Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.

abstract：:Reports differ as to whether reconstitution of telomerase activity alone is sufficient for immortalization of different types of human somatic cells or whether additional activities encoded by other "immortalizing" genes are also required. Here we show that ectopic expression of either the catalytic subunit of human t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Hare MJ,Bond J,Clarke C,Takeuchi Y,Atherton AJ,Berry C,Moody J,Silver AR,Davies DC,Alsop AE,Neville AM,Jat PS

更新日期：2001-01-16 00:00:00

abstract：:The increasing frequency of antibiotic resistance in hospital-acquired infections is a major public health concern that has both biological and economic causes. Here we develop conceptual mathematical models that couple the economic incentives and population biology of hospital infection control (HIC). We show that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DL,Levin SA,Laxminarayan R

更新日期：2005-02-22 00:00:00

abstract：:Many current treatments for the reclamation of contaminated water sources are chemical-intensive, energy-intensive, and/or require posttreatment due to unwanted by-product formation. We demonstrate that through the integration of nanostructured materials, enzymatic catalysis, and iron-catalyzed free radical reactions ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis SR,Datta S,Gui M,Coker EL,Huggins FE,Daunert S,Bachas L,Bhattacharyya D

更新日期：2011-05-24 00:00:00

abstract：:Mutagenic specificity of 2-acetylaminofluorene (AAF) has been established in mammalian cells and several strains of bacteria by using a shuttle plasmid vector containing a single N-(deoxyguanosin-8-yl)acetylaminofluorene (C8-dG-AAF) adduct. The nucleotide sequence of the gene conferring tetracycline resistance was mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moriya M,Takeshita M,Johnson F,Peden K,Will S,Grollman AP

更新日期：1988-03-01 00:00:00

abstract：:Helping and sharing among humans is often motivated by empathy and accompanied by a sense of satisfaction. To determine whether similar self-rewarding mechanisms may underpin assistance among nonhuman primates, eight female brown capuchin monkeys (Cebus apella) underwent testing in a simple choice paradigm. Paired wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Waal FB,Leimgruber K,Greenberg AR

更新日期：2008-09-09 00:00:00

abstract：:We have investigated whether interleukin 3 (IL-3) supports the growth of cells of different lineages by the same mechanism(s). The experiments were carried out with Ea3 cells, a mouse pre-B cell line, and S-480-3 cells, a mouse basophil cell line, both of which are totally IL-3 dependent. We found that Ea3 lymphocytes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palacios R,Garland J

更新日期：1984-02-01 00:00:00

abstract：:Reduction of prefrontal cortex glutamic acid decarboxylase (GAD67) and reelin (mRNAs and proteins) expression is the most consistent finding reported by several studies of postmortem schizophrenia (SZ) brains. Converging evidence suggests that the reduced GAD67 and reelin expression in cortical GABAergic interneurons ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong E,Agis-Balboa RC,Simonini MV,Grayson DR,Costa E,Guidotti A

更新日期：2005-08-30 00:00:00

abstract：:Adenosine, dibutyryl cyclic AMP, monobutyryl cyclic AMP, cyclic AMP, and 5'-AMP have a remarkable morphogenetic effect on cultured iris epithelial cells obtained from adult newt. They alter the broad undulating membrane of the cell into branching strands of cytoplasm, a configuration that has been named "stellate." Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz JR,Yamada T,Hsie AW

更新日期：1973-08-01 00:00:00

abstract：:Ion channel proteins control ionic flux across biological membranes through conformational changes in their transmembrane pores. An exponentially increasing number of channel structures captured in different conformational states are now being determined; however, these newly resolved structures are commonly classifie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao S,Klesse G,Stansfeld PJ,Tucker SJ,Sansom MSP

更新日期：2019-07-09 00:00:00

abstract：:One of the morphological hallmarks of terminally differentiated secretory cells is highly proliferated membrane of the rough endoplasmic reticulum (ER), but the molecular basis for the high rate of protein biosynthesis in these cells remains poorly documented. An important aspect of ER translational control is the mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueno T,Taga Y,Yoshimoto R,Mayeda A,Hattori S,Ogawa-Goto K

