HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen.

abstract：:Rat superior cervical sympathetic ganglion was used to begin studying the regulation of molecular components of the synapse. Ganglionic postsynaptic densities (PSDs)exhibited a thin, disc-shaped profile electron microscopically, comparable to that described for brain. Moreover, the presumptive ganglionic PSD protein (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu K,Black IB

更新日期：1987-12-01 00:00:00

abstract：:A fundamental problem in cell biology is to understand how spatial information is recognized and integrated into morphogenetic responses. Budding yeast undergoes differentiation to filamentous growth, which involves changes in cell polarity through mechanisms that remain obscure. Here we define a regulatory input wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu S,Vadaie N,Prabhakar A,Li B,Adhikari H,Pitoniak A,Chow J,Chavel CA,Cullen PJ

更新日期：2016-04-05 00:00:00

abstract：:We simulated the behavior of suspended carbon nanotube resonators over a broad range of temperatures to explore the physics of semiflexible polymers in underdamped environments. We find that thermal fluctuations induce strong coupling between resonance modes. This effect leads to spectral fluctuations that readily acc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnard AW,Sazonova V,van der Zande AM,McEuen PL

更新日期：2012-11-20 00:00:00

abstract：:R. A. Fisher's 1930 "reproductive value" is defined as the contribution made by a population's initial age elements to its asymptotically dominating exponential growth mode. For the Leslie discrete-time model, it is the characteristic row vector of the Leslie matrix, and for the integral-equation model of Lotka the si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelson PA

更新日期：1977-11-01 00:00:00

abstract：:Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon cancer cells cultured as xenografts or under nonadherent conditions in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bersani F,Lee E,Kharchenko PV,Xu AW,Liu M,Xega K,MacKenzie OC,Brannigan BW,Wittner BS,Jung H,Ramaswamy S,Park PJ,Maheswaran S,Ting DT,Haber DA

更新日期：2015-12-08 00:00:00

abstract：:We have tested the extent of immune self-tolerance to the ubiquitously expressed nuclear/cytoplasmic autoantigens La (SS-B) and Ro (SS-A) in healthy, nonautoimmune mice. Immunization of mice with recombinant mouse La resulted in a specific, isotype-switched autoantibody response, which was initially directed toward th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Topfer F,Gordon T,McCluskey J

更新日期：1995-01-31 00:00:00

abstract：:Alpha-Klotho (alpha-Kl) and its homolog, beta-Klotho (beta-Kl) are key regulators of mineral homeostasis and bile acid/cholesterol metabolism, respectively. FGF15/ humanFGF19, FGF21, and FGF23, members of the FGF19 subfamily, are believed to act as circulating metabolic regulators. Analyses of functional interactions ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomiyama K,Maeda R,Urakawa I,Yamazaki Y,Tanaka T,Ito S,Nabeshima Y,Tomita T,Odori S,Hosoda K,Nakao K,Imura A,Nabeshima Y

更新日期：2010-01-26 00:00:00

abstract：:The synthesis of antiviral beta-chemokines has joined cytolysis as a potential mechanism for the control of HIV-1 infection by CD8(+) T cells. Recent evidence suggests that these two effector functions can diverge in some individuals infected with HIV-1; however, little is known about the CD8(+) T cell subsets in norm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamin-Lewis R,Abdelwahab SF,Trang C,Baker A,DeVico AL,Gallo RC,Lewis GK

更新日期：2001-07-31 00:00:00

abstract：:Identifying potentially unique features of the human cerebral cortex is a first step to understanding how evolution has shaped the brain in our species. By analyzing MR images obtained from 177 humans and 73 chimpanzees, we observed a human-specific asymmetry in the superior temporal sulcus at the heart of the communi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leroy F,Cai Q,Bogart SL,Dubois J,Coulon O,Monzalvo K,Fischer C,Glasel H,Van der Haegen L,Bénézit A,Lin CP,Kennedy DN,Ihara AS,Hertz-Pannier L,Moutard ML,Poupon C,Brysbaert M,Roberts N,Hopkins WD,Mangin JF,Dehaene-

