Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.

abstract：:Three lines of evidence for abrupt tropical climate change, both past and present, are presented. First, annually and decadally averaged delta(18)O and net mass-balance histories for the last 400 and 2,000 yr, respectively, demonstrate that the current warming at high elevations in the mid- to low latitudes is unprece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson LG,Mosley-Thompson E,Brecher H,Davis M,León B,Les D,Lin PN,Mashiotta T,Mountain K

更新日期：2006-07-11 00:00:00

abstract：:We have used expression cloning in Xenopus oocytes to isolate two different cDNAs encoding functional N-methyl-D-aspartate (NMDA) receptor subunits. The two receptors (NMDA-R1A and -R1B) display different pharmacologic properties as a consequence of alternative exon addition within the putative ligand-binding domain. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakanishi N,Axel R,Shneider NA

更新日期：1992-09-15 00:00:00

abstract：:Genetic and biochemical studies have revealed that the 5' noncoding region of poliovirus mediates translation of the viral mRNA by an unusual mechanism involving entry of ribosomes in internal sequences of mRNA molecules. We have found that mRNAs bearing the 5' noncoding region of poliovirus were translated at an enha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hambidge SJ,Sarnow P

更新日期：1992-11-01 00:00:00

abstract：:Endothelial cells (ECs) line the mammalian vascular system and respond to the hemodynamic stimulus of fluid shear stress, the frictional force produced by blood flow. When ECs are exposed to shear stress, one of the fastest responses is an increase of K(+) conductance, which suggests that ion channels are involved in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoger JH,Ilyin VI,Forsyth S,Hoger A

更新日期：2002-05-28 00:00:00

abstract：:The biological realm has inherited symmetries from the physicochemical realm, but with the increasing complexity at higher phenomenological levels of life, some inherited symmetries are broken while novel symmetries appear. These symmetries are of two types, structural and operational. Biological novelties result from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García-Bellido A

更新日期：1996-12-10 00:00:00

abstract：:Hypophosphatasia is an inherited disorder characterized by defective bone mineralization and a deficiency of serum and tissue liver/bone/kidney alkaline phosphatase (L/B/K ALP) activity. Clinical severity is variable, ranging from death in utero (due to severe rickets) to pathologic fractures first presenting in adult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss MJ,Cole DE,Ray K,Whyte MP,Lafferty MA,Mulivor RA,Harris H

更新日期：1988-10-01 00:00:00

abstract：:Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catoire M,Alex S,Paraskevopulos N,Mattijssen F,Evers-van Gogh I,Schaart G,Jeppesen J,Kneppers A,Mensink M,Voshol PJ,Olivecrona G,Tan NS,Hesselink MK,Berbée JF,Rensen PC,Kalkhoven E,Schrauwen P,Kersten S

更新日期：2014-03-18 00:00:00

abstract：:The efficacy of boron neutron capture therapy (BNCT) for the treatment of intracerebrally implanted rat gliosarcomas was tested. Preferential accumulation of 10B in tumors was achieved by continuous infusion of the sulfhydryl borane dimer, Na4(10)B24H22S2, at a rate of 45-50 micrograms of 10B per g of body weight per ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joel DD,Fairchild RG,Laissue JA,Saraf SK,Kalef-Ezra JA,Slatkin DN

更新日期：1990-12-01 00:00:00

abstract：:We previously have shown that proliferating lymphoid cells contain an extractable cytoplasmic protein that is capable of inducing DNA synthesis in isolated quiescent nuclei (activator of DNA replication, ADR). ADR is present in continuously proliferating (transformed) lymphoblastoid cell lines and in mitogen- or inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gutowski JK,West A,Cohen S

更新日期：1985-08-01 00:00:00

abstract：:Sca-1 (stem cell antigen-1) enriches for murine prostate cells capable of regenerating tubular structures containing basal and luminal cell lineages in a dissociated cell prostate regeneration system. Sca-1(+) fractions are enriched for cells at the G(0) stage of the cell cycle, and Sca-1(+) cells cluster in the proxi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xin L,Lawson DA,Witte ON

更新日期：2005-05-10 00:00:00

abstract：:Many chemoattractants cause chemotaxis of leukocytes by stimulating a structurally distinct class of G protein-coupled receptors. To identify receptor functions required for chemotaxis, we studied chemotaxis in HEK293 cells transfected with receptors for nonchemokine ligands or for interleukin 8 (IL-8), a classical ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neptune ER,Bourne HR

更新日期：1997-12-23 00:00:00

abstract：:We have generated a hybridoma cell line secreting a monoclonal antibody that specifically binds to the surfaces of oligodendrocytes and Schwann cells, the cells involved in myelin formation in the central and peripheral nervous systems, respectively. Binding studies using purified sphingolipids showed that this antibo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranscht B,Clapshaw PA,Price J,Noble M,Seifert W

更新日期：1982-04-01 00:00:00

abstract：:Irrigation of the dog's oxyntic glandular mucosa contained in a chronically prepared, vagally denervated, separated pouch of the dog's stomach with a solution (0.5 mg ml-1) of lyophilized venom of the hooded cobra (Naja naja) increases the permeability of the mucosa. If irrigation with venom solution is repeated at we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davenport HW

更新日期：1976-03-01 00:00:00

abstract：:The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood. Using Ubc13 conditional knockout mice, we show that somatic deletion of the Ubc13 gene cau...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Yamamoto M,Akira S,Sun SC

更新日期：2009-12-08 00:00:00

abstract：:We used 5,6-dichloro-beta D-ribofuranosyl-benzimidazole (DRB), a selective and reversible inhibitor of mRNA production, to investigate the regulation of the pathway leading to resistance to viruses in cells treated with interferon (IF). DRB allows initiation of transcription but promotes premature termination of the n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon I,Stevenson D

