Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise.

abstract：:The extensive refolding of the membrane-anchoring chain of hemagglutinin (HA) of influenza virus (termed HA2) in cellular endosomes, which initiates viral entry by membrane fusion, suggests that viral HA is meta-stable. HA2 polypeptide residues 38-175 expressed in Escherichia coli are reported here to fold in vivo int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Wharton SA,Weissenhorn W,Calder LJ,Hughson FM,Skehel JJ,Wiley DC

更新日期：1995-12-19 00:00:00

abstract：:Recent archaeological discoveries have revealed that pigment use, beads, engravings, and sophisticated stone and bone tools were already present in southern Africa 75,000 y ago. Many of these artifacts disappeared by 60,000 y ago, suggesting that modern behavior appeared in the past and was subsequently lost before be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d'Errico F,Backwell L,Villa P,Degano I,Lucejko JJ,Bamford MK,Higham TF,Colombini MP,Beaumont PB

更新日期：2012-08-14 00:00:00

abstract：:A combined genetic, biochemical, and immunological approach has clarified structural relationships involving the first three enzymes of de novo pyrimidine biosynthesis. A procedure involving antibody and protein A-Sepharose was used to isolate the enzymes carbamoyl-phosphate synthase [ATP:carbamate phosphotransferase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davidson JN,Patterson D

更新日期：1979-04-01 00:00:00

abstract：:The role of Notch signaling in cartilage differentiation and maturation in vivo was examined. Conditional Notch pathway gain and loss of function was achieved using a Cre/loxP approach to manipulate Notch signaling in cartilage precursors and chondrocytes of the developing mouse embryo. Conditional overexpression of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mead TJ,Yutzey KE

更新日期：2009-08-25 00:00:00

abstract：:Cyclic AMP concentrations were low for an adenylate cyclase-deficient mutant (cya(-)) and abnormally high for a catabolite receptor protein-deficient mutant (crp(-)). A fall in cellular cAMP concentration was always found when cells were subjected to transient repression. No consistent correlations were observed betwe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wayne PK,Rosen OM

更新日期：1974-04-01 00:00:00

abstract：:Bordetella pertussis, the causative agent of whooping cough, secretes several toxins implicated in this disease. One of these putative virulence factors is the adenylate cyclase (AC) toxin that elevates intracellular cAMP in eukaryotic cells to cytotoxic levels. This toxin is a bifunctional protein comprising both AC ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross MK,Au DC,Smith AL,Storm DR

更新日期：1992-06-01 00:00:00

abstract：:Plasma membrane fractions from Xenopus laevis oocytes were incorporated into planar lipid bilayers. We show the existence of numerous Ca2+-activated nonspecific channels that are more permeable to anions. These channels are activated by Ca2+ at micromolar concentration but not by Mg2+, Zn2+, or Mn2+, even at millimola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young GP,Young JD,Deshpande AK,Goldstein M,Koide SS,Cohn ZA

更新日期：1984-08-01 00:00:00

abstract：:We investigated the binding of 125I-labeled alpha-inhibin-92 (a 92-residue peptide) to human pituitary membrane preparations. Unlabeled alpha-inhibin-92 competed effectively with the labeled peptide for binding to the membranes. Binding was also inhibited by both alpha-inhibin-52 and alpha-inhibin-31, but less effecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramasharma K,Li CH

更新日期：1987-06-01 00:00:00

abstract：:High vein density, a distinctive trait of C4 leaves, is central to both C3-to-C4 evolution and conversion of C3 to C4-like crops. We tested the hypothesis that high vein density in C4 leaves is due to elevated auxin biosynthesis and transport in developing leaves. Up-regulation of genes in auxin biosynthesis pathways ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CF,Yu CP,Wu YH,Lu MJ,Tu SL,Wu SH,Shiu SH,Ku MSB,Li WH

更新日期：2017-08-15 00:00:00

abstract：:Several recombinant cowpox viruses were constructed and used to identify a viral gene that controls the production of hemorrhage in lesions caused by the Brighton Red strain of cowpox virus (CPV-BR). This gene is located in the KpnD fragment of CPV-BR DNA, between 31 and 32 kilobases from the end of the genome. This p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pickup DJ,Ink BS,Hu W,Ray CA,Joklik WK

