Formation of IgE-binding factors by T cells of patients infected with human immunodeficiency virus type 1.

abstract：:Phosphatidylinositol (3,4,5)-triphosphate (PtdInsP(3)) mediates intracellular signaling for directional sensing and pseudopod extension at the leading edge of migrating cells during chemotaxis. How this PtdInsP(3) signal is translated into remodeling of the actin cytoskeleton is poorly understood. Here, using a proteo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang P,Wang Y,Sesaki H,Iijima M

更新日期：2010-06-29 00:00:00

abstract：:Complexin activates Ca(2+)-triggered neurotransmitter release and regulates spontaneous release in the presynaptic terminal by cooperating with the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and the Ca(2+)-sensor synaptotagmin. The N-terminal domain of complexin is importa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Y,Choi UB,Zhang Y,Zhao M,Pfuetzner RA,Wang AL,Diao J,Brunger AT

更新日期：2016-08-09 00:00:00

abstract：:The question was addressed whether the risk of cancer of an individual in a heterogeneous population can be predicted on the basis of measurable biochemical and biological variables postulated to be associated with the process of chemical carcinogenesis. Using the skin tumor model with outbred male NMRI mice, the late...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer WH,Lutz WK

更新日期：1995-06-20 00:00:00

abstract：:The exquisite NMR spectral sensitivity and negligible reactivity of hyperpolarized xenon-129 (HP(129)Xe) make it attractive for a number of magnetic resonance applications; moreover, HP(129)Xe embodies an alternative to rare and nonrenewable (3)He. However, the ability to reliably and inexpensively produce large quant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikolaou P,Coffey AM,Walkup LL,Gust BM,Whiting N,Newton H,Barcus S,Muradyan I,Dabaghyan M,Moroz GD,Rosen MS,Patz S,Barlow MJ,Chekmenev EY,Goodson BM

更新日期：2013-08-27 00:00:00

abstract：:Collective intelligence refers to the ability of groups to outperform individual decision makers when solving complex cognitive problems. Despite its potential to revolutionize decision making in a wide range of domains, including medical, economic, and political decision making, at present, little is known about the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurvers RH,Herzog SM,Hertwig R,Krause J,Carney PA,Bogart A,Argenziano G,Zalaudek I,Wolf M

更新日期：2016-08-02 00:00:00

abstract：:A novel type I transmembrane protein of COPI-coated vesicles, p23, has been demonstrated to be localized mainly to the Golgi complex. This protein and p24, another member of the p24 family, have been shown to bind coatomer via their short cytoplasmic tails. Here we demonstrate that p23 continuously cycles through the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nickel W,Sohn K,Bünning C,Wieland FT

更新日期：1997-10-14 00:00:00

abstract：:Phosphatidylinositol 3,4,5-triphosphate (PIP3) plays a key role in neuronal polarization and axon formation. PIP3-containing vesicles are transported to axon tips by the kinesin KIF13B via an adaptor protein, centaurin α1 (CENTA1). KIF13B interacts with CENTA1 through its forkhead-associated (FHA) domain. We solved th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tong Y,Tempel W,Wang H,Yamada K,Shen L,Senisterra GA,MacKenzie F,Chishti AH,Park HW

更新日期：2010-11-23 00:00:00

abstract：:The stability and integrity of mRNAs encoding neurotransmitter receptors and voltage-activated channels in the postmortem rat brain was investigated by isolating poly(A)+ mRNA, injecting it into Xenopus oocytes, and then examining the expression of functional neurotransmitter receptors and voltage-activated channels i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ragsdale DS,Miledi R

更新日期：1991-03-01 00:00:00

abstract：:We present a method for designing a funnel-shaped free-energy surface that reproducibly assembles secondary structure elements of proteins into their native conformations from a random extended configuration. Assuming a priori knowledge of secondary structure, our method can design a funnel-shaped surface for folding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fain B,Levitt M

更新日期：2003-09-16 00:00:00

abstract：:Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood. Here we report that mammary tumors induced by components of the Wnt signaling pathway contain heterogeneous cell types an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Welm B,Podsypanina K,Huang S,Chamorro M,Zhang X,Rowlands T,Egeblad M,Cowin P,Werb Z,Tan LK,Rosen JM,Varmus HE

