Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.

abstract：:To identify genes important for hair-cell function, we conducted a mutagenic screen in zebrafish. Larvae from one mutant line, ru848, were unresponsive to acoustic stimuli and unable to balance. The mutation results in a 90% reduction in hair-cell number and partial retinal degeneration by 5 days postfertilization. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Starr CJ,Kappler JA,Chan DK,Kollmar R,Hudspeth AJ

更新日期：2004-02-24 00:00:00

abstract：:The results of electron-nuclear double resonance and electron paramagnetic resonance (EPR) studies on the hydrogen peroxide compound of yeast cytochrome c peroxidase are inconsistent with previous proposals for the source of the EPR signal in this compound, in particular with its identification with an aromatic amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman BM,Roberts JE,Brown TG,Kang CH,Margoliash E

更新日期：1979-12-01 00:00:00

abstract：:Habituation is a form of simple memory that suppresses neural activity in response to repeated, neutral stimuli. This process is critical in helping organisms guide attention toward the most salient and novel features in the environment. Here, we follow known circuit mechanisms in the fruit fly olfactory system to der...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen Y,Dasgupta S,Navlakha S

更新日期：2020-06-02 00:00:00

abstract：:Charge transport (CT) through the DNA base pairs provides a means to promote redox reactions at a remote site and potentially to effect signaling between molecules bound to DNA. Here we describe the oxidation of a cell-cycle regulatory protein, p53, from a distance through DNA-mediated CT. A consensus p53 binding site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Augustyn KE,Merino EJ,Barton JK

更新日期：2007-11-27 00:00:00

abstract：:The poison frogs (family Dendrobatidae) are terrestrial anuran amphibians displaying a wide range of coloration and toxicity. These frogs generally have been considered to be aposematic, but relatively little research has been carried out to test the predictions of this hypothesis. Here we use a comparative approach t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Summers K,Clough ME

更新日期：2001-05-22 00:00:00

abstract：:The segmented body plan of vertebrates is prefigured by reiterated embryonic mesodermal structures called somites. In the mouse embryo, timely somite formation from the presomitic mesoderm (PSM) is controlled by the "segmentation clock," a molecular oscillator that triggers progressive waves of Notch activity througho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez TP,Fan CM

更新日期：2013-05-28 00:00:00

abstract：:Earlier papers demonstrated an extensive genetic exchange among fluorescent Pseudomonads; this one documents for genes specifying enzymes of peripheral dissimilation an extrachromosomal array, segregation, and frequent interstrain transfer. An hypothesis is presented of a general mechanism for the formation and mainte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rheinwald JG,Chakrabarty AM,Gunsalus IC

更新日期：1973-03-01 00:00:00

abstract：:Exocytosis allows the release of secretory products and the delivery of new membrane material to the plasma membrane. So far, little is known about the underlying molecular mechanism and its control in plant cells. We have used the whole-cell patch-clamp technique to monitor changes in membrane capacitance to study ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Homann U,Tester M

更新日期：1997-06-10 00:00:00

abstract：:The "chlamydial anomaly," first coined by James Moulder, describes the inability of researchers to detect or purify peptidoglycan (PG) from pathogenic Chlamydiae despite genetic and biochemical evidence and antibiotic susceptibility data that suggest its existence. We recently detected PG in Chlamydia trachomatis by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Packiam M,Weinrick B,Jacobs WR Jr,Maurelli AT

更新日期：2015-09-15 00:00:00

abstract：:TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53-/-) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. RALBP1 (RLIP76, Rlip) is a stress-protective, mercapturic acid pathway transporter protein that also functions as a Ral ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awasthi S,Tompkins J,Singhal J,Riggs AD,Yadav S,Wu X,Singh S,Warden C,Liu Z,Wang J,Slavin TP,Weitzel JN,Yuan YC,Awasthi M,Srivastava SK,Awasthi YC,Singhal SS

