Receptor- and heparin-binding domains of basic fibroblast growth factor.

abstract：:Protein kinase A (PKA) is activated during sympathetic stimulation of the heart and phosphorylates key proteins involved in cardiac Ca(2+) handling, including the L-type Ca(2+) channel (Ca(V)1.2) and phospholamban (PLN). This results in acceleration and amplification of the beat-to-beat changes in cytosolic Ca(2+) in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones BW,Brunet S,Gilbert ML,Nichols CB,Su T,Westenbroek RE,Scott JD,Catterall WA,McKnight GS

更新日期：2012-10-16 00:00:00

abstract：:The importance of gene gain through duplication has long been appreciated. In contrast, the importance of gene loss has only recently attracted attention. Indeed, studies in organisms ranging from plants to worms and humans suggest that duplication of some genes might be better tolerated than that of others. Here we h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Smet R,Adams KL,Vandepoele K,Van Montagu MC,Maere S,Van de Peer Y

更新日期：2013-02-19 00:00:00

abstract：:An Epstein-Barr virus (EBV) deletion mutant, HR-1, cannot immortalize lymphocytes. HR-1 was derived from a virus strain, Jijoye, that is immortalization competent. Using human antiserum from certain patients with chronic active EBV infection, we have identified in Jijoye cells a protein of apparent mass of 78-80 kDa t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe D,Heston L,Metlay J,Miller G

更新日期：1985-11-01 00:00:00

abstract：:Pristine meteoritic materials carry light element isotopic fractionations that constrain physiochemical conditions during solar system formation. Here we report the discovery of a unique xenolith in the metal-rich chondrite Isheyevo. Its fine-grained, highly pristine mineralogy has similarity with interplanetary dust ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briani G,Gounelle M,Marrocchi Y,Mostefaoui S,Leroux H,Quirico E,Meibom A

更新日期：2009-06-30 00:00:00

abstract：:The issue of protein dynamics and its implications in the biological function of proteins are arousing greater and greater interest in different fields of molecular biology. In cryo-electron tomography experiments one may take several snapshots of a given biological macromolecule. In principle, a large enough collecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bongini L,Fanelli D,Piazza F,De Los Rios P,Sandin S,Skoglund U

更新日期：2004-04-27 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-regulated gene expression is stimulated independently by the cellular trans-activator NF-kappa B and the viral protein Tat. Noncytotoxic concentrations of the drug pentoxifylline (PTX) inhibited interaction of NF-kappa B with its motif and the stim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biswas DK,Ahlers CM,Dezube BJ,Pardee AB

更新日期：1993-12-01 00:00:00

abstract：:Managing excess nutrients remains a major obstacle to improving ecosystem service benefits of urban waters. To inform more ecologically based landscape nutrient management, we compared watershed inputs, outputs, and retention for nitrogen (N) and phosphorus (P) in seven subwatersheds of the Mississippi River in St. Pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie SE,Finlay JC,Janke BD,Nidzgorski DA,Millet DB,Baker LA

更新日期：2017-04-18 00:00:00

abstract：:Mechanisms and signals that regulate transcriptional coactivators are still largely unknown. Here we provide genetic evidence for a repressor that interacts with and regulates the nuclear receptor coactivator PGC-1. Association with the repressor requires a PGC-1 protein interface that is similar to the one used by nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knutti D,Kressler D,Kralli A

更新日期：2001-08-14 00:00:00

abstract：:In contrast to the immunosuppressive potential of UVB (280-320 nm) radiation in experimental animals and humans, UVA (320-400 nm) radiation at environmentally relevant doses appears to be immunologically inert. However, such exposure to UVA radiation has been observed unexpectedly to induce resistance to UVB-induced i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve VE,Tyrrell RM

更新日期：1999-08-03 00:00:00

abstract：:Cellular telomere length is linked to replicative life span. Telomere repeats are lost in peripheral blood cells in vivo by age, and women show less telomere attrition than men. Previous reports have indicated that telomere length and chromosome-specific telomere-length patterns partly are inherited. The mode of hered...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nordfjäll K,Larefalk A,Lindgren P,Holmberg D,Roos G

