A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.

abstract：:Biological membranes contain an extraordinary diversity of lipids. Phospholipids function as major structural elements of cellular membranes, and analysis of changes in the highly heterogeneous mixtures of lipids found in eukaryotic cells is central to understanding the complex functions in which lipids participate. P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanova PT,Cerda BA,Horn DM,Cohen JS,McLafferty FW,Brown HA

更新日期：2001-06-19 00:00:00

abstract：:Integral membrane proteins that form water-filled channels through membranes often exist as aggregates of similar or identical subunits spanning the membrane. It has been suggested that the insertion into the membrane of the channel-forming domains of the subunits may impart unusual structural features to the membrane...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maher PA,Singer SJ

更新日期：1985-02-01 00:00:00

abstract：:A full-length cDNA clone encoding a purified augmenter of liver regeneration (ALR) factor prepared from the cytosol of weanling rat livers was isolated. The 1.2-kb cDNA included a 299-bp 5' untranslated region, a 375-bp coding region, and a 550-bp 3' untranslated region. It encoded a protein consisting of 125 amino ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagiya M,Francavilla A,Polimeno L,Ihara I,Sakai H,Seki T,Shimonishi M,Porter KA,Starzl TE

更新日期：1994-08-16 00:00:00

abstract：:We present evidence of rapid and reliable associative learning by the terrestrial mollusc, Limax maximus. Slugs were exposed once to a pairing of a highly attractive food odor (potato or carrot) and a saturated solution of quinidine sulfate, a bitter-tasting plant substance. In comparison with control slugs, the expos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sahley C,Gelperin A,Rudy JW

更新日期：1981-01-01 00:00:00

abstract：:Myelin basic proteins (MBP) are major constituents of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. We previously showed that MBP-related transcripts are present in the bone marrow and the immune system. These mRNAs are transcribe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marty MC,Alliot F,Rutin J,Fritz R,Trisler D,Pessac B

更新日期：2002-06-25 00:00:00

abstract：:Competing populations in shared spaces with nonrenewable resources do not necessarily wage a battle for dominance at the cost of extinction of the less-fit strain if there are fitness advantages to the presence of the other strain. We report on the use of nanofabricated habitat landscapes to study the population dynam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keymer JE,Galajda P,Lambert G,Liao D,Austin RH

更新日期：2008-12-23 00:00:00

abstract：:Earlier Monte Carlo studies on a single-helix model of the GTP cap at the end of a microtubule are extended here to a more realistic five-start helix model of the microtubule end. As in the earlier work, phase changes occur at the microtubule end: the end is either capped with GTP and growing slowly or uncapped and sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1985-02-01 00:00:00

abstract：:Gliogenesis in animal development is spatiotemporally regulated so that correct numbers of glia are present to support various neuronal functions. During Drosophila embryonic development, the glial regulatory gene, glial cell missing/glial cell deficient (gcm/glide), promotes glial cell fate and differentiation. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MS,Chen H,Chen M,Jacques C,Giangrande A,Chien CT

更新日期：2009-04-21 00:00:00

abstract：:Conflicting data have been reported with regard to the infectability, dysfunction, and depletion of dendritic cells (DCs) in human immunodeficiency virus (HIV) disease. These discrepancies could potentially be explained by the existence of multiple subsets of cells with dendritic morphology in peripheral blood. The is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissman D,Li Y,Ananworanich J,Zhou LJ,Adelsberger J,Tedder TF,Baseler M,Fauci AS

更新日期：1995-01-31 00:00:00

abstract：:Myosins play countless critical roles in the cell, each requiring it to be activated at a specific location and time. To control myosin VI with this specificity, we created an optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa phototropin1 LOV2 domain to a peptide from Dab2 (LOVDab), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： French AR,Sosnick TR,Rock RS

