Frontalin pheromone biosynthesis in the mountain pine beetle, Dendroctonus ponderosae, and the role of isoprenyl diphosphate synthases.

abstract：:Some tumor cell lines secrete high concentrations of TGFbeta or IL-1. Similarly high concentrations of each of these cytokines cross-activate the other pathway: TGFbeta activates NFkappaB, and IL-1beta activates Smads. The IL-1 signaling components IRAK, MyD88, TRAF6, and TAK1 are all required for cross-activation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu T,Tian L,Han Y,Vogelbaum M,Stark GR

更新日期：2007-03-13 00:00:00

abstract：:Although it is well described in model membranes, little is known about phase separation in biological membranes. Here, we provide evidence for a coexistence of at least two different lipid bilayer phases in the apical plasma membrane of epithelial cells. Phase connectivity was assessed by measuring long-range diffusi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meder D,Moreno MJ,Verkade P,Vaz WL,Simons K

更新日期：2006-01-10 00:00:00

abstract：:During tRNA biosynthesis the 5'-leader sequences in precursor tRNAs are removed by the ribonucleoprotein RNase P, an enzyme whose RNA moiety is required for activity. To clarify some aspects of the enzyme mechanism, we examined substrate binding and product formation with mutant precursor tRNAs. Mutations G-1----A or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nichols M,Söll D,Willis I

更新日期：1988-03-01 00:00:00

abstract：:The excitatory neurotransmitter, glutamate, activates N-methyl-d-aspartate (NMDA) receptors to induce long-lasting synaptic changes through alterations in gene expression. It is believed that these long-lasting changes contribute to learning and memory, drug tolerance, and ischemic preconditioning. To identify NMDA-in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong SJ,Li H,Becker KG,Dawson VL,Dawson TM

更新日期：2004-02-17 00:00:00

abstract：:The involvement of gangliosides in processes related to nerve regeneration and sprouting has been demonstrated recently. The type of interaction by which gangliosides may influence neuronal sprouting was investigated in the present work. Affinity-purified rabbit anti-GM1 antibodies were found to block the sprouting fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz M,Spirman N

更新日期：1982-10-01 00:00:00

abstract：:Interferon regulatory factor (IRF) 4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4(+) T cells into Th2 and Th17 cells. Using the infection model of Nippostrongyrus brasiliensis, we have confirmed the critical roles of IRF-4 in Th2 development in vivo by using...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honma K,Kimura D,Tominaga N,Miyakoda M,Matsuyama T,Yui K

更新日期：2008-10-14 00:00:00

abstract：:In most cervical carcinoma cells the E6 and E7 genes of specific human papillomaviruses are transcribed from viral sequences integrated into host cell chromosomes. Glucocorticoids activate the promoter elements of various human papillomaviruses in transient-expression assays. We have analyzed the effect of dexamethaso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Knebel Doeberitz M,Bauknecht T,Bartsch D,zur Hausen H

更新日期：1991-02-15 00:00:00

abstract：:We investigate the roles of the pseudospin and the valley degeneracy in electron scattering at graphene edges. It is found that they are strongly correlated with charge density modulations of short-wavelength oscillations and slowly decaying beat patterns in the electronic density profile. Theoretical analyses using n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park C,Yang H,Mayne AJ,Dujardin G,Seo S,Kuk Y,Ihm J,Kim G

更新日期：2011-11-15 00:00:00

abstract：:After prolonged visual adaptation of Drosophila, dramatic long-term changes of in vitro phosphorylation of a 50-kDa brain protein that is identical to the Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.37) can be measured in isolated heads. By selective receptor cell desensitization in blue light, subcellular dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willmund R,Mitschulat H,Schneider K

更新日期：1986-12-01 00:00:00

abstract：:The identity of the oldest lineage of monocotyledons is a subject of debate. Alternative interpretations of morphological homologies are variously consistent with proposals that species of Alismatanae, Dioscoreales, or Melanthiales were the earliest descendants of the first monocotyledons. We present phylogenetic anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duvall MR,Learn GH Jr,Eguiarte LE,Clegg MT

