The properties of a mammary gland cancer stem cell.

abstract：:Metabolic imaging of the relative amounts of reduced NADH and FAD and the microenvironment of these metabolic electron carriers can be used to noninvasively monitor changes in metabolism, which is one of the hallmarks of carcinogenesis. This study combines cellular redox ratio, NADH and FAD lifetime, and subcellular m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skala MC,Riching KM,Gendron-Fitzpatrick A,Eickhoff J,Eliceiri KW,White JG,Ramanujam N

更新日期：2007-12-04 00:00:00

abstract：:The cdc25 phosphatases play key roles in cell cycle progression by activating cyclin-dependent kinases. Two members of the 14-3-3 protein family have been isolated in a yeast two-hybrid screen designed to identify proteins that interact with the human cdc25A and cdc25B phosphatases. Genes encoding the human homolog of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conklin DS,Galaktionov K,Beach D

更新日期：1995-08-15 00:00:00

abstract：:Albatrosses (Diomedeidae) do not occur in the North Atlantic Ocean today except as vagrants, although five species were present in the early Pliocene. No fossil breeding sites of albatrosses were known previously. The timing of extinction of albatrosses in the North Atlantic was likewise unknown. Deposits that formed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olson SL,Hearty PJ

更新日期：2003-10-28 00:00:00

abstract：:Activation of the androgen receptor (AR) may play a role in androgen-independent progression of prostate cancer. Multiple mechanisms of AR activation, including stimulation by tyrosine kinases, have been postulated. We and others have recently shown involvement of activated Cdc42-associated tyrosine kinase Ack1 in adv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahajan NP,Liu Y,Majumder S,Warren MR,Parker CE,Mohler JL,Earp HS,Whang YE

更新日期：2007-05-15 00:00:00

abstract：:Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in frozen glassy matrices). This approach has shown enormous pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gajan D,Bornet A,Vuichoud B,Milani J,Melzi R,van Kalkeren HA,Veyre L,Thieuleux C,Conley MP,Grüning WR,Schwarzwälder M,Lesage A,Copéret C,Bodenhausen G,Emsley L,Jannin S

更新日期：2014-10-14 00:00:00

abstract：:Analyses of genomic DNA and clones indicate that the pyruvate, orthophosphate dikinase (PPDK; ATP: pyruvate, orthophosphate phosphotransferase, EC 2.7.9.1) gene family of maize (Zea mays L. subsp. mays, line B73) contains two members. Restriction site and DNA sequence comparisons between PPDK genomic and leaf cDNA clo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glackin CA,Grula JW

更新日期：1990-04-01 00:00:00

abstract：:Column chromatography on (dT)(12-18)-cellulose was used to detect and isolate a novel DNA polymerase activity from human breast tumor cell line HBT-3. The new enzyme is similar to those of mammalian RNA tumor viruses in its molecular size, preference for poly(A).(dT)(12-18) as compared to either poly(dA).(dT)(12-18) o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerwin BI,Bassin RH

更新日期：1973-08-01 00:00:00

abstract：:Electron collisions with atoms, ions, molecules, and surfaces are critically important to the understanding and modeling of low-temperature plasmas (LTPs), and so in the development of technologies based on LTPs. Recent progress in obtaining experimental benchmark data and the development of highly sophisticated compu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartschat K,Kushner MJ

更新日期：2016-06-28 00:00:00

abstract：:Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and enigmatic enzymes of the CNS. Based on existing UCH-L1 knockout models, UCH-L1 is thought to be required for the maintenance of axonal integrity, but not for neuronal development despite its high expression in neurons. Several lines of evidence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reinicke AT,Laban K,Sachs M,Kraus V,Walden M,Damme M,Sachs W,Reichelt J,Schweizer M,Janiesch PC,Duncan KE,Saftig P,Rinschen MM,Morellini F,Meyer-Schwesinger C

更新日期：2019-04-16 00:00:00

abstract：:Understanding Hadean (>4 Ga) Earth requires knowledge of its crust. The composition of the crust and volatiles migrating through it directly influence the makeup of the atmosphere, the composition of seawater, and nutrient availability. Despite its importance, there is little known and less agreed upon regarding the n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boehnke P,Bell EA,Stephan T,Trappitsch R,Keller CB,Pardo OS,Davis AM,Harrison TM,Pellin MJ

