Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator.

abstract：:Penicillin-binding proteins (PBPs) are synthases required to build the essential peptidoglycan (PG) cell wall surrounding most bacterial cells. The mechanisms regulating the activity of these enzymes to control PG synthesis remain surprisingly poorly defined given their status as key antibiotic targets. Several years ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greene NG,Fumeaux C,Bernhardt TG

更新日期：2018-03-20 00:00:00

abstract：:A metabolite of estradiol, 2-methoxyestradiol (2ME), inhibits angiogenesis in the chicken embryo chorioallantoic membrane assay. Since 2ME causes mitotic perturbations, we examined its interactions with tubulin. In our standard 1.0 M glutamate system (plus 1.0 mM MgCl2 at 37 degrees C), superstoichiometric concentrati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Amato RJ,Lin CM,Flynn E,Folkman J,Hamel E

更新日期：1994-04-26 00:00:00

abstract：:Given their relatively small area, mangroves and their organic sediments are of disproportionate importance to global carbon sequestration and carbon storage. Peat deposition and preservation allows some mangroves to accrete vertically and keep pace with sea-level rise by growing on their own root remains. In this stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ezcurra P,Ezcurra E,Garcillán PP,Costa MT,Aburto-Oropeza O

更新日期：2016-04-19 00:00:00

abstract：:On the basis of task-related imaging studies in normal human subjects, it has been suggested that two attention systems exist in the human brain: a bilateral dorsal attention system involved in top-down orienting of attention and a right-lateralized ventral attention system involved in reorienting attention in respons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox MD,Corbetta M,Snyder AZ,Vincent JL,Raichle ME

更新日期：2006-06-27 00:00:00

abstract：:Organic substances can adopt an amorphous solid or semisolid state, influencing the rate of heterogeneous reactions and multiphase processes in atmospheric aerosols. Here we demonstrate how molecular diffusion in the condensed phase affects the gas uptake and chemical transformation of semisolid organic particles. Flo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiraiwa M,Ammann M,Koop T,Pöschl U

更新日期：2011-07-05 00:00:00

abstract：:The x-ray structure of rubredoxin has been refined by energy minimization. The computed structure is constrained to have standard bond lengths, bond angles, and planar trans peptide groups. Also, since most of the steric overlaps have been relieved, it has a very low energy. As judged by the root mean square (RMS) dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasse D,Warme PK,Scheraga HA

更新日期：1974-09-01 00:00:00

abstract：:RNA is involved in a variety of chromatin modification events, ranging from large-scale structural rearrangements to subtle local affects. Here, we extend the evidence for RNA-chromatin interactions to the centromere core. The data indicate that maize centromeric retrotransposons (CRMs) and satellite repeats (CentC) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Topp CN,Zhong CX,Dawe RK

更新日期：2004-11-09 00:00:00

abstract：:Midbrain dopamine (DA) neurons respond to sensory stimuli associated with future rewards. When reward is delivered probabilistically, DA neurons reflect this uncertainty by increasing their firing rates in a period between the sensory cue and reward delivery time. Probability of reward, however, has been externally co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Lafuente V,Romo R

更新日期：2011-12-06 00:00:00

abstract：:DNA origami enables the precise fabrication of nanoscale geometries. We demonstrate an approach to engineer complex and reversible motion of nanoscale DNA origami machine elements. We first design, fabricate, and characterize the mechanical behavior of flexible DNA origami rotational and linear joints that integrate s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marras AE,Zhou L,Su HJ,Castro CE

更新日期：2015-01-20 00:00:00

abstract：:The circadian clock in eukaryotes controls transcriptional and posttranscriptional events, including regulation of the levels and phosphorylation state of translation factors. However, the mechanisms underlying clock control of translation initiation, and the impact of this potential regulation on rhythmic protein syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karki S,Castillo K,Ding Z,Kerr O,Lamb TM,Wu C,Sachs MS,Bell-Pedersen D

更新日期：2020-05-19 00:00:00

abstract：:Parinaric acid (9,11,13,15-octadecatetraenoic acid), a conjugated tetraene fatty acid, undergoes a second-order photochemical reaction in phospholipid bilayers. The reaction results in the loss of the characteristic absorption of this chromophore and the development of new absorption demonstrating the presence of a tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan CG,Hudson B,Wolber PK

