Dietary branched chain amino acids ameliorate injury-induced cognitive impairment.

abstract：:Toward understanding their redundancies and interactions in hemostasis and thrombosis, we examined the roles of thrombin receptors (protease-activated receptors, PARs) and the ADP receptor P2RY12 (purinergic receptor P2Y G protein-coupled 12) in human and mouse platelets ex vivo and in mouse models. Par3(-/-) and Par4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornelissen I,Palmer D,David T,Wilsbacher L,Concengco C,Conley P,Pandey A,Coughlin SR

更新日期：2010-10-26 00:00:00

abstract：:The C-terminal domains of the two alpha-subunits (alphaCTD) in Escherichia coli RNA polymerase (RNAP) recognize specific sequences called UP elements in some promoters. These interactions can increase transcription dramatically. Previously, effects of upstream DNA-alphaCTD interactions on transcription were quantified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross W,Gourse RL

更新日期：2005-01-11 00:00:00

abstract：:Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrence in human cancers and a major promoter of chemotherapeutic resistance. Inhibition of one downstream target in this pathway, mTORC1, has shown potential to improve chemosensitivity. However, the mechanisms and genetic m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mills JR,Hippo Y,Robert F,Chen SM,Malina A,Lin CJ,Trojahn U,Wendel HG,Charest A,Bronson RT,Kogan SC,Nadon R,Housman DE,Lowe SW,Pelletier J

更新日期：2008-08-05 00:00:00

abstract：:Antisense oligodeoxyribonucleotides targeted to the epidermal growth factor (EGF) receptor were encapsulated into liposomes linked to folate via a polyethylene glycol spacer (folate-PEG-liposomes) and efficiently delivered into cultured KB cells via folate receptor-mediated endocytosis. The oligonucleotides were a pho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Lee RJ,Cauchon G,Gorenstein DG,Low PS

更新日期：1995-04-11 00:00:00

abstract：:Numerous relatively short regions within intrinsically disordered proteins (IDPs) serve as molecular recognition elements (MoREs). They fold into ordered structures upon binding to their partner molecules. Currently, there is still a lack of in-depth understanding of how coupled binding and folding occurs in MoREs. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Chu X,Longhi S,Roche P,Han W,Wang E,Wang J

更新日期：2013-10-01 00:00:00

abstract：:Improving global yields of important agricultural crops is a complex challenge. Enhancing yield and resource use by engineering improvements to photosynthetic carbon assimilation is one potential solution. During the last 40 million years C(4) photosynthesis has evolved multiple times, enabling plants to evade the cat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitney SM,Sharwood RE,Orr D,White SJ,Alonso H,Galmés J

更新日期：2011-08-30 00:00:00

abstract：:An expression vector containing the murine c-ets-2 protooncogene cDNA was introduced into NIH 3T3 cells by DNA transfection. The cells transfected with this construct showed foci of densely growing, morphologically altered cells, when grown either in low-serum (0.05%) or in serum-free medium. The c-ets-2-derived foci ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seth A,Watson DK,Blair DG,Papas TS

更新日期：1989-10-01 00:00:00

abstract：:Male mice were injected intraperitoneally with 125 microCi (1 Ci = 3.7 X 10(10) becquerels) of [3H]thymidine at 1-hr intervals and killed 1 hr after the second injection. Testes were prepared for bright-field and electron microscopic autoradiography. Primary spermatocytes, identified by light microscopy to be at the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grell RF,Oakberg EF,Generoso EE

更新日期：1980-11-01 00:00:00

abstract：:Serum amyloid A (SAA) is an acute-phase plasma protein that functions in innate immunity and lipid homeostasis. SAA is a protein precursor of reactive AA amyloidosis, the major complication of chronic inflammation and one of the most common human systemic amyloid diseases worldwide. Most circulating SAA is protected f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaraman S,Gantz DL,Haupt C,Gursky O

