Vmax per cell) in cultured mammalian cells. A suitable spin probe and a cell suspension ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai CS,Hopwood LE,Hyde JS,Lukiewicz S

更新日期：1982-02-01 00:00:00

abstract：:The genomes of hyperthermophilic Archaea encode dozens of methylation guide, C/D box small RNAs that guide 2'-O-methylation of ribose to specific sites in rRNA and various tRNAs. The genes encoding the Sulfolobus homologues of eukaryotic proteins that are known to be present in C/D box small nucleolar ribonucleoprotei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Omer AD,Ziesche S,Ebhardt H,Dennis PP

更新日期：2002-04-16 00:00:00

abstract：:Animal studies have shown that the brain is an insulin-responsive organ and that central nervous insulin resistance induces obesity and disturbances in glucose metabolism. In humans, insulin effects in the brain are poorly characterized. We used a magnetoencephalography approach during a two-step hyperinsulinemic eugl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tschritter O,Preissl H,Hennige AM,Stumvoll M,Porubska K,Frost R,Marx H,Klösel B,Lutzenberger W,Birbaumer N,Häring HU,Fritsche A

更新日期：2006-08-08 00:00:00

abstract：:A theoretical description of aqueous hydration in the minor groove of a B-form DNA is presented on the basis of a liquid-state Monte Carlo computer simulation on a system consisting of the oligonucleotide duplex d(CGCGAATTCGCG).d(GCGCTTAAGCGC) in a canonical B-form together with 1777 water molecules contained in a hex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subramanian PS,Ravishanker G,Beveridge DL

更新日期：1988-03-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) knockout mice raised in the laboratory of Fujii-Kuriyama have been under investigation for several years because of the presence in their urinary bladder of large, yellowish stones. The stones are composed of uric acid and become apparent in the bladders as tiny stones when mice are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler R,Inzunza J,Suzuki H,Fujii-Kuriyama Y,Warner M,Gustafsson JÅ

更新日期：2012-01-24 00:00:00

abstract：:Protein aggregation is a complex physiological process, primarily determined by stress-related factors revealing the hidden aggregation propensity of proteins that otherwise are fully soluble. Here we report a mechanism by which glycolytic glyceraldehyde-3-phosphate dehydrogenase of Arabidopsis thaliana (AtGAPC1) is p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaffagnini M,Marchand CH,Malferrari M,Murail S,Bonacchi S,Genovese D,Montalti M,Venturoli G,Falini G,Baaden M,Lemaire SD,Fermani S,Trost P

更新日期：2019-12-17 00:00:00

abstract：:For more than a century we have understood that our brain's left hemisphere is the primary site for processing language, yet why this is so has remained more elusive. Using positron emission tomography, we report cerebral blood flow activity in profoundly deaf signers processing specific aspects of sign language in ke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petitto LA,Zatorre RJ,Gauna K,Nikelski EJ,Dostie D,Evans AC

更新日期：2000-12-05 00:00:00

abstract：:Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zoltowski BD,Chelliah Y,Wickramaratne A,Jarocha L,Karki N,Xu W,Mouritsen H,Hore PJ,Hibbs RE,Green CB,Takahashi JS

更新日期：2019-09-24 00:00:00

abstract：:Our research addresses the relationship between subnuclear localization and gene expression in fission yeast. We observed the relocalization of a heterochromatic region, the mating-type region, from its natural location at the spindle-pole body to the immediate vicinity of the nucleolus. Relocalization occurred in res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jakociunas T,Domange Jordö M,Aït Mebarek M,Bünner CM,Verhein-Hansen J,Oddershede LB,Thon G

更新日期：2013-11-19 00:00:00

abstract：:Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, we used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Chao TC,Chang KY,Lin N,Patil VS,Shimizu C,Head SR,Burns JC,Rana TM

