Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.

abstract：:Two strains that overproduce endonuclease III were found in a colony bank containing hybrid ColE1-Escherichia coli plasmids. The enzyme was identified in crude extracts by the degradation of partially depyrimidinated DNA in the presence of EDTA, by its sedimentation velocity, and by its associated thymine glycol-DNA g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cunningham RP,Weiss B

更新日期：1985-01-01 00:00:00

abstract：:Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to immune-dependent and conventional therapeutic modalities. As a hallmark of glioblastoma (GBM), TAMCs are massively recruited to reach up to 50% of the brain tumor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang P,Miska J,Lee-Chang C,Rashidi A,Panek WK,An S,Zannikou M,Lopez-Rosas A,Han Y,Xiao T,Pituch KC,Kanojia D,Balyasnikova IV,Lesniak MS

更新日期：2019-11-19 00:00:00

abstract：:Disruption of Rauscher leukemia virus (RLV) with low levels of Nonidet P-40 yielded "immature" cores. These cores have a diameter of about 920 A, as opposed to the 1300-A diameter of RLV, possess knob-like protuberances, and contain a concentrically coiled internal strand apposed to the core shell. The two major polyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshinaka Y,Luftig RB

更新日期：1977-08-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization (MALDI) time of flight mass spectrometry was used to detect and order DNA fragments generated by Sanger dideoxy cycle sequencing. This was accomplished by improving the sensitivity and resolution of the MALDI method using a delayed ion extraction technique (DE-MALDI). The cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roskey MT,Juhasz P,Smirnov IP,Takach EJ,Martin SA,Haff LA

更新日期：1996-05-14 00:00:00

abstract：:Searches of ribosomal RNA sequences for compensatory base changes preserving Watson-Crick base pairing have led to detailed models of the conserved secondary structures of these RNAs. In principle, tertiary interactions can also be detected by searches for phylogenetically covariant bases. Within a highly conserved re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryan PC,Draper DE

更新日期：1991-07-15 00:00:00

abstract：:Previous studies have failed to detect an interaction between monomeric soluble CD4 (sCD4) and class II major histocompatibility complex (MHC) proteins, suggesting that oligomerization of CD4 on the cell surface may be required to form a stable class II MHC binding site. To test this possibility, we transfected the F4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakihama T,Smolyar A,Reinherz EL

更新日期：1995-07-03 00:00:00

abstract：:Prostaglandin E1 and the beta-adrenergic hormone l-isoproterenol stimulated cyclic AMP formation in both nucleated and enucleated myeloid leukemic cells that could be induced to differentiate normally to mature cells by the macrophage- and granulocyte-inducing protein MGI (MGI+D+ cells). Enucleated as well as nucleate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simantov R,Shkolnik T,Sachs L

更新日期：1980-08-01 00:00:00

abstract：:Phytohormones have essential roles in coordinately regulating a large array of developmental processes. Studies have revealed that brassinosteroids (BRs) and abscisic acid (ABA) interact to regulate hundreds of expression in genes, governing many biological processes. However, whether their interaction is through modi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang S,Cai Z,Wang X

更新日期：2009-03-17 00:00:00

abstract：:High-pressure single-crystal X-ray diffraction method with precise control of hydrostatic conditions, typically with helium or neon as the pressure-transmitting medium, has significantly changed our view on what happens with low-density silica phases under pressure. Coesite is a prototype material for pressure-induced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu W,Wu X,Liang Y,Liu C,Miranda CR,Scandolo S

更新日期：2017-12-05 00:00:00

abstract：:The expansion of machine learning to high-stakes application domains such as medicine, finance, and criminal justice, where making informed decisions requires clear understanding of the model, has increased the interest in interpretable machine learning. The widely used Classification and Regression Trees (CART) have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luna JM,Gennatas ED,Ungar LH,Eaton E,Diffenderfer ES,Jensen ST,Simone CB 2nd,Friedman JH,Solberg TD,Valdes G