更新日期：2017-08-08 00:00:00

abstract：:Studies in rodents and nonhuman primates have linked the activity of N-methyl-D-aspartate (NMDA) receptors within the hippocampus to animals' performance on memory-related tasks. However, whether these receptors are similarly essential for human memory is still an open question. Here we present evidence suggesting tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grunwald T,Beck H,Lehnertz K,Blümcke I,Pezer N,Kurthen M,Fernández G,Van Roost D,Heinze HJ,Kutas M,Elger CE

更新日期：1999-10-12 00:00:00

abstract：:We report here that during a permanent cardiac arrest, rodent brain tissue is "physiologically" preserved in situ in a particular quiescent state. This state is characterized by the absence of electrical activity and by a critical period of 5-6 hr during which brain tissue can be reactivated upon restoration of a simp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Charpak S,Audinat E

更新日期：1998-04-14 00:00:00

abstract：:Development of type 1 diabetes in the nonobese diabetic (NOD) mouse is preceded by an immune cell infiltrate in the pancreatic islets. The exact role of the attracted cells is still poorly understood. Chemokine CCL2/MCP-1 is known to attract CCR2(+) monocytes and dendritic cells (DCs). We have previously shown that tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriegel MA,Rathinam C,Flavell RA

更新日期：2012-02-28 00:00:00

abstract：:A detailed phenomenology of low energy excitations is a crucial starting point for microscopic understanding of complex materials, such as the cuprate high-temperature superconductors. Because of its unique momentum-space discrimination, angle-resolved photoemission spectroscopy (ARPES) is ideally suited for this task...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vishik IM,Hashimoto M,He RH,Lee WS,Schmitt F,Lu D,Moore RG,Zhang C,Meevasana W,Sasagawa T,Uchida S,Fujita K,Ishida S,Ishikado M,Yoshida Y,Eisaki H,Hussain Z,Devereaux TP,Shen ZX

更新日期：2012-11-06 00:00:00

abstract：:A human lambdaV (Mcg) and a human lambdaII (Vil) myeloma protein have identical sequences in their first hypervariable segments although they differ at 21 positions throughout the variable region. If a different structural gene is responsible for each subgroup, the findings favor insertion of information for the hyper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TT,Kabat EA,Bilofsky H

更新日期：1975-12-01 00:00:00

abstract：:Twenty-five years ago this month, Thomas Gold published a seminal manuscript suggesting the presence of a "deep, hot biosphere" in the Earth's crust. Since this publication, a considerable amount of attention has been given to the study of deep biospheres, their role in geochemical cycles, and their potential to infor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colman DR,Poudel S,Stamps BW,Boyd ES,Spear JR

更新日期：2017-07-03 00:00:00

abstract：:Spider-like forms of purified reovirus RNA have been characterized by electron microscopy. These structures contained 11.3 +/- 0.8 mum of double-stranded RNA and up to 20 arms, each of distinct length. Length measurements of 64 "spiders" suggest that in these structures the viral genome is folded fairly specifically. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavenoff R,Talcove D,Mudd JA

更新日期：1975-11-01 00:00:00

abstract：:A remarkable property of Ca2+ fluxes through the inositol 1,4,5-trisphosphate (InsP3)-gated Ca2+ channel is that successive increments of InsP3 induce repeated transient release of accumulated Ca2+. The initial aim of this study was to propose a model, based on hypotheses compatible with the current description of thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swillens S,Combettes L,Champeil P

更新日期：1994-10-11 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health problem. Evasion of IFN-mediated antiviral signaling is a common defense strategy that pathogenic viruses use to replicate and propagate in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miorin L,Kehrer T,Sanchez-Aparicio MT,Zhang K,Cohen P,Patel RS,Cupic A,Makio T,Mei M,Moreno E,Danziger O,White KM,Rathnasinghe R,Uccellini M,Gao S,Aydillo T,Mena I,Yin X,Martin-Sancho L,Krogan NJ,Chanda SK,Schot

更新日期：2020-11-10 00:00:00

abstract：:The causes of major and rapid transitions observed in biological macroevolution as well as in the evolution of social systems are a subject of much debate. Here we identify the proximate causes of crashes and recoveries that arise dynamically in a model system in which populations of (molecular) species coevolve with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jain S,Krishna S