更新日期：2019-05-07 00:00:00

abstract：:Large-scale biogeographical shifts in vegetation are predicted in response to the altered precipitation and temperature regimes associated with global climate change. Vegetation shifts have profound ecological impacts and are an important climate-ecosystem feedback through their alteration of carbon, water, and energy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams HD,Guardiola-Claramonte M,Barron-Gafford GA,Villegas JC,Breshears DD,Zou CB,Troch PA,Huxman TE

更新日期：2009-04-28 00:00:00

abstract：:Monotremes have left a poor fossil record, and paleontology has been virtually mute during two decades of discussion about molecular clock estimates of the timing of divergence between the platypus and echidna clades. We describe evidence from high-resolution x-ray computed tomography indicating that Teinolophos, an E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe T,Rich TH,Vickers-Rich P,Springer M,Woodburne MO

更新日期：2008-01-29 00:00:00

abstract：:Aerosols impact climate, human health, and the chemistry of the atmosphere, and aerosol pH plays a major role in the physicochemical properties of the aerosol. However, there remains uncertainty as to whether aerosols are acidic, neutral, or basic. In this research, we show that the pH of freshly emitted (nascent) sea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angle KJ,Crocker DR,Simpson RMC,Mayer KJ,Garofalo LA,Moore AN,Mora Garcia SL,Or VW,Srinivasan S,Farhan M,Sauer JS,Lee C,Pothier MA,Farmer DK,Martz TR,Bertram TH,Cappa CD,Prather KA,Grassian VH

更新日期：2021-01-12 00:00:00

abstract：:Herein, we report the identification of a unique HIV-1 integrase (IN) inhibitor-binding site using photoaffinity labeling and mass spectrometric analysis. We chemically incorporated a photo-activatable benzophenone moiety into a series of coumarin-containing IN inhibitors. A representative of this series was covalentl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Al-Mawsawi LQ,Fikkert V,Dayam R,Witvrouw M,Burke TR Jr,Borchers CH,Neamati N

更新日期：2006-06-27 00:00:00

abstract：:The antigenic mosaic of the Archaebacterium Methanobacterium thermoautotrophicum, strain delta H, was analyzed with a panel of six monoclonal antibodies. Five antigenic determinants were identified. One contains N-acetyl-D-glucosamine, another contains N-acetyl-D-galactosamine, and a third contains gamma-glutamylalani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway de Macario E,Macario AJ,Magariños MC,König H,Kandler O

更新日期：1983-10-01 00:00:00

abstract：:Deciding whether a set of objects are the same or different is a cornerstone of perception and cognition. Surprisingly, no principled quantitative model of sameness judgment exists. We tested whether human sameness judgment under sensory noise can be modeled as a form of probabilistically optimal inference. An optimal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van den Berg R,Vogel M,Josic K,Ma WJ

更新日期：2012-02-21 00:00:00

abstract：:A dynamical theory for the evolution of the genetic code is presented, which accounts for its universality and optimality. The central concept is that a variety of collective, but non-Darwinian, mechanisms likely to be present in early communal life generically lead to refinement and selection of innovation-sharing pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vetsigian K,Woese C,Goldenfeld N

更新日期：2006-07-11 00:00:00

abstract：:Identifying the downstream targets of microRNAs (miRNAs) is essential to understanding cellular regulatory networks. We devised a direct biochemical method for miRNA target discovery that combined RNA-induced silencing complex (RISC) purification with microarray analysis of bound mRNAs. Because targets of miR-124a hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karginov FV,Conaco C,Xuan Z,Schmidt BH,Parker JS,Mandel G,Hannon GJ

更新日期：2007-12-04 00:00:00

abstract：:The enterotoxigenic Escherichia coli (ETEC) are among the most common causes of diarrheal illness and death due to diarrhea among young children in low-/middle-income countries (LMICs). ETEC have also been associated with important sequelae including malnutrition and stunting, placing children at further risk of death...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheikh A,Tumala B,Vickers TJ,Alvarado D,Ciorba MA,Bhuiyan TR,Qadri F,Singer BB,Fleckenstein JM

更新日期：2020-11-17 00:00:00

abstract：:The sessile plants have evolved a large number of receptor-like kinases (RLKs) and receptor-like cytoplasmic kinases (RLCKs) to modulate diverse biological processes, including plant innate immunity. Phosphorylation of the RLK/RLCK complex constitutes an essential step to initiate immune signaling. Two Arabidopsis pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin W,Li B,Lu D,Chen S,Zhu N,He P,Shan L

