Cytoskeletal tension regulates mesodermal spatial organization and subsequent vascular fate.

abstract：:Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. The crystal structure of human recombinant MTCP-1 protein has been determined at 2.0 A r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu ZQ,Du Bois GC,Song SP,Kulikovskaya I,Virgilio L,Rothstein JL,Croce CM,Weber IT,Harrison RW

更新日期：1998-03-31 00:00:00

abstract：:Although much evidence suggests that the plasma membrane of eukaryotic cells is not homogenous, the precise architecture of this important structure has not been clear. Here we use transmission electron microscopy of plasma membrane sheets and specific probes to show that most or all plasma membrane-associated protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lillemeier BF,Pfeiffer JR,Surviladze Z,Wilson BS,Davis MM

更新日期：2006-12-12 00:00:00

abstract：:When long polymers such as DNA are in a highly concentrated state they may become entangled, leading to restricted self-diffusion. Here, we investigate the effect of molecular topology on diffusion in concentrated DNA solutions and find surprisingly large effects, even with molecules of modest length and concentration...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robertson RM,Smith DE

更新日期：2007-03-20 00:00:00

abstract：:The solution conformations of 2-substituted derivatives of 1-(beta-D-ribofuranosyl)benzimidazole have been determined by circular dichroism spectroscopy in aqueous solutions. It is shown that analogs with methyl, amino, or methylamino substituents at position 2 of the benzimidazole ring (position 8 of the purine ring)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Townsend LB,Miles DL,Eyring H

更新日期：1979-02-01 00:00:00

abstract：:During natural fertilization, mammalian spermatozoa must pass through the zona pellucida before reaching the plasma membrane of the oocyte. It is assumed that this step involves partial lysis of the zona by sperm acrosomal enzymes, but there has been no unequivocal evidence to support this view. Here we present eviden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirose M,Honda A,Fulka H,Tamura-Nakano M,Matoba S,Tomishima T,Mochida K,Hasegawa A,Nagashima K,Inoue K,Ohtsuka M,Baba T,Yanagimachi R,Ogura A

更新日期：2020-02-04 00:00:00

abstract：:Newly translated tubulin molecules undergo a series of complex interactions with nascent chain-binding chaperones, including prefoldin (PFD) and chaperonin-containing TCP-1 (CCT). By screening for oryzalin hypersensitivity, we identified several mutants of Arabidopsis that have lesions in PFD subunits. The pfd6-1 muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu Y,Deng Z,Paredez AR,DeBolt S,Wang ZY,Somerville C

更新日期：2008-11-18 00:00:00

abstract：:Regulation of translation is critical for maintaining cellular protein levels, and thus protein homeostasis. The conserved RNA-binding protein CsrA (also called RsmA; for carbon storage regulator and regulator of secondary metabolism, respectively; hereafter called CsrA) represents a well-characterized example of regu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altegoer F,Rensing SA,Bange G

更新日期：2016-09-06 00:00:00

abstract：:The activity-regulated cytoskeleton-associated protein (Arc) gene is a neural immediate early gene that is involved in synaptic downscaling and is robustly induced by prolonged wakefulness in rodent brains. Converging evidence has led to the hypothesis that wakefulness potentiates, and sleep reduces, synaptic strength...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki A,Yanagisawa M,Greene RW

更新日期：2020-05-12 00:00:00

abstract：:Since their discovery as key regulators of early animal development, microRNAs now are recognized as widespread regulators of gene expression. Despite their abundance, little is known regarding the regulation of microRNA biogenesis. We show that three highly conserved muscle-specific microRNAs, miR-1, miR-133 and miR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao PK,Kumar RM,Farkhondeh M,Baskerville S,Lodish HF

更新日期：2006-06-06 00:00:00

abstract：:We isolated erythroleukemic cell lines arrested at different levels of the erythroid differentiation pathway. One cell line (CB5), established from mice infected with the helper-independent Friend murine leukemia virus (F-MuLV), exhibited properties similar to those of the normal erythroid progenitor burst-forming cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shibuya T,Mak TW

