Reconstructing orogens without biostratigraphy: The Saharides and continental growth during the final assembly of Gondwana-Land.

abstract：:The levels of c-myc, c-fos, and JE mRNAs accumulate in a biphasic pattern following infection of quiescent BALB/c 3T3 mouse cells with polyomavirus. Maximal levels of c-myc and c-fos mRNAs were seen within 1 hr and were nearly undetectable at 6 hr after infection. At 12 hr after infection mRNA levels were again maxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zullo J,Stiles CD,Garcea RL

更新日期：1987-03-01 00:00:00

abstract：:GTP-tubulin forms a cap on microtubule ends during aggregation. The bulk of the microtubule is GDP-tubulin. This complicates the usual simple kinetic theory of subunit exchange at microtubule ends to such an extent that Monte Carlo calculations are needed to handle the complications, except in special cases. The Monte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Hill TL

更新日期：1983-12-01 00:00:00

abstract：:Genetic studies in mice suggest that Wnt4 signaling antagonizes expression of male hormones and effectively blocks male development in the female embryo. We recently identified an XY intersex patient carrying a chromosomal duplication of the WNT4 locus and proposed that this patient's feminization arises from an incre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan BK,Shen JH,Olaso R,Ingraham HA,Vilain E

更新日期：2003-09-16 00:00:00

abstract：:It has been shown that [35S]methionine is incorporated into the [Met]enkephalin sequences of a 22,000-dalton enkephalin-containing protein in the adrenal medulla. Pulse-chase experiments indicate that label is incorporated into the large polypeptide before it appears in free [Met]enkephalin and a smaller [Met]enkephal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rossier J,Trifaró JM,Lewis RV,Lee RW,Stern A,Kimura S,Stein S,Udenfriend S

更新日期：1980-11-01 00:00:00

abstract：:Extracellular fatty acid incorporation into the phospholipids of Staphylococcus aureus occurs via fatty acid phosphorylation. We show that fatty acid kinase (Fak) is composed of two dissociable protein subunits encoded by separate genes. FakA provides the ATP binding domain and interacts with two distinct FakB protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parsons JB,Broussard TC,Bose JL,Rosch JW,Jackson P,Subramanian C,Rock CO

更新日期：2014-07-22 00:00:00

abstract：:We report two instances of selective accumulation of herpes simplex 1 RNA transcripts in different compartments of infected HEp-2 cells. In the first, transcripts derived from about 50% of the viral DNA accumulated in the nuclei of cells 8 hr after infection. However, only 40-42% of the DNA was represented in transcri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozak M,Roizman B

更新日期：1974-11-01 00:00:00

abstract：:Studies to elucidate the mode of action of aldosterone have been carried out in the amphibian urinary bladder. The following previously reported hypotheses were evaluated: (1) aldosterone stimulates sodium transport by increasing the amount of sodium available to the sodium pump; (2) aldosterone enhances energy produc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodman DB,Allen JE,Rasmussen H

更新日期：1969-09-01 00:00:00

abstract：:One of sleep's putative functions is mediation of adaptation to waking experiences. Chronic stress is a common waking experience; however, which specific aspect of sleep is most responsive, and how sleep changes relate to behavioral disturbances and molecular correlates remain unknown. We quantified sleep, physical, e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nollet M,Hicks H,McCarthy AP,Wu H,Möller-Levet CS,Laing EE,Malki K,Lawless N,Wafford KA,Dijk DJ,Winsky-Sommerer R

更新日期：2019-02-12 00:00:00

abstract：:Exposure to green space has been associated with better physical and mental health. Although this exposure could also influence cognitive development in children, available epidemiological evidence on such an impact is scarce. This study aimed to assess the association between exposure to green space and measures of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dadvand P,Nieuwenhuijsen MJ,Esnaola M,Forns J,Basagaña X,Alvarez-Pedrerol M,Rivas I,López-Vicente M,De Castro Pascual M,Su J,Jerrett M,Querol X,Sunyer J

更新日期：2015-06-30 00:00:00

abstract：:The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)-pyrimido[1, 2-a]purin-10(3H)-one (M1G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG).d(CGGACACC) or d(ATCGCMCGGCATG). d(C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao H,Schnetz-Boutaud NC,Weisenseel JP,Marnett LJ,Stone MP

