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On the mechanism of action of aldosterone.

Abstract：

:Studies to elucidate the mode of action of aldosterone have been carried out in the amphibian urinary bladder. The following previously reported hypotheses were evaluated: (1) aldosterone stimulates sodium transport by increasing the amount of sodium available to the sodium pump; (2) aldosterone enhances energy production for the sodium pump; and (3) aldosterone-stimulated sodium transport is obligatorily coupled to aerobic metabolism. In the present experiments, aldosterone potentiated the effect of vasopressin on sodium transport in the absence of aerobic metabolism or oxidative phosphorylation. This effect was not due to enhanced energy supply. Thus both hypotheses 2 and 3 appear not to be valid. In addition, aldosterone-stimulated sodium transport exhibited increased sensitivity to the specific inhibitor, ouabain, and this inhibition was readily reversed by K(+). These findings, as well as previously reported work, have led us to propose that aldosterone stimulates sodium transport by inducing a change either in the sodium pump itself, i.e., synthesis or activation, or in its environment in the serosal plasma membrane of the responsive cells.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Goodman DB,Allen JE,Rasmussen H

doi

10.1073/pnas.64.1.330

subject

Has Abstract

pub_date

1969-09-01 00:00:00

pages

330-7

issue

1

eissn

0027-8424

issn

1091-6490

journal_volume

64

pub_type

杂志文章

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