更新日期：2018-04-10 00:00:00

abstract：:Endothelial heterogeneity has important implications in health and disease. Molecular markers selectively expressed in the vasculature of different organs and tissues are currently being explored in targeted therapies with promising results in preclinical and clinical studies. Noteworthy is the role that combinatorial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang FHF,Staquicini FI,Teixeira AAR,Michaloski JS,Namiyama GM,Taniwaki NN,Setubal JC,da Silva AM,Sidman RL,Pasqualini R,Arap W,Giordano RJ

更新日期：2019-02-05 00:00:00

abstract：:Excitation of HbCO by a single 6-psec 530-nm pulse results in photodissociation with a first-order constant of 0.89 X 10(11) sec-1. The kinetics of photodissociation, monitored by following absorbance changes in the Soret band at 440 nm, are interpreted as corresponding to predissociation followed by a corssing into a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noe LJ,Eisert WG,Rentzepis PM

更新日期：1978-02-01 00:00:00

abstract：:Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood. Here we report that mammary tumors induced by components of the Wnt signaling pathway contain heterogeneous cell types an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Welm B,Podsypanina K,Huang S,Chamorro M,Zhang X,Rowlands T,Egeblad M,Cowin P,Werb Z,Tan LK,Rosen JM,Varmus HE

更新日期：2003-12-23 00:00:00

abstract：:Seed germination is a complex trait of key ecological and agronomic significance. Few genetic factors regulating germination have been identified, and the means by which their concerted action controls this developmental process remains largely unknown. Using publicly available gene expression data from Arabidopsis th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassel GW,Lan H,Glaab E,Gibbs DJ,Gerjets T,Krasnogor N,Bonner AJ,Holdsworth MJ,Provart NJ

更新日期：2011-06-07 00:00:00

abstract：:Intracellular calcium-binding proteins are abundantly expressed in many neuronal populations. Previous evidence suggests that calcium-binding proteins can modulate various neuronal properties, presumably by their action as calcium buffers. The importance of calcium-binding proteins for nervous system function in an in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Airaksinen MS,Eilers J,Garaschuk O,Thoenen H,Konnerth A,Meyer M

更新日期：1997-02-18 00:00:00

abstract：:For most intracellular structures with larger than molecular dimensions, little is known about the connection between underlying molecular activities and higher order organization such as size and shape. Here, we show that both the size and shape of the amphibian oocyte nucleolus ultimately arise because nucleoli beha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brangwynne CP,Mitchison TJ,Hyman AA

更新日期：2011-03-15 00:00:00

abstract：:Frizzled polypeptides are integral membrane proteins that recently were shown to function as receptors for Wnt signaling molecules. Here, we report the identification of a novel, secreted 36-kDa protein that contains a region homologous to a putative Wnt-binding domain of Frizzleds. This protein, called Frizzled-relat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finch PW,He X,Kelley MJ,Uren A,Schaudies RP,Popescu NC,Rudikoff S,Aaronson SA,Varmus HE,Rubin JS

更新日期：1997-06-24 00:00:00

abstract：:Superhydrophobic surfaces display water contact angles greater than 150 degrees in conjunction with low contact angle hysteresis. Microscopic pockets of air trapped beneath the water droplets placed on these surfaces lead to a composite solid-liquid-air interface in thermodynamic equilibrium. Previous experimental and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuteja A,Choi W,Mabry JM,McKinley GH,Cohen RE

更新日期：2008-11-25 00:00:00

abstract：:Global agricultural emissions of the greenhouse gas nitrous oxide (N2O) have increased by around 20% over the last 100 y, but regulation of these emissions and their impact on bacterial cellular metabolism are poorly understood. Denitrifying bacteria convert nitrate in soils to inert di-nitrogen gas (N2) via N2O and t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sullivan MJ,Gates AJ,Appia-Ayme C,Rowley G,Richardson DJ

更新日期：2013-12-03 00:00:00

abstract：:Global loss of DNA methylation has been known for decades as an epigenomic aberration associated with carcinogenesis and cancer progression. Loss of DNA methylation affects predominantly repetitive elements, which encompass >50% of the CpG dinucleotides present in the human genome. Because of the lack of an effective ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie H,Wang M,Bonaldo Mde F,Rajaram V,Stellpflug W,Smith C,Arndt K,Goldman S,Tomita T,Soares MB

