Gene expression distribution deconvolution in single-cell RNA sequencing.

abstract：:Oxidative stress exacerbates neovascularization (NV) in many disease processes. In this study we investigated the mechanism of that effect. Mice deficient in superoxide dismutase 1 (Sod1(-/-) mice) have increased oxidative stress and show severe ocular NV that is reduced to baseline by antioxidants. Compared with wild...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong A,Shen J,Zeng M,Campochiaro PA

更新日期：2011-08-30 00:00:00

abstract：:Growing human and ecological costs due to increasing wildfire are an urgent concern in policy and management, particularly given projections of worsening fire conditions under climate change. Thus, understanding the relationship between climatic variation and fire activity is a critically important scientific question...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Syphard AD,Keeley JE,Pfaff AH,Ferschweiler K

更新日期：2017-12-26 00:00:00

abstract：:Antidiuretic hormone (ADH) increases the water permeability of the toad urinary bladder. The increase occurs in the apical plasma membrane of granular cells that line the urinary surface of the bladder and is produced by the insertion of water permeability units that have been identified by freeze-fracture electron mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris HW Jr,Wade JB,Handler JS

更新日期：1988-03-01 00:00:00

abstract：:HIV-1, the cause of AIDS, is composed of four phylogenetic lineages, groups M, N, O, and P, each of which resulted from an independent cross-species transmission event of simian immunodeficiency viruses (SIVs) infecting African apes. Although groups M and N have been traced to geographically distinct chimpanzee commun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'arc M,Ayouba A,Esteban A,Learn GH,Boué V,Liegeois F,Etienne L,Tagg N,Leendertz FH,Boesch C,Madinda NF,Robbins MM,Gray M,Cournil A,Ooms M,Letko M,Simon VA,Sharp PM,Hahn BH,Delaporte E,Mpoudi Ngole E,Peeters M

更新日期：2015-03-17 00:00:00

abstract：:Previous work showed that cultured human pancreatic cancer cells overexpress the epidermal growth factor (EGF) receptor. In the present study, we sought to determine whether some of these cell lines produce transforming growth factor alpha (TGF-alpha). Utilizing a radiolabeled TGF-alpha cDNA in hybridization experimen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith JJ,Derynck R,Korc M

更新日期：1987-11-01 00:00:00

abstract：:mtDNA mutations occur in a wide variety of degenerative diseases and cancer. mtDNA seems to be more susceptible to DNA damage and consequently sustains higher rates of mutation than does nuclear DNA (nDNA). Many of the somatic mtDNA mutations in human cancers are located in the displacement loop (D-loop) and in partic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mambo E,Gao X,Cohen Y,Guo Z,Talalay P,Sidransky D

更新日期：2003-02-18 00:00:00

abstract：:The migration of species across interfaces can crucially affect the performance of heterogeneous catalysts. A key concept in using bimetallic catalysts for hydrogenation is that the active metal supplies hydrogen atoms to the host metal, where selective hydrogenation can then occur. Herein, we demonstrate that, follow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Connor CR,Duanmu K,Patel DA,Muramoto E,van Spronsen MA,Stacchiola D,Sykes ECH,Sautet P,Madix RJ,Friend CM

更新日期：2020-09-15 00:00:00

abstract：:A comprehensive mapping of interactions among Epstein-Barr virus (EBV) proteins and interactions of EBV proteins with human proteins should provide specific hypotheses and a broad perspective on EBV strategies for replication and persistence. Interactions of EBV proteins with each other and with human proteins were as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calderwood MA,Venkatesan K,Xing L,Chase MR,Vazquez A,Holthaus AM,Ewence AE,Li N,Hirozane-Kishikawa T,Hill DE,Vidal M,Kieff E,Johannsen E

更新日期：2007-05-01 00:00:00

abstract：:Current structural genomics projects are yielding structures for proteins whose functions are unknown. Accordingly, there is a pressing requirement for computational methods for function prediction. Here we present PHUNCTIONER, an automatic method for structure-based function prediction using automatically extracted f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pazos F,Sternberg MJ

