Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus.

abstract：:A (Mg(2+) + Ca(2+))ATPase (ATP phosphohydrolase, EC 3.6.1.3) has been purified from sarcoplasmic reticulum using a single step centrifugation procedure. The preparation is >95% pure by weight and contains only 25-30% of the lipid associated with the enzyme in native sarcoplasmic reticulum. The purified enzyme is unabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren GB,Toon PA,Birdsall NJ,Lee AG,Metcalfe JC

更新日期：1974-03-01 00:00:00

abstract：:White matter stroke is a distinct stroke subtype, accounting for up to 25% of stroke and constituting the second leading cause of dementia. The biology of possible tissue repair after white matter stroke has not been determined. In a mouse stroke model, white matter ischemia causes focal damage and adjacent areas of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sozmen EG,Rosenzweig S,Llorente IL,DiTullio DJ,Machnicki M,Vinters HV,Havton LA,Giger RJ,Hinman JD,Carmichael ST

更新日期：2016-12-27 00:00:00

abstract：:One of the critical issues regarding proteins with a four-helix bundle motif is which interactions play the major role in stabilizing this type of folded structure: the interaction among the four alpha-helices or the interaction between the loop and helix segments. To answer this question, an energetic analysis has be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou KC,Maggiora GM,Scheraga HA

更新日期：1992-08-15 00:00:00

abstract：:A varying oxygen environment is known to affect cellular function in disease as well as activity of various therapeutics. For transient structures, whether they are unconstrained therapeutic transplants, migrating cells during tumor metastasis, or cell populations induced by an immunological response, the role of oxyg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanoudaki V,Doloff JC,Huang W,Norcross SR,Farah S,Langer R,Anderson DG

更新日期：2019-03-12 00:00:00

abstract：:Mast cells and nerve growth factor (NGF) have both been reported to be involved in neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells interact with the innervating fibers. Changes in the behaviors of both of these elements occur after tissue injury/inflammation. As such conditions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leon A,Buriani A,Dal Toso R,Fabris M,Romanello S,Aloe L,Levi-Montalcini R

更新日期：1994-04-26 00:00:00

abstract：:Is the pathway of protein folding determined by the relative stability of folding intermediates, or by the relative height of the activation barriers leading to these intermediates? This is a fundamental question for resolving the Levinthal paradox, which stated that protein folding by a random search mechanism would ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su ZD,Arooz MT,Chen HM,Gross CJ,Tsong TY

更新日期：1996-03-19 00:00:00

abstract：:We identified cell surface markers associated with repression of p16(INK4a)/cyclin-dependent kinase inhibitor 2A(CDKN2A), a critical determinant in the acquisition of a plastic state. These cell surface markers allowed direct isolation of rare cells from healthy human breast tissue that exhibit extensive lineage plast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roy S,Gascard P,Dumont N,Zhao J,Pan D,Petrie S,Margeta M,Tlsty TD

更新日期：2013-03-19 00:00:00

abstract：:MST1, mammalian STE20-like kinase 1, is a serine/threonine kinase that is cleaved and activated by caspases during apoptosis. MST1 is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. In this study, we show that MST1 contains two functional nuclear export signals (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ura S,Masuyama N,Graves JD,Gotoh Y

更新日期：2001-08-28 00:00:00

abstract：:Earlier we have shown that oscillations with a long period ("supercycles") may arise in two-locus systems experiencing cyclical selection with a short period. However, this mode of complex limiting behavior appeared to be possible for narrow ranges of parameters. Here we demonstrate that a multilocus system subjected ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirzhner VM,Korol AB,Nevo E

更新日期：1996-06-25 00:00:00

abstract：:By harnessing the oxidative power of microorganisms, energy can be recovered from reservoirs of less-concentrated organic matter, such as marine sediment, wastewater, and waste biomass. Left unmanaged, these reservoirs can become eutrophic dead zones and sites of greenhouse gas generation. Here, we introduce a unique ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie X,Ye M,Hsu PC,Liu N,Criddle CS,Cui Y