更新日期：2014-01-21 00:00:00

abstract：:Smooth muscle cells (SMCs) have been shown to migrate in response to insulin-like growth factor I (IGF-I). However, the mechanism mediating this response has not been determined. The migration rates of porcine and human vascular SMCs were assessed in a monolayer wounding assay. IGF-I and IGF-II induced increases of 14...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones JI,Prevette T,Gockerman A,Clemmons DR

更新日期：1996-03-19 00:00:00

abstract：:Our laboratory has previously developed cell lines derived from mouse NIH 3T3 fibroblasts and C127 mammary tumor cells that stably express mouse mammary tumor virus (MMTV) long terminal repeat fusion genes in bovine papillomavirus-based episomes. Glucocorticoid hormone strongly activates transcription from episomes an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bresnick EH,John S,Berard DS,LeFebvre P,Hager GL

更新日期：1990-05-01 00:00:00

abstract：:Sympathetic ganglia and some peripheral tissues of adult guinea pig and cat were analyzed by the indirect immunofluorescence technique with antisera to catecholamine-synthesizing enzymes and some peptides. In the guinea pig, noradrenergic neurons could be subdivided into three populations containing respectively (i) s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lundberg JM,Hökfelt T,Anggård A,Terenius L,Elde R,Markey K,Goldstein M,Kimmel J

更新日期：1982-02-01 00:00:00

abstract：:A detailed model for the structure and dynamics of the interior of the lipid bilayer in the liquid crystal phase is presented. The model includes two classes of motion: (i) the internal dynamics of the chains, determined from Brownian dynamics simulations with a continuous version of the Marcelja mean-field potential,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pastor RW,Venable RM,Karplus M

更新日期：1991-02-01 00:00:00

abstract：:The majority of bacteria in the natural environment live within the confines of a biofilm. The Gram-positive bacterium Bacillus subtilis forms biofilms that exhibit a characteristic wrinkled morphology and a highly hydrophobic surface. A critical component in generating these properties is the protein BslA, which form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bromley KM,Morris RJ,Hobley L,Brandani G,Gillespie RM,McCluskey M,Zachariae U,Marenduzzo D,Stanley-Wall NR,MacPhee CE

更新日期：2015-04-28 00:00:00

abstract：:The energetics of the TiO(2) polymorphs (rutile, anatase, and brookite) were studied by high temperature oxide melt drop solution calorimetry. Relative to bulk rutile, bulk brookite is 0.71 +/- 0.38 kJ/mol (6) and bulk anatase is 2.61 +/- 0.41 kJ/mol higher in enthalpy. The surface enthalpies of rutile, brookite, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranade MR,Navrotsky A,Zhang HZ,Banfield JF,Elder SH,Zaban A,Borse PH,Kulkarni SK,Doran GS,Whitfield HJ

更新日期：2002-04-30 00:00:00

abstract：:Protecting hydrologic connectivity of freshwater ecosystems is fundamental to ensuring species persistence, ecosystem integrity, and human well-being. More frequent and severe droughts associated with climate change are poised to significantly alter flow intermittence patterns and hydrologic connectivity in dryland st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaeger KL,Olden JD,Pelland NA

更新日期：2014-09-23 00:00:00

abstract：:Germ-line stem cells (GSCs) are maintained by the somatic microenvironment, or GSC niche, which ensures that GSCs can both self-renew and produce functional gametes. However, it remains unclear how the proper niche size and location are regulated within the developing gonads. In the Drosophila testis, the hub cells th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitadate Y,Kobayashi S

更新日期：2010-08-10 00:00:00

abstract：:The exquisite selectivity and catalytic activity of enzymes have been shaped by the effects of positive and negative selection pressure during the course of evolution. In contrast, enzyme variants engineered by using in vitro screening techniques to accept novel substrates typically display a higher degree of catalyti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varadarajan N,Gam J,Olsen MJ,Georgiou G,Iverson BL

更新日期：2005-05-10 00:00:00