更新日期：2004-10-12 00:00:00

abstract：:Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oda S,Toyoshima Y,de Bono M

更新日期：2017-06-06 00:00:00

abstract：:Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine's antidepressant and adverse effects, the potency of (2R,6R)-HNK to inhibit NMDARs has not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lumsden EW,Troppoli TA,Myers SJ,Zanos P,Aracava Y,Kehr J,Lovett J,Kim S,Wang FH,Schmidt S,Jenne CE,Yuan P,Morris PJ,Thomas CJ,Zarate CA Jr,Moaddel R,Traynelis SF,Pereira EFR,Thompson SM,Albuquerque EX,Gould TD

更新日期：2019-03-12 00:00:00

abstract：:Defining prospective pathways by which zoonoses evolve and emerge as human pathogens is critical for anticipating and controlling both natural and deliberate pandemics. However, predicting tenable pathways of animal-to-human movement has been hindered by challenges in identifying reservoir species, cultivating zoonoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker MM,Graham RL,Donaldson EF,Rockx B,Sims AC,Sheahan T,Pickles RJ,Corti D,Johnston RE,Baric RS,Denison MR

更新日期：2008-12-16 00:00:00

abstract：:Bufonid anurans of the genus Atelopus contain both steroidal bufadienolides and various guanidinium alkaloids of the tetrodotoxin class. The former inhibit sodium-potassium ATPases, whereas the latter block voltage-dependent sodium channels. The structure of one guanidinium alkaloid, zetekitoxin AB, has remained a mys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yotsu-Yamashita M,Kim YH,Dudley SC Jr,Choudhary G,Pfahnl A,Oshima Y,Daly JW

更新日期：2004-03-30 00:00:00

abstract：:Although the left and right human cerebral hemispheres differ both functionally and anatomically, little is known about the environmental or genetic factors that govern central nervous system asymmetry. Nevertheless, cerebral asymmetry is strongly correlated with handedness, and handedness does have a significant gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geschwind DH,Miller BL,DeCarli C,Carmelli D

更新日期：2002-03-05 00:00:00

abstract：:Many thylakoid lumen proteins are synthesized outside the chloroplast as larger molecular weight precursors and then processed to their mature size during transport to the lumenal space. We have examined the post-translational processing of thylakoid lumen proteins in vivo by pulse-radiolabeling experiments with Chlam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howe G,Merchant S

更新日期：1993-03-01 00:00:00

abstract：:Global increases in population, consumption, and gross domestic product raise concerns about the sustainability of the current and future use of natural resources. The human appropriation of net primary production (HANPP) provides a useful measure of human intervention into the biosphere. The productive capacity of la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krausmann F,Erb KH,Gingrich S,Haberl H,Bondeau A,Gaube V,Lauk C,Plutzar C,Searchinger TD

更新日期：2013-06-18 00:00:00

abstract：:Different splice variants of the proinflammatory cytokine IL-32 are found in various tissues; their putative differences in biological function remain unknown. In the present study, we report that IL-32γ is the most active isoform of the cytokine. Splicing to one less active IL-32β appears to be a salvage mechanism to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heinhuis B,Koenders MI,van de Loo FA,Netea MG,van den Berg WB,Joosten LA

更新日期：2011-03-22 00:00:00

abstract：:We investigate the role of identity and self-image consideration under "pay-what-you-want" pricing. Results from three field experiments show that often, when granted the opportunity to name the price of a product, fewer consumers choose to buy it than when the price is fixed and low. We show that this opt-out behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gneezy A,Gneezy U,Riener G,Nelson LD

更新日期：2012-05-08 00:00:00

abstract：:Since the end of World War II, much evidence has accrued of the primary phase of village-farming community life in Southwestern Asia, which began about 7000 B.C. The remains of (usually) several of the positively domesticated animals (dog, sheep, goat, pig) and plants (wheat, barley, legumes such as peas and lentils) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braidwood RJ,Cambel H,Redman CL,Watson PJ

更新日期：1971-06-01 00:00:00

abstract：:Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an exte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai SY,Pokrass MJ,Klauer NR,Nohara H,Su TP