更新日期：2005-11-08 00:00:00

abstract：:Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oda S,Toyoshima Y,de Bono M

更新日期：2017-06-06 00:00:00

abstract：:Interactions between two excitatory monosynaptic inputs to hippocampal neurons of the CA1 region were examined in the in vitro slice. By adjusting the strengths of the electrical stimuli delivered to the two input pathways, one was made to generate a weak and the other a strong synaptic response. Simultaneous tetanic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrionuevo G,Brown TH

更新日期：1983-12-01 00:00:00

abstract：:Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of successful human responses to immunotherapy. As a model for changes induced in nonmalignant cells by cancer, we examined T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorgun G,Ramsay AG,Holderried TA,Zahrieh D,Le Dieu R,Liu F,Quackenbush J,Croce CM,Gribben JG

更新日期：2009-04-14 00:00:00

abstract：:This study details the immune response to cartilage proteoglycan in experimental chronic IgG-induced immune synovitis. Antibodies reactive with purified rabbit proteoglycan monomer were observed in nine of nine rabbits with immune synovitis. IgG-immunized but nonsynovitic control animals with no pathology showed no an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoo JU,Kresina TF,Malemud CJ,Goldberg VM

更新日期：1987-02-01 00:00:00

abstract：:This paper investigates quantitatively the characteristics of the local folding code. The overlapping four-residue fragments which make up the amino acid sequences of 114 proteins are divided into classes on the basis of the physical properties of their constituent amino acids. The distribution of structural types ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S

更新日期：1993-01-15 00:00:00

abstract：:Golgi-associated cytoplasmic proteins, such as the coatomer protein complex, are required for vesicle budding and trafficking. We have previously described a cytoplasmic phosphoprotein, p200, which binds dynamically and specifically to Golgi membranes. The p200 protein is dissociated from Golgi membranes in the presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narula N,Stow JL

更新日期：1995-03-28 00:00:00

abstract：:The ability of polynucleotides or polynucleotide duplexes such as poly(I).poly(C) to induce interferon production is proposed to depend on the existence of certain stable glycosidic orientations. It appears that a slight increase in instability of 1--3 kcal/mole (1 cal = 4.184 J) in the conformational regions near 20 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DL,Miles DW,Eyring H

更新日期：1979-03-01 00:00:00

abstract：:Parkin functions as a multipurpose E3 ubiquitin ligase, and Parkin loss of function is associated with both sporadic and familial Parkinson's disease (PD). We report that the Bin/Amphiphysin/Rvs (BAR) domain of protein interacting with PRKCA1 (PICK1) bound to the really interesting new gene 1 (RING1) domain of Parkin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He J,Xia M,Yeung PKK,Li J,Li Z,Chung KK,Chung SK,Xia J

更新日期：2018-07-24 00:00:00

abstract：:When yeast from the early stages of meiosis are transferred from sporulation to growth medium, they can reenter the mitotic cell cycle directly. In contrast, cells from later stages of meiosis (after the initiation of the first nuclear division) will complete meiosis and sporulation despite the shift to growth medium,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honigberg SM,Esposito RE

更新日期：1994-07-05 00:00:00

abstract：:Homing endonucleases stimulate gene conversion by generating site-specific DNA double-strand breaks that are repaired by homologous recombination. These enzymes are potentially valuable tools for targeted gene correction and genome engineering. We have engineered a variant of the I-AniI homing endonuclease that nicks ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McConnell Smith A,Takeuchi R,Pellenz S,Davis L,Maizels N,Monnat RJ Jr,Stoddard BL

更新日期：2009-03-31 00:00:00

abstract：:A close study of the metabolic regulation of hexose transport in a hamster fibroblast mutant, highly defective in the enzyme phosphoglucose isomerase (PGI mutant), reveals the requirement for at least three vectors for transport regulation. The downward regulation of the hexose transport system, called the "transport ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalckar HM,Ullrey DB