更新日期：2018-06-19 00:00:00

abstract：:Preterm birth (PTB) complications are the leading cause of long-term morbidity and mortality in children. By using whole blood samples, we integrated whole-genome sequencing (WGS), RNA sequencing (RNA-seq), and DNA methylation data for 270 PTB and 521 control families. We analyzed this combined dataset to identify gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knijnenburg TA,Vockley JG,Chambwe N,Gibbs DL,Humphries C,Huddleston KC,Klein E,Kothiyal P,Tasseff R,Dhankani V,Bodian DL,Wong WSW,Glusman G,Mauldin DE,Miller M,Slagel J,Elasady S,Roach JC,Kramer R,Leinonen K,Linth

更新日期：2019-03-19 00:00:00

abstract：:Global increases in population, consumption, and gross domestic product raise concerns about the sustainability of the current and future use of natural resources. The human appropriation of net primary production (HANPP) provides a useful measure of human intervention into the biosphere. The productive capacity of la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krausmann F,Erb KH,Gingrich S,Haberl H,Bondeau A,Gaube V,Lauk C,Plutzar C,Searchinger TD

更新日期：2013-06-18 00:00:00

abstract：:Adoptive T cell therapy, involving the ex vivo selection and expansion of antigen-specific T cell clones, provides a means of augmenting antigen-specific immunity without the in vivo constraints that can accompany vaccine-based strategies. A phase I study was performed to evaluate the safety, in vivo persistence, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yee C,Thompson JA,Byrd D,Riddell SR,Roche P,Celis E,Greenberg PD

更新日期：2002-12-10 00:00:00

abstract：:Antibodies directed against a synthetic peptide (src-c) containing the six carboxyl-terminal amino acids of p60src, the transforming protein of Rous sarcoma virus, recognize p60src. However, when used at sufficiently high concentrations they also react with a number of constituents of untransformed cells. These reacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nigg EA,Walter G,Singer SJ

更新日期：1982-10-01 00:00:00

abstract：:Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Hox@C82 (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Hox@C82(OH)y. This metallofullerol was then neutron-activated (165Ho[n,g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cagle DW,Kennel SJ,Mirzadeh S,Alford JM,Wilson LJ

更新日期：1999-04-27 00:00:00

abstract：:We present a theory, and its computer implementation, of how mental simulations underlie the abductions of informal algorithms and deductions from these algorithms. Three experiments tested the theory's predictions, using an environment of a single railway track and a siding. This environment is akin to a universal Tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khemlani SS,Mackiewicz R,Bucciarelli M,Johnson-Laird PN

更新日期：2013-10-15 00:00:00

abstract：:An antiserum was prepared in rabbits against an antigen obtained by density gradient sedimentation of centrifuged medium from monolayer cultures of spleens involved by Hodgkin's disease. The antiserum was tested by isotopic antibody techniques with cells from each of eight cultures derived from spleens involved by Hod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Long JC,Aisenberg AC,Zamecnik PC

更新日期：1974-07-01 00:00:00

abstract：:We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 x 10(3)) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells. White Swiss mice show nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold LJ Jr,Dagan A,Gutheil J,Kaplan NO

更新日期：1979-07-01 00:00:00

abstract：:By using a structure-based computer-assisted search, we have found a butyrophenone derivative that is a selective inhibitor of the human immunodeficiency virus 1 (HIV-1) protease. The computer program creates a negative image of the active site cavity using the crystal structure of the HIV-1 protease. This image was c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DesJarlais RL,Seibel GL,Kuntz ID,Furth PS,Alvarez JC,Ortiz de Montellano PR,DeCamp DL,Babé LM,Craik CS

更新日期：1990-09-01 00:00:00

abstract：:A hitherto unknown Neoproterozoic orogenic system, the Saharides, is described in North Africa. It formed during the 900-500-Ma interval. The Saharides involved large subduction accretion complexes occupying almost the entire Arabian Shield and much of Egypt and parts of the small Precambrian inliers in the Sahara inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Şengör AMC,Lom N,Zabcı C,Sunal G,Öner T

