当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Scaling of number, size, and metabolic rate of cells with body size in mammals.

Scaling of number, size, and metabolic rate of cells with body size in mammals.

Abstract：

:The size and metabolic rate of cells affect processes from the molecular to the organismal level. We present a quantitative, theoretical framework for studying relationships among cell volume, cellular metabolic rate, body size, and whole-organism metabolic rate that helps reveal the feedback between these levels of organization. We use this framework to show that average cell volume and average cellular metabolic rate cannot both remain constant with changes in body size because of the well known body-size dependence of whole-organism metabolic rate. Based on empirical data compiled for 18 cell types in mammals, we find that many cell types, including erythrocytes, hepatocytes, fibroblasts, and epithelial cells, follow a strategy in which cellular metabolic rate is body size dependent and cell volume is body size invariant. We suggest that this scaling holds for all quickly dividing cells, and conversely, that slowly dividing cells are expected to follow a strategy in which cell volume is body size dependent and cellular metabolic rate is roughly invariant with body size. Data for slowly dividing neurons and adipocytes show that cell volume does indeed scale with body size. From these results, we argue that the particular strategy followed depends on the structural and functional properties of the cell type. We also discuss consequences of these two strategies for cell number and capillary densities. Our results and conceptual framework emphasize fundamental constraints that link the structure and function of cells to that of whole organisms.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Savage VM,Allen AP,Brown JH,Gillooly JF,Herman AB,Woodruff WH,West GB

doi

10.1073/pnas.0611235104

subject

Has Abstract

pub_date

2007-03-13 00:00:00

pages

4718-23

issue

11

eissn

0027-8424

issn

1091-6490

pii

0611235104

journal_volume

104

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Crosslinking of the receptors for immunoglobulin E depolarizes the plasma membrane of rat basophilic leukemia cells.

    abstract：:Aggregation of the receptor for IgE on mast cells, basophils, and a tumor analog, rat basophilic leukemia (RBL) cells, induces a calcium-dependent degranulation of the cells. We have measured the membrane potential (delta psi) of RBL cells during this reaction by using the tetraphenylphosphonium ion (Ph4P+) equilibrat...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.18.5744

    authors： Kanner BI,Metzger H

    更新日期：1983-09-01 00:00:00

  • Arc regulates spine morphology and maintains network stability in vivo.

    abstract：:Long-term memory relies on modulation of synaptic connections in response to experience. This plasticity involves trafficking of AMPA receptors (AMPAR) and alteration of spine morphology. Arc, a gene induced by synaptic activity, mediates the endocytosis of AMPA receptors and is required for both long-term and homeost...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1006546107

    authors： Peebles CL,Yoo J,Thwin MT,Palop JJ,Noebels JL,Finkbeiner S

    更新日期：2010-10-19 00:00:00

  • Collective evolution and the genetic code.

    abstract：:A dynamical theory for the evolution of the genetic code is presented, which accounts for its universality and optimality. The central concept is that a variety of collective, but non-Darwinian, mechanisms likely to be present in early communal life generically lead to refinement and selection of innovation-sharing pr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0603780103

    authors： Vetsigian K,Woese C,Goldenfeld N

    更新日期：2006-07-11 00:00:00

  • Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

    abstract：:Ca(V)1 channels initiate excitation-contraction coupling in skeletal and cardiac muscle. During the fight-or-flight response, epinephrine released by the adrenal medulla and norepinephrine released from sympathetic nerves increase muscle contractility by activation of the β-adrenergic receptor/cAMP-dependent protein k...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1012384107

    authors： Emrick MA,Sadilek M,Konoki K,Catterall WA

    更新日期：2010-10-26 00:00:00

  • Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.

    abstract：:The nicotinic acetylcholine receptor (nAChR) and the acetylcholine binding protein (AChBP) are pentameric oligomers in which binding sites for nicotinic agonists and competitive antagonists are found at selected subunit interfaces. The nAChR spontaneously exists in multiple conformations associated with its activation...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1410992111

    authors： Kaczanowska K,Harel M,Radić Z,Changeux JP,Finn MG,Taylor P

    更新日期：2014-07-22 00:00:00

  • Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3.

    abstract：:Salt and water secretion from intestinal epithelia requires enhancement of anion permeability across the apical membrane of Cl- secreting cells lining the crypt, the secretory gland of the intestine. Paneth cells located at the base of the small intestinal crypt release enteric defensins (cryptdins) apically into the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.16.8585

    authors： Lencer WI,Cheung G,Strohmeier GR,Currie MG,Ouellette AJ,Selsted ME,Madara JL

