Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1.

abstract：:Pancreatic beta cells respond to changes in blood glucose by secreting insulin and increasing insulin synthesis. To identify genes used in these responses, we have carried out expression profiling of beta cells exposed to high (25 mM) or low (5.5 mM) glucose by using oligonucleotide microarrays. Functional clustering ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Webb GC,Akbar MS,Zhao C,Steiner DF

更新日期：2000-05-23 00:00:00

abstract：:The retroviral integrase protein (IN) is responsible for catalyzing a concerted integration reaction in which the two termini of linear viral DNA are joined to host DNA. To probe the potential for IN to form protein multimers, we used the yeast two-hybrid system. The coexpression of a GAL4 DNA binding domain-IN fusion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalpana GV,Goff SP

更新日期：1993-11-15 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) defines a group of autosomal recessive disorders characterized by deficiencies in lysosome-related organelles such as melanosomes and platelet-dense granules. Several HPS genes encode proteins of unknown function including HPS1, HPS3, and HPS4. Here we have identified and characterized ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nazarian R,Falcón-Pérez JM,Dell'Angelica EC

更新日期：2003-07-22 00:00:00

abstract：:The conformation of L-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) has been derived from electron-density maps calculated at 2.8-A resolution with phases obtained from two heavy-atom derivatives and the bound coenzyme, NAD. Like other dehydrogenases, 3-hydroxyacyl-CoA dehydrogenase is a double-domain structure, but t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birktoft JJ,Holden HM,Hamlin R,Xuong NH,Banaszak LJ

更新日期：1987-12-01 00:00:00

abstract：:The electrical currents at the surface of the proximal portion of an isolated and transected lamprey spinal cord were measured with an extracellular vibrating probe. Soon after transection, currents of about 0.5 mA/cm2 enter the cut surface of the spinal cord. These currents fall to about a quarter of their initial va...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borgens RB,Jaffe LF,Cohen MJ

更新日期：1980-02-01 00:00:00

abstract：:Androgen receptor (AR) target genes direct development and survival of the prostate epithelial lineage, including prostate cancer (PCa). Thus, endocrine therapies that inhibit the AR ligand-binding domain (LBD) are effective in treating PCa. AR transcriptional reactivation is central to resistance, as evidenced by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nyquist MD,Li Y,Hwang TH,Manlove LS,Vessella RL,Silverstein KA,Voytas DF,Dehm SM

更新日期：2013-10-22 00:00:00

abstract：:Synthesis of the iron-storage protein ferritin is thought to be regulated at the translational level by the cytosolic content of chelatable iron. This response to iron is regulated by the iron-modulated binding to ferritin mRNAs of a repressor protein, the iron regulatory element-binding protein. From measurements mad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenstein RS,Garcia-Mayol D,Pettingell W,Munro HN

更新日期：1991-02-01 00:00:00

abstract：:During oxygenic photosynthesis in cyanobacteria and chloroplasts of plants and eukaryotic algae, conversion of light energy to biologically useful chemical energy occurs in the specialized thylakoid membranes. Light-induced charge separation at the reaction centers of photosystems I and II, two multisubunit pigment-pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zak E,Norling B,Maitra R,Huang F,Andersson B,Pakrasi HB

更新日期：2001-11-06 00:00:00

abstract：:CD83 is commonly known as a specific marker for mature dendritic cells. It has been shown to be important for CD4(+) T-cell development in the thymus. However, its function in the peripheral immune system remains enigmatic. Here, we show that CD83 inhibits proliferation and production of IL-2 and IFN-γ by T cells, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen L,Zhu Y,Zhang G,Gao C,Zhong W,Zhang X

更新日期：2011-11-15 00:00:00

abstract：:This paper reviews the developments that have occurred in the field of human genetics of infectious diseases from the second half of the 20th century onward. In particular, it stresses and explains the importance of the recently described monogenic inborn errors of immunity underlying resistance or susceptibility to s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casanova JL

更新日期：2015-12-22 00:00:00

abstract：:Division of labor among the workers of insect societies is a conspicuous feature of their biology. Social tasks are commonly shared among age groups but not between larvae and adults with completely different morphologies, as in bees, wasps, ants, and beetles (i.e., Holometabola). A unique yet hardly studied holometab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biedermann PH,Taborsky M