更新日期：1993-05-15 00:00:00

abstract：:Because synaptic vesicle exocytosis is a nano-mechanical process, it should be influenced by the mechanical properties of the cell membrane to which the vesicle fuses. By dissolving surfactants at various concentrations in the neuronal membrane, we have perturbed mechanical properties of the membrane and have found th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Y,Stevens CF

更新日期：2008-11-18 00:00:00

abstract：:Voltage-dependent anion channels (VDACs) are pore-forming proteins (porins) that form the major pathway for movement of adenine nucleotides through the outer mitochondrial membrane. Electrophysiological studies indicate that VDAC-like channel activity is also prevalent in the cell membranes of many mammalian cells. Ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buettner R,Papoutsoglou G,Scemes E,Spray DC,Dermietzel R

更新日期：2000-03-28 00:00:00

abstract：:Refinement of neural circuits in the mammalian cerebral cortex shapes brain function during development and in the adult. However, the signaling mechanisms underlying the synapse-specific shrinkage and loss of spiny synapses when neural circuits are remodeled remain poorly defined. Here, we show that low-frequency glu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oh WC,Hill TC,Zito K

更新日期：2013-01-22 00:00:00

abstract：:The dynamic responses of the hearing organ to acoustic overstimulation were investigated using the guinea pig isolated temporal bone preparation. The organ was loaded with the fluorescent Ca2+ indicator Fluo-3, and the cochlear electric responses to low-level tones were recorded through a microelectrode in the scala m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fridberger A,Flock A,Ulfendahl M,Flock B

更新日期：1998-06-09 00:00:00

abstract：:Fragility is an empirical property that describes how abruptly a glass-forming material solidifies upon supercooling. The degree of fragility carries important implications for the functionality and processability of a material, as well as for our fundamental understanding of the glass transition. However, the microst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ciarella S,Biezemans RA,Janssen LMC

更新日期：2019-12-10 00:00:00

abstract：:14-3-3 proteins are ubiquitously expressed regulators of various cellular functions, including proliferation, metabolism, and differentiation, and altered 14-3-3 expression is associated with development and progression of cancer. We report a transforming 14-3-3 oncoprotein, which we identified through conventional cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CH,Ou WB,Mariño-Enriquez A,Zhu M,Mayeda M,Wang Y,Guo X,Brunner AL,Amant F,French CA,West RB,McAlpine JN,Gilks CB,Yaffe MB,Prentice LM,McPherson A,Jones SJ,Marra MA,Shah SP,van de Rijn M,Huntsman DG,Dal Cin P

更新日期：2012-01-17 00:00:00

abstract：:The clinical efficacy of local anesthetic and antiarrhythmic drugs is due to their voltage- and frequency-dependent block of Na+ channels. Quaternary local anesthetic analogs such as QX-314, which are permanently charged and membrane-impermeant, effectively block cardiac Na+ channels when applied from either side of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qu Y,Rogers J,Tanada T,Scheuer T,Catterall WA

更新日期：1995-12-05 00:00:00

abstract：:Endothelial cells (ECs) line the mammalian vascular system and respond to the hemodynamic stimulus of fluid shear stress, the frictional force produced by blood flow. When ECs are exposed to shear stress, one of the fastest responses is an increase of K(+) conductance, which suggests that ion channels are involved in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoger JH,Ilyin VI,Forsyth S,Hoger A

更新日期：2002-05-28 00:00:00

abstract：:A single-chain Fv (scFv) fusion phage library derived from random combinations of VH and VL (variable heavy and light chains) domains in the antibody repertoire of a vaccinated melanoma patient was previously used to isolate clones that bind specifically to melanoma cells. An unexpected finding was that one of the clo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai X,Garen A

更新日期：1997-08-19 00:00:00

abstract：:Recently, it has been reported that there is a differential subcellular distribution of components of the minor U12-dependent and major U2-dependent spliceosome, and further that the minor spliceosome functions in the cytoplasm. To study the subcellular localization of the snRNA components of both the major and minor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pessa HK,Will CL,Meng X,Schneider C,Watkins NJ,Perälä N,Nymark M,Turunen JJ,Lührmann R,Frilander MJ

