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Antigenic variation in Plasmodium falciparum.

Abstract：

:Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum. In this study, cloned parasites were examined serologically and biochemically for the expression of erythrocyte surface antigens. A cloned line of P. falciparum gave rise to progeny that expressed antigenically distinct forms of an erythrocyte surface antigen but were otherwise identical. This demonstrates that antigenic differences on the surface of P. falciparum-infected erythrocytes can arise by antigenic variation of clonal parasite populations. The antigenic differences were shown to result from antigenic variation of the parasite-encoded protein, the P. falciparum erythrocyte membrane protein 1.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Biggs BA,Goozé L,Wycherley K,Wollish W,Southwell B,Leech JH,Brown GV

doi

10.1073/pnas.88.20.9171

subject

Has Abstract

pub_date

1991-10-15 00:00:00

pages

9171-4

issue

20

eissn

0027-8424

issn

1091-6490

journal_volume

88

pub_type

杂志文章

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