更新日期：2011-10-11 00:00:00

abstract：:DNA-based identification depends on the probability that two different individuals have the same phenotype, which is given by kinship theory. Together with the large and consistent body of evidence on human population structure, kinship theory provides a sound basis for forensic use of DNA markers. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton NE

更新日期：1992-04-01 00:00:00

abstract：:The N-terminal 392 amino acids of the Drosophila kinesin alpha subunit (designated DKH392) form a dimer in solution that releases only one of its two tightly bound ADP molecules on association with a microtubule, whereas a shorter monomeric construct (designated DKH340) releases > or = 95% of its one bound ADP on asso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hackney DD

更新日期：1994-07-19 00:00:00

abstract：:H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta). Like classical MHC class I genes, the expression of M3 can be stimulated by gamma-interferon and its message can be detected from mid-gestational embryos (day 8) through adulthood. HMTb, a non...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang CR,Lindahl KF

更新日期：1993-04-01 00:00:00

abstract：:Cell adhesion molecules (CAMs) are cell surface glycoproteins that may play a variety of roles in morphogenesis and histogenesis, particularly in defining borders of discrete cell populations. To examine the influence of CAM expression on such cell segregation events in vitro, we have transfected cells with cDNAs codi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friedlander DR,Mège RM,Cunningham BA,Edelman GM

更新日期：1989-09-01 00:00:00

abstract：:The epothilones are naturally occurring, cytotoxic macrolides that function through a paclitaxel (Taxol)-like mechanism. Although structurally dissimilar, both classes of molecules lead to the arrest of cell division and eventual cell death by stabilizing cellular microtubule assemblies. The epothilones differ in thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou TC,Zhang XG,Harris CR,Kuduk SD,Balog A,Savin KA,Bertino JR,Danishefsky SJ

更新日期：1998-12-22 00:00:00

abstract：:Dihydropteridine reductase (EC 1.6.99.7) is a member of the recently identified family of proteins known as short-chain dehydrogenases. When the x-ray structure of dihydropteridine reductase is correlated with conserved amino acid sequences characteristic of this enzyme class, two important common structural regions c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varughese KI,Xuong NH,Kiefer PM,Matthews DA,Whiteley JM

更新日期：1994-06-07 00:00:00

abstract：:Recently, the focus of network research shifted to network controllability, prompting us to determine proteins that are important for the control of the underlying interaction webs. In particular, we determined minimum dominating sets of proteins (MDSets) in human and yeast protein interaction networks. Such groups of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wuchty S

更新日期：2014-05-13 00:00:00

abstract：:The role of geographic isolation in marine microbial speciation is hotly debated because of the high dispersal potential and large population sizes of planktonic microorganisms and the apparent lack of strong dispersal barriers in the open sea. Here, we show that gene flow between distant populations of the globally d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casteleyn G,Leliaert F,Backeljau T,Debeer AE,Kotaki Y,Rhodes L,Lundholm N,Sabbe K,Vyverman W

更新日期：2010-07-20 00:00:00

abstract：:PSD-95 is a scaffolding protein that regulates the synaptic localization of many receptors, channels, and signaling proteins. The NLGN gene family encodes single-pass transmembrane postsynaptic cell adhesion molecules that are important for synapse assembly and function. At excitatory synapses, NLGN1 mediates transsyn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeong J,Pandey S,Li Y,Badger JD 2nd,Lu W,Roche KW

更新日期：2019-06-11 00:00:00

abstract：:The quorum sensing signal autoinducer-2 (AI-2) regulates important bacterial behaviors, including biofilm formation and the production of virulence factors. Some bacteria, such as Escherichia coli, can quench the AI-2 signal produced by a variety of species present in the environment, and thus can influence AI-2-depen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marques JC,Oh IK,Ly DC,Lamosa P,Ventura MR,Miller ST,Xavier KB