更新日期：2013-10-01 00:00:00

abstract：:To identify proteins that regulate the transcriptional activity of c-Jun, we have used the yeast two-hybrid screen to detect mammalian polypeptides that might interact functionally with the N-terminal segment of c-Jun, a known regulatory region. Among the proteins identified is a short form of Stat3 (designated Stat3 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaefer TS,Sanders LK,Nathans D

更新日期：1995-09-26 00:00:00

abstract：:Many materials phenomena are governed by the interaction between chemistry and mechanics. However, it was only in the second half of the 20th century that the theory of open system elasticity by Francis Larché and John W. Cahn concatenated the fields of solid mechanics and alloy chemistry. As the theory's central mate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi S,Markmann J,Weissmüller J

更新日期：2018-10-23 00:00:00

abstract：:Distribution studies disclosed that all major cerebral arteries and cortical arterioles of the cat were invested with fine varicose nerve fibers that contained calcitonin gene-related peptide (CGRP)-like immunoreactivity; the trigeminal ganglia likewise contained CGRP immunoreactivity. Sequential immunostaining with a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCulloch J,Uddman R,Kingman TA,Edvinsson L

更新日期：1986-08-01 00:00:00

abstract：:A 16-amino acid residue peptide derived from a consensus motif of natural ferredoxins incorporates a tetranuclear iron sulfur cluster under physiological conditions. Successful assembly of the [4Fe-4S]2+/1+ cluster within a monomeric peptide was demonstrated using size exclusion chromatography, UV-visible, visible CD,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibney BR,Mulholland SE,Rabanal F,Dutton PL

更新日期：1996-12-24 00:00:00

abstract：:The midcycle luteinizing hormone (LH) surge triggers several tightly linked ovarian processes, including steroidogenesis, oocyte maturation, and ovulation. We designed studies to determine whether epidermal growth factor receptor (EGFR)-mediated signaling might serve as a common regulator of these activities. Our resu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jamnongjit M,Gill A,Hammes SR

更新日期：2005-11-08 00:00:00

abstract：:This paper presents a computational model for color coding that provides a functional explanation of how humans perceive colors in a homogeneous color space. Beginning with known properties of human cone photoreceptors, the model estimates the locations of the reflectance spectra of Munsell color chips in perceptual c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romney AK,Chiao CC

更新日期：2009-06-23 00:00:00

abstract：:Bacterial proteins often localize to distinct sites within the cell, but the primary cues that dictate localization are largely unknown. Recent evidence has shown that positive membrane curvature can serve as a cue for localization of a peripheral membrane protein. Here we report that localization of the peripheral me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramamurthi KS,Losick R

更新日期：2009-08-11 00:00:00

abstract：:The rearrangement of immunoglobulin genes in B-lymphocyte precursors requires the expression of the recombination activating genes (Rag), which leads to the generation of a highly diverse B-cell repertoire. We can use the level of Rag-1 mRNA in the bone marrow as an index of its capacity to support the maturation of B...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Yehuda A,Szabo P,Dyall R,Weksler ME

更新日期：1994-12-06 00:00:00

abstract：:Stat3 protein has an important role in oncogenesis and is a promising anticancer target. Indirubin, the active component of a traditional Chinese herbal medicine, has been shown previously to inhibit cyclin-dependent kinases, resulting in cell cycle arrest. Here, we show that the indirubin derivatives E564, E728, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nam S,Buettner R,Turkson J,Kim D,Cheng JQ,Muehlbeyer S,Hippe F,Vatter S,Merz KH,Eisenbrand G,Jove R

更新日期：2005-04-26 00:00:00

abstract：:The recombinant plasmid p102 based on pBR322 carrying approximately equal to 50% of the replicator proximal early region of simian virus 40 (SV40) DNA, including the viral origin of replication, has been constructed. It lacks a major part of the large tumor (T) antigen 3'-coding region, the T-antigen termination codon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horst J,Weckler C,Jacob E,Aulehla-Scholz C,Deppert W

