Coastal landforms and accumulation of mangrove peat increase carbon sequestration and storage.

abstract：:An in vitro enzyme system for the conversion of amino acid to oxime in the biosynthesis of glucosinolates has been established by the combined use of an improved isolation medium and jasmonic acid-induced etiolated seedlings of Sinapis alba L. An 8-fold induction of de novo biosynthesis of the L-tyrosine-derived p-hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du L,Lykkesfeldt J,Olsen CE,Halkier BA

更新日期：1995-12-19 00:00:00

abstract：:Viruses have unique lifestyles. To describe the pathogenesis and significance of viral infection in terms of host responses, resultant injury, and therapy, we focused on two RNA viruses: lymphocytic choriomeningitis (LCMV) and influenza (Flu). Many of the currently established concepts and consequences about viruses a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldstone MB

更新日期：2013-03-12 00:00:00

abstract：:Transcription factors (TFs) are primary regulators of gene expression in cells, where they bind specific genomic target sites to control transcription. Quantitative measurements of TF-DNA binding energies can improve the accuracy of predictions of TF occupancy and downstream gene expression in vivo and shed light on h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le DD,Shimko TC,Aditham AK,Keys AM,Longwell SA,Orenstein Y,Fordyce PM

更新日期：2018-04-17 00:00:00

abstract：:The protein kinase A stimulator cAMP can potentiate the ability of progestins to induce the transactivation function of the human progesterone receptor (hPR). We questioned in the present study whether cAMP could functionally cooperate with the progestin antagonist RU486. In T47D human breast cancer cells, RU486 behav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beck CA,Weigel NL,Moyer ML,Nordeen SK,Edwards DP

更新日期：1993-05-15 00:00:00

abstract：:The measurement of any nonchromosomal genetic contribution to the heritability of a trait is often confounded by the inability to control both the chromosomal and nonchromosomal information in a population. We have designed a unique system in yeast where we can control both sources of information so that the phenotype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards MD,Symbor-Nagrabska A,Dollard L,Gifford DK,Fink GR

更新日期：2014-05-27 00:00:00

abstract：:Kinesin-73 cDNA was shown to encode a kinesin heavy chain protein that contains an N-terminal motor domain and a long central region that lacks extensive coiled-coils. The amino acid sequence of the motor domain of kinesin-73 protein is most closely related to the motor domains of Caenorhabditis elegans unc-104 and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li HP,Liu ZM,Nirenberg M

更新日期：1997-02-18 00:00:00

abstract：:Each person's genome sequence has thousands of missense variants. Practical interpretation of their functional significance must rely on computational inferences in the absence of exhaustive experimental measurements. Here we analyzed the efficacy of these inferences in 33 de novo missense mutations revealed by sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miosge LA,Field MA,Sontani Y,Cho V,Johnson S,Palkova A,Balakishnan B,Liang R,Zhang Y,Lyon S,Beutler B,Whittle B,Bertram EM,Enders A,Goodnow CC,Andrews TD

更新日期：2015-09-15 00:00:00

abstract：:Traits that enable species to persist in ecological environments are often maintained over time, a phenomenon known as niche conservatism. Here we argue that ecological niches function at levels above species, notably at the level of genus for mammals, and that niche conservatism is also evident above the species leve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hadly EA,Spaeth PA,Li C

更新日期：2009-11-17 00:00:00

abstract：:Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron E,Pauling L

更新日期：1976-10-01 00:00:00

abstract：:The molecular mechanisms by which transcription is selectively activated and precisely controlled by signal transducer and activator of transcription (Stat) factors represent a central issue in cytokine-mediated cellular responses. Stat6 mediates responses to IL-4 and antagonizes Stat1 activated by IFN-gamma. We have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goenka S,Boothby M

更新日期：2006-03-14 00:00:00

abstract：:A procedure for combined sequential affinity adsorption-electrophoresis has been devised. Its use for the rapid purification of a calcium-dependent cyclic nucleotide phosphodiesterase from bovine brain in high yield is described. In this procedure, proteins bound to a solid phase of calcium-dependent regulatory protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kincaid RL,Vaughan M