更新日期：2014-03-04 00:00:00

abstract：:The genetic basis for virulence in influenza virus is largely unknown. To explore the mutational basis for increased virulence in the lung, the H3N2 prototype clinical isolate, A/HK/1/68, was adapted to the mouse. Genomic sequencing provided the first demonstration, to our knowledge, that a group of 11 mutations can c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown EG,Liu H,Kit LC,Baird S,Nesrallah M

更新日期：2001-06-05 00:00:00

abstract：:Chondrules may have played a critical role in the earliest stages of planet formation by mediating the accumulation of dust into planetesimals. However, the origin of chondrules and their significance for planetesimal accretion remain enigmatic. Here, we show that chondrules and matrix in the carbonaceous chondrite Al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Budde G,Kleine T,Kruijer TS,Burkhardt C,Metzler K

更新日期：2016-03-15 00:00:00

abstract：:The induction of hemoglobin synthesis by dimethylsulfoxide in cells infected with Friend leukemia virus has been shown to depend on the number of cell divisions after the addition of the inducing agent. In asynchronous cultures the cells have a generation time of 24 hr, and hemoglobin synthesis occurs after 48 hr in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClintock PR,Papaconstantinou J

更新日期：1974-11-01 00:00:00

abstract：:Maturation of Asn-linked oligosaccharides in the eukaryotic secretory pathway requires the trimming of nascent glycan chains to remove all glucose and several mannose residues before extension into complex-type structures on the cell surface and secreted glycoproteins. Multiple glycoside hydrolase family 47 (GH47) α-m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiang Y,Karaveg K,Moremen KW

更新日期：2016-12-06 00:00:00

abstract：:Recent work using culture-independent methods suggests that the lungs of cystic fibrosis (CF) patients harbor a vast array of bacteria not conventionally implicated in CF lung disease. However, sampling lung secretions in living subjects requires that expectorated specimens or collection devices pass through the oroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goddard AF,Staudinger BJ,Dowd SE,Joshi-Datar A,Wolcott RD,Aitken ML,Fligner CL,Singh PK

更新日期：2012-08-21 00:00:00

abstract：:Asn-linked glycans (N-glycans) play important roles in the quality control (QC) of glycoprotein folding in the endoplasmic reticulum (ER) lumen and in ER-associated degradation (ERAD) of proteins by cytosolic proteasomes. A UDP-Glc:glycoprotein glucosyltransferase glucosylates N-glycans of misfolded proteins, which ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee S,Vishwanath P,Cui J,Kelleher DJ,Gilmore R,Robbins PW,Samuelson J

更新日期：2007-07-10 00:00:00

abstract：:The heat-stable enterotoxin B (STB) of Escherichia coli is a 48-amino acid extracellular peptide that induces rapid fluid accumulation in animal intestinal models. Unlike other E. coli enterotoxins that elicit cAMP or cGMP responses in the gut [heat-labile toxin (LT) and heat-stable toxin A (STA), respectively], STB i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dreyfus LA,Harville B,Howard DE,Shaban R,Beatty DM,Morris SJ

更新日期：1993-04-15 00:00:00

abstract：:The postdevelopmental basis of cellular identity and the unique cellular output of a particular neuron type are of particular interest in the nervous system because a detailed understanding of circuits responsible for complex processes in the brain is impeded by the often ambiguous classification of neurons in these c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz DJ,Goaillard JM,Marder EE

更新日期：2007-08-07 00:00:00

abstract：:An established line of mouse fibroblasts, C3H/10T1/2 cells, was used for the assessment in vitro of oncogenic transformations caused by single and split doses of x-rays. The shape of the dose-response relationship was determined over the range from 0.1 to 10 Gy. It was found that splitting the x-ray dose into two equa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller RC,Hall EJ,Rossi HH

更新日期：1979-11-01 00:00:00

abstract：:Sepiapterin reductase (7,8-dihydrobiopterin: NADP+ oxidoreductase, EC 1.1.1.153) catalyzes the terminal step in the biosynthetic pathway for tetrahydrobiopterin, the cofactor necessary for aromatic amino acid hydroxylation. We report here the isolation of a cDNA clone for rat liver sepiapterin reductase. The cDNA has ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Citron BA,Milstien S,Gutierrez JC,Levine RA,Yanak BL,Kaufman S

更新日期：1990-08-01 00:00:00