Rescue of a foreign gene by Sendai virus.

abstract：:We investigated the effect of actin filament barbed end uncapping on Arp23 complex function both in vivo and in vitro. Arp23 complex redistributes rapidly and uniformly to the lamellar edge of activated wild-type platelets and fibroblasts but clusters in marginal actin filament clumps in gelsolin-null cells. Treatment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falet H,Hoffmeister KM,Neujahr R,Italiano JE Jr,Stossel TP,Southwick FS,Hartwig JH

更新日期：2002-12-24 00:00:00

abstract：:The timing of human colonization of East Polynesia, a vast area lying between Hawai'i, Rapa Nui, and New Zealand, is much debated and the underlying causes of this great migration have been enigmatic. Our study generates evidence for human dispersal into eastern Polynesia from islands to the west from around AD 900 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sear DA,Allen MS,Hassall JD,Maloney AE,Langdon PG,Morrison AE,Henderson ACG,Mackay H,Croudace IW,Clarke C,Sachs JP,Macdonald G,Chiverrell RC,Leng MJ,Cisneros-Dozal LM,Fonville T,Pearson E

更新日期：2020-04-21 00:00:00

abstract：:Vanilloid receptor subunit 1 (VR1) appears to play a critical role in the transduction of noxious chemical and thermal stimuli by sensory nerve endings in peripheral tissues. Thus, VR1 antagonists are useful compounds to unravel the contribution of this receptor to pain perception, as well as to induce analgesia. We h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García-Martinez C,Humet M,Planells-Cases R,Gomis A,Caprini M,Viana F,De La Pena E,Sanchez-Baeza F,Carbonell T,De Felipe C,Pérez-Paya E,Belmonte C,Messeguer A,Ferrer-Montiel A

更新日期：2002-02-19 00:00:00

abstract：:Chylomicron catabolism is known to be initiated by the enzyme lipoprotein lipase (triacylglycero-protein acylhydrolase, EC 3.1.1.34). Chylomicron remnants, produced by lipolysis, are rapidly taken up by the liver via an apolipoprotein E (apoE)-mediated, receptor-dependent process. The low density lipoprotein (LDL) rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beisiegel U,Weber W,Bengtsson-Olivecrona G

更新日期：1991-10-01 00:00:00

abstract：:Creatine kinase from rabbit muscle has been specifically labeled with a derivative of a nitroxide free radical on the two essential sulfhydryl groups, one per active site. The conformation in the environment of the enzyme-bound free radical and the change in conformation induced upon binding of the substrate, metal ad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor JS,Leigh JS Jr,Cohn M

更新日期：1969-09-01 00:00:00

abstract：:The cancer stem cell hypothesis posits that tumors are derived from a single cancer-initiating cell with stem cell properties. The task of identifying and characterizing a single cancer-initiating cell with stem cell properties has proven technically difficult because of the scarcity of the cancer stem cells in the ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zucchi I,Sanzone S,Astigiano S,Pelucchi P,Scotti M,Valsecchi V,Barbieri O,Bertoli G,Albertini A,Reinbold RA,Dulbecco R

更新日期：2007-06-19 00:00:00

abstract：:A series of hairpin pyrrole-imidazole polyamide-fluorescein conjugates were synthesized and assayed for cellular localization. Thirteen cell lines, representing 11 human cancers, one human transformed kidney cell line, and one murine leukemia cell line, were treated with 5 microM polyamide-fluorescein conjugates for 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Best TP,Edelson BS,Nickols NG,Dervan PB

更新日期：2003-10-14 00:00:00

abstract：:Mutations in the gene encoding the endothelin receptor type B (EDNRB) produce congenital aganglionic megacolon and pigment abnormalities in mice and humans. Here we report a naturally occurring null mutation of the EDNRB gene in spotting lethal (sl) rats, which exhibit aganglionic megacolon associated with white coat ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gariepy CE,Cass DT,Yanagisawa M

更新日期：1996-01-23 00:00:00

abstract：:Comparative genomics of closely related bacterial isolates is a powerful method for uncovering virulence and other important genome elements. We determined draft sequences (8-fold coverage) of the genomes of strains JD1 and N40 of Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease, and we compared...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu WG,Schutzer SE,Bruno JF,Attie O,Xu Y,Dunn JJ,Fraser CM,Casjens SR,Luft BJ

