Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.

abstract：:Immunoreactive and bioreactive corticotropin (ACTH-like) activities have been detected in the median eminence and remaining medial basal hypothalamus of both normal and hypophysectomized adult male rats: bioreactive ACTH (pg/100 mug of protein) 1028 in median eminence and 1289 in medial basal hypothalamus; immunoreact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krieger DT,Liotta A,Brownstein MJ

更新日期：1977-02-01 00:00:00

abstract：:One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with relatively larger lesions generally did not display a CR. To investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welters MJ,Kenter GG,de Vos van Steenwijk PJ,Löwik MJ,Berends-van der Meer DM,Essahsah F,Stynenbosch LF,Vloon AP,Ramwadhdoebe TH,Piersma SJ,van der Hulst JM,Valentijn AR,Fathers LM,Drijfhout JW,Franken KL,Oostendorp J,Fle

更新日期：2010-06-29 00:00:00

abstract：:Soft corals of the family Xeniidae exhibit a unique, rhythmic pulsation of their tentacles (Movie S1), first noted by Lamarck nearly 200 y ago. However, the adaptive benefit of this perpetual, energetically costly motion is poorly understood. Using in situ underwater particle image velocimetry, we found that the pulsa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kremien M,Shavit U,Mass T,Genin A

更新日期：2013-05-28 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a common genetic disorder characterized by excess absorption of dietary iron and progressive iron deposition in several tissues, particularly liver. The vast majority of individuals with HH are homozygous for mutations in the HFE gene. Recently a second transferrin receptor (TFR2) wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleming RE,Ahmann JR,Migas MC,Waheed A,Koeffler HP,Kawabata H,Britton RS,Bacon BR,Sly WS

更新日期：2002-08-06 00:00:00

abstract：:Two molecular forms of pyrophosphate-dependent phosphofructokinase (PP(i)-PFK; pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase; EC 2.7.1.90) have been found whose activity depends upon association and dissociation characteristics regulated by fructose 2,6-bisphosphate (Fru-2,6-P(2)). PP(i)-PFK was purified 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu MX,Smyth DA,Black CC

更新日期：1984-08-01 00:00:00

abstract：:Ubiquitination regulates, via different modes of modifications, a variety of biological processes, and aberrations in the process have been implicated in the pathogenesis of several neurodegenerative diseases. However, our ability to dissect the pathophysiological relevance of the ubiquitination code has been hampered...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haj-Yahya M,Fauvet B,Herman-Bachinsky Y,Hejjaoui M,Bavikar SN,Karthikeyan SV,Ciechanover A,Lashuel HA,Brik A

更新日期：2013-10-29 00:00:00

abstract：:A central unresolved issue in evolutionary biology is how metabolic innovations emerge. Low-level enzymatic side activities are frequent and can potentially be recruited for new biochemical functions. However, the role of such underground reactions in adaptation toward novel environments has remained largely unknown a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Notebaart RA,Szappanos B,Kintses B,Pál F,Györkei Á,Bogos B,Lázár V,Spohn R,Csörgő B,Wagner A,Ruppin E,Pál C,Papp B

更新日期：2014-08-12 00:00:00

abstract：:Sensitive optical signal detection can often be confounded by the presence of a significant background, and, as such, predetection background suppression is substantively important for weak signal detection. In this paper, we present a novel optical structure design, termed surface-wave-enabled darkfield aperture (SWE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng G,Cui X,Yang C

更新日期：2010-05-18 00:00:00

abstract：:A critical step in neuronal development is the formation of axon/dendrite polarity, a process involving symmetry breaking in the newborn neuron. Local self-amplifying processes could enhance and stabilize the initial asymmetry in the distribution of axon/dendrite determinants, but the identity of these processes remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng PL,Song AH,Wong YH,Wang S,Zhang X,Poo MM

更新日期：2011-11-08 00:00:00

abstract：:Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum. In this study, cloned parasites were examined serologically and biochemically for the expression of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biggs BA,Goozé L,Wycherley K,Wollish W,Southwell B,Leech JH,Brown GV