更新日期：1983-06-01 00:00:00

abstract：:Tobacco mosaic virus (TMV) RNA was encapsulated in large, unilamellar phospholipid vesicles (liposomes), and the encapsulated TMV RNA was shown to be infectious when incubated with tobacco protoplasts under appropriate conditions. Maximal virus production in protoplasts was observed after their incubation with TMV RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraley RT,Dellaporta SL,Papahadjopoulos D

更新日期：1982-03-01 00:00:00

abstract：:Chromatophores of Rhodopseudomonas sphaeroides yield the antenna complex B850 in either of two states, depending on the method of isolation. Methods using dodecyl (= lauryl) dimethylamine oxide yield B850 with an absorption spectrum like that in vivo: the bands at 800 and 850 nm, due to the bacteriochlorophyll (Bchl) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clayton RK,Clayton BJ

更新日期：1981-09-01 00:00:00

abstract：:Cortical blood flow at the level of individual capillaries and the coupling of neuronal activity to flow in capillaries are fundamental aspects of homeostasis in the normal and the diseased brain. To probe the dynamics of blood flow at this level, we used two-photon laser scanning microscopy to image the motion of red...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinfeld D,Mitra PP,Helmchen F,Denk W

更新日期：1998-12-22 00:00:00

abstract：:The assembly of actin monomers into filaments and networks plays vital roles throughout eukaryotic biology, including intracellular transport, cell motility, cell division, determining cellular shape, and providing cells with mechanical strength. The regulation of actin assembly and modulation of filament mechanical p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang H,Bradley MJ,McCullough BR,Pierre A,Grintsevich EE,Reisler E,De La Cruz EM

更新日期：2012-10-16 00:00:00

abstract：:Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator for antioxidant and anti-inflammation enzymes that binds to its endogenous inhibitor protein, Kelch-like ECH (erythroid cell-derived protein with CNC homology)-associated protein 1, in the cytoplasm under normal conditions. Various e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SB,Pandita RK,Eskiocak U,Ly P,Kaisani A,Kumar R,Cornelius C,Wright WE,Pandita TK,Shay JW

更新日期：2012-10-23 00:00:00

abstract：:Peroxiredoxins (Prx), a family of peroxidases that reduce intracellular peroxides with the thioredoxin system as the electron donor, are highly expressed in various cellular compartments. Among the antioxidant Prx enzymes, Prx2 is the most abundant in mammalian neurons, making it a prime candidate to defend against ox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang J,Nakamura T,Cho DH,Gu Z,Lipton SA

更新日期：2007-11-20 00:00:00

abstract：:The 2.1-A resolution crystal structure of wild-type green fluorescent protein and comparison of it with the recently determined structure of the Ser-65 --> Thr (S65T) mutant explains the dual wavelength absorption and photoisomerization properties of the wild-type protein. The two absorption maxima are caused by a cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brejc K,Sixma TK,Kitts PA,Kain SR,Tsien RY,Ormö M,Remington SJ

更新日期：1997-03-18 00:00:00

abstract：:Gamma delta (γδ) T cells represent a major IL-17 committed T-cell population (γδT17 cells) in the mouse dermis. Following exposure to the inflammatory agent imiquimod (IMQ) the Vγ4(+) subset of γδT cells produce IL-17 in the skin and expand rapidly in draining lymph nodes (LNs). Local IMQ treatment in humans is known ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramírez-Valle F,Gray EE,Cyster JG

更新日期：2015-06-30 00:00:00

abstract：:T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systematic analysis of T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lever M,Lim HS,Kruger P,Nguyen J,Trendel N,Abu-Shah E,Maini PK,van der Merwe PA,Dushek O

更新日期：2016-10-25 00:00:00

abstract：:The influx of Ca ions into the presynaptic nerve terminal through ion channels is a key link between the action potential and the release of chemical transmitters. It is not clear, however, which types of Ca channel are involved in neurosecretion at vertebrate synapses. In particular, there is disagreement as to wheth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanley EF,Atrakchi AH