更新日期：1979-10-01 00:00:00

abstract：:Surgical removal of one or both atrial appendages was employed in rats to reduce the intrinsic stores of atriopeptin (AP). In conscious rats (with intact baroreceptor reflexes), bilateral or unilateral atrial appendectomy suppressed the diuresis and natriuresis produced by acute volume expansion. Surprisingly, volume ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakata M,Greenwald JE,Needleman P

更新日期：1988-05-01 00:00:00

abstract：:Electromyographic recordings from individual identified ankle muscles of the 7-day chick embryo (stage 31) were used to determine the organization of motor output at a developmental stage shortly after the onset of spontaneous motility in the leg. During spontaneous motility of the embryo, the electromyographic record...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bekoff A,Stein PS,Hamburger V

更新日期：1975-04-01 00:00:00

abstract：:To relate transients of force by single kinesin molecules with the elementary steps of the ATPase cycle, we measured the time to force generation by kinesin after photorelease of ATP from caged ATP. Kinesin-coated beads were trapped by an infrared laser and brought onto microtubules fixed to a coverslip. Tension was a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higuchi H,Muto E,Inoue Y,Yanagida T

更新日期：1997-04-29 00:00:00

abstract：:The G protein-coupled m1 and m3 muscarinic acetylcholine receptors increase tyrosine phosphorylation of several proteins, including the focal adhesion-associated proteins paxillin and focal adhesion kinase (FAK), but the mechanism is not understood. Activation of integrins during adhesion of cells to extracellular mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slack BE

更新日期：1998-06-23 00:00:00

abstract：:Hypophosphatasia is a heritable form of rickets/osteomalacia with extremely variable clinical expression. Severe forms are inherited in an autosomal recessive fashion; the mode of transmission of mild forms is uncertain. The biochemical hallmark of hypophosphatasia is deficient activity of the tissue-nonspecific isozy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henthorn PS,Raducha M,Fedde KN,Lafferty MA,Whyte MP

更新日期：1992-10-15 00:00:00

abstract：:Enkephalins, a group of small peptides with opiate-like activity, have been defined originally as neuropeptides. Recent reports showed, using in situ hybridization, that the enkephalin-encoding gene, proenkephalin A (pEnkA), is expressed in nondifferentiated cells of diverse mesodermal lineages. The transient expressi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosen H,Polakiewicz RD,Benzakine S,Bar-Shavit Z

更新日期：1991-05-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expressed by liver macropha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drakesmith H,Sweetland E,Schimanski L,Edwards J,Cowley D,Ashraf M,Bastin J,Townsend AR

更新日期：2002-11-26 00:00:00

abstract：:Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL(-/-) RCC). Loss of VHL protein function is associated with constitutive expression of mRNAs encoding hypoxia-inducible proteins, such as vascular endothelial growth factor. Ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Paulsen N,Brychzy A,Fournier MC,Klausner RD,Gnarra JR,Pause A,Lee S

更新日期：2001-02-13 00:00:00

abstract：:Over the past decade, seafood mislabeling has been increasingly documented, raising public concern over the identity, safety, and sustainability of seafood. Negative outcomes from seafood mislabeling are suspected to be substantial and pervasive as seafood is the world's most highly traded food commodity. Here we prov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroetz K,Luque GM,Gephart JA,Jardine SL,Lee P,Chicojay Moore K,Cole C,Steinkruger A,Donlan CJ

更新日期：2020-12-01 00:00:00

abstract：:The E1A gene of adenovirus type 5 encodes two major proteins of 289 and 243 amino acid residues, which are identical except that the larger protein has an internal stretch of 46 amino acids required for efficient trans-activation of early viral promoters. This domain contains a consensus zinc finger motif (Cys-Xaa2-Cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Culp JS,Webster LC,Friedman DJ,Smith CL,Huang WJ,Wu FY,Rosenberg M,Ricciardi RP