更新日期：2002-02-19 00:00:00

abstract：:The formation and migration of disconnections (line defects constrained to the grain boundary [GB] plane with both dislocation and step character) control many of the kinetic and dynamical properties of GBs and the polycrystalline materials of which they are central constituents. We demonstrate that GBs undergo a fini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen K,Srolovitz DJ,Han J

更新日期：2020-12-29 00:00:00

abstract：:Urea (200-400 milliosmolar) activates transcription, translation of, and trans-activation by the immediate-early gene transcription factor Egr-1 in a renal epithelial cell-specific fashion. The effect at the transcriptional level has been attributed to multiple serum response elements and their adjacent Ets motifs loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen DM

更新日期：1996-10-01 00:00:00

abstract：:A single intravenous (i.v.) injection of the water-soluble mammary carcinogen N-nitroso-N-methylurea (NMU; 35 mg/kg of body weight) elicited cancer of the breast in young female rats of two strains in the following incidence: Long-Evans strain, 4%; Sprague-Dawley strain, 70%. In sisters of these rats, a set of 5 i.v. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huggins CB,Ueda N,Wiessler M

更新日期：1981-02-01 00:00:00

abstract：:Over the last two decades, the number of gene/protein sequences gleaned from sequencing projects of individual genomes and environmental DNA has grown exponentially. Only a tiny fraction of these predicted proteins has been experimentally characterized, and the function of most proteins remains hypothetical or only pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helbert W,Poulet L,Drouillard S,Mathieu S,Loiodice M,Couturier M,Lombard V,Terrapon N,Turchetto J,Vincentelli R,Henrissat B

更新日期：2019-03-26 00:00:00

abstract：:Climate change is expected to influence the capacities of the land and oceans to act as repositories for anthropogenic CO2 and hence provide a feedback to climate change. A series of experiments with the National Center for Atmospheric Research-Climate System Model 1 coupled carbon-climate model shows that carbon sink...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fung IY,Doney SC,Lindsay K,John J

更新日期：2005-08-09 00:00:00

abstract：:Chemoresistance of cisplatin therapy is related to extensive repair of cisplatin-modified DNA in the nucleus by the nucleotide excision repair (NER). Delivering cisplatin to the mitochondria to attack mitochondrial genome lacking NER machinery can lead to a rationally designed therapy for metastatic, chemoresistant ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marrache S,Pathak RK,Dhar S

更新日期：2014-07-22 00:00:00

abstract：:The mucopolysaccharidoses are a group of genetic diseases characterized by storage of incompletely degraded glycosaminoglycans. Such storage causes marked distortion of many tissues with consequent severe somatic changes and mental retardation. Storage of glycosaminoglycans results from markedly diminished activity of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorfman A,Matalon R

更新日期：1976-02-01 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:Knowledge of vibratory patterns in the cochlea is crucial to understanding the stimulation of mechanosensory cells. Experiments to determine the motion of the cochlear partition and surrounding fluid are extremely challenging. As a result, the motion data are incomplete and often contradictory. The bending mechanism o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai H,Shoelson B,Chadwick RS

更新日期：2004-04-20 00:00:00

abstract：:Mouse myeloma cells were pulse-labeled in vitro with (3)H-D-glucosamine and (14)C-L-leucine. Analysis on sucrose gradients revealed incorporation of both isotopes into polyribosomes and release of most of such radioactivity after treatment of labeled cells in vitro with puromycin. A mixing experiment excluded the in v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sherr CJ,Uhr JW

更新日期：1969-09-01 00:00:00

abstract：:To investigate the evolution of the mammalian sex chromosomes, we have compared the gene content of the X chromosomes in the mammalian groups most distantly related to man (marsupials and monotremes). Previous work established that genes on the long arm of the human X chromosome are conserved on the X chromosomes in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watson JM,Spencer JA,Riggs AD,Graves JA

更新日期：1991-12-15 00:00:00