Two distinct populations of synaptic-like vesicles from rat brain.

abstract：:The plant hormones abscisic acid (ABA) and gibberellic acid (GA) are important regulators of the dormancy and germination of seeds. In cereals, GA enhances the synthesis and secretion of enzymes (principally alpha-amylases) in the aleurone cells of the endosperm, which then mobilize the storage reserves that fuel germ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritchie S,Gilroy S

更新日期：1998-03-03 00:00:00

abstract：:The intracellular localization of phytochrome was seen in dark-grown oat (Avena sativa L., cv. Garry) and rice (Oryza sativa L., cv. unknown) shoots after various light treatments using an indirect peroxidase-antiperoxidase antibody labeling method. Phytochrome is generally distributed throughout the cytoplasm in cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackenzie JM Jr,Coleman RA,Briggs WR,Pratt LH

更新日期：1975-03-01 00:00:00

abstract：:Structure and function of p185neu receptor tyrosine kinase were found to be regulated in a cell cycle-dependent manner. In M phase, p185neu is hyperphosphorylated at serine and/or threonine residues. The phosphotyrosine [Tyr(P)] content of p185neu is at its highest level in G0/G1 phase, decreases through S and G2 phas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiyokawa N,Yan DH,Brown ME,Hung MC

更新日期：1995-02-14 00:00:00

abstract：:Retinoic acid receptor beta (RAR beta), which codes for a nuclear receptor for retinoic acid, is localized in a chromosomal region frequently deleted in lung cancer cells. The gene is expressed in normal lung tissue and in the majority of the cell lines derived from lung tumors but not in most of the lines derived fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houle B,Rochette-Egly C,Bradley WE

更新日期：1993-02-01 00:00:00

abstract：:In the manufacture of chemical feedstocks and subsequent processing into derivatives and materials, the U.S. chemical industry sets the current standard of excellence for technological competitiveness. This world-class leadership is attributed to the innovation and advancement of chemical engineering process technolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell JW

更新日期：1992-02-01 00:00:00

abstract：:Retroviral entry into cells depends on envelope glycoproteins, whereby receptor binding to the surface-exposed subunit triggers membrane fusion by the transmembrane protein (TM) subunit. We determined the crystal structure at 2.5-A resolution of the ectodomain of gp21, the TM from human T cell leukemia virus type 1. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobe B,Center RJ,Kemp BE,Poumbourios P

更新日期：1999-04-13 00:00:00

abstract：:Glutamyl-tRNA (Glu-tRNA), formed by Glu-tRNA synthetase (GluRS), is a substrate for protein biosynthesis and tetrapyrrole formation by the C(5) pathway. In this route Glu-tRNA is transformed to delta-aminolevulinic acid, the universal precursor of tetrapyrroles (e.g., heme and chlorophyll) by the action of Glu-tRNA re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levicán G,Katz A,de Armas M,Núñez H,Orellana O

更新日期：2007-02-27 00:00:00

abstract：:A broad program of freezing species in threatened ecospheres could preserve biodiversity for eventual use by future generations. Sampling without studying can lower costs dramatically. Local labor can do most of the gathering. Plausible costs of collecting and cryogenically suspending the tropical rain forest species,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benford G

更新日期：1992-11-15 00:00:00

abstract：:Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to characterize naturally occurring mutants from tumor cells to pinpoint potential domains of RB protein crucial for tumor suppression. We show here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shew JY,Lin BT,Chen PL,Tseng BY,Yang-Feng TL,Lee WH

更新日期：1990-01-01 00:00:00

abstract：:Phosphatase PP2A expression levels are positively correlated to the clinical severity of systemic lupus erythematosus (SLE) and IL17A cytokine overproduction, indicating a potential role of PP2A in controlling TH17 differentiation and inflammation. By generating a mouse strain with ablation of the catalytic subunit α ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Q,Jin X,Zheng M,Rohila D,Fu G,Wen Z,Lou J,Wu S,Sloan R,Wang L,Hu H,Gao X,Lu L