    更新日期：1997-08-05 00:00:00

  • A novel type of RNA editing occurs in the mitochondrial tRNAs of the centipede Lithobius forficatus.

    abstract：:We determined the complete mtDNA sequence of the centipede Lithobius forficatus and found that only one of the 22 inferred tRNA genes encodes a fully paired aminoacyl acceptor stem. The other 21 genes encode tRNAs with up to five mismatches in these stems, and some of these overlap extensively with the downstream gene...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.250402997

    authors： Lavrov DV,Brown WM,Boore JL

    更新日期：2000-12-05 00:00:00

  • Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation.

    abstract：:The transcription factor zinc-finger protein Miz1 represses TNF-α-induced JNK activation and the repression is relieved upon TNF-α stimulation. However, the underlying mechanism is incompletely understood. Here we report that Miz1 interferes with the ubiquitin conjugating enzyme (E2) Ubc13 for binding to the RING doma...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1105176108

    authors： Liu J,Yan J,Jiang S,Wen J,Chen L,Zhao Y,Lin A

    更新日期：2012-01-03 00:00:00

  • Allorecognition of purified major histocompatibility complex glycoproteins by cytotoxic T lymphocytes.

    abstract：:To investigate how T cells recognize allogeneic class I proteins encoded by the major histocompatibility complex (MHC), we examined the human cytotoxic T lymphocytes (CTL) elicited in a mixed lymphocyte reaction against a lymphoblastoid B-cell line (JY) whose MHC-class I proteins are HLA-A2 and -B7. By panning the res...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.8.2728

    authors： Elliott TJ,Eisen HN

    更新日期：1988-04-01 00:00:00

  • Myosin V processivity: multiple kinetic pathways for head-to-head coordination.

    abstract：:Myosin V, a double-headed molecular motor, transports organelles within cells by walking processively along actin, a process that requires coordination between the heads. To understand the mechanism underlying this coordination, processive runs of single myosin V molecules were perturbed by varying nucleotide content....

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0307247101

    authors： Baker JE,Krementsova EB,Kennedy GG,Armstrong A,Trybus KM,Warshaw DM

    更新日期：2004-04-13 00:00:00

  • Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

    abstract：:Insulinomas are pancreatic islet tumors that inappropriately secrete insulin, producing hypoglycemia. Exome and targeted sequencing revealed that 14 of 43 insulinomas harbored the identical somatic mutation in the DNA-binding zinc finger of the transcription factor Yin Yang 1 (YY1). Chromatin immunoprecipitation seque...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1503696112

    authors： Cromer MK,Choi M,Nelson-Williams C,Fonseca AL,Kunstman JW,Korah RM,Overton JD,Mane S,Kenney B,Malchoff CD,Stalberg P,Akerström G,Westin G,Hellman P,Carling T,Björklund P,Lifton RP

    更新日期：2015-03-31 00:00:00

  • Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.

    abstract：:The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription factors, has been implicated in diverse cellular responses, including the response to osmotic stress, integrin-dependent cell migration, T cell activation, and the Ras pathway in Drosophila. To clarify the in vivo role of NFAT5, we...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0308703100

    authors： López-Rodríguez C,Antos CL,Shelton JM,Richardson JA,Lin F,Novobrantseva TI,Bronson RT,Igarashi P,Rao A,Olson EN

    更新日期：2004-02-24 00:00:00

  • Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs).

    abstract：:Two major DNA double-strand break repair pathways exist in all eukaryotes, nonhomologous DNA end joining (NHEJ) and homologous recombination (HR). Although both pathways can function throughout the cell cycle, NHEJ predominates in G0/G1) (when a replicated sister chromatid is unavailable), whereas HR makes a more subs...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0406466102

    authors： Convery E,Shin EK,Ding Q,Wang W,Douglas P,Davis LS,Nickoloff JA,Lees-Miller SP,Meek K

    更新日期：2005-02-01 00:00:00

  • Extraocular muscle is defined by a fundamentally distinct gene expression profile.

    abstract：:Skeletal muscle fibers are defined by patterned covariation of key traits that determine contractile and metabolic characteristics. Although the functional properties of most skeletal muscles result from their proportional content of a few conserved muscle fiber types, some, typically craniofacial, muscles exhibit fib...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.211257298

    authors： Porter JD,Khanna S,Kaminski HJ,Rao JS,Merriam AP,Richmonds CR,Leahy P,Li J,Andrade FH