更新日期：2004-09-28 00:00:00

abstract：:Relatively little is known about neurobiological changes attributable to early-life stressors (e.g., orphanage rearing), even though they have been associated with a heightened risk for later psychopathology. Human neuroimaging and animal studies provide complementary insights into the neural basis of problem behavior...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malter Cohen M,Jing D,Yang RR,Tottenham N,Lee FS,Casey BJ

更新日期：2013-11-05 00:00:00

abstract：:Endoproteolytic processing of the human protein C (HPC) precursor to its mature form involves cleavage of the propeptide after amino acids Lys-2-Arg-1 and removal of a Lys156-Arg157 dipeptide connecting the light and heavy chains. This processing was inefficient in the mammary gland of transgenic mice and pigs. We hyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drews R,Paleyanda RK,Lee TK,Chang RR,Rehemtulla A,Kaufman RJ,Drohan WN,Luboń H

更新日期：1995-11-07 00:00:00

abstract：:Break-induced replication (BIR) refers to recombination-dependent DNA synthesis initiated from one end of a DNA double-strand break and can extend for more than 100 kb. BIR initiates by Rad51-catalyzed strand invasion, but the mechanism for DNA synthesis is not known. Here, we used BrdU incorporation to track DNA synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donnianni RA,Symington LS

更新日期：2013-08-13 00:00:00

abstract：:Experimental systemic lupus erythematosus (SLE) can be induced in naive mice by immunization with a murine monoclonal anti-DNA antibody (mAb), 5G12, that bears a major idiotype designated 16/6 Id. Strain-dependent differences were observed in the proliferative responses of lymph node cells of mice immunized with two p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waisman A,Ruiz PJ,Israeli E,Eilat E,Könen-Waisman S,Zinger H,Dayan M,Mozes E

更新日期：1997-04-29 00:00:00

abstract：:Small molecules produced by Actinobacteria have played a prominent role in both drug discovery and organic chemistry. As part of a larger study of the actinobacterial symbionts of fungus-growing ants, we discovered a small family of three previously unreported piperazic acid-containing cyclic depsipeptides, gerumycins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sit CS,Ruzzini AC,Van Arnam EB,Ramadhar TR,Currie CR,Clardy J

更新日期：2015-10-27 00:00:00

abstract：:The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leadi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliveira JB,Bidère N,Niemela JE,Zheng L,Sakai K,Nix CP,Danner RL,Barb J,Munson PJ,Puck JM,Dale J,Straus SE,Fleisher TA,Lenardo MJ

更新日期：2007-05-22 00:00:00

abstract：:Expression systems based on the Escherichia coli arabinose operon P(BAD) promoter exhibit the all-or-nothing (autocatalytic) induction of expression that was first documented in the lac operon. Under conditions of subsaturating levels of inducer, some of the cells of the population are fully induced, whereas other cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan-Kiss RM,Wadler C,Cronan JE Jr

更新日期：2002-05-28 00:00:00

abstract：:Plants have evolved adaptive strategies that involve transcriptional networks to cope with and survive environmental challenges. Key transcriptional regulators that mediate responses to environmental fluctuations in nitrate have been identified; however, little is known about how these regulators interact to orchestra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan P,Ripoll JJ,Wang R,Vuong L,Bailey-Steinitz LJ,Ye D,Crawford NM

更新日期：2017-02-28 00:00:00

abstract：:Protein misfolding and deposition underlie an increasing number of debilitating human disorders. We have shown that model proteins unrelated to disease, such as the Src homology 3 (SH3) domain of the p58alpha subunit of bovine phosphatidyl-inositol-3'-kinase (PI3-SH3), can be converted in vitro into assemblies with st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura S,Zurdo J,Narayanan S,Parreño M,Mangues R,Reif B,Chiti F,Giannoni E,Dobson CM,Aviles FX,Serrano L

更新日期：2004-05-11 00:00:00

abstract：:We use the inverse scattering method to determine the weak limit of solutions of the Korteweg-deVries equation as dispersion tends to zero. The limit, valid for all time, is characterized in terms of a quadratic programming problem which can be solved with the aid of function theoretic methods. For large t, the soluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lax PD,Levermore CD