更新日期：2019-01-15 00:00:00

abstract：:Four polyimidazoles were used in the binding and cleavage studies with poly(U). The two polydisperse polyvinylimidazoles were previously described by others, while the other two new polymers of polyethyleneimines were prepared by cationic polymerization of oxazolines. The latter had imidazole units attached to each ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng L,Abhilash KG,Breslow R

更新日期：2012-08-07 00:00:00

abstract：:Spectral methods are of fundamental importance in statistics and machine learning, because they underlie algorithms from classical principal components analysis to more recent approaches that exploit manifold structure. In most cases, the core technical problem can be reduced to computing a low-rank approximation to a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belabbas MA,Wolfe PJ

更新日期：2009-01-13 00:00:00

abstract：:Cancer therapies using genes and other macromolecules might realize their full clinical potential if they could be delivered to tumor tissue in optimal quantities. Unfortunately, the compromised circulation within tumors poses a formidable resistance to adequate and uniform penetration of these agents. Previously, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Netti PA,Hamberg LM,Babich JW,Kierstead D,Graham W,Hunter GJ,Wolf GL,Fischman A,Boucher Y,Jain RK

更新日期：1999-03-16 00:00:00

abstract：:The Na,K-ATPase contains a binding site for cardiac glycosides, such as ouabain, digoxin, and digitoxin, which is highly conserved among species ranging from Drosophila to humans. Although advantage has been taken of this site to treat congestive heart failure with drugs such as digoxin, it is unknown whether this sit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dostanic-Larson I,Van Huysse JW,Lorenz JN,Lingrel JB

更新日期：2005-11-01 00:00:00

abstract：:Immunoprecipitation of proteins extracted from metabolically labeled human glioblastoma and fibrosarcoma cells with antiserum to platelet-derived growth factor (PDGF) showed that these cells express and secrete proteins that are recognized specifically by the antiserum. The molecular masses of immunoprecipitated prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pantazis P,Pelicci PG,Dalla-Favera R,Antoniades HN

更新日期：1985-04-01 00:00:00

abstract：:Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Crowther RA,Jakes R,Hasegawa M,Goedert M

更新日期：1998-05-26 00:00:00

abstract：:Intestinal trefoil factor (ITF) is an essential regulator of colonic epithelial restitution, the rapid migration of colonocytes over mucosal wounds. High levels of ITF are frequently present in colorectal cancers and derived cell lines. Mucosal restitution requires the detachment of epithelium from substrate, which wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taupin DR,Kinoshita K,Podolsky DK

更新日期：2000-01-18 00:00:00

abstract：:Hybridization of human T cells with an azaguanine-resistant human T cell line gave rise to T hybrid cell lines secreting several immunoregulatory molecules. Analyses of karyotypes, HLA phenotypes, and other surface phenotypes, such as T-cell-specific antigens or receptors for sheep erythrocytes and the patterns of mit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada M,Yoshimura N,Kaieda T,Yamamura Y,Kishimoto T

更新日期：1981-12-01 00:00:00

abstract：:The properties of glycine receptors (GlyRs) from newborn and adult rat spinal cord were studied in Xenopus oocytes injected with whole mRNA or the heavy (H) or light (L) mRNA fractions encoding their respective GlyRs. Mean open times and conductances of channels gated by H- or L-GlyRs were determined by noise analysis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morales A,Nguyen QT,Miledi R

更新日期：1994-04-12 00:00:00

abstract：:This report provides direct evidence that strigolactone (SL) positively regulates drought and high salinity responses in Arabidopsis. Both SL-deficient and SL-response [more axillary growth (max)] mutants exhibited hypersensitivity to drought and salt stress, which was associated with shoot- rather than root-related t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha CV,Leyva-González MA,Osakabe Y,Tran UT,Nishiyama R,Watanabe Y,Tanaka M,Seki M,Yamaguchi S,Dong NV,Yamaguchi-Shinozaki K,Shinozaki K,Herrera-Estrella L,Tran LS

更新日期：2014-01-14 00:00:00

abstract：:Criegee intermediates are thought to play a role in atmospheric chemistry, in particular, the oxidation of SO2, which produces SO3 and subsequently H2SO4, an important constituent of aerosols and acid rain. However, the impact of such oxidation reactions is affected by the reactions of Criegee intermediates with water...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang HL,Chao W,Lin JJ