更新日期：2017-02-28 00:00:00

abstract：:Two approaches have been explored for the synthesis of double-stranded DNA from single-stranded DNA template complementary to rabbit 9S globin mRNA (cDNA). (i) cDNA was elongated with dCMP or dTMP homopolymeric tracts using terminal deoxynucleotidyltransferase (EC 2.7.7.31; nucleosidetriphosphate:DNA deoxynucleotidyle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rougeon F,Mach B

更新日期：1976-10-01 00:00:00

abstract：:Chemical coding in the sympathetic nervous system involves both noradrenergic and, for a minority of neurons, cholinergic neurotransmission. The expression of the cholinergic phenotype in the developing sympathetic nervous system was examined to determine if coding for cholinergic transmission occurs before or after i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer MK,Schütz B,Weihe E,Eiden LE

更新日期：1997-04-15 00:00:00

abstract：:We use stable isotope ratios in feces of wild mountain gorillas (Gorilla beringei) to test the hypothesis that diet shifts within a single year, as measured by dry mass intake, can be recovered. Isotopic separation of staple foods indicates that intraannual changes in the isotopic composition of feces reflect shifts i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumenthal SA,Chritz KL,Rothman JM,Cerling TE

更新日期：2012-12-26 00:00:00

abstract：:Branched polyethylenimine (PEI) chains with an average molecular mass of 2 kDa (PEI2) have been covalently attached to gold nanoparticles (GNPs), and the potency of the resulting PEI2-GNPs conjugates as vectors for the delivery of plasmid DNA into monkey kidney (COS-7) cells in the presence of serum in vitro has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas M,Klibanov AM

更新日期：2003-08-05 00:00:00

abstract：:Intracellular recordings were obtained from vagal neurons and their response to oxytocin was investigated in slices from the rat and the guinea pig brainstem. After recording, Lucifer yellow was injected into the cells to verify their localization within the dorsal motor nucleus of the vagus nerve (dmnX). In the rat, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raggenbass M,Dubois-Dauphin M,Charpak S,Dreifuss JJ

更新日期：1987-06-01 00:00:00

abstract：:Ski8p is implicated in degradation of non-poly(A) and double-stranded RNA, and in meiotic DNA recombination. We have identified the Sordaria macrospora SKI8 gene. Ski8p is cytoplasmically localized in all vegetative and sexual cycle cells, and is nuclear localized, specifically in early-mid-meiotic prophase, in tempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tessé S,Storlazzi A,Kleckner N,Gargano S,Zickler D

更新日期：2003-10-28 00:00:00

abstract：:Three proteins required for poly(U)-directed polyphenylalanine synthesis have been separated from yeast. Two of the factors correspond to the elongation factors 1 and 2 described for other eukaryotic systems, according to the criteria of phenylalanyl-tRNA binding and diphtheria toxin-catalyzed ADP-ribosylation. The th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skogerson L,Wakatama E

更新日期：1976-01-01 00:00:00

abstract：:Rad51 is a core component of the eukaryotic homologous recombination machinery and is responsible for key mechanistic steps during strand invasion. Higher order oligomers of Rad51 display a remarkable degree of structural variation, forming rings, compressed filaments, and elongated filaments. It is unclear whether Ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robertson RB,Moses DN,Kwon Y,Chan P,Chi P,Klein H,Sung P,Greene EC

更新日期：2009-08-04 00:00:00

abstract：:Epstein-Barr virus (EBV) is associated with epithelial and lymphoid malignancies, establishes latent infection in memory B cells, and intermittently produces infectious virions through lytic replication. Released virions play a key role in latent reservoir maintenance and transmission. Lytic EBV transcription differs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma D,Church TM,Swaminathan S

更新日期：2020-06-09 00:00:00

abstract：:Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao W,Rovin BH,Friedman A