更新日期：1991-10-15 00:00:00

abstract：:HIV protease inhibitors are a key component of anti-retroviral therapy, but their susceptibility to cytochrome P(450) metabolism reduces their systemic availability and necessitates repetitive dosing. Importantly, failure to maintain adequate inhibitor levels is believed to provide an opportunity for resistance to eme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marinec PS,Chen L,Barr KJ,Mutz MW,Crabtree GR,Gestwicki JE

更新日期：2009-02-03 00:00:00

abstract：:Relatively little is known about neurobiological changes attributable to early-life stressors (e.g., orphanage rearing), even though they have been associated with a heightened risk for later psychopathology. Human neuroimaging and animal studies provide complementary insights into the neural basis of problem behavior...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malter Cohen M,Jing D,Yang RR,Tottenham N,Lee FS,Casey BJ

更新日期：2013-11-05 00:00:00

abstract：:Phosphorylation-based signaling pathways employ dephosphorylation mechanisms for signal termination. Histidine to aspartate phosphosignaling in the two-component system that controls bacterial chemotaxis has been studied extensively. Rhodobacter sphaeroides has a complex chemosensory pathway with multiple homologues o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter SL,Roberts MA,Manning CS,Armitage JP

更新日期：2008-11-25 00:00:00

abstract：:Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been identified in these regions, no causative correlations have been drawn between deletion or mutation of these and lung carcinogenesis. We identify XPC and Gadd45a as ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollander MC,Philburn RT,Patterson AD,Velasco-Miguel S,Friedberg EC,Linnoila RI,Fornace AJ Jr

更新日期：2005-09-13 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent of a large group of related proteinopathies for which there is currently no cure. Here, we used Drosophila to explore a strategy to block Aβ42 neurotoxicity through engineering of the Heat shock protein 70 (Hsp70), a chaperone that has demonstrated neuroprotective activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez-Funez P,Sanchez-Garcia J,de Mena L,Zhang Y,Levites Y,Khare S,Golde TE,Rincon-Limas DE

更新日期：2016-08-30 00:00:00

abstract：:The carboxy-terminal domain (CTD) code encrypted within the Y1S2P3T4S5P6S7 heptad repeats of RNA polymerase II (Pol2) is deeply rooted in eukaryal biology. Key steps to deciphering the code are identifying the events in gene expression that are governed by individual "letters" and then defining a vocabulary of multile...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez AM,Shuman S,Schwer B

更新日期：2018-11-06 00:00:00

abstract：:We recently reported that the posttraumatic spread of degeneration in the damaged optic nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin basic protein. However, it would be desirable to obtain immune neuroprotection free of any possible autoimmune disease. In an attempt to obta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kipnis J,Yoles E,Porat Z,Cohen A,Mor F,Sela M,Cohen IR,Schwartz M

更新日期：2000-06-20 00:00:00

abstract：:The nuclear LIM domain protein LMO2, a T cell oncoprotein, is essential for embryonic erythropoiesis. LIM-only proteins are presumed to act primarily through protein-protein interactions. We, and others, have identified a widely expressed protein, Ldb1, whose C-terminal 76-residues are sufficient to mediate interactio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Visvader JE,Mao X,Fujiwara Y,Hahm K,Orkin SH

更新日期：1997-12-09 00:00:00

abstract：:The generation of diverse neuronal types and subtypes from multipotent progenitors during development is crucial for assembling functional neural circuits in the adult central nervous system. During mouse retinogenesis, early retinal progenitors give rise to several cell types, including ganglion, amacrine, horizontal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo H,Jin K,Xie Z,Qiu F,Li S,Zou M,Cai L,Hozumi K,Shima DT,Xiang M

更新日期：2012-02-28 00:00:00

abstract：:The E2F1 transcription factor has a well-characterized activation domain at its C terminus and the E1A protein has a recently defined activation domain at its N terminus. Here we show that these activation domains are highly related in sequence. The sequence homology reflects, at least partly, the conservation of comm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trouche D,Kouzarides T

更新日期：1996-02-20 00:00:00

abstract：:The 24-hr intracarotid infusion of plasma-treated glycyl-L-glutamine (3 microM) produced significant enhancement of the monomeric G1 and tetrameric G4 forms of acetylcholinesterase of the cat superior cervical ganglion 48 hr after denervation, in comparison with denervated, noninfused controls. No significant effect o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koelle GB,Skau KA,Thampi NS,Hymel DM,Han MS

