Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory.

Abstract:

:Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK-/- mice lacked neocortical LTP and showed deficits in a cue-cue associative learning paradigm; and administration of CCK rescued associative learning deficits. High-frequency stimulation-induced neocortical LTP was completely blocked by either the NMDAR antagonist or the CCKBR antagonist, while application of either NMDA or CCK induced LTP after low-frequency stimulation. In the presence of CCK, LTP was still induced even after blockade of NMDARs. Local application of NMDA induced the release of CCK in the neocortex. These findings suggest that NMDARs control the release of CCK, which enables neocortical LTP and the formation of cue-cue associative memory.

authors

Chen X,Li X,Wong YT,Zheng X,Wang H,Peng Y,Feng H,Feng J,Baibado JT,Jesky R,Wang Z,Xie H,Sun W,Zhang Z,Zhang X,He L,Zhang N,Zhang Z,Tang P,Su J,Hu LL,Liu Q,He X,Tan A,Sun X,Li M,Wong K,Wang X,Cheung

doi

10.1073/pnas.1816833116

subject

Has Abstract

pub_date

2019-03-26 00:00:00

pages

6397-6406

issue

13

eissn

0027-8424

issn

1091-6490

pii

1816833116

journal_volume

116

pub_type

杂志文章
  • Structural basis for high-affinity HER2 receptor binding by an engineered protein.

    abstract::The human epidermal growth factor receptor 2 (HER2) is specifically overexpressed in tumors of several cancers, including an aggressive form of breast cancer. It is therefore a target for both cancer diagnostics and therapy. The 58 amino acid residue Zher2 affibody molecule was previously engineered as a high-affinity...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1005025107

    authors: Eigenbrot C,Ultsch M,Dubnovitsky A,Abrahmsén L,Härd T

    更新日期:2010-08-24 00:00:00

  • Antagonistic pleiotropic effects reduce the potential adaptive value of the FRIGIDA locus.

    abstract::Although the occurrence of epistasis and pleiotropy is widely accepted at the molecular level, its effect on the adaptive value of fitness-related genes is rarely investigated in plants. Knowledge of these features of a gene is critical to understand the molecular basis of adaptive evolution. Here we investigate the i...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0708209104

    authors: Scarcelli N,Cheverud JM,Schaal BA,Kover PX

    更新日期:2007-10-23 00:00:00

  