更新日期：2019-10-01 00:00:00

abstract：:The sequence of spontaneous Epstein-Barr virus activation was studied in P3HR-1 carrier cells and in P3HR-1(BrdU) cells made resistant to 5-bromodeoxyuridine. Virus activation was initiated during the normal cell cycle, and recruitment of additional virus-activated cells was prevented by the DNA inhibitors, 1-beta-D-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampar B,Derge JG,Martos LM,Tagamets MA,Burroughs MA

更新日期：1972-09-01 00:00:00

abstract：:Neurological dysfunction caused by traumatic brain injury results in profound changes in net synaptic efficacy, leading to impaired cognition. Because excitability is directly controlled by the balance of excitatory and inhibitory activity, underlying mechanisms causing these changes were investigated using lateral fl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole JT,Mitala CM,Kundu S,Verma A,Elkind JA,Nissim I,Cohen AS

更新日期：2010-01-05 00:00:00

abstract：:Cytochrome c oxidase (COX) is a 13-subunit protein complex that catalyzes the last step in mitochondrial electron transfer in mammals. Of the 10 subunits encoded by nuclear DNA (three are mtDNA products), some are expressed as tissue- and/or development-specific isoforms. For COX subunit VIII, previous work showed tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg A,Wildman DE,Schmidt TR,Huttemann M,Goodman M,Weiss ML,Grossman LI

更新日期：2003-05-13 00:00:00

abstract：:Methanogenic archaea are major contributors to the global carbon cycle and were long thought to belong exclusively to the euryarchaeal phylum. Discovery of the methanogenesis gene cluster methyl-coenzyme M reductase (Mcr) in the Bathyarchaeota, and thereafter the Verstraetearchaeota, led to a paradigm shift, pushing b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berghuis BA,Yu FB,Schulz F,Blainey PC,Woyke T,Quake SR

更新日期：2019-03-12 00:00:00

abstract：:This article emphasizes the role played by a remarkable pointwise inequality satisfied by fractionary derivatives in order to obtain maximum principles and Lp-decay of solutions of several interesting partial differential equations. In particular, there are applications to quasigeostrophic flows, in two space variable...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cordoba A,Cordoba D

更新日期：2003-12-23 00:00:00

abstract：:Parinaric acid (9,11,13,15-octadecatetraenoic acid), a conjugated tetraene fatty acid, undergoes a second-order photochemical reaction in phospholipid bilayers. The reaction results in the loss of the characteristic absorption of this chromophore and the development of new absorption demonstrating the presence of a tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan CG,Hudson B,Wolber PK

更新日期：1980-01-01 00:00:00

abstract：:When the magnetic susceptibility of frozen aqueous solutions of human oxyhemoglobin was measured in the range between 25 and 250 K, it showed a temperature-dependent behavior typical of a thermal equilibrium between a ground singlet state and an excited triplet state for two electrons per heme, the energy separation b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerdonio M,Congiu-Castellano A,Mogno F,Pispisa B,Romani GL,Vitale S

更新日期：1977-02-01 00:00:00

abstract：:Saccharomyces cerevisiae cells reproduce by budding to yield a mother cell and a smaller daughter cell. Although both mother and daughter begin G1 simultaneously, the mother cell progresses through G1 more rapidly. Daughter cell G1 delay has long been thought to be due to a requirement for attaining a certain critical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laabs TL,Markwardt DD,Slattery MG,Newcomb LL,Stillman DJ,Heideman W

更新日期：2003-09-02 00:00:00

abstract：:The structural and functional organization of the Cct complex was addressed by genetic analyses of subunit interactions and catalytic cooperativity among five of the eight different essential subunits, Cct1p-Cct8p, in the yeast Saccharomyces cerevisiae. The cct1-1, cct2-3, and cct3-1 alleles, containing mutations at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin P,Sherman F

更新日期：1997-09-30 00:00:00

abstract：:By manufacturing a single-particle system in two particulate forms (i.e., micrometer size and nanometer size), we have designed a bacterial vaccine form that exhibits improved efficacy of immunization. Microstructural properties are adapted to alter dispersive and aerosol properties independently. Dried "nanomicropart...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia-Contreras L,Wong YL,Muttil P,Padilla D,Sadoff J,Derousse J,Germishuizen WA,Goonesekera S,Elbert K,Bloom BR,Miller R,Fourie PB,Hickey A,Edwards D