更新日期：2010-04-13 00:00:00

abstract：:A sensitive assay for detection of eukaryotic RNA polymerase II has been developed. This assay depends on the ability of polymerase II to elongate a small RNA primer, oligo(U), hybridized to a single-stranded homopolymeric DNA template, poly(dA). The poly(dA).oligo(U)-dependent RNA polymerase II from calf thymus has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fradkin LG,Leong K,Morrow CD,Berk AJ,Dasgupta A

更新日期：1985-12-01 00:00:00

abstract：:The G protein-coupled m1 and m3 muscarinic acetylcholine receptors increase tyrosine phosphorylation of several proteins, including the focal adhesion-associated proteins paxillin and focal adhesion kinase (FAK), but the mechanism is not understood. Activation of integrins during adhesion of cells to extracellular mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slack BE

更新日期：1998-06-23 00:00:00

abstract：:The S(N)2 displacement of Cl(-) from 1,2-dichloroethane by acetate (CH(3)CO(2)(-)) in water and by the carboxylate of the active site aspartate in the haloalkane dehalogenase of Xanthobacter autothropicus have been compared by using molecular dynamics simulations. In aqueous solution, six families of contact-pair stru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hur S,Kahn K,Bruice TC

更新日期：2003-03-04 00:00:00

abstract：:In this study we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal α2 nicotinic acetylcholine receptor (nAChR) subunit in complex with the agonist epibatidine at 3.2 Å. Interestingly, α2 was crystallized as a pentamer, revealing the intersubunit interactions in a wild type neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kouvatsos N,Giastas P,Chroni-Tzartou D,Poulopoulou C,Tzartos SJ

更新日期：2016-08-23 00:00:00

abstract：:Complex gene regulatory circuits contain many interacting components. In principle, all of these components and interactions may be essential to the function of the circuit. Alternatively, some of them may be refinements to a simpler version of the circuit that improve its fitness. In this work, we have tested whether...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Babić AC,Little JW

更新日期：2007-11-06 00:00:00

abstract：:Visual speech facilitates auditory speech perception, but the visual cues responsible for these benefits and the information they provide remain unclear. Low-level models emphasize basic temporal cues provided by mouth movements, but these impoverished signals may not fully account for the richness of auditory informa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Plass J,Brang D,Suzuki S,Grabowecky M

更新日期：2020-07-21 00:00:00

abstract：:Acquisition of acetylcholine receptors during differentiation of a clonal myoblast cell line was monitored with a neurotoxin isolated from venom of the Indian Cobra Naja naja. Toxin bound specifically and reversibly to acetylcholine receptors of the differentiated cells. Specificity of the binding reaction was assayed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patrick J,Heinemann SF,Lindstrom J,Schubert D,Steinbach JH

更新日期：1972-10-01 00:00:00

abstract：:L-type Ca(2+) currents conducted by CaV1.2 channels initiate excitation-contraction coupling in the heart. Their activity is increased by β-adrenergic/cAMP signaling via phosphorylation by PKA in the fight-or-flight response, but the sites of regulation are unknown. We describe the functional role of phosphorylation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu Y,Westenbroek RE,Scheuer T,Catterall WA

更新日期：2013-11-26 00:00:00

abstract：:Despite the prevalence of transposable elements in the genomes of higher eukaryotes, what is virtually unknown is how they amplify to very high copy numbers without killing their host. Here, we report the discovery of rice strains where a miniature inverted-repeat transposable element (mPing) has amplified from approx...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naito K,Cho E,Yang G,Campbell MA,Yano K,Okumoto Y,Tanisaka T,Wessler SR

更新日期：2006-11-21 00:00:00

abstract：:Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowak MA,Komarova NL,Sengupta A,Jallepalli PV,Shih IeM,Vogelstein B,Lengauer C

更新日期：2002-12-10 00:00:00