更新日期：2020-12-22 00:00:00

abstract：:Peptide ligand selection by MHC class I molecules, which occurs by iterative optimization, is the centerpiece of immunodominance in antiviral and antitumor immune responses. For its understanding, the molecular mechanisms of peptide binding and dissociation by class I molecules must be elucidated. To this end, we have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saini SK,Schuster H,Ramnarayan VR,Rammensee HG,Stevanović S,Springer S

更新日期：2015-01-06 00:00:00

abstract：:The use of carbon dioxide as a renewable and environmentally friendly source of carbon in organic synthesis is a highly attractive approach, but its real world applications remain a great challenge. The major obstacles for commercialization of most current protocols are their low catalytic performances, harsh reaction...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu D,Zhang Y

更新日期：2010-11-23 00:00:00

abstract：:Accumulating evidence suggests that subcutaneous and visceral adipose tissues are differentially associated with metabolic disorders. In obesity, subcutaneous adipose tissue is beneficial for metabolic homeostasis because of repressed inflammation. However, the underlying mechanism remains unclear. Here, we demonstrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang I,Jo K,Shin KC,Kim JI,Ji Y,Park YJ,Park J,Jeon YG,Ka S,Suk S,Noh HL,Choe SS,Alfadda AA,Kim JK,Kim S,Kim JB

更新日期：2019-06-11 00:00:00

abstract：:The protein-protein interaction (PPI) network is crucial for cellular information processing and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional outcomes such as cell proliferation or cell death. Here, we characterize the structural controllability of a large directed human PP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vinayagam A,Gibson TE,Lee HJ,Yilmazel B,Roesel C,Hu Y,Kwon Y,Sharma A,Liu YY,Perrimon N,Barabási AL

更新日期：2016-05-03 00:00:00

abstract：:Vesicles were constituted with glycophorin, the Sendai virus receptor of human erythrocytes, and loaded with calcein, a polar derivative of fluorescein, at self-quenching concentrations. On exposure to Sendai virus and mild hypo-osmotic stress, vesicles of the appropriate composition released a significant portion of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kundrot CE,Spangler EA,Kendall DA,MacDonald RC,MacDonald RI

更新日期：1983-03-01 00:00:00

abstract：:Although the left and right human cerebral hemispheres differ both functionally and anatomically, little is known about the environmental or genetic factors that govern central nervous system asymmetry. Nevertheless, cerebral asymmetry is strongly correlated with handedness, and handedness does have a significant gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geschwind DH,Miller BL,DeCarli C,Carmelli D

更新日期：2002-03-05 00:00:00

abstract：:Cytochrome c oxidase, the terminal protein in the respiratory chain, converts oxygen into water and helps generate the electrochemical gradient used in the synthesis of ATP. The catalytic action of cytochrome c oxidase involves electron transfer, proton transfer, and O2 reduction. These events trigger specific molecul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nyquist RM,Heitbrink D,Bolwien C,Gennis RB,Heberle J

更新日期：2003-07-22 00:00:00

abstract：:Recent structural studies of the minimal core DNA-binding domain of p53 (p53DBD) complexed to a single consensus pentamer sequence and of the isolated p53 tetramerization domain have provided valuable insights into their functions, but many questions about their interacting roles and synergism remain unanswered. To be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balagurumoorthy P,Sakamoto H,Lewis MS,Zambrano N,Clore GM,Gronenborn AM,Appella E,Harrington RE

更新日期：1995-09-12 00:00:00

abstract：:A major goal for developmental biologists is to define the behaviors and molecular contents of differentiating cells. We have devised a strategy for isolating cells from diverse embryonic regions and stages in the zebrafish, using computer-guided laser photoconversion of injected Kaede protein and flow cytometry. This...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JL,Snir M,Noushmehr H,Kirby M,Hong SK,Elkahloun AG,Feldman B

更新日期：2008-08-26 00:00:00

abstract：:An examination of life expectancy in 1963 reveals twin peaks in the empirical distribution across countries: one group of countries clustered around a life expectancy of 40 years and a second group clustered around a life expectancy of 65 years. By 2003, the mode of each cluster had moved up by approximately 10 years....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bloom DE,Canning D

更新日期：2007-10-09 00:00:00