更新日期：1990-12-01 00:00:00

abstract：:The issue of protein dynamics and its implications in the biological function of proteins are arousing greater and greater interest in different fields of molecular biology. In cryo-electron tomography experiments one may take several snapshots of a given biological macromolecule. In principle, a large enough collecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bongini L,Fanelli D,Piazza F,De Los Rios P,Sandin S,Skoglund U

更新日期：2004-04-27 00:00:00

abstract：:Histone acetylation is a major epigenetic control mechanism that is tightly linked to the promotion of gene expression. Histone acetylation levels are balanced through the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Arabidopsis HDAC genes (AtHDACs) compose a large gene fa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YJ,Wang R,Gao L,Li D,Xu C,Mang H,Jeon J,Chen X,Zhong X,Kwak JM,Mo B,Xiao L,Chen X

更新日期：2016-12-20 00:00:00

abstract：:Stimulation of catecholamine release was studied in the isolated adrenal of the cat during retrograde perfusion. Theophylline, adenosine 3':5'-cyclic monophosphate (cyclic AMP), and dibutyryl-cyclic AMP stimulated catecholamine release in adrenal chromaffin tissue; adenosine, 2'-AMP, 3'-AMP, and 5'-AMP were ineffectiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peach MJ

更新日期：1972-04-01 00:00:00

abstract：:Most variation in behavior has a genetic basis, but the processes determining the level of diversity at behavioral loci are largely unknown for natural populations. Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lonn E,Koskela E,Mappes T,Mokkonen M,Sims AM,Watts PC

更新日期：2017-04-04 00:00:00

abstract：:Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes. By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors on several autophagy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter B,Sliter DA,Herhaus L,Stolz A,Wang C,Beli P,Zaffagnini G,Wild P,Martens S,Wagner SA,Youle RJ,Dikic I

更新日期：2016-04-12 00:00:00

abstract：:Cytosine methylation at CpG dinucleotides contributes to the epigenetic maintenance of gene silencing. Dynamic reprogramming of DNA methylation patterns is believed to play a key role during development and differentiation in vertebrates. The mechanisms of DNA demethylation remain unclear and controversial. Here, we p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kress C,Thomassin H,Grange T

更新日期：2006-07-25 00:00:00

abstract：:We test the conjecture that becoming unemployed erodes the extent to which a person acknowledges earned entitlement. We use behavioral experiments to generate incentive-compatible measures of individuals' tendencies to acknowledge earned entitlement and incorporate these experiments in a two-stage study. In the first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barr A,Miller L,Ubeda P

更新日期：2016-04-26 00:00:00

abstract：:Single-cell RNA sequencing (scRNA-seq) enables the quantification of each gene's expression distribution across cells, thus allowing the assessment of the dispersion, nonzero fraction, and other aspects of its distribution beyond the mean. These statistical characterizations of the gene expression distribution are cri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang J,Huang M,Torre E,Dueck H,Shaffer S,Murray J,Raj A,Li M,Zhang NR

更新日期：2018-07-10 00:00:00

abstract：:Heymann nephritis is an experimental autoimmune disease model for human membranous nephropathy. We have recently identified a pathogenic epitope, clone 14 (C14), responsible for formation and deposition of glomerular immune complexes that is contained within the small subunit of the Heymann nephritis antigenic complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kerjaschki D,Ullrich R,Diem K,Pietromonaco S,Orlando RA,Farquhar MG

更新日期：1992-12-01 00:00:00

abstract：:Genomic RNA from the human prototype strain H of the hepatitis C virus (HCV-H) has been molecularly cloned and sequenced. The HCV-H sequence reported consists of 9416 nucleotides including the 5' and 3' untranslated regions. HCV-H shows 96% amino acid identity with the American isolate HCV-1 but only 84.9% with the Ja...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inchauspe G,Zebedee S,Lee DH,Sugitani M,Nasoff M,Prince AM

更新日期：1991-11-15 00:00:00