更新日期：1988-08-01 00:00:00

abstract：:In epithelial cells, sorting of membrane proteins to the basolateral surface depends on the presence of a basolateral sorting signal (BaSS) in their cytoplasmic domain. Amyloid precursor protein (APP), a basolateral protein implicated in the pathogenesis of Alzheimer's disease, contains a tyrosine-based BaSS, and muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng P,Eastman J,Vande Pol S,Pimplikar SW

更新日期：1998-12-08 00:00:00

abstract：:We model experience-dependent plasticity in the cortical representation of whiskers (the barrel cortex) in normal adult rats, and in adult rats that were prenatally exposed to alcohol. Prenatal exposure to alcohol (PAE) caused marked deficits in experience-dependent plasticity in a cortical barrel-column. Cortical pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benusková L,Rema V,Armstrong-James M,Ebner FF

更新日期：2001-02-27 00:00:00

abstract：:Hydrothermal vent ecosystems support diverse life forms, many of which rely on symbiotic associations to perform functions integral to survival in these extreme physicochemical environments. Epsilonproteobacteria, found free-living and in intimate associations with vent invertebrates, are the predominant vent-associat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grzymski JJ,Murray AE,Campbell BJ,Kaplarevic M,Gao GR,Lee C,Daniel R,Ghadiri A,Feldman RA,Cary SC

更新日期：2008-11-11 00:00:00

abstract：:The impacts of global climate change on different aspects of humanity's diverse life-support systems are complex and often difficult to predict. To facilitate policy decisions on mitigation and adaptation strategies, it is necessary to understand, quantify, and synthesize these climate-change impacts, taking into acco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piontek F,Müller C,Pugh TA,Clark DB,Deryng D,Elliott J,Colón González Fde J,Flörke M,Folberth C,Franssen W,Frieler K,Friend AD,Gosling SN,Hemming D,Khabarov N,Kim H,Lomas MR,Masaki Y,Mengel M,Morse A,Neumann K,N

更新日期：2014-03-04 00:00:00

abstract：:While the concept of intercellular mechanical communication has been revealed, the mechanistic insights have been poorly evidenced in the context of myofibroblast-fibroblast interaction during fibrosis expansion. Here we report and systematically investigate the mechanical force-mediated myofibroblast-fibroblast cross...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Yu H,Zhao H,Wu Z,Long Y,Zhang J,Yan X,You Z,Zhou L,Xia T,Shi Y,Xiao B,Wang Y,Huang C,Du Y

更新日期：2020-05-19 00:00:00

abstract：:The commitment of differentiating cells to a specialized fate is fundamental to the correct assembly of tissues within a multicellular organism. Because commitment is often irreversible, entry into and progression through this phase of development must be tightly regulated. Under nitrogen-limiting conditions, the mult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Videau P,Rivers OS,Hurd K,Ushijima B,Oshiro RT,Ende RJ,O'Hanlon SM,Cozy LM

更新日期：2016-11-08 00:00:00

abstract：:With current concerns of antibiotic-resistant bacteria and biodefense, it has become important to rapidly identify infectious bacteria. Traditional technologies involving isolation and amplification of the pathogenic bacteria are time-consuming. We report a rapid and simple method that combines in vivo biotinylation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edgar R,McKinstry M,Hwang J,Oppenheim AB,Fekete RA,Giulian G,Merril C,Nagashima K,Adhya S

更新日期：2006-03-28 00:00:00

abstract：:Soot particles produced by incomplete combustion processes are one of the major components of urban air pollution. Chemistry at their surfaces lead to the heterogeneous conversion of several key trace gases; for example NO(2) interacts with soot and is converted into HONO, which rapidly photodissociates to form OH in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monge ME,D'Anna B,Mazri L,Giroir-Fendler A,Ammann M,Donaldson DJ,George C

更新日期：2010-04-13 00:00:00

abstract：:Previous studies imply that the intracellular domain of Notch1 must translocate to the nucleus for its activity. In this study, we demonstrate that a mNotch1 mutant protein that lacks its extracellular domain but retains its membrane-spanning region becomes proteolytically processed on its intracellular surface and, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopan R,Schroeter EH,Weintraub H,Nye JS

更新日期：1996-02-20 00:00:00