更新日期：1980-01-01 00:00:00

abstract：:Behavioral and neural evidence reveal a prospective goal-directed decision process that relies on mental simulation of the environment, and a retrospective habitual process that caches returns previously garnered from available choices. Artificial systems combine the two by simulating the environment up to some depth ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keramati M,Smittenaar P,Dolan RJ,Dayan P

更新日期：2016-11-08 00:00:00

abstract：:Cultured fibroblast cells derived from a skin biopsy sample taken from normal human adult were exposed to a potent carcinogen, 4-nitroquinoline 1-oxide. Alterations of cell growth pattern such as higher density and piling up of cells were noticed in some fractions of cultures that were successively subcultured after n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kakunaga T

更新日期：1978-03-01 00:00:00

abstract：:Infants' sensitivity to contingent reactivity as an indicator of intentional agency has been demonstrated by numerous referential gaze-following studies. Here we propose that variability of signal sequences in a turn-taking exchange provides an informative cue for infants to recognize interactions that may involve com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tauzin T,Gergely G

更新日期：2019-07-30 00:00:00

abstract：:If RNA editing could be rationally directed to mutated RNA sequences, genetic diseases caused by certain base substitutions could be treated. Here we use a synthetic complementary RNA oligonucleotide to direct the correction of a premature stop codon mutation in dystrophin RNA. The complementary RNA oligonucleotide wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woolf TM,Chase JM,Stinchcomb DT

更新日期：1995-08-29 00:00:00

abstract：:Myocardin and the myocardin-related transcription factors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiovascular development. To determine the functions of MRTF-B in vivo, we generated MRTF-B mutant mice by targeted inactivation of the MRTF-B gene. We show that mice hom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oh J,Richardson JA,Olson EN

更新日期：2005-10-18 00:00:00

abstract：:Although much evidence suggests that the plasma membrane of eukaryotic cells is not homogenous, the precise architecture of this important structure has not been clear. Here we use transmission electron microscopy of plasma membrane sheets and specific probes to show that most or all plasma membrane-associated protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lillemeier BF,Pfeiffer JR,Surviladze Z,Wilson BS,Davis MM

更新日期：2006-12-12 00:00:00

abstract：:Work with non-human primates had previously demonstrated that the mid-dorsolateral frontal cortex, which comprises cytoarchitectonic areas 46 and 9, plays a critical role in the performance of non-spatial self-ordered working memory tasks, whereas the immediately adjacent posterior dorsolateral frontal cortex (area 8)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrides M,Alivisatos B,Evans AC,Meyer E

更新日期：1993-02-01 00:00:00

abstract：:We present a simple molecular indexing method for quantitative targeted RNA sequencing, in which mRNAs of interest are selectively captured from complex cDNA libraries and sequenced to determine their absolute concentrations. cDNA fragments are individually labeled so that each molecule can be tracked from the origina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu GK,Xu W,Wilhelmy J,Mindrinos MN,Davis RW,Xiao W,Fodor SP

更新日期：2014-02-04 00:00:00

abstract：:Assembly of protein complexes is a key mechanism for achieving spatial and temporal coordination in processes involving many enzymes. Growth of rod-shaped bacteria is a well-studied example requiring such coordination; expansion of the cell wall is thought to involve coordination of the activity of synthetic enzymes w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee TK,Tropini C,Hsin J,Desmarais SM,Ursell TS,Gong E,Gitai Z,Monds RD,Huang KC

更新日期：2014-03-25 00:00:00

abstract：:We have developed an in vivo system to engender supercoiled "minicircle" DNA containing a single promoter by using the integrative recombination system of bacteriophage lambda. The resulting minicircle templates allow quantitative analysis of the stages of transcription initiation from a promoter, including synthesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choy HE,Adhya S

更新日期：1993-01-15 00:00:00

abstract：:B-1a cells, an anatomically, phenotypically, and functionally distinct subset of B cells that produce the bulk of natural serum IgM and much of gut-associated IgA, are an important component of the early response to pathogens. Because the induced expression of CD5, a hallmark of B-1a cells, requires a nuclear factor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berland R,Wortis HH

更新日期：2003-11-11 00:00:00

abstract：:Protein-protein and protein-ligand interactions are ubiquitous in a biological cell. Here, we report a comprehensive study of the distribution of protein-ligand interaction sites, namely ligand-binding pockets, around protein-protein interfaces where protein-protein interactions occur. We inspected a representative se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao M,Skolnick J

更新日期：2012-03-06 00:00:00

abstract：:The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains unclear. We found that although Ras interfered with Myc-induced apoptosis, Myc repressed Ras-induced senescence, together abrogating two main barriers of tumori...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hydbring P,Bahram F,Su Y,Tronnersjö S,Högstrand K,von der Lehr N,Sharifi HR,Lilischkis R,Hein N,Wu S,Vervoorts J,Henriksson M,Grandien A,Lüscher B,Larsson LG

更新日期：2010-01-05 00:00:00

abstract：:The complement system has evolved to annul pathogens, but its improper regulation is linked with diseases. Efficient regulation of the system is primarily provided by a family of proteins termed regulators of complement activation (RCA). The knowledge of precise structural determinants of RCA proteins critical for imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gautam AK,Panse Y,Ghosh P,Reza MJ,Mullick J,Sahu A

更新日期：2015-10-13 00:00:00

abstract：:Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Although the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. Because many questions rega...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linnemann AK,O'Geen H,Keles S,Farnham PJ,Bresnick EH

更新日期：2011-08-16 00:00:00