更新日期：1979-08-01 00:00:00

abstract：:Brief learning experience (classical conditioning) induces frequency-specific receptive-field (RF) plasticity in the auditory cortex, characterized as increased response to the frequency of the conditioned stimulus and decreased responses to most other frequencies, including the pretraining best frequency. This experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinberger NM,Javid R,Lepan B

更新日期：1993-03-15 00:00:00

abstract：:Global energy demand and environmental concerns have stimulated increasing efforts to produce carbon-neutral fuels directly from renewable resources. Microbially derived aliphatic hydrocarbons, the petroleum-replica fuels, have emerged as promising alternatives to meet this goal. However, engineering metabolic pathway...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu P,Li L,Zhang F,Stephanopoulos G,Koffas M

更新日期：2014-08-05 00:00:00

abstract：:The growth of a small number of cells from each of two chemically induced BALB/c sarcomas was enhanced when x-irradiated (15,000 rads) cells of the same sarcoma were mixed with the tumor inoculum. This enhancement did not occur if the recipients had been given a total body x-irradiation of 450 rads. Tumor neutralizati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellström KE,Hellström I

更新日期：1978-01-01 00:00:00

abstract：:We solve a discrete version of the classic Plateau problem, which asks for a minimal surface spanning a given curve. Our algorithm is based on a network-flow formulation that finds minimal slabs, intuitively corresponding to minimal "surfaces" of prescribed thickness. We let the slab thickness approach zero in order t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu TC,Kahng AB,Robins G

更新日期：1992-10-01 00:00:00

abstract：:To reduce greenhouse gas emissions from deforestation, Indonesia instituted a nationwide moratorium on new license areas ("concessions") for oil palm plantations, timber plantations, and logging activity on primary forests and peat lands after May 2011. Here we indirectly evaluate the effectiveness of this policy usin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busch J,Ferretti-Gallon K,Engelmann J,Wright M,Austin KG,Stolle F,Turubanova S,Potapov PV,Margono B,Hansen MC,Baccini A

更新日期：2015-02-03 00:00:00

abstract：:Let T(k) (epsilon)(lambda; t(1),..., t(k)) = rho(X(t) (1))q(epsilon)(X(t) (2) - X(t) (1))... q(epsilon)(X(t(k) ) - X(t(k) )-1), where X(t) is a Brownian motion in R(2), lambda(dx) = rho(x)dx, and q(epsilon) converges to Dirac's delta function as epsilon downward arrow 0. The self-intersection local times of order k ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dynkin EB

更新日期：1986-06-01 00:00:00

abstract：:Burkitt's lymphomas, linked by previous studies with the DNA-containing Epstein-Barr virus, contain an RNA related in sequence to that of Rauscher leukemia virus. The present study establishes that the viral-related RNA found in Burkitt's tumors is a 70S component encapsulated with RNA-instructed DNA polymerase in a p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kufe D,Magrath IT,Ziegler JL,Spiegelman S

更新日期：1973-03-01 00:00:00

abstract：:By double indirect immunofluorescence, using primary rabbit antibodies to tubulin and guinea pig antibodies to vimentin, we have simultaneously labeled microtubules and intermediate filaments in several types of cultured normal fibroblasts. With well-spread interphase cells there was an extensive but not complete corr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ball EH,Singer SJ

更新日期：1981-11-01 00:00:00

abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. The Rag heterodimer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen K,Sabatini DM

更新日期：2018-09-18 00:00:00

abstract：:The prediction of binding sites and the understanding of interfaces associated with protein complexation remains an open problem in molecular biophysics. This work shows that a crucial factor in predicting and rationalizing protein-protein interfaces can be inferred by assessing the extent of intramolecular desolvatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Scheraga HA

更新日期：2003-01-07 00:00:00

abstract：:Adult human brains retain the capacity to undergo tissue reorganization during second-language learning. Brain-imaging studies show a relationship between neuroanatomical properties and learning for adults exposed to a second language. However, the role of genetic factors in this relationship has not been investigated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mamiya PC,Richards TL,Coe BP,Eichler EE,Kuhl PK

更新日期：2016-06-28 00:00:00