Abstract:
:We recently reported that the posttraumatic spread of degeneration in the damaged optic nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin basic protein. However, it would be desirable to obtain immune neuroprotection free of any possible autoimmune disease. In an attempt to obtain disease-free immune neuroprotection, we used the synthetic four-amino acid polymer copolymer 1 (Cop-1), which is known not to be encephalitogenic despite its cross-reactivity with myelin basic protein. We show here that active immunization with Cop-1 administered in adjuvant, as well as adoptive transfer of T cells reactive to Cop-1, can inhibit the progression of secondary degeneration after crush injury of the rat optic nerve. These results have implications for the treatment of optic neuropathies.
journal_name
Proc Natl Acad Sci U S Aauthors
Kipnis J,Yoles E,Porat Z,Cohen A,Mor F,Sela M,Cohen IR,Schwartz Mdoi
10.1073/pnas.97.13.7446keywords:
subject
Has Abstractpub_date
2000-06-20 00:00:00pages
7446-51issue
13eissn
0027-8424issn
1091-6490pii
97/13/7446journal_volume
97pub_type
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