    更新日期：2001-10-09 00:00:00

  • Immunoglobulins D and M mediate signals that are qualitatively different in B cells with an immature phenotype.

    abstract：:The CH family of murine B-cell lymphomas includes several members that are sensitive to growth inhibition when their membrane IgM (mIgM) receptors are cross-linked by anti-mu chain, anti-kappa chain, or anti-idiotypic antibodies. These lymphomas are IgM+, Ia+, and IgD +/- and resemble neonatal B cells in terms of thei...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.18.6919

    authors： Alés-Martínez JE,Warner GL,Scott DW

    更新日期：1988-09-01 00:00:00

  • Tracking evolving communities in large linked networks.

    abstract：:We are interested in tracking changes in large-scale data by periodically creating an agglomerative clustering and examining the evolution of clusters (communities) over time. We examine a large real-world data set: the NEC CiteSeer database, a linked network of >250,000 papers. Tracking changes over time requires a c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0307750100

    authors： Hopcroft J,Khan O,Kulis B,Selman B

    更新日期：2004-04-06 00:00:00

  • Macrofaunal control of microbial community structure in continental margin sediments.

    abstract：:Through a process called "bioturbation," burrowing macrofauna have altered the seafloor habitat and modified global carbon cycling since the Cambrian. However, the impact of macrofauna on the community structure of microorganisms is poorly understood. Here, we show that microbial communities across bioturbated, but ge...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1917494117

    authors： Deng L,Bölsterli D,Kristensen E,Meile C,Su CC,Bernasconi SM,Seidenkrantz MS,Glombitza C,Lagostina L,Han X,Jørgensen BB,Røy H,Lever MA

    更新日期：2020-07-07 00:00:00

  • Revised age of late Neanderthal occupation and the end of the Middle Paleolithic in the northern Caucasus.

    abstract：:Advances in direct radiocarbon dating of Neanderthal and anatomically modern human (AMH) fossils and the development of archaeostratigraphic chronologies now allow refined regional models for Neanderthal-AMH coexistence. In addition, they allow us to explore the issue of late Neanderthal survival in regions of Western...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 历史文章,杂志文章

    doi：10.1073/pnas.1018938108

    authors： Pinhasi R,Higham TF,Golovanova LV,Doronichev VB

    更新日期：2011-05-24 00:00:00

  • Full-length CD4 electroinserted in the erythrocyte membrane as a long-lived inhibitor of infection by human immunodeficiency virus.

    abstract：:Recombinant full-length CD4 expressed in Spodoptera frugiperda 9 cells with the baculovirus system was electroinserted in erythrocyte (RBC) membranes. Of the inserted CD4, 70% was "correctly" oriented as shown by fluorescence quenching experiments with fluorescein-labeled CD4. The inserted CD4 displayed the same epito...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.10.4409

    authors： Zeira M,Tosi PF,Mouneimne Y,Lazarte J,Sneed L,Volsky DJ,Nicolau C

    更新日期：1991-05-15 00:00:00

  • Single-stranded DNA from oncornavirus-infected cells enriched in virus-specific DNA sequences.

    abstract：:We previously found that a minor fraction of single-stranded DNA (ss-DNA) isolated from native nuclear DNA of normal chicken embryonic cells and cells of other species hybridized with bulk nuclear DNA or cellular RNA in great excess. At least one-third of ss-DNA belonging to the nonrepetitious part of the cell genome ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.74.9.3720

    authors： Leibovitch SA,Tapiero H,Harel J

    更新日期：1977-09-01 00:00:00

  • Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarc...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1706248114

    authors： Yang J,Zhang X,Yuan P,Yang J,Xu Y,Grutzendler J,Shao Y,Moore A,Ran C

    更新日期：2017-11-21 00:00:00

  • Biosynthesis and endocrine control of the production of the German cockroach sex pheromone 3,11-dimethylnonacosan-2-one.

    abstract：:The biosynthesis and endocrine regulation of sex pheromone production in the female German cockroach (Blattella germanica) were determined. Radio-TLC and radio-GLC were used to demonstrate the metabolism of 3,11-dimethylnonacosane, a major cuticular lipid component, to the corresponding alkan-2-ol and methyl ketone. [...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.13.6050

    authors： Chase J,Touhara K,Prestwich GD,Schal C,Blomquist GJ

    更新日期：1992-07-01 00:00:00

  • Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.