更新日期：2008-06-24 00:00:00

abstract：:L-Asparaginase (EC 3.5.1.1) inhibited respiration in sensitive, but not resistant, lines of murine lymphoma 6C3HED. Glucose, in these tumor lines, was principally converted to lactate, and very little was oxidized in the citric acid cycle or hexose monophosphate shunt. The cells derived 70-80% of their respiratory CO(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavietes BB,Regan DH,Demopoulos HB

更新日期：1974-10-01 00:00:00

abstract：:Gene expression in higher organisms is thought to be regulated by a complex network of transcription factor binding and chromatin modifications, yet the relative importance of these two factors remains a matter of debate. Here, we show that a computational approach allows surprisingly accurate prediction of histone mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benveniste D,Sonntag HJ,Sanguinetti G,Sproul D

更新日期：2014-09-16 00:00:00

abstract：:Aerobic respiration is a fundamental energy-generating process; however, there is cost associated with living in an oxygen-rich environment, because partially reduced oxygen species can damage cellular components. Organisms evolved enzymes that alleviate this damage and protect the intracellular milieu, most notably t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaya A,Gerashchenko MV,Seim I,Labarre J,Toledano MB,Gladyshev VN

更新日期：2015-08-25 00:00:00

abstract：:Two functional domains in the primary structure of basic fibroblast growth factor (FGF) have been identified on the basis of their ability to interact with the FGF receptor, bind radiolabeled heparin, and modulate the cellular response to FGF. Peptides derived from these two functional domains can act as partial agoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Schubert D,Ling N,Guillemin R

更新日期：1988-04-01 00:00:00

abstract：:Aggregation chimeras were formed between C57BL/6 mice heterozygous for the Apc(min) (Min) mutation and wild-type SWR mice, that differ in their Pla2g2a status, a modifier of Apc(min), and also in their resistance to intestinal polyp formation. Variation in the dolichos biflorus agglutinin-staining patterns of the inte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novelli MR,Wasan H,Rosewell I,Bee J,Tomlinson IP,Wright NA,Bodmer WF

更新日期：1999-10-26 00:00:00

abstract：:By using titin as a model system, we have demonstrated that fluorescence quenching can be used to study protein folding at the single molecule level. The unfolded titin molecules with multiple dye molecules attached are able to fold to the native state. In the native folded state, the fluorescence from dye molecules i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang X,Ha T,Kim HD,Centner T,Labeit S,Chu S

更新日期：2000-12-19 00:00:00

abstract：:There are approximately 350 non-odorant G protein-coupled receptors (GPCRs) encoded by the human genome, many of which are predicted to be potential therapeutic targets, but there are only two structures available to represent the whole of the family. We hypothesized that improving the detergent stability of these rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serrano-Vega MJ,Magnani F,Shibata Y,Tate CG

更新日期：2008-01-22 00:00:00

abstract：:The nuclear exosome-targeting (NEXT) complex functions as an RNA exosome cofactor and is involved in surveillance and turnover of aberrant transcripts and noncoding RNAs. NEXT is a ternary complex composed of the RNA-binding protein RBM7, the scaffold zinc-knuckle protein ZCCHC8, and the helicase MTR4. While RNA inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puno MR,Lima CD

更新日期：2018-06-12 00:00:00

abstract：:Hypothalamic malonyl-CoA has been shown to function in global energy homeostasis by modulating food intake and energy expenditure. Little is known, however, about the regulation of malonyl-CoA concentration in the central nervous system. To address this issue we investigated the response of putative intermediates in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolfgang MJ,Cha SH,Sidhaye A,Chohnan S,Cline G,Shulman GI,Lane MD

更新日期：2007-12-04 00:00:00

abstract：:One of the striking features of vascular endothelium, the single-cell-thick lining of the cardiovascular system, is its phenotypic plasticity. Various pathophysiologic factors, such as cytokines, growth factors, hormones, and metabolic products, can modulate its functional phenotype in health and disease. In addition ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia-Cardeña G,Comander J,Anderson KR,Blackman BR,Gimbrone MA Jr

更新日期：2001-04-10 00:00:00