Cardiac arrest in rodents: maximal duration compatible with a recovery of neuronal activity.

abstract：:Triose-phosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketol-isomerase, EC 5.3.1.1) deficiency is a recessive disorder that results in hemolytic anemia and neuromuscular dysfunction. To determine the molecular basis of this disorder, a TPI allele from two unrelated patients homozygous for TPI deficiency was com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daar IO,Artymiuk PJ,Phillips DC,Maquat LE

更新日期：1986-10-01 00:00:00

abstract：:cDNA clones encoding a glutamic acid-rich protein were isolated from a bovine retina cDNA expression library. The cDNA sequence contained an open reading frame of 1770 base pairs encoding a protein of 590 amino acids (64,509 Da) and untranslated regions of 60 and 490 base pairs at the 5' and 3' ends, respectively. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugimoto Y,Yatsunami K,Tsujimoto M,Khorana HG,Ichikawa A

更新日期：1991-04-15 00:00:00

abstract：:Whole-chromosome copy number alterations, also known as aneuploidy, are associated with adverse consequences in most cells and organisms. However, high frequencies of aneuploidy have been reported to occur naturally in the mammalian liver and brain, fueling speculation that aneuploidy provides a selective advantage in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knouse KA,Wu J,Whittaker CA,Amon A

更新日期：2014-09-16 00:00:00

abstract：:To initiate fertilization, mouse sperm bind to Ser- (O-) linked oligosaccharides located at the sperm combining site of zona pellucida glycoprotein mZP3. Apparently, the oligosaccharides are present on one or more of five Ser residues clustered in the carboxyl-terminal region of the mZP3 polypeptide. Here, each of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Litscher ES,Wassarman PM

更新日期：1998-05-26 00:00:00

abstract：:DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA resynthesis. Dominant MMR models posit that after mismatch recognition, ATP converts MutS to a hydrolysis-independent, diffusive mobile clamp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao P,LeBlanc SJ,Case BC,Elston TC,Hingorani MM,Erie DA,Weninger KR

更新日期：2020-07-28 00:00:00

abstract：:Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Li X,Wong YT,Zheng X,Wang H,Peng Y,Feng H,Feng J,Baibado JT,Jesky R,Wang Z,Xie H,Sun W,Zhang Z,Zhang X,He L,Zhang N,Zhang Z,Tang P,Su J,Hu LL,Liu Q,He X,Tan A,Sun X,Li M,Wong K,Wang X,Cheung

更新日期：2019-03-26 00:00:00

abstract：:We previously reported that long-term cyclic estrogen (E) treatment reverses age-related impairment of cognitive function mediated by the dorsolateral prefrontal cortex (dlPFC) in ovariectomized (OVX) female rhesus monkeys, and that E induces a corresponding increase in spine density in layer III dlPFC pyramidal neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao J,Rapp PR,Janssen WG,Lou W,Lasley BL,Hof PR,Morrison JH

更新日期：2007-07-03 00:00:00

abstract：:The anticonvulsants phenytoin and carbamazepine interact allosterically with the batrachotoxin binding site of sodium channels. In the present study, we demonstrate an autoradiographic technique to localize the batrachotoxin binding site on sodium channels in rat brain using [3H]batrachotoxinin-A 20-alpha-benzoate (BT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Worley PF,Baraban JM

更新日期：1987-05-01 00:00:00

abstract：:Droplet manipulation is playing an important role in various fields, including scientific research, industrial production, and daily life. Here, inspired by the microstructures and functions of Namib desert beetles, Nepenthes pitcher plants, and emergent aquatic plants, we present a multibioinspired slippery surface f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang X,Sun L,Wang Y,Bian F,Wang Y,Zhao Y

更新日期：2019-10-15 00:00:00

abstract：:2-[4-(3,4-Dichlorophenylureido)phenoxy]-2-methylpropionic acid, LR16, combines with two symmetrically related sites in the central cavity of deoxyhemoglobin, 20 A away from the binding site of 2,3-bisphosphoglycerate, and acts as an allosteric effector synergistic with 2,3-bisphosphoglycerate. LR16 (1 mM) raises P50, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalezari I,Rahbar S,Lalezari P,Fermi G,Perutz MF