更新日期：1999-06-08 00:00:00

abstract：:Phytoplankton often encounter turbulence in their habitat. As most toxic phytoplankton species are motile, resolving the interplay of motility and turbulence has fundamental repercussions on our understanding of their own ecology and of the entire ecosystems they inhabit. The spatial distribution of motile phytoplankt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breier RE,Lalescu CC,Waas D,Wilczek M,Mazza MG

更新日期：2018-11-27 00:00:00

abstract：:A detailed model of the G(2) DNA damage checkpoint (G2DDC) system is presented that includes complex regulatory networks of the mitotic kinase Cdc2, phosphatase Cdc25, Wee1 kinase, and damage signal transduction pathways involving Chk1 and p53. Assumptions on the kinetic equations of the G2DDC are made, and computer s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aguda BD

更新日期：1999-09-28 00:00:00

abstract：:Immediately after adsorption, phages T4 and T5 induce a partial depolarization of the host cytoplasmic membrane. Infected bacteria respond to this phage-induced effect by a repolarization that leads to a new steady state of reduced membrane potential. The rate and extent of repolarization are adjusted to the intensity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Labedan B,Letellier L

更新日期：1981-01-01 00:00:00

abstract：:Unprecedented population declines and extinctions because of human activities, combined with a growing recognition that such losses affect the stability of ecosystems, underscore the need to better understand how populations persist naturally. We provide field experimental evidence that high biodiversity-in particular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carr MH,Anderson TW,Hixon MA

更新日期：2002-08-20 00:00:00

abstract：:Six alternative hypotheses for the phylogenetic origin of Bilateria are evaluated by using complete 18S rRNA gene sequences for 52 taxa. These data suggest that there is little support for three of these hypotheses. Bilateria is not likely to be the sister group of Radiata or Ctenophora, nor is it likely that Bilateri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins AG

更新日期：1998-12-22 00:00:00

abstract：:Adipose triglyceride lipase (ATGL) initiates intracellular triglyceride (TG) catabolism. In humans, ATGL deficiency causes neutral lipid storage disease with myopathy (NLSDM) characterized by a systemic TG accumulation. Mice with a genetic deletion of ATGL (AKO) also accumulate TG in many tissues. However, neither NLS...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schreiber R,Hofer P,Taschler U,Voshol PJ,Rechberger GN,Kotzbeck P,Jaeger D,Preiss-Landl K,Lord CC,Brown JM,Haemmerle G,Zimmermann R,Vidal-Puig A,Zechner R

更新日期：2015-11-10 00:00:00

abstract：:Antibody-coated latex beads (Ab-beads) were attached to Leptospira interrogans serovars illini 3055 and icterohaemorrhagiae SC1157. The movement of the Ab-beads relative to the motion of the cells was observed by direct darkfield microscopy or was recorded on videotape. When the Ab-beads were attached to the front end...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Charon NW,Lawrence CW,O'Brien S

更新日期：1981-11-01 00:00:00

abstract：:The growth of colloidal metal nanocrystals typically involves an autocatalytic process, in which the salt precursor adsorbs onto the surface of a growing nanocrystal, followed by chemical reduction to atoms for their incorporation into the nanocrystal. Despite its universal role in the synthesis of colloidal nanocryst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang TH,Zhou S,Gilroy KD,Figueroa-Cosme L,Lee YH,Wu JM,Xia Y

更新日期：2017-12-26 00:00:00

abstract：:Homopyrimidine oligonucleotides bind to the major groove of a complementary homopyrimidine.homopurine stretch by triple helix formation. The bla gene from transposon Tn3 contains a homopyrimidine.homopurine sequence of 13 base pairs located just downstream of the RNA polymerase binding site. A 13-mer homopyrimidine ol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duval-Valentin G,Thuong NT,Hélène C

更新日期：1992-01-15 00:00:00

abstract：:Very little is known about how animals discriminate pathogens from innocuous microbes. To address this question, we examined infection-response gene induction in the nematode Caenorhabditis elegans. We focused on genes that are induced in C. elegans by infection with the bacterial pathogen Pseudomonas aeruginosa, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Estes KA,Dunbar TL,Powell JR,Ausubel FM,Troemel ER

