Convergent gene loss following gene and genome duplications creates single-copy families in flowering plants.

Abstract:

:The importance of gene gain through duplication has long been appreciated. In contrast, the importance of gene loss has only recently attracted attention. Indeed, studies in organisms ranging from plants to worms and humans suggest that duplication of some genes might be better tolerated than that of others. Here we have undertaken a large-scale study to investigate the existence of duplication-resistant genes in the sequenced genomes of 20 flowering plants. We demonstrate that there is a large set of genes that is convergently restored to single-copy status following multiple genome-wide and smaller scale duplication events. We rule out the possibility that such a pattern could be explained by random gene loss only and therefore propose that there is selection pressure to preserve such genes as singletons. This is further substantiated by the observation that angiosperm single-copy genes do not comprise a random fraction of the genome, but instead are often involved in essential housekeeping functions that are highly conserved across all eukaryotes. Furthermore, single-copy genes are generally expressed more highly and in more tissues than non-single-copy genes, and they exhibit higher sequence conservation. Finally, we propose different hypotheses to explain their resistance against duplication.

authors

De Smet R,Adams KL,Vandepoele K,Van Montagu MC,Maere S,Van de Peer Y

doi

10.1073/pnas.1300127110

subject

Has Abstract

pub_date

2013-02-19 00:00:00

pages

2898-903

issue

8

eissn

0027-8424

issn

1091-6490

pii

1300127110

journal_volume

110

pub_type

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