更新日期：1986-10-01 00:00:00

abstract：:Type I and type III IFNs bind to different cell-surface receptors but induce identical signal transduction pathways, leading to the expression of antiviral host effector molecules. Despite the fact that type III IFN (IFN-λ) has been shown to predominantly act on mucosal organs, in vivo infection studies have failed to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pott J,Mahlakõiv T,Mordstein M,Duerr CU,Michiels T,Stockinger S,Staeheli P,Hornef MW

更新日期：2011-05-10 00:00:00

abstract：:The membrane glycoproteins specified by herpes simplex virus are synthesized concurrently with structural viral proteins and accumulate in the cytoplasm and in the membranes lining it. Analyses of free and membranebound polyribosomes, the cytoplasmic pool of soluble proteins, and purified smooth membranes showed that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spear PG,Roizman B

更新日期：1970-07-01 00:00:00

abstract：:Delta 5-3-Ketosteroid isomerase (EC 5.3.3.1) promotes an allylic rearrangement involving intramolecular proton transfer via a dienolic intermediate. This enzyme enhances the catalytic rate by a factor of 10(10). Two residues, Tyr-14, the general acid that polarizes the steroid 3-carbonyl group and facilitates enolizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Q,Abeygunawardana C,Talalay P,Mildvan AS

更新日期：1996-08-06 00:00:00

abstract：:A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding suggests that the Ub system may be involved in common mechanisms underlying these otherwise unrelated diseases. Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson KM,Li W,Ching KA,Batalov S,Tsai CC,Joazeiro CA

更新日期：2003-07-22 00:00:00

abstract：:After more than two decades of study, many fundamental questions remain unanswered about the dynamics of glass-forming materials confined to thin films. Experiments and simulations indicate that free interfaces enhance dynamics over length scales larger than molecular sizes, and this effect strengthens at lower temper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivancic RJS,Riggleman RA

更新日期：2020-10-13 00:00:00

abstract：:The sequence of the cloned Bacillus amyloliquefaciens subtilisin gene suggested that this secreted serine protease is produced as a larger precursor, designated preprosubtilisin [Wells, J. A., Ferrari, E., Henner, D. J., Estell, D. A. & Chen, E. Y. (1983) Nucleic Acids Res. 11, 7911-7925]. Biochemical evidence present...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Power SD,Adams RM,Wells JA

更新日期：1986-05-01 00:00:00

abstract：:A compact, well-organized, and natural motif, stabilized by three disulfide bonds, is proposed as a basic scaffold for protein engineering. This motif contains 37 amino acids only and is formed by a short helix on one face and an antiparallel triple-stranded beta-sheet on the opposite face. It has been adopted by scor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vita C,Roumestand C,Toma F,Ménez A

更新日期：1995-07-03 00:00:00

abstract：:Natural resistance-associated macrophage protein (Nramp) family transporters catalyze uptake of essential divalent transition metals like iron and manganese. To discriminate against abundant competitors, the Nramp metal-binding site should favor softer transition metals, which interact either covalently or ionically w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bozzi AT,Bane LB,Weihofen WA,McCabe AL,Singharoy A,Chipot CJ,Schulten K,Gaudet R

更新日期：2016-09-13 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent in the gene therapy of cancer. This therapy is based on the preferential phosphorylation of nucleoside analogs by tumor cells expressing HSV-1 thymidine kinase. However, the use of HSV-1 thymidine kinase is limited in part by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black ME,Newcomb TG,Wilson HM,Loeb LA

更新日期：1996-04-16 00:00:00

abstract：:The AML1 gene, located on chromosome 21, is involved in several distinct chromosomal translocations in human leukemia. In t(8;21) acute myelogenous leukemia (AML), the AML1 gene is juxtaposed to the ETO gene located on chromosome 8, generating an AML1/ETO fusion protein. Both AML1/ETO and the AML1 proteins recognize t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klampfer L,Zhang J,Zelenetz AO,Uchida H,Nimer SD