更新日期：1984-02-01 00:00:00

abstract：:Steroidogenic factor-1 (SF-1) and liver receptor homologue-1 (LRH-1) belong to the fushi tarazu factor 1 subfamily of nuclear receptors. SF-1 is an essential factor for sex determination during development and regulates adrenal and gonadal steroidogenesis in the adult, whereas LRH-1 is a critical factor for developmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Zhang C,Marimuthu A,Krupka HI,Tabrizizad M,Shelloe R,Mehra U,Eng K,Nguyen H,Settachatgul C,Powell B,Milburn MV,West BL

更新日期：2005-05-24 00:00:00

abstract：:Madagascar periwinkle (Catharanthus roseus) is the sole source of the anticancer drugs vinblastine and vincristine, bisindole alkaloids derived from the dimerization of the terpenoid indole alkaloids vindoline and catharanthine. Full elucidation of the biosynthetic pathways of these compounds is a prerequisite for met...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liscombe DK,Usera AR,O'Connor SE

更新日期：2010-11-02 00:00:00

abstract：:The tumorigenic properties of Rous sarcoma virus are attributable to a 60,000-dalton protein, pp60v--src, encoded by a single viral gene, v-src. A homologous gene, c-src, that contains the information for a 60,000-dalton protein, pp60c--src, has been identified in all tested vertebrate cells. By screening a recombinan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker RC,Varmus HE,Bishop JM

更新日期：1981-09-01 00:00:00

abstract：:In some countries across the globe, tropical forest cover is increasing. The national-scale reforestation of Vietnam since 1992 is assumed to contribute to this recovery. It is achieved, however, by the displacement of forest extraction to other countries on the order of 49 (34-70) M m(3), or approximately 39% of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyfroidt P,Lambin EF

更新日期：2009-09-22 00:00:00

abstract：:All extant life employs the same 20 amino acids for protein biosynthesis. Studies on the number of amino acids necessary to produce a foldable and catalytically active polypeptide have shown that a basis set of 7-13 amino acids is sufficient to build major structural elements of modern proteins. Hence, the reasons for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granold M,Hajieva P,Toşa MI,Irimie FD,Moosmann B

更新日期：2018-01-02 00:00:00

abstract：:Full activation of T cells requires signaling through the T-cell antigen receptor (TCR) and additional surface molecules interacting with ligands on the antigen-presenting cell. TCR recognition of agonist ligands in the absence of accessory signals frequently results in the induction of a state of unresponsiveness ter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madrenas J,Schwartz RH,Germain RN

更新日期：1996-09-03 00:00:00

abstract：:It is a well known fact that stirring keeps particles suspended in fluids. This is apparent, for instance, when shaking medicine flasks, when agitating tea deposits in a mug, or when heavy winds fill the air with dust particles. The commonplace nature of such observations makes it easy to accept that this feature will...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz J,Macías D,Peters F

更新日期：2004-12-21 00:00:00

abstract：:Long-term plasticity can differ from short-term in recruiting the growth of new synaptic connections, a process that requires the participation of both the presynaptic and postsynaptic components of the synapse. How does information about synaptic plasticity spread from its site of origin to recruit the other componen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin I,Puthanveettil S,Udo H,Karl K,Kandel ER,Hawkins RD

更新日期：2012-06-05 00:00:00

abstract：:The proteolytic cleavage of sterol regulatory element-binding proteins (SREBPs) is regulated by SREBP cleavage-activating protein (SCAP), which forms complexes with SREBPs in membranes of the endoplasmic reticulum (ER). In sterol-depleted cells, SCAP facilitates cleavage of SREBPs by Site-1 protease, thereby initiatin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nohturfft A,DeBose-Boyd RA,Scheek S,Goldstein JL,Brown MS

更新日期：1999-09-28 00:00:00