T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies.

Abstract:

:We recently reported that the posttraumatic spread of degeneration in the damaged optic nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin basic protein. However, it would be desirable to obtain immune neuroprotection free of any possible autoimmune disease. In an attempt to obtain disease-free immune neuroprotection, we used the synthetic four-amino acid polymer copolymer 1 (Cop-1), which is known not to be encephalitogenic despite its cross-reactivity with myelin basic protein. We show here that active immunization with Cop-1 administered in adjuvant, as well as adoptive transfer of T cells reactive to Cop-1, can inhibit the progression of secondary degeneration after crush injury of the rat optic nerve. These results have implications for the treatment of optic neuropathies.

authors

Kipnis J,Yoles E,Porat Z,Cohen A,Mor F,Sela M,Cohen IR,Schwartz M

doi

10.1073/pnas.97.13.7446

keywords:

subject

Has Abstract

pub_date

2000-06-20 00:00:00

pages

7446-51

issue

13

eissn

0027-8424

issn

1091-6490

pii

97/13/7446

journal_volume

97

pub_type

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