更新日期：1982-08-01 00:00:00

abstract：:Gamma-Glutamyl transpeptidase, which consists of two nonidentical subunits, is rapidly inactivated with respect to its transpeptidase and hydrolase activities by the gamma-glutamyl analogs 6-diazo-5-oxo-L-norleucine and L-azaserine. Inactivation, which is prevented by gamma-glutamyl substrates (but not by acceptor sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate SS,Meister A

更新日期：1977-03-01 00:00:00

abstract：:Because it is able to produce desalinated water directly using solar energy with minimum carbon footprint, solar steam generation and desalination is considered one of the most important technologies to address the increasingly pressing global water scarcity. Despite tremendous progress in the past few years, efficien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Xu W,Tang M,Zhou L,Zhu B,Zhu S,Zhu J

更新日期：2016-12-06 00:00:00

abstract：:The segmented body plan of vertebrates is prefigured by reiterated embryonic mesodermal structures called somites. In the mouse embryo, timely somite formation from the presomitic mesoderm (PSM) is controlled by the "segmentation clock," a molecular oscillator that triggers progressive waves of Notch activity througho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez TP,Fan CM

更新日期：2013-05-28 00:00:00

abstract：:In order to understand the functions of simian virus 40 genes, permissive cells (TC7) were infected with mutants temperature sensitive in the complementation groups A, B, C, BC, and D at permissive and nonpermissive temperatures. Cells were examined for the localization of viral polypeptide antigens by immunofluoresce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kasamatsu H,Nehorayan A

更新日期：1979-06-01 00:00:00

abstract：:Exposure of cholera toxin to membrane particles prepared from sarcoma 180 cells gives rise to a variety of fragments which are capable of activating adenylate cyclase [ATP:pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. A major component of these fragments has an apparent molecular weight in the 8,000-10,000 range. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matuo Y,Wheeler MA,Bitensky MW

更新日期：1976-08-01 00:00:00

abstract：:Coiled-coil motifs are ubiquitous mediators of specific protein-protein interactions through the formation of interlocking hydrophobic seams between alpha-helical chains. Residues that form these seams occur at the first (a) and fourth (d) positions of a characteristic 7-aa repeat and are primarily aliphatic. The pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Yong W,Deng Y,Kallenbach NR,Lu M

更新日期：2004-11-16 00:00:00

abstract：:Cells are wrapped in inelastic membranes, yet they can sustain large mechanical strains by regulating their area. The area regulation in cells is achieved either by membrane folding or by membrane exo- and endocytosis. These processes involve complex morphological transformations of the cell membrane, i.e., invaginati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Staykova M,Holmes DP,Read C,Stone HA

更新日期：2011-05-31 00:00:00

abstract：:Fuchs endothelial corneal dystrophy (FECD) is a leading cause of corneal endothelial (CE) degeneration resulting in impaired visual acuity. It is a genetically complex and age-related disorder, with higher incidence in females. In this study, we established a nongenetic FECD animal model based on the physiologic outco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Miyajima T,Melangath G,Miyai T,Vasanth S,Deshpande N,Kumar V,Ong Tone S,Gupta R,Zhu S,Vojnovic D,Chen Y,Rogan EG,Mondal B,Zahid M,Jurkunas UV

更新日期：2020-01-07 00:00:00

abstract：:A recombinant vaccinia virus that directs the synthesis of bacteriophage T7 RNA polymerase provides the basis for the expression of genes that are regulated by T7 promoters in mammalian cells. The T7 transcripts, which account for as much as 30% of the total cytoplasmic RNA at 24 hr after infection, are largely uncapp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elroy-Stein O,Fuerst TR,Moss B

更新日期：1989-08-01 00:00:00

abstract：:Diverse motivations for preserving nature both inspire and hinder its conservation. Optimal conservation strategies may differ radically depending on the objective. For example, creating nature reserves may prevent extinctions through protecting severely threatened species, whereas incentivizing farmland hedgerows may...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karp DS,Mendenhall CD,Callaway E,Frishkoff LO,Kareiva PM,Ehrlich PR,Daily GC

更新日期：2015-09-01 00:00:00