更新日期：2014-09-30 00:00:00

abstract：:Saposin A, a heat-stable 16-kDa glycoprotein, was isolated from Gaucher disease spleen and purified to homogeneity. Chemical sequencing from its amino terminus and of peptides obtained by digestion with protease from Staphylococcus aureus strain V-8 demonstrated that saposin A is derived from proteolytic processing of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morimoto S,Martin BM,Yamamoto Y,Kretz KA,O'Brien JS,Kishimoto Y

更新日期：1989-05-01 00:00:00

abstract：:Saccharomyces cerevisiae cells reproduce by budding to yield a mother cell and a smaller daughter cell. Although both mother and daughter begin G1 simultaneously, the mother cell progresses through G1 more rapidly. Daughter cell G1 delay has long been thought to be due to a requirement for attaining a certain critical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laabs TL,Markwardt DD,Slattery MG,Newcomb LL,Stillman DJ,Heideman W

更新日期：2003-09-02 00:00:00

abstract：:Species- and strain-specific spontaneously occurring tumors have been observed in rodents maintained under normal laboratory conditions. Elucidation of the molecular mechanisms associated with the development of these spontaneous tumors may provide a better understanding of tumor development associated with exposure t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds SH,Stowers SJ,Maronpot RR,Anderson MW,Aaronson SA

更新日期：1986-01-01 00:00:00

abstract：:Twenty-five years ago this month, Thomas Gold published a seminal manuscript suggesting the presence of a "deep, hot biosphere" in the Earth's crust. Since this publication, a considerable amount of attention has been given to the study of deep biospheres, their role in geochemical cycles, and their potential to infor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colman DR,Poudel S,Stamps BW,Boyd ES,Spear JR

更新日期：2017-07-03 00:00:00

abstract：:We previously developed a biological containment system using recombinant Salmonella Typhimurium strains that are attenuated yet capable of synthesizing protective antigens. The regulated delayed attenuation and programmed self-destructing features designed into these S. Typhimurium strains enable them to efficiently ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong W,Brovold M,Koeneman BA,Clark-Curtiss J,Curtiss R 3rd

更新日期：2012-11-20 00:00:00

abstract：:The testis-determining gene Sry is located on the short arm of the mouse Y chromosome in a region known to have undergone duplications and rearrangements in comparison with the equivalent portion of the human Y chromosome. Detailed analysis of the Sry genomic locus reveals a further difference in that the mouse Sry op...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gubbay J,Vivian N,Economou A,Jackson D,Goodfellow P,Lovell-Badge R

更新日期：1992-09-01 00:00:00

abstract：:A genetic analysis is necessary to gain a greater understanding of the complex developmental processes in mammals. Toward this end, an insertional transgenic mouse mutant has been isolated that results in abnormal germ-cell development. This recessive mutation manifests as infertility in both males and females and is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellas TC,Ramachandran B,Duncan M,Pan SS,Marone M,Chada K

更新日期：1991-10-01 00:00:00

abstract：:Direct visualization of genomic loci in the 3D nucleus is important for understanding the spatial organization of the genome and its association with gene expression. Various DNA FISH methods have been developed in the past decades, all involving denaturing dsDNA and hybridizing fluorescent nucleic acid probes. Here w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deng W,Shi X,Tjian R,Lionnet T,Singer RH

更新日期：2015-09-22 00:00:00

abstract：:Mechanisms by which macrophages discriminate between "mature-self" and "senescent-self" were investigated using the human red blood cell (RBC) system as a model. Conditions simulating those encountered in situ were adhered to as closely as possible by using short term culture techniques and incubating with autologous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM

更新日期：1975-09-01 00:00:00

abstract：:The tumor suppressor activity of p53 is regulated by interactions with the ubiquitin ligase HDM2 and the general transcriptional coactivators CBP and p300. Using NMR spectroscopy and isothermal titration calorimetry, we have dissected the binding interactions between the N-terminal transactivation domain (TAD) of p53,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferreon JC,Lee CW,Arai M,Martinez-Yamout MA,Dyson HJ,Wright PE

更新日期：2009-04-21 00:00:00