更新日期：2003-12-23 00:00:00

abstract：:We report the nucleotide sequences of iaaM and iaaH, the genetic determinants for, respectively, tryptophan 2-monooxygenase and indoleacetamide hydrolase, the enzymes that catalyze the conversion of L-tryptophan to indoleacetic acid in the tumor-forming bacterium Pseudomonas syringae pv. savastanoi. The sequence analy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamada T,Palm CJ,Brooks B,Kosuge T

更新日期：1985-10-01 00:00:00

abstract：:A methionine-rich low complexity (LC) domain is found within a C-terminal region of the TDP43 RNA-binding protein. Self-association of this domain leads to the formation of labile cross-β polymers and liquid-like droplets. Treatment with H2O2 caused phenomena of methionine oxidation and droplet melting that were rever...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Y,Zhou X,Kato M,Liu D,Ghaemmaghami S,Tu BP,McKnight SL

更新日期：2020-11-17 00:00:00

abstract：:Sulfoquinovose (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the plant sulfolipid SQ-diacylglycerol, and SQ comprises a major proportion of the organosulfur in nature, where it is degraded by bacteria. A first degradation pathway for SQ has been demonstrated recently, a "sulfoglycolytic" pathway, in addition...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felux AK,Spiteller D,Klebensberger J,Schleheck D

更新日期：2015-08-04 00:00:00

abstract：:It was proved that the protoplasts prepared from mesophyll of Nicotiana tabacum are infected by tobacco mosaic virus. The infection occurred when purified tobacco mosaic virus particles were added to a protoplast suspension in the presence of poly-L-ornithine. The virus multiplied in these protoplasts to a level of 10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takebe I,Otsuki Y

更新日期：1969-11-01 00:00:00

abstract：:A sensitive target binding assay has recently been shown to detect natural killer (NK) cells in the mouse. Preincubation of NK cells with detergent-solubilized cell-surface proteins of YAC lymphoma cells prevented subsequent binding to intact YAC targets. The NK target structures (NK-TS) consisted of three molecular s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roder JC,Rosén A,Fenyö EM,Troy FA

更新日期：1979-03-01 00:00:00

abstract：:The Mars Organic Analyzer (MOA), a microfabricated capillary electrophoresis (CE) instrument for sensitive amino acid biomarker analysis, has been developed and evaluated. The microdevice consists of a four-wafer sandwich combining glass CE separation channels, microfabricated pneumatic membrane valves and pumps, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skelley AM,Scherer JR,Aubrey AD,Grover WH,Ivester RH,Ehrenfreund P,Grunthaner FJ,Bada JL,Mathies RA

更新日期：2005-01-25 00:00:00

abstract：:Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Q,Wu D,Chen W,Yan Z,Yan C,He T,Liang Q,Shi Y

更新日期：2014-11-18 00:00:00

abstract：:To initiate transcription from specific promoters, the bacterial RNA polymerase (RNAP) core enzyme must associate with the initiation factor sigma, which contains determinants that allow sequence-specific interactions with promoter DNA. Most bacteria contain several sigma factors, each of which directs recognition of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuan AH,Nickels BE,Hochschild A

更新日期：2009-04-21 00:00:00

abstract：:In enzyme catalysis, where exquisitely positioned functionality is the sine qua non, atomic coordinates for a Michaelis complex can provide powerful insights into activation of the substrate. We focus here on the initial proton transfer of the isomerization reaction catalyzed by triosephosphate isomerase and present t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jogl G,Rozovsky S,McDermott AE,Tong L

更新日期：2003-01-07 00:00:00

abstract：:Sex determination in mammals is governed by antagonistic interactions of two genetic pathways, imbalance in which may lead to disorders/differences of sex development (DSD) in human. Among 46,XX individuals with testicular DSD (TDSD) or ovotesticular DSD (OTDSD), testicular tissue is present in the gonad. Although the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eozenou C,Gonen N,Touzon MS,Jorgensen A,Yatsenko SA,Fusee L,Kamel AK,Gellen B,Guercio G,Singh P,Witchel S,Berman AJ,Mainpal R,Totonchi M,Mohseni Meybodi A,Askari M,Merel-Chali T,Bignon-Topalovic J,Migale R,Costanzo

更新日期：2020-06-16 00:00:00

abstract：:We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated endocytosis to carry DNA macromolecules into cells. We accomplished this by conjugating the iron-transport protein transferrin to polycations that bind nucleic acids. Human transferrin, as well as the chicken homologue conalbu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Zenke M,Cotten M,Beug H,Birnstiel ML