更新日期：2010-02-02 00:00:00

abstract：:Gyrate atrophy of the choroid and retina (GA) is an inherited chorioretinal degeneration caused by deficiency of ornithine delta-aminotransferase (OAT; L-ornithine: 2-oxo-acid aminotransferase; EC 2.6.1.13). GA is one of the "Finnish genetic diseases," a group of several rare monogenic disorders that occur with increa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell GA,Brody LC,Sipila I,Looney JE,Wong C,Engelhardt JF,Patel AS,Steel G,Obie C,Kaiser-Kupfer M

更新日期：1989-01-01 00:00:00

abstract：:The size and metabolic rate of cells affect processes from the molecular to the organismal level. We present a quantitative, theoretical framework for studying relationships among cell volume, cellular metabolic rate, body size, and whole-organism metabolic rate that helps reveal the feedback between these levels of o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Savage VM,Allen AP,Brown JH,Gillooly JF,Herman AB,Woodruff WH,West GB

更新日期：2007-03-13 00:00:00

abstract：:The effect of 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent tumor promoter, on the synthesis of proteins in BALB/c 3T3 mouse fibroblasts has been studied. When [35S]methionine-labeled proteins synthesized after the addition of TPA were analyzed by one- or two-dimensional polyacrylamide gel electrophoresis, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiwasa T,Fujimura S,Sakiyama S

更新日期：1982-03-01 00:00:00

abstract：:Huntington's disease (HD) is an untreatable neurological disorder caused by selective and progressive degeneration of the caudate nucleus and putamen of the basal ganglia. Although the etiology of HD pathology is not fully understood, the observed loss of neuronal cells is thought to occur primarily through apoptosis....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keene CD,Rodrigues CM,Eich T,Chhabra MS,Steer CJ,Low WC

更新日期：2002-08-06 00:00:00

abstract：:In most Gram-positive bacteria, serine-46-phosphorylated HPr (P-Ser-HPr) controls the expression of numerous catabolic genes ( approximately 10% of their genome) by acting as catabolite corepressor. HPr kinase/phosphorylase (HprK/P), the bifunctional sensor enzyme for catabolite repression, phosphorylates HPr, a phosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mijakovic I,Poncet S,Galinier A,Monedero V,Fieulaine S,Janin J,Nessler S,Marquez JA,Scheffzek K,Hasenbein S,Hengstenberg W,Deutscher J

更新日期：2002-10-15 00:00:00

abstract：:Aberrations in the T cell repertoire with the emergence of oligoclonal populations have been described in patients with rheumatoid arthritis (RA). However, the extent of the repertoire perturbations as well as the underlying mechanisms are not known. We now have examined the diversity of the peripheral CD4 T cell repe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner UG,Koetz K,Weyand CM,Goronzy JJ

更新日期：1998-11-24 00:00:00

abstract：:In genotypic mutation analysis DNA sequence changes are determined without the in vivo or in vitro selection of phenotypically altered cells. We have studied the induction of base-pair changes by N-ethyl-N-nitrosourea in Taq I endonuclease recognition site 2508-2511 (TCGA) of the c-H-ras1 gene in human fibroblasts by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiocca SM,Sandy MS,Cerutti PA

更新日期：1992-06-15 00:00:00

abstract：:Lifelong interactions between host and the ubiquitous and persistent cytomegalovirus (CMV) have been proposed to contribute to the age-related decline in immunity. Prior work from us and others found some support for that idea, yet evidence that this led to increased vulnerability to other infections was not obtained....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smithey MJ,Venturi V,Davenport MP,Buntzman AS,Vincent BG,Frelinger JA,Nikolich-Žugich J

更新日期：2018-07-17 00:00:00

abstract：:A cDNA clone that hybridizes to an mRNA (1A10) that accumulates to a substantial level in the axis of the germinating soybean seed was sequenced. The amino acid sequence of the clone indicates an almost perfect repeat of Pro-Pro-Val-Tyr-Lys resulting in a protein containing 40% proline and lacking serine and histidine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averyhart-Fullard V,Datta K,Marcus A

更新日期：1988-02-01 00:00:00

abstract：:The expression of a number of genes encoding products involved in copper ion uptake in yeast is specifically inhibited by copper ions. We show here that copper metalloregulation occurs through Cu-dependent repression of the transactivation activity of Mac1p. A segment of the yeast transcription factor Mac1p was identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graden JA,Winge DR

更新日期：1997-05-27 00:00:00