更新日期：2008-03-25 00:00:00

abstract：:The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)+ intestinal stem cell (ISC) survival through NOD2 activation upon an otherwise lethal oxid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levy A,Stedman A,Deutsch E,Donnadieu F,Virgin HW,Sansonetti PJ,Nigro G

更新日期：2020-01-28 00:00:00

abstract：:Chromatin states can be distinguished by differential covalent modifications of histones or by utilization of histone variants. Chromatin associated with transcriptionally active loci becomes enriched for histones with particular lysine modifications and accumulates the H3.3 histone variant, the substrate for replicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKittrick E,Gafken PR,Ahmad K,Henikoff S

更新日期：2004-02-10 00:00:00

abstract：:Dominant mutations in the maize homeobox gene knotted1 (kn1) act nonautonomously during maize leaf development, indicating that Kn1 is involved in the generation or transmission of a developmental signal that passes from the inner layers of the leaf to epidermal cells. We previously found that this nonautonomous activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim JY,Yuan Z,Cilia M,Khalfan-Jagani Z,Jackson D

更新日期：2002-03-19 00:00:00

abstract：:Synthesis of normal human hemoglobin A, alpha 2 beta 2, is based upon balanced expression of genes in the alpha-globin gene cluster on chromosome 16 and the beta-globin gene cluster on chromosome 11. Full levels of erythroid-specific activation of the beta-globin cluster depend on sequences located at a considerable d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liebhaber SA,Griese EU,Weiss I,Cash FE,Ayyub H,Higgs DR,Horst J

更新日期：1990-12-01 00:00:00

abstract：:Double-stranded oligodeoxynucleotides that represent protein binding sites in the regulatory regions of the mouse genes encoding transthyretin (TTR) and alpha 1-antitrypsin (alpha 1-AT) bound a nuclear protein factor(s) found mainly in hepatocytes. A site in the regulatory region of the gene encoding rat serum albumin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costa RH,Grayson DR,Xanthopoulos KG,Darnell JE Jr

更新日期：1988-06-01 00:00:00

abstract：:Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER

更新日期：2017-11-28 00:00:00

abstract：:The ecological niche is a key concept for elucidating patterns of species distributions and developing strategies for conserving biodiversity. However, recent times are seeing a widespread debate whether species niches are conserved across space and time (niche conservatism hypothesis). Biological invasions represent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Wolter C,Xian W,Jeschke JM

更新日期：2020-09-22 00:00:00

abstract：:Horse heart cytochrome c can be split with cyanogen bromide into a heme peptide (residues 1-65) and a nonheme peptide (residues 66-104). In a process involving (i) complex formation between the two fragments and (ii) restoration of the severed peptide linkage, a fully active cytochrome c preparation can be re-formed. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barstow LE,Young RS,Yakali E,Sharp JJ,O'Brien JC,Berman PW,Harbury HA

更新日期：1977-10-01 00:00:00

abstract：:Bilateria are currently subdivided into three superclades: Deuterostomia, Ecdysozoa, and Lophotrochozoa. Within this new taxonomic frame, acoelomate Platyhelminthes, for a long time held to be basal bilaterians, are now considered spiralian lophotrochozoans. However, recent 18S rDNA [small subunit (SSU)] analyses have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Trillo I,Paps J,Loukota M,Ribera C,Jondelius U,Baguna J,Riutort M

更新日期：2002-08-20 00:00:00

abstract：:Successful adaptation to changes in an animal's emotional and motivational environment depends on behavioral flexibility accompanied by changes in bodily responses, e.g., autonomic and endocrine, which support the change in behavior. Here, we identify the orbitofrontal cortex (OFC) as pivotal in the flexible regulatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reekie YL,Braesicke K,Man MS,Roberts AC

更新日期：2008-07-15 00:00:00