Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor.

abstract：:The question of what is a perceptual object is one of the most central and also controversial issues in cognitive science. According to the topological approach to perceptual organization, the core intuitive notion of an object--the holistic identity preserved over shape-changing transformations--may be characterized ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou K,Luo H,Zhou T,Zhuo Y,Chen L

更新日期：2010-12-14 00:00:00

abstract：:Microinjection of plasmids encoding human tau (htau) protein into identified lamprey reticulospinal neurons (anterior bulbar cells, or ABCs) in situ induces chronic htau expression. htau protein is transported to both the axon and dendrites of expressing ABCs by mechanisms that require the C-terminal domain of htau pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hall GF,Yao J,Lee G

更新日期：1997-04-29 00:00:00

abstract：:Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same period...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-Emmenegger C,Xiao Q,Kostina NY,Sherman SE,Rahimi K,Partridge BE,Li S,Sahoo D,Reveron Perez AM,Buzzacchera I,Han H,Kerzner M,Malhotra I,Möller M,Wilson CJ,Good MC,Goulian M,Baumgart T,Klein ML,Percec V

更新日期：2019-03-19 00:00:00

abstract：:DNA was extracted from the remains of 35 ground sloths from various parts of North and South America. Two specimens of Mylodon darwinii, a species that went extinct at the end of the last glaciation, yielded amplifiable DNA. However, of the total DNA extracted, only approximately 1/1000 originated from the sloth, wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Höss M,Dilling A,Currant A,Pääbo S

更新日期：1996-01-09 00:00:00

abstract：:Unlike αβ-T lineage cells, where the role of ligand in intrathymic selection is well established, the role of ligand in the development of γδ-T cells remains controversial. Here we provide evidence for the role of a bona fide selecting ligand in shaping the γδ-T cell-receptor (TCR) repertoire. Reactivity of the γδ-TCR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fahl SP,Coffey F,Kain L,Zarin P,Dunbrack RL Jr,Teyton L,Zúñiga-Pflücker JC,Kappes DJ,Wiest DL

更新日期：2018-02-20 00:00:00

abstract：:Astrocytes regulate synaptic transmission through controlling neurotransmitter concentrations around synapses. Little is known, however, about their roles in neural circuit development. Here we report that Bergmann glia (BG), specialized cerebellar astrocytes that thoroughly enwrap Purkinje cells (PCs), are essential ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyazaki T,Yamasaki M,Hashimoto K,Kohda K,Yuzaki M,Shimamoto K,Tanaka K,Kano M,Watanabe M

更新日期：2017-07-11 00:00:00

abstract：:Over the past 50 y, behavioral experiments have produced a large body of evidence for the existence of a magnetic sense in a wide range of animals. However, the underlying sensory physiology remains poorly understood due to the elusiveness of the magnetosensory structures. Here we present an effective method for isola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eder SH,Cadiou H,Muhamad A,McNaughton PA,Kirschvink JL,Winklhofer M

更新日期：2012-07-24 00:00:00

abstract：:Interleukin 1 (IL-1) is a two-member family of proteins (IL-1 alpha and IL-1 beta) that mediates a diverse series of immune and inflammatory responses. These two proteins have only 26% amino acid homology yet bind to the same receptor. It is of importance to define the active sites of these molecules in order to under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosley B,Dower SK,Gillis S,Cosman D

更新日期：1987-07-01 00:00:00

abstract：:Multiple cues, across multiple sensory modalities, are involved in mate choice in a wide range of animal taxa. This multiplicity leads to the prediction that, in adaptive radiations, sexual isolation results from divergence in multiple dimensions. However, difficulties in directly measuring preferences and detecting m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohenlohe PA,Arnold SJ

更新日期：2010-09-21 00:00:00

abstract：:The interaction of carboxylate ions (acetate, butyrate) with nucleic aicd bases and nucleosides has been investigated by proton magnetic resonance in dimethyl sulfoxide (d6)/H2O mixtures. Carboxylate ions interacted only with guanine derivatives and led to a large downfield shift of the NH2 resonance. A 1:1 stoichiome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lancelot G,Hélène C