更新日期：1988-08-01 00:00:00

abstract：:The mitogenic neuropeptides bombesin and vasopressin markedly increased tyrosine and serine phosphorylation of multiple substrates in quiescent Swiss 3T3 fibroblasts, including two major bands of Mr 90,000 and 115,000. Tyrosine phosphorylation of these proteins was increased as judged by immunoprecipitation of 32Pi-la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zachary I,Gil J,Lehmann W,Sinnett-Smith J,Rozengurt E

更新日期：1991-06-01 00:00:00

abstract：:The thymus lacks self-renewing hematopoietic cells, and thymopoiesis fails rapidly when the migration of progenitor cells to the thymus ceases. Hence, the process of thymus homing is an essential step for T-cell development and cellular immunity. Despite decades of research, the molecular details of thymus homing have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calderón L,Boehm T

更新日期：2011-05-03 00:00:00

abstract：:Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lima B,Lam GK,Xie L,Diesen DL,Villamizar N,Nienaber J,Messina E,Bowles D,Kontos CD,Hare JM,Stamler JS,Rockman HA

更新日期：2009-04-14 00:00:00

abstract：:The mountain pine beetle (Dendroctonus ponderosae Hopkins) is the most destructive pest of western North American pine forests. Adult males produce frontalin, an eight-carbon antiaggregation pheromone, via the mevalonate pathway, as part of several pheromones that initiate and modulate the mass attack of host trees. F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keeling CI,Chiu CC,Aw T,Li M,Henderson H,Tittiger C,Weng HB,Blomquist GJ,Bohlmann J

更新日期：2013-11-19 00:00:00

abstract：:Oligomerization plays a critical role in shaping the light-harvesting properties of many photosynthetic pigment-protein complexes, but a detailed understanding of this process at the level of individual pigments is still lacking. To study the effects of oligomerization, we designed a single-molecule approach to probe ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Q,Moerner WE

更新日期：2015-11-10 00:00:00

abstract：:Using [3H]quinuclidinyl benzilate as a specific cholinergic muscarinic ligand, it has been demonstrated that lymphocytes have muscarinic binding sites. There are approximately 200 sites per cell and the dissociation constant for quinuclidinyl benzilate is approximately 1 X 10(-9) M. Quinuclidinyl benzilate receptor bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon MA,Cohen JJ,Wilson IB

更新日期：1978-06-01 00:00:00

abstract：:Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switch between ground an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaikuad A,Froese DS,Berridge G,von Delft F,Oppermann U,Yue WW

更新日期：2011-12-27 00:00:00

abstract：:Genetic and biochemical studies have revealed that the 5' noncoding region of poliovirus mediates translation of the viral mRNA by an unusual mechanism involving entry of ribosomes in internal sequences of mRNA molecules. We have found that mRNAs bearing the 5' noncoding region of poliovirus were translated at an enha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hambidge SJ,Sarnow P

更新日期：1992-11-01 00:00:00

abstract：:The chemotaxis network in Escherichia coli is remarkable for its sensitivity to small relative changes in the concentrations of multiple chemical signals. We present a model for signal integration by mixed clusters of interacting two-state chemoreceptors. Our model results compare favorably to the results obtained by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keymer JE,Endres RG,Skoge M,Meir Y,Wingreen NS

更新日期：2006-02-07 00:00:00

abstract：:Benthic foraminifers inhabit a wide range of aquatic environments including open marine, brackish, and freshwater environments. Here we show that several different and diverse foraminiferal groups (miliolids, rotaliids, textulariids) and Gromia, another taxon also belonging to Rhizaria, accumulate and respire nitrates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piña-Ochoa E,Høgslund S,Geslin E,Cedhagen T,Revsbech NP,Nielsen LP,Schweizer M,Jorissen F,Rysgaard S,Risgaard-Petersen N

更新日期：2010-01-19 00:00:00

abstract：:Whole-cell DNA preparations isolated from SC-1 cells chronically infected with N- or B-tropic murine leukemia viruses (MuLV) were tested for infectious activity in an Fv-1n (NIH-3T3) and two Fv-Ib (C57BL/6 and SV-A31) cell cultures. Efficiency of transfection for all DNAs was better in the NIH-3T3 cells than in C57BL/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu IC,Yang WK,Tennant RW,Brown A