    abstract：:Embryonic stem cells (derived from 129/Ola mice) containing a mutant hypoxanthine phosphoribosyltransferase gene that had been corrected in vitro in a planned manner by homologous recombination were injected into blastocysts obtained from C57BL/6J mice. The injected blastocysts were introduced into pseudopregnant fema...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.22.8927

    authors： Koller BH,Hagemann LJ,Doetschman T,Hagaman JR,Huang S,Williams PJ,First NL,Maeda N,Smithies O

    更新日期：1989-11-01 00:00:00

  • Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

    abstract：:Arachidonic acid (AA) metabolites derived from both cyclooxygenase (COX) and lipoxygenase (LOX) pathways transduce a variety of signals related to cell growth. Here, we report that the AA LOX pathway also functions as a critical regulator of cell survival and apoptosis. Rat Walker 256 (W256) carcinosarcoma cells expre...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.11.5241

    authors： Tang DG,Chen YQ,Honn KV

    更新日期：1996-05-28 00:00:00

  • Multistep regulation of autophagy by WNK1.

    abstract：:The with-no-lysine (K) (WNK) kinases are an atypical family of protein kinases that regulate ion transport across cell membranes. Mutations that result in their overexpression cause hypertension-related disorders in humans. Of the four mammalian WNKs, only WNK1 is expressed throughout the body. We report that WNK1 inh...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1617649113

    authors： Gallolu Kankanamalage S,Lee AY,Wichaidit C,Lorente-Rodriguez A,Shah AM,Stippec S,Whitehurst AW,Cobb MH

    更新日期：2016-12-13 00:00:00

  • Sensitivity to inhibition by beta-chemokines correlates with biological phenotypes of primary HIV-1 isolates.

    abstract：:Primary HIV-1 isolates were evaluated for their sensitivity to inhibition by beta-chemokines RANTES (regulated upon activation, normal T-cell expressed and secreted), macrophage inflammatory protein 1 alpha (MIP-1 alpha), and MIP-1 beta. Virus isolates of both nonsyncytium-inducing (NSI) and syncytium-inducing (SI) bi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.26.15382

    authors： Jansson M,Popovic M,Karlsson A,Cocchi F,Rossi P,Albert J,Wigzell H

    更新日期：1996-12-24 00:00:00

  • System-wide organization of actin cytoskeleton determines organelle transport in hypocotyl plant cells.

    abstract：:The actin cytoskeleton is an essential intracellular filamentous structure that underpins cellular transport and cytoplasmic streaming in plant cells. However, the system-level properties of actin-based cellular trafficking remain tenuous, largely due to the inability to quantify key features of the actin cytoskeleton...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1706711114

    authors： Breuer D,Nowak J,Ivakov A,Somssich M,Persson S,Nikoloski Z

    更新日期：2017-07-11 00:00:00

  • Rapid de novo generation of defective interfering RNA by cucumber necrosis virus mutants that do not express the 20-kDa nonstructural protein.

    abstract：:It is generally believed that serial passage at high multiplicity of infection (moi) is required for the generation of defective interfering (DI) particles. High levels of DI RNAs are found associated with persistent infections initiated with laboratory cultures of cucumber necrosis virus (CNV). Two synthetic CNV tran...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.24.11153

    authors： Rochon DM

    更新日期：1991-12-15 00:00:00

  • Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain.

    abstract：:Myosin X (MyoX), encoded by Myo10, is a representative member of the MyTH4-FERM domain-containing myosins, and this family of unconventional myosins shares common functions in promoting formation of filopodia/stereocilia structures in many cell types with unknown mechanisms. Here, we present the structure of the MyoX ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1016567108

    authors： Wei Z,Yan J,Lu Q,Pan L,Zhang M

    更新日期：2011-03-01 00:00:00

  • T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease.

    abstract：:Predominant usage of V beta 8.2 gene segments, encoding a T-cell receptor (TCR) beta chain variable region, has been reported for pathogenic Lewis rat T cells reactive to myelin basic protein (MBP). However, up to 75% of the alpha/beta T cells in a panel of MBP-specific T-cell lines did not display TCR V beta 8.2, V b...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.13.5850

    authors： Gold R,Giegerich G,Hartung HP,Toyka KV

    更新日期：1995-06-20 00:00:00