更新日期：1977-11-01 00:00:00

abstract：:A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growing number of candidate risk genes and gene variants of unknown functional significance. Here, we used Caenorhabditis elegans to systematically functionally characterize ASD-associated genes in vivo. Using our custom machine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McDiarmid TA,Belmadani M,Liang J,Meili F,Mathews EA,Mullen GP,Hendi A,Wong WR,Rand JB,Mizumoto K,Haas K,Pavlidis P,Rankin CH

更新日期：2020-01-07 00:00:00

abstract：:Neutrophils and dendritic cells when migrating in confined environments have been shown to actuate a directional choice toward paths of least hydraulic resistance (barotaxis), in some cases overriding chemotactic responses. Here, we investigate whether this barotactic response is conserved in the more primitive model ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belotti Y,McGloin D,Weijer CJ

更新日期：2020-10-13 00:00:00

abstract：:Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. Here, we combine principles of microengineering, surface chemistry, and molecular biology to address the major limitations of standard ChIP-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dainese R,Gardeux V,Llimos G,Alpern D,Jiang JY,Meireles-Filho ACA,Deplancke B

更新日期：2020-06-16 00:00:00

abstract：:Gamma-band synchronization adjusts the timing of excitatory and inhibitory inputs to a neuron. Neurons in the visual cortex are selective for stimulus orientation because of dynamic interactions between excitatory and inhibitory inputs. We hypothesized that these interactions and hence also orientation selectivity var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Womelsdorf T,Lima B,Vinck M,Oostenveld R,Singer W,Neuenschwander S,Fries P

更新日期：2012-03-13 00:00:00

abstract：:A major goal of tumor immunotherapy is the effective eradication of established metastases associated with the induction of a T cell-mediated protective immunity. We achieved this in a poorly immunogenic murine neuroblastoma model by gene therapy with a single chain interleukin 12 (scIL-12) fusion protein that assures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lode HN,Dreier T,Xiang R,Varki NM,Kang AS,Reisfeld RA

更新日期：1998-03-03 00:00:00

abstract：:Mixed synthetic oligonucleotides encoding sequences conserved among tyrosine-specific protein kinases were used to probe the genome of the budding yeast Saccharomyces cerevisiae. Two genes with homology to protein kinases were isolated and characterized by DNA sequence analysis. These genes, designated KIN1 and KIN2, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin DE,Hammond CI,Ralston RO,Bishop JM

更新日期：1987-09-01 00:00:00

abstract：:Retinal prosthetics offer hope for patients with retinal degenerative diseases. There are 20-25 million people worldwide who are blind or facing blindness due to these diseases, and they have few treatment options. Drug therapies are able to help a small fraction of the population, but for the vast majority, their bes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nirenberg S,Pandarinath C

更新日期：2012-09-11 00:00:00

abstract：:Periodic fluctuations in past biodiversity, speciation, and extinction have been proposed, with extremely long periods ranging from 26 to 62 million years, although forcing mechanisms remain speculative. In contrast, well-understood periodic Milankovitch climate forcing represents a viable driver for macroevolutionary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crampton JS,Meyers SR,Cooper RA,Sadler PM,Foote M,Harte D

更新日期：2018-05-29 00:00:00

abstract：:The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for studying inhibitory molecules that can modify the degree of cell proliferation. The discovery of specific inhibitors of CDKs such as polyhydroxylated flavones has opened the way to investigation and design of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Azevedo WF Jr,Mueller-Dieckmann HJ,Schulze-Gahmen U,Worland PJ,Sausville E,Kim SH

更新日期：1996-04-02 00:00:00

abstract：:Let Lambda=SL(2)(Z) be the modular group and let c(n)(Lambda) be the number of congruence subgroups of Lambda of index at most n. We prove that lim(n--> infinity )(log c(n)(Lambda)/((log n)(2)/log log n))=(3-2(sqrt)2)/4. The proof is based on the Bombieri-Vinogradov "Riemann hypothesis on the average" and on the solut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldfeld D,Lubotzky A,Nikolov N,Pyber L