更新日期：2015-01-27 00:00:00

abstract：:Knowledge of vibratory patterns in the cochlea is crucial to understanding the stimulation of mechanosensory cells. Experiments to determine the motion of the cochlear partition and surrounding fluid are extremely challenging. As a result, the motion data are incomplete and often contradictory. The bending mechanism o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai H,Shoelson B,Chadwick RS

更新日期：2004-04-20 00:00:00

abstract：:Murine suppressor T-cell hybridoma cells (231F1) secrete not only bioactive glycosylation-inhibiting factor (GIF) but also an inactive peptide comparable to bioactive GIF peptide in its molecular size and reactivity with anti-GIF; the amino acid sequence of the inactive peptide is identical to that of the bioactive ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano T,Liu YC,Mikayama T,Watarai H,Taniguchi M,Ishizaka K

更新日期：1995-09-26 00:00:00

abstract：:Long-term plasticity can differ from short-term in recruiting the growth of new synaptic connections, a process that requires the participation of both the presynaptic and postsynaptic components of the synapse. How does information about synaptic plasticity spread from its site of origin to recruit the other componen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin I,Puthanveettil S,Udo H,Karl K,Kandel ER,Hawkins RD

更新日期：2012-06-05 00:00:00

abstract：:Although prairie voles (Microtus ochrogaster) are socially monogamous, males vary in both sexual and spatial fidelity. Most males form pairbonds, cohabit with one female, and defend territories. Wandering males, in contrast, have expansive home ranges that overlap many males and females. In the laboratory, pairing is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ophir AG,Wolff JO,Phelps SM

更新日期：2008-01-29 00:00:00

abstract：:Protein folding poses unique challenges for large, disordered proteins due to the low resolution of structural data accessible in experiment and on the basis of short time scales and limited sampling attainable in computation. Such molecules are uniquely suited to accelerated-sampling molecular dynamics algorithms due...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarakanova A,Yeo GC,Baldock C,Weiss AS,Buehler MJ

更新日期：2018-07-10 00:00:00

abstract：:Changes in climate during the 20th century differ from region to region across the United States. We provide strong evidence that spatial variations in US temperature trends are linked to the hydrologic cycle, and we also present unique information on the seasonal and latitudinal structure of the linkage. We show that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Portmann RW,Solomon S,Hegerl GC

更新日期：2009-05-05 00:00:00

abstract：:In this study, we compared the transport of newly synthesized cholesterol with that of influenza virus hemagglutinin (HA) from the endoplasmic reticulum to the plasma membrane. The arrival of cholesterol on the cell surface was monitored by cyclodextrin removal, and HA transport was monitored by surface trypsinization...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heino S,Lusa S,Somerharju P,Ehnholm C,Olkkonen VM,Ikonen E

更新日期：2000-07-18 00:00:00

abstract：:Expression of the bovine papillomavirus E2 regulatory protein in human cervical carcinoma cell lines repressed expression of the resident human papillomavirus E6 and E7 oncogenes and within a few days caused essentially all of the cells to synchronously display numerous phenotypic markers characteristic of cells under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodwin EC,Yang E,Lee CJ,Lee HW,DiMaio D,Hwang ES

更新日期：2000-09-26 00:00:00

abstract：:Factor XI (plasma thromboplastin antecedent) deficiency is a blood coagulation abnormality occurring in high frequency in Ashkenazi Jews. Three independent point mutations that result in a blood coagulation abnormality have been identified in the factor XI gene of six unrelated Ashkenazi patients. These mutations eith...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asakai R,Chung DW,Ratnoff OD,Davie EW

更新日期：1989-10-01 00:00:00

abstract：:Eradication of an invasive species can provide significant environmental, economic, and social benefits, but eradication programs often fail. Constant and careful monitoring improves the chance of success, but an invasion may seem to be in decline even when it is expanding in abundance or spatial extent. Determining w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keith JM,Spring D

更新日期：2013-08-13 00:00:00

abstract：:Disordered proteins play an essential role in a wide variety of biological processes, and are often posttranslationally modified. One such protein is histone H1; its highly disordered C-terminal tail (CH1) condenses internucleosomal linker DNA in chromatin in a way that is still poorly understood. Moreover, CH1 is pho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner AL,Watson M,Wilkins OG,Cato L,Travers A,Thomas JO,Stott K