更新日期：1980-01-01 00:00:00

abstract：:Using the technique of DNA fingerprinting, we investigated the genetic structure within and among four wild-caught colonies (n = 50 individuals) of a eusocial mammal, the naked mole-rat (Heterocephalus glaber; Rodentia: Bathyergidae). We found that DNA fingerprints of colony-mates were strikingly similar and that betw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve HK,Westneat DF,Noon WA,Sherman PW,Aquadro CF

更新日期：1990-04-01 00:00:00

abstract：:Even in the absence of sensory stimulation, the neocortex shows complex spontaneous activity patterns, often consisting of alternating "DOWN" states of generalized neural silence and "UP" states of massive, persistent network activity. To investigate how this spontaneous activity propagates through neuronal assemblies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luczak A,Barthó P,Marguet SL,Buzsáki G,Harris KD

更新日期：2007-01-02 00:00:00

abstract：:Grain growth under shear annealing is crucial for controlling the properties of polycrystalline materials. However, their microscopic kinetics are not well understood because individual atomic trajectories are difficult to track. Here, we study grain growth with single-particle kinetics in colloidal polycrystals using...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Peng Y,Zhang Y,Still T,Yodh AG,Han Y

更新日期：2020-09-29 00:00:00

abstract：:Calls for the eradication of malaria require the development of global and regional strategies based on a strong and consistent evidence base. Evidence from the previous global malaria eradication program and more recent transborder control campaigns have shown the importance of accounting for human movement in introd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatem AJ,Smith DL

更新日期：2010-07-06 00:00:00

abstract：:Branched polyethylenimine (PEI) chains with an average molecular mass of 2 kDa (PEI2) have been covalently attached to gold nanoparticles (GNPs), and the potency of the resulting PEI2-GNPs conjugates as vectors for the delivery of plasmid DNA into monkey kidney (COS-7) cells in the presence of serum in vitro has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas M,Klibanov AM

更新日期：2003-08-05 00:00:00

abstract：:Treatment of small resting B cells with soluble F(ab')2 fragments of anti-IgM, an analogue of T-independent type 2 antigens, induced activation characterized by proliferation and the expression of surface CD5. In contrast, B cells induced to proliferate in response to thymus-dependent inductive signals provided by eit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wortis HH,Teutsch M,Higer M,Zheng J,Parker DC

更新日期：1995-04-11 00:00:00

abstract：:Several lines of evidence suggest that the mixed lineage leukemia protein (MLL, ALL-1, HRX) plays a role in regulating myelomonocytic differentiation. In this study we examined the effect of expression of MLL-AF9 on differentiation of the monoblastic U937 cell line by using a tetracycline-inducible expression system. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caslini C,Shilatifard A,Yang L,Hess JL

更新日期：2000-03-14 00:00:00

abstract：:Cities are concentrated areas of CO2 emissions and have become the foci of policies for mitigation actions. However, atmospheric measurement networks suitable for evaluating urban emissions over time are scarce. Here we present a unique long-term (decadal) record of CO2 mole fractions from five sites across Utah's met...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell LE,Lin JC,Bowling DR,Pataki DE,Strong C,Schauer AJ,Bares R,Bush SE,Stephens BB,Mendoza D,Mallia D,Holland L,Gurney KR,Ehleringer JR

更新日期：2018-03-20 00:00:00

abstract：:This communication describes the preparation of antibodies to human interleukin 2 (IL-2), using as immunogens synthetic peptides derived from the predicted amino acid sequence of IL-2. Rabbits and mice were immunized with protein carrier conjugates of eight chemically synthesized IL-2-derived peptides, each consisting...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altman A,Cardenas JM,Houghten RA,Dixon FJ,Theofilopoulos AN