更新日期：1978-03-01 00:00:00

abstract：:The conformation of DNA bound in nucleosomes depends on the DNA sequence. Questions such as how nucleosomes are positioned and how they potentially bind sequence-dependent nuclear factors require near-atomic resolution structures of the nucleosome core containing different DNA sequences; despite this, only the DNA for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frouws TD,Duda SC,Richmond TJ

更新日期：2016-02-02 00:00:00

abstract：:We are interested in tracking changes in large-scale data by periodically creating an agglomerative clustering and examining the evolution of clusters (communities) over time. We examine a large real-world data set: the NEC CiteSeer database, a linked network of >250,000 papers. Tracking changes over time requires a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hopcroft J,Khan O,Kulis B,Selman B

更新日期：2004-04-06 00:00:00

abstract：:Millions of individuals routinely remain awake for more than 18 h daily, which causes performance decrements. It is unknown if these functional impairments are the result of that extended wakefulness or from the associated shortened sleep durations. We therefore examined changes in objective reaction time performance ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McHill AW,Hull JT,Wang W,Czeisler CA,Klerman EB

更新日期：2018-06-05 00:00:00

abstract：:Androgens and the androgen receptor (AR) play important roles in the testes. Previously we have shown that male total AR knockout (T-AR-/y) mice revealed incomplete germ cell development and lowered serum testosterone levels, which resulted in azoospermia and infertility. However, the consequences of AR loss in partic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Yeh S,Chen YT,Wu CC,Chuang KH,Lin HY,Wang RS,Chang YJ,Mendis-Handagama C,Hu L,Lardy H,Chang C

更新日期：2006-11-21 00:00:00

abstract：:Staphylococcus aureus is a major cause of community-acquired and nosocomial infections including the life-threatening conditions endocarditis, necrotizing pneumonia, necrotizing fasciitis, and septicemia. Toll-like receptor (TLR)-2, a membrane-bound microbial sensor, detects staphylococcal components, but macrophages ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hruz P,Zinkernagel AS,Jenikova G,Botwin GJ,Hugot JP,Karin M,Nizet V,Eckmann L

更新日期：2009-08-04 00:00:00

abstract：:Polyploidy, the presence of more than two complete sets of chromosomes in an organism, has significantly shaped the genomes of angiosperms during evolution. Two forms of polyploidy are often considered: allopolyploidy, which originates from interspecies hybrids, and autopolyploidy, which originates from intraspecies g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Z,Haberer G,Matthes M,Rattei T,Mayer KF,Gierl A,Torres-Ruiz RA

更新日期：2010-10-12 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) like other herpesviruses, expresses sequentially immediate early (IE), early, and late genes during lytic infection. Evidence of ability to establish latent infection has not been available, but by analogy with other herpesviruses it could be expected that IE genes that regulate and transac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotola A,Ravaioli T,Gonelli A,Dewhurst S,Cassai E,Di Luca D

更新日期：1998-11-10 00:00:00

abstract：:Non-human primates (NHP) provide crucial research models. Their strong similarities to humans make them particularly valuable for understanding complex behavioral traits and brain structure and function. We report here the genetic mapping of an NHP nervous system biologic trait, the cerebrospinal fluid (CSF) concentra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freimer NB,Service SK,Ophoff RA,Jasinska AJ,McKee K,Villeneuve A,Belisle A,Bailey JN,Breidenthal SE,Jorgensen MJ,Mann JJ,Cantor RM,Dewar K,Fairbanks LA

更新日期：2007-10-02 00:00:00

abstract：:Inactivation of the retinoblastoma gene (RB gene) is associated with the development of several human malignancies including retinoblastomas, some osteo- and soft tissue sarcomas, small cell lung cancer, and possibly breast and bladder cancers. To our knowledge, this gene has not been evaluated in human germ-cell mali...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strohmeyer T,Reissmann P,Cordon-Cardo C,Hartmann M,Ackermann R,Slamon D

更新日期：1991-08-01 00:00:00