更新日期：1990-05-01 00:00:00

abstract：:Multicomponent therapies, originating through deliberate mixing of drugs in a clinical setting, through happenstance, and through rational design, have a successful history in a number of areas of medicine, including cancer, infectious diseases, and CNS disorders. We have developed a high-throughput screening method f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borisy AA,Elliott PJ,Hurst NW,Lee MS,Lehar J,Price ER,Serbedzija G,Zimmermann GR,Foley MA,Stockwell BR,Keith CT

更新日期：2003-06-24 00:00:00

abstract：:In the goldfish, the optic nerve decussation occurs without intermingling of fibers from the two eyes. In two-thirds of juvenile and adult specimens, the left optic nerve is dorsal at the midline. In about 60% of the specimens, the decussation of Mauthner's neuron also has a left-dorsal-to-right (L/R) configuration. C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth RL

更新日期：1979-08-01 00:00:00

abstract：:Streptococcus pneumoniae cause considerable morbidity and mortality, with persistent neurological sequelae, particularly in young children and the elderly. It is widely assumed that carriage occurs through direct mucosal colonization from the environment whereas meningitis results from invasion from the blood. However...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Ginkel FW,McGhee JR,Watt JM,Campos-Torres A,Parish LA,Briles DE

更新日期：2003-11-25 00:00:00

abstract：:High molecular weight polypeptides (HMWPs) of 270,000 to 340,000 were found to be major components of intermediate filaments prepared by Triton X-100 extraction after spreading of rat glioma C6, HeLa, Chinese hamster ovary, and simian virus 40-transformed Chinese hamster lung cells. C6 HMWPs were shown to resemble hig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pytela R,Wiche G

更新日期：1980-08-01 00:00:00

abstract：:Synthesis of normal human hemoglobin A, alpha 2 beta 2, is based upon balanced expression of genes in the alpha-globin gene cluster on chromosome 16 and the beta-globin gene cluster on chromosome 11. Full levels of erythroid-specific activation of the beta-globin cluster depend on sequences located at a considerable d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liebhaber SA,Griese EU,Weiss I,Cash FE,Ayyub H,Higgs DR,Horst J

更新日期：1990-12-01 00:00:00

abstract：:The human eosinophil differentiation factor (EDF) gene was cloned from a genomic library in lambda phage EMBL3A by using a murine EDF cDNA clone as a probe. The DNA sequence of a 3.2-kilobase BamHI fragment spanning the gene was determined. The gene contains three introns. The predicted amino acid sequence of 134 amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell HD,Tucker WQ,Hort Y,Martinson ME,Mayo G,Clutterbuck EJ,Sanderson CJ,Young IG

更新日期：1987-10-01 00:00:00

abstract：:Inactivating mutations in chromodomain helicase DNA binding protein 7 (CHD7) cause CHARGE syndrome, a severe multiorgan system disorder of which Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is a minor feature. Recent reports have described predominantly missense CHD7 alleles in IGD patients, but it ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balasubramanian R,Choi JH,Francescatto L,Willer J,Horton ER,Asimacopoulos EP,Stankovic KM,Plummer L,Buck CL,Quinton R,Nebesio TD,Mericq V,Merino PM,Meyer BF,Monies D,Gusella JF,Al Tassan N,Katsanis N,Crowley WF Jr

更新日期：2014-12-16 00:00:00

abstract：:In addition to their well-recognized hepatotropism, all hepatitis B viruses (HBVs) display marked species specificity, growing poorly or not at all in species other than those closely related to their natural hosts. We have examined the molecular basis for this narrow host range, using duck HBV (DHBV) and heron HBV (H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishikawa T,Ganem D

更新日期：1995-07-03 00:00:00

abstract：:Normal neural development is essential for the formation of neuronal networks and brain function. Cutaneous T cell lymphoma-associated antigen 5 (cTAGE5)/meningioma expressed antigen 6 (MEA6) plays a critical role in the secretion of proteins. However, its roles in the transport of nonsecretory cellular components and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang F,Wang Y,Wang T,Yao L,Lam SM,Huang X,Fan J,Wang Q,Liu L,Jiang Y,Zhang H,Shi L,Yu M,Shui G,Wang Y,Gao F,Zhang X,Xu Z

更新日期：2018-10-02 00:00:00