更新日期：1984-04-01 00:00:00

abstract：:Morphogenesis during human development relies on the interplay between physiochemical cues that are mediated in part by cellular density and cytoskeletal tension. Here, we interrogated these factors on vascular lineage specification during human-induced pluripotent stem-cell (hiPSC) fate decision. We found that indepe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith Q,Rochman N,Carmo AM,Vig D,Chan XY,Sun S,Gerecht S

更新日期：2018-08-07 00:00:00

abstract：:Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3'-end linked to a tyrosyl moiety and has been implicated in the repair of topoisomerase I (Top1)-DNA covalent complexes. TDP1 can also hydrolyze other 3'-end DNA alterations including 3'-phosphoglycolate and 3'-abasic sites, and ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das BB,Dexheimer TS,Maddali K,Pommier Y

更新日期：2010-11-16 00:00:00

abstract：:The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than in men, even when the women and men maintain nearly identical and consistent bedtimes and wake times. Moreover, women tend to wake up earlier than men and exhibit a greater preference for morning activities than men. Altho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffy JF,Cain SW,Chang AM,Phillips AJ,Münch MY,Gronfier C,Wyatt JK,Dijk DJ,Wright KP Jr,Czeisler CA

更新日期：2011-09-13 00:00:00

abstract：:Radiation dose rates were evaluated in three areas neighboring a restricted area within a 20- to 50-km radius of the Fukushima Daiichi Nuclear Power Plant in August-September 2012 and projected to 2022 and 2062. Study participants wore personal dosimeters measuring external dose equivalents, almost entirely from depos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada KH,Niisoe T,Imanaka M,Takahashi T,Amako K,Fujii Y,Kanameishi M,Ohse K,Nakai Y,Nishikawa T,Saito Y,Sakamoto H,Ueyama K,Hisaki K,Ohara E,Inoue T,Yamamoto K,Matsuoka Y,Ohata H,Toshima K,Okada A,Sato H,Kuwa

更新日期：2014-03-11 00:00:00

abstract：:We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG) for contrast enhancement. The optical examination was performed concurrently with a magnetic resonance imaging (MRI) exam ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ntziachristos V,Yodh AG,Schnall M,Chance B

更新日期：2000-03-14 00:00:00

abstract：:In nonneuronal cells, several plasma membrane proteins such as exofacial enzymes, receptors, and ion channels recycle between their intracellular compartment(s) and the cell surface via an endosomal pathway. In neurons, however, this pathway has not been extensively characterized. In particular, it remains unclear whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thoidis G,Chen P,Pushkin AV,Vallega G,Leeman SE,Fine RE,Kandror KV

更新日期：1998-01-06 00:00:00

abstract：:Angiosperms are the largest and most successful clade of land plants with >250,000 species distributed in nearly every terrestrial habitat. Many phylogenetic studies have been based on DNA sequences of one to several genes, but, despite decades of intensive efforts, relationships among early diverging lineages and sev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jansen RK,Cai Z,Raubeson LA,Daniell H,Depamphilis CW,Leebens-Mack J,Müller KF,Guisinger-Bellian M,Haberle RC,Hansen AK,Chumley TW,Lee SB,Peery R,McNeal JR,Kuehl JV,Boore JL

更新日期：2007-12-04 00:00:00

abstract：:Most neurotransmission is mediated by action potentials, whereas sensory neurons propagate electrical signals passively and release neurotransmitter in a graded manner. Here, we demonstrate that Caenorhabditis elegans neuromuscular junctions release neurotransmitter in a graded fashion. When motor neurons were depolar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Q,Hollopeter G,Jorgensen EM

更新日期：2009-06-30 00:00:00

abstract：:Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs' biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with a monoclonal Ab (DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrelli A,Circosta P,Granziero L,Mazzone M,Pisacane A,Fenoglio S,Comoglio PM,Giordano S

更新日期：2006-03-28 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a common genetic disorder characterized by excess absorption of dietary iron and progressive iron deposition in several tissues, particularly liver. The vast majority of individuals with HH are homozygous for mutations in the HFE gene. Recently a second transferrin receptor (TFR2) wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleming RE,Ahmann JR,Migas MC,Waheed A,Koeffler HP,Kawabata H,Britton RS,Bacon BR,Sly WS

更新日期：2002-08-06 00:00:00