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Extraocular muscle is defined by a fundamentally distinct gene expression profile.

Abstract：

:Skeletal muscle fibers are defined by patterned covariation of key traits that determine contractile and metabolic characteristics. Although the functional properties of most skeletal muscles result from their proportional content of a few conserved muscle fiber types, some, typically craniofacial, muscles exhibit fiber types that appear to lie outside the common phenotypic range. We analyzed gene expression profiles of three putative muscle classes, limb, masticatory, and extraocular muscle (EOM), in adult mice by high-density oligonucleotide arrays. Pairwise comparisons using conservative acceptance criteria identified expression differences in 287 genes between EOM and limb and/or masticatory muscles. Use of significance analysis of microarrays methodology identified up to 400 genes as having an EOM-specific expression pattern. Genes differentially expressed in EOM reflect key aspects of muscle biology, including transcriptional regulation, sarcomeric organization, excitation-contraction coupling, intermediary metabolism, and immune response. These patterned differences in gene expression define EOM as a distinct muscle class and may explain the unique response of these muscles in neuromuscular diseases.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Porter JD,Khanna S,Kaminski HJ,Rao JS,Merriam AP,Richmonds CR,Leahy P,Li J,Andrade FH

doi

10.1073/pnas.211257298

keywords:

subject

Has Abstract

pub_date

2001-10-09 00:00:00

pages

12062-7

issue

21

eissn

0027-8424

issn

1091-6490

pii

211257298

journal_volume

98

pub_type

杂志文章

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