更新日期：2004-09-14 00:00:00

abstract：:We have found that 1 of 20 human tumors transplanted and passaged in nude mice was associated with a massive induction of endogenous murine leukemia virus (MuLV). Separation and growth of these viruses on various substrates indicated that both ecotropic and xenotropic MuLV were present in the induced mixture. Tryptic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gautsch JW,Knowles AF,Jensen FC,Kaplan NO

更新日期：1980-04-01 00:00:00

abstract：:A molecular dynamics study was performed to compare the differences in the active-site dynamics of the wild-type and W137F mutant enzymes of 4-chlorobenzoyl-CoA dehalogenase. Only in the wild-type simulation are conformations formed between the catalytic Asp-145 and 4-chlorobenzoyl-CoA, which resemble the ab initio ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau EY,Bruice TC

更新日期：2001-08-14 00:00:00

abstract：:Conjugative DNA transfer of the self-transmissible broad-host-range plasmid RP4 is initiated by strand- and site-specific cleavage at the nick site (nic) of the transfer origin (oriT). Cleavage results in covalent attachment of the plasmid-encoded relaxase (TraI) to the 5'-terminal 2'-deoxycytidine residue at nic. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pansegrau W,Schröder W,Lanka E

更新日期：1993-04-01 00:00:00

abstract：:A simple protocol for the rescue of a synthetic genome into a paramyxovirus has been developed. First, a synthetic Sendai virus-like RNA, containing the antisense coding region of the chloramphenicol acetyltransferase gene replacing the coding region of the Sendai virus genome, was transcribed from a cDNA. When introd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park KH,Huang T,Correia FF,Krystal M

更新日期：1991-07-01 00:00:00

abstract：:Fungi must recognize plant-specific signals to initiate subsequent morphogenetic events such as filamentation that lead to infection. Here we show that the plant hormone indoleacetic acid (IAA) induces adhesion and filamentation of Saccharomyces cerevisiae. Genome expression profiling of cells treated with IAA identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prusty R,Grisafi P,Fink GR

更新日期：2004-03-23 00:00:00

abstract：:Plant cuticles are composed of wax and cutin and evolved in the land plants as a hydrophobic boundary that reduces water loss from the plant epidermis. The expanding maize adult leaf displays a dynamic, proximodistal gradient of cuticle development, from the leaf base to the tip. Laser microdissection RNA Sequencing (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiao P,Bourgault R,Mohammadi M,Matschi S,Philippe G,Smith LG,Gore MA,Molina I,Scanlon MJ

更新日期：2020-06-02 00:00:00

abstract：:Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen KL,Eberli D,Yoo JJ,Atala A

更新日期：2010-02-23 00:00:00

abstract：:Much of the success of Plasmodium falciparum in establishing persistent infections is attributed to immune evasion through antigenic variation. This process involves periodically exchanging variants of the major surface antigen PfEMP1, a protein also responsible for parasite cytoadherence. PfEMP1 is encoded by genes o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ralph SA,Scheidig-Benatar C,Scherf A

更新日期：2005-04-12 00:00:00

abstract：:Several different families of DNA viruses encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions to bind E2F transcription factors and restrict expression of genes necessary for cellular processes including DNA replication. Human cytomegalovirus (HCMV) UL97...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamil JP,Hume AJ,Jurak I,Münger K,Kalejta RF,Coen DM

更新日期：2009-09-29 00:00:00

abstract：:By use of the indirect peroxidase-antiperoxidase complex immunocytochemical technique, antibody to purified human renal renin was applied to formalin-fixed paraffin sections of human cadaver brain. Immune reaction products were observed in most nerve cells in all areas of the brain examined; staining was limited to th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slater EE,Defendini R,Zimmerman EA

更新日期：1980-09-01 00:00:00