更新日期：2015-05-26 00:00:00

abstract：:Dimension reduction methods are commonly applied to high-throughput biological datasets. However, the results can be hindered by confounding factors, either biological or technical in origin. In this study, we extend principal component analysis (PCA) to propose AC-PCA for simultaneous dimension reduction and adjustme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Z,Yang C,Zhu Y,Duchi J,Fu Y,Wang Y,Jiang B,Zamanighomi M,Xu X,Li M,Sestan N,Zhao H,Wong WH

更新日期：2016-12-20 00:00:00

abstract：:Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for determining the seve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani N,Dupuy B

更新日期：2001-05-08 00:00:00

abstract：:Antigen-independent cell lines were derived from mouse helper T-cell clones by culture in autologous supernatant obtained after stimulation with concanavalin A. A factor, termed P40, supporting the growth of these lines was purified and characterized as a basic 32- to 39-kDa single-chain glycoprotein functionally dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uyttenhove C,Simpson RJ,Van Snick J

更新日期：1988-09-01 00:00:00

abstract：:The distribution of actin stress fibers in normal and regenerating (after endothelial denudation by means of a balloon catheter) rabbit aortic endothelial cells has been studied by means of immunofluorescence with human actin autoantibodies on en face endothelial cell preparations. Our results show that: (i) under nor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gabbiani G,Gabbiani F,Lombardi D,Schwartz SM

更新日期：1983-04-01 00:00:00

abstract：:The DNA-containing Epstein-Barr herpesvirus has been implicated in the etiology of Burkitt's lymphoma, a malignant tumor of children in Africa. Recently, however, particles possessing four biochemical characteristics of RNA tumor viruses have also been identified in these tumors. The fact that both types of viruses ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peters WP,Kufe D,Schlom J,Frankel JW,Prickett CO,Groupé V,Spiegelman S

更新日期：1973-11-01 00:00:00

abstract：:Noncompliance with social distancing during the early stage of the coronavirus disease 2019 (COVID-19) pandemic poses a great challenge to the public health system. These noncompliance behaviors partly reflect people's concerns for the inherent costs of social distancing while discounting its public health benefits. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie W,Campbell S,Zhang W

更新日期：2020-07-28 00:00:00

abstract：:Protein stability is usually studied in simple buffered solutions, but most proteins function inside cells, where the heterogeneous and crowded environment presents a complex, nonideal system. Proteins are expected to behave differently under cellular crowding owing to two types of contacts: hard-core repulsions and w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar M,Smith AE,Pielak GJ

更新日期：2013-11-26 00:00:00

abstract：:The orphan nuclear receptor Nur77/N10 has recently been demonstrated to be involved in apoptosis of T cell hybridomas. We report here that chronic expression of Nur77/N10 in thymocytes of transgenic mice results in a dramatic reduction of CD4+CD8+ double-positive as well as CD4+CD8- and CD4-CD8+ single-positive cell p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weih F,Ryseck RP,Chen L,Bravo R

更新日期：1996-05-28 00:00:00

abstract：:The type I collagenopathies are a group of heterogeneous connective tissue disorders, that are caused by mutations in the genes encoding type I collagen and include specific forms of osteogenesis imperfecta (OI) and the Ehlers-Danlos syndrome (EDS). These disorders present with a broad disease spectrum and large clini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gistelinck C,Kwon RY,Malfait F,Symoens S,Harris MP,Henke K,Hawkins MB,Fisher S,Sips P,Guillemyn B,Bek JW,Vermassen P,De Saffel H,Witten PE,Weis M,De Paepe A,Eyre DR,Willaert A,Coucke PJ

更新日期：2018-08-21 00:00:00

abstract：:Much debate has revolved around the question of whether the mode of evolutionary and ecological turnover in the fossil record of African mammals was continuous or pulsed, and the degree to which faunal turnover tracked changes in global climate. Here, we assembled and analyzed large specimen databases of the fossil re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi F,Kiessling W

更新日期：2015-08-25 00:00:00