更新日期：2015-09-01 00:00:00

abstract：:Intrinsic genetic instability of RNA viruses may lead to the accumulation of revertants during manufacture of live viral vaccines, requiring rigorous quality control to ensure vaccine safety. Each lot of oral poliovirus vaccine (OPV) is tested for neurovirulence in animals and also for the presence of neurovirulent re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neverov A,Chumakov K

更新日期：2010-11-16 00:00:00

abstract：:Synthesis of mouse metallothionein (MT)-I and MT-II is transcriptionally induced by the synthetic glucocorticoid, dexamethasone (DEX) or both in vivo as well as in numerous cell lines. However, the location(s) of a glucocorticoid response element (GRE) has not been described. The observation that a marked MT-I gene, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly EJ,Sandgren EP,Brinster RL,Palmiter RD

更新日期：1997-09-16 00:00:00

abstract：:The maytansinoid drug DM1 is 100- to 1000-fold more cytotoxic than anticancer drugs that are currently in clinical use. The immunoconjugate C242-DM1 was prepared by conjugating DM1 to the monoclonal antibody C242, which recognizes a mucin-type glycoprotein expressed to various extents by human colorectal cancers. C242...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Tadayoni BM,Bourret LA,Mattocks KM,Derr SM,Widdison WC,Kedersha NL,Ariniello PD,Goldmacher VS,Lambert JM,Blättler WA,Chari RV

更新日期：1996-08-06 00:00:00

abstract：:Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in chronic inflammation and immunodeficiency. Although antiretroviral the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crakes KR,Santos Rocha C,Grishina I,Hirao LA,Napoli E,Gaulke CA,Fenton A,Datta S,Arredondo J,Marco ML,Sankaran-Walters S,Cortopassi G,Giulivi C,Dandekar S

更新日期：2019-12-03 00:00:00

abstract：:We describe a cell-free system in which the transcription of the yeast metallothionein gene is inducible by the addition of metal ions plus a specific regulatory protein. Efficient transcription requires the complete yeast ACE1 metalloregulatory protein, including both its DNA-binding and transactivation domains; a mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Culotta VC,Hsu T,Hu S,Fürst P,Hamer D

更新日期：1989-11-01 00:00:00

abstract：:Determinants of the recommended dietary allowance (RDA) for vitamin C include the relationship between vitamin C dose and steady-state plasma concentration, bioavailability, urinary excretion, cell concentration, and potential adverse effects. Because current data are inadequate, an in-hospital depletion-repletion stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine M,Conry-Cantilena C,Wang Y,Welch RW,Washko PW,Dhariwal KR,Park JB,Lazarev A,Graumlich JF,King J,Cantilena LR

更新日期：1996-04-16 00:00:00

abstract：:Full-length 66-kDa estrogen receptor alpha (ERalpha) stimulates target gene transcription through two activation functions (AFs), AF-1 in the N-terminal domain and AF-2 in the ligand binding domain. Another physiologically expressed 46-kDa ERalpha isoform lacks the N-terminal A/B domains and is consequently devoid of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Billon-Galés A,Fontaine C,Filipe C,Douin-Echinard V,Fouque MJ,Flouriot G,Gourdy P,Lenfant F,Laurell H,Krust A,Chambon P,Arnal JF

更新日期：2009-02-10 00:00:00

abstract：:A transient transfection assay using Drosophila S2 tissue culture cells and WT and mutant Drosophila vnd/NK-2 homeobox cDNAs was used to localize repression and activation domains of vnd/NK-2 homeodomain protein. A repression domain was identified near the N terminus of vnd/NK-2 homeodomain protein (amino acid residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stepchenko A,Nirenberg M

更新日期：2004-09-07 00:00:00

abstract：:By using a systematic genetic approach, the resonances in the 19F NMR spectrum of 3-fluorotyrosine-substituted lac repressor protein have been assigned. The NMR data indicate that each monomer of the repressor consists of two distinct and independent domains. One domain, the NH2-terminal sixth of the primary sequence,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarema MA,Lu P,Miller JH

更新日期：1981-05-01 00:00:00