更新日期：1988-09-01 00:00:00

abstract：:mTOR is an evolutionarily conserved kinase that plays a critical role in sensing and responding to environmental determinants. Recent studies have shown that fine-tuning of the activity of mTOR complexes contributes to organogenesis and tumorigenesis. Although rapamycin, an allosteric mTOR inhibitor, is an effective i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshii T,Kasada A,Hatakeyama T,Ohtani M,Tadokoro Y,Naka K,Ikenoue T,Ikawa T,Kawamoto H,Fehling HJ,Araki K,Yamamura K,Matsuda S,Hirao A

更新日期：2014-03-11 00:00:00

abstract：:The fetal genome regulates maternal physiology and behavior via its placenta, which produces hormones that act on the maternal hypothalamus. At the same time, the fetus itself develops a hypothalamus. In this study we show that many of the genes that regulate placental development also regulate the developing hypothal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broad KD,Keverne EB

更新日期：2011-09-13 00:00:00

abstract：:For more than a century we have understood that our brain's left hemisphere is the primary site for processing language, yet why this is so has remained more elusive. Using positron emission tomography, we report cerebral blood flow activity in profoundly deaf signers processing specific aspects of sign language in ke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petitto LA,Zatorre RJ,Gauna K,Nikelski EJ,Dostie D,Evans AC

更新日期：2000-12-05 00:00:00

abstract：:A deficit in early clearance of Pseudomonas aeruginosa (P. aeruginosa) is crucial in nosocomial pneumonia and in chronic lung infections. Few studies have addressed the role of Toll-like receptors (TLRs), which are early pathogen associated molecular pattern receptors, in pathogen uptake and clearance by alveolar macr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Descamps D,Le Gars M,Balloy V,Barbier D,Maschalidi S,Tohme M,Chignard M,Ramphal R,Manoury B,Sallenave JM

更新日期：2012-01-31 00:00:00

abstract：:Each G protein-coupled receptor recognizes only a distinct subset of the many structurally closely related G proteins expressed within a cell. How this selectively is achieved at a molecular level is not well understood, particularly since no specific point-to-point contact sites between a receptor and its cognate G p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Conklin BR,Blin N,Yun J,Wess J

更新日期：1995-12-05 00:00:00

abstract：:The feeling of being observed or merely participating in an experiment can affect individuals' behavior. Referred to as the Hawthorne effect, this inconsistently observed phenomenon can both provide insight into individuals' behavior and confound the interpretation of experimental manipulations. Here, we pursue both t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz D,Fischhoff B,Krishnamurti T,Sowell F

更新日期：2013-09-17 00:00:00

abstract：:The mechanism of proton transfer from the bulk into the membrane protein interior was studied. The light-induced reduction of a bound ubiquinone molecule Q(B) by the photosynthetic reaction center is accompanied by proton trapping. We used kinetic spectroscopy to measure (i) the electron transfer to Q(B) (at 450 nm), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gopta OA,Cherepanov DA,Junge W,Mulkidjanian AY

更新日期：1999-11-09 00:00:00

abstract：:The caspases are cysteine proteases that have been implicated in the execution of programmed cell death in organisms ranging from nematodes to humans. Many members of the Bcl-2 family, including Bcl-XL, are potent inhibitors of programmed cell death and inhibit activation of caspases in cells. Here, we report a direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clem RJ,Cheng EH,Karp CL,Kirsch DG,Ueno K,Takahashi A,Kastan MB,Griffin DE,Earnshaw WC,Veliuona MA,Hardwick JM

更新日期：1998-01-20 00:00:00

abstract：:The Lyz endolysin of bacteriophage P1 was found to cause lysis of the host without a holin. Induction of a plasmid-cloned lyz resulted in lysis, and the lytic event could be triggered prematurely by treatments that dissipate the proton-motive force. Instead of requiring a holin, export was mediated by an N-terminal tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Struck DK,Deaton J,Wang IN,Young R

更新日期：2004-04-27 00:00:00