更新日期：2014-09-30 00:00:00

abstract：:The medial preoptic area has been shown to be intricately involved in many behaviors, including locomotion, sexual behavior, maternal care, and aggression. The gene encoding estrogen receptor-α (ERα) protein is expressed in preoptic area neurons, and a very dense immunoreactive field of ERα is found in the preoptic re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro AC,Musatov S,Shteyler A,Simanduyev S,Arrieta-Cruz I,Ogawa S,Pfaff DW

更新日期：2012-10-02 00:00:00

abstract：:Vaccination has been used to control the spread of seasonal flu; however, the virus continues to evolve and escape from host immune response through mutation and increasing glycosylation. Efforts have been directed toward development of a universal vaccine with broadly protective activity against multiple influenza st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao HY,Wang SC,Ko YA,Lin KI,Ma C,Cheng TR,Wong CH

更新日期：2020-07-28 00:00:00

abstract：:Ovarian cancer remains the most lethal gynecologic malignancy. We analyzed the mutational landscape of 64 primary, 41 metastatic, and 17 recurrent fresh-frozen tumors from 77 patients along with matched normal DNA, by whole-exome sequencing (WES). We also sequenced 13 pairs of synchronous bilateral ovarian cancer (SBO...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li C,Bonazzoli E,Bellone S,Choi J,Dong W,Menderes G,Altwerger G,Han C,Manzano A,Bianchi A,Pettinella F,Manara P,Lopez S,Yadav G,Riccio F,Zammataro L,Zeybek B,Yang-Hartwich Y,Buza N,Hui P,Wong S,Ravaggi A,Bigno

更新日期：2019-01-08 00:00:00

abstract：:Mammalian homologues of Drosophila Trp form plasma membrane channels that mediate Ca(2+) influx in response to activation of phospholipase C and internal Ca(2+) store depletion. Previous studies showed that human Trp3 is activated by inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) and identified interacting d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Z,Tang J,Tikunova S,Johnson JD,Chen Z,Qin N,Dietrich A,Stefani E,Birnbaumer L,Zhu MX

更新日期：2001-03-13 00:00:00

abstract：:By exploiting the cell-cycle-dependent proteolysis of two ubiquitination oscillators, human Cdt1 and geminin, which are the direct substrates of SCF(Skp2) and APC(Cdh1) complexes, respectively, Fucci technique labels mammalian cell nuclei in G(1) and S/G(2)/M phases with different colors. Transgenic mice expressing th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugiyama M,Sakaue-Sawano A,Iimura T,Fukami K,Kitaguchi T,Kawakami K,Okamoto H,Higashijima S,Miyawaki A

更新日期：2009-12-08 00:00:00

abstract：:Recently, it has been reported that there is a differential subcellular distribution of components of the minor U12-dependent and major U2-dependent spliceosome, and further that the minor spliceosome functions in the cytoplasm. To study the subcellular localization of the snRNA components of both the major and minor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pessa HK,Will CL,Meng X,Schneider C,Watkins NJ,Perälä N,Nymark M,Turunen JJ,Lührmann R,Frilander MJ

更新日期：2008-06-24 00:00:00

abstract：:Mind wandering represents the human capacity for internally focused thought and relies upon the brain's default network and its interactions with attentional networks. Studies have characterized mind wandering in healthy people, yet there is limited understanding of how this capacity is affected in clinical population...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Callaghan C,Shine JM,Hodges JR,Andrews-Hanna JR,Irish M

更新日期：2019-02-19 00:00:00

abstract：:The induction of heat shock proteins in three species of Leishmania, L. tropica, L. enrietti, and L. donovani is reported. When cultures of promastigotes are shifted from 26 degrees C to 37 degrees C or 40 degrees C, the synthesis of proteins with apparent molecular weights of 88,000, 74,000, and 54,000 is stimulated....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawrence F,Robert-Gero M

更新日期：1985-07-01 00:00:00

abstract：:Studies were undertaken to determine the applicability and effectiveness of immunoadsorption chromatography on anti-low density lipoprotein (LDL) columns as a plasma-cholesterol-lowering procedure. Mass production and isolation of monospecific antibodies against swine LDL (rho = 1.006-1.063 g/ml) was carried out by im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoffel W,Demant T

更新日期：1981-01-01 00:00:00