更新日期：1996-11-26 00:00:00

abstract：:We present evidence that the JAK-STAT signal transduction pathway regulates multiple developmental processes in Drosophila. We screened for second-site mutations that suppress the phenotype of the hyperactive hopTum-1 Jak kinase, and recovered a mutation that meiotically maps to the known chromosomal position of D-Sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Luo H,Darnell JE Jr,Dearolf CR

更新日期：1996-06-11 00:00:00

abstract：:Previously it was shown that yeast ADA2 protein is necessary for the full activity of some activation domains, such as VP16 and GCN4, in vivo and in vitro. These results suggest that ADA2 protein functions as a transcriptional coactivator or adaptor that bridges the interaction between certain acidic activation domain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silverman N,Agapite J,Guarente L

更新日期：1994-11-22 00:00:00

abstract：:Research on tuberculosis and leprosy was revolutionized by the development of a plasmid transformation system in the fast-growing surrogate, Mycobacterium smegmatis. This transformation system was made possible by the successful isolation of a M. smegmatis mutant strain mc(2)155, whose efficient plasmid transformation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panas MW,Jain P,Yang H,Mitra S,Biswas D,Wattam AR,Letvin NL,Jacobs WR Jr

更新日期：2014-09-16 00:00:00

abstract：:Inherited colorectal cancer syndromes in humans exhibit regional specificity for tumor formation. By using mice with germline mutations in the adenomatous polyposis coli gene (Apc) and/or DNA mismatch repair genes, we have analyzed the genetic control of tumor regionality in the mouse small intestine. In C57BL/6 mice ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haigis KM,Hoff PD,White A,Shoemaker AR,Halberg RB,Dove WF

更新日期：2004-06-29 00:00:00

abstract：:The rate of reproduction of deep-sea bacteria from six different capture depths between 1957 and 10,476 meters was studied as a function of temperature and pressure. The results showed the following: the true deep-sea bacteria of different depths have several characteristics, presumably evolutionally derived, distingu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yayanos AA

更新日期：1986-12-01 00:00:00

abstract：:Cotranslational folding (CTF) is a fundamental molecular process that ensures efficient protein biosynthesis and minimizes the formation of misfolded states. However, the complexity of this process makes it extremely challenging to obtain structural characterizations of CTF pathways. Here, we correlate observations of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waudby CA,Wlodarski T,Karyadi ME,Cassaignau AME,Chan SHS,Wentink AS,Schmidt-Engler JM,Camilloni C,Vendruscolo M,Cabrita LD,Christodoulou J

更新日期：2018-09-25 00:00:00

abstract：:Strength and other mechanical properties of cement and concrete rely upon the formation of calcium-silicate-hydrates (C-S-H) during cement hydration. Controlling structure and properties of the C-S-H phase is a challenge, due to the complexity of this hydration product and of the mechanisms that drive its precipitatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ioannidou K,Krakowiak KJ,Bauchy M,Hoover CG,Masoero E,Yip S,Ulm FJ,Levitz P,Pellenq RJ,Del Gado E

更新日期：2016-02-23 00:00:00

abstract：:Biochemical evidence is presented for the disintegration of the lens fiber plasma membrane in human cataracts. The intrinsic membrane proteins are found in both the water-soluble and water-insoluble nonmembrane fractions of the cataract lens but not in the normal tissue. Furthermore, in contrast to the normal lens, no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garner MH,Roy D,Rosenfeld L,Garner WH,Spector A

更新日期：1981-03-01 00:00:00

abstract：:Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant mtDNA expanded from single initial mutant mtDNA molecules. We demonstrate that intracellular clonal expansion of somatic point mutatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nekhaeva E,Bodyak ND,Kraytsberg Y,McGrath SB,Van Orsouw NJ,Pluzhnikov A,Wei JY,Vijg J,Khrapko K

更新日期：2002-04-16 00:00:00

abstract：:MST1, mammalian STE20-like kinase 1, is a serine/threonine kinase that is cleaved and activated by caspases during apoptosis. MST1 is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. In this study, we show that MST1 contains two functional nuclear export signals (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ura S,Masuyama N,Graves JD,Gotoh Y

更新日期：2001-08-28 00:00:00