更新日期：2018-11-20 00:00:00

abstract：:The molecular weight of the major glycoprotein from the human erythrocyte membrane is 29,000, of which 55% is carbohydrate and 45% is protein. The binding of sodium dodecyl sulfate to this glycoprotein is anomalous when compared to water soluble proteins and leads to migration rates in sodium dodecyl sulfate-polyacryl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grefrath SP,Reynolds JA

更新日期：1974-10-01 00:00:00

abstract：:Glucose-dependent insulinotropic peptide (GIP) is a 42-amino acid gastrointestinal regulatory peptide that stimulates insulin secretion from pancreatic beta cells in the presence of glucose. Approximately 7.8 x 10(5) recombinant clones of a neonatal rat intestinal cDNA library were screened by using plaque hybridizati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tseng CC,Jarboe LA,Landau SB,Williams EK,Wolfe MM

更新日期：1993-03-01 00:00:00

abstract：:A full-length placental alkaline phosphatase (PLAP) cDNA was used to identify and clone the PLAP-like Nagao isozyme gene from human genomic libraries. The entire nucleotide sequence of the gene reveals the existence of 11 exons interrupted by 10 small introns (76-427 base pairs). Putative regulatory sequences have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millán JL,Manes T

更新日期：1988-05-01 00:00:00

abstract：:The role of endocytosis in the control of EGF receptor (EGFR) activation and cell signaling was explored by using mouse fibroblasts in which dynamin was conditionally depleted. Dynamin is a GTPase shown to play an important role in the control clathrin mediated endocytosis of EGFR and other cell surface receptors. In ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sousa LP,Lax I,Shen H,Ferguson SM,De Camilli P,Schlessinger J

更新日期：2012-03-20 00:00:00

abstract：:Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. mu, delta, and kappa opiate receptor subtypes are expressed in circuits that can modulate nociception and receive inputs from endogenous opioid neuropeptide ligands. The roles played by each receptor subtype in nociceptive processing in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sora I,Takahashi N,Funada M,Ujike H,Revay RS,Donovan DM,Miner LL,Uhl GR

更新日期：1997-02-18 00:00:00

abstract：:The INK4a-ARF locus encodes two proteins, p16(INK4a) and p19(ARF), that restrain cell growth by affecting the functions of the retinoblastoma protein and p53, respectively. Disruption of this locus by deletions or point mutations is a common event in human cancer, perhaps second only to the loss of p53. Using insect c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamijo T,Weber JD,Zambetti G,Zindy F,Roussel MF,Sherr CJ

更新日期：1998-07-07 00:00:00

abstract：:Arginine methylation has emerged as a widespread and reversible protein modification with the potential to regulate a multitude of cellular processes, but its function is poorly understood. Endolysosomes play an important role in Wnt signaling, in which glycogen synthase kinase 3 (GSK3) becomes sequestered inside mult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albrecht LV,Ploper D,Tejeda-Muñoz N,De Robertis EM

更新日期：2018-06-05 00:00:00

abstract：:We have selected from a mixture of random polynucleotides an RNA that is able to replicate in the presence of the DNA-dependent RNA polymerase of Escherichia coli, provided the medium contains Mn(2+) and ITP, in addition to ATP, CTP, and UTP. The RNA consists of a chain of about 125 (+/-25) nucleotides and appears to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biebricher CK,Orgel LE

更新日期：1973-03-01 00:00:00

abstract：:Two pools of heparan sulfate proteoglycans have been selectively solubilized from rat liver plasma membranes by successive incubations with heparin and detergent. The two populations of proteoglycans have similar polyanionic properties as indicated by identical elution positions on ion-exchange chromatography on DEAE-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kjellén L,Pettersson I,Höök M

更新日期：1981-09-01 00:00:00

abstract：:A somatic mutation in the X linked PIGA gene is responsible for the deficiency of glycosyl phosphatidylinositol (GPI)-anchored proteins on blood cells from patients with paroxysmal nocturnal hemoglobinuria. No inherited form of GPI-anchor deficiency has been described. Because conventional Piga gene knockout is associ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keller P,Tremml G,Rosti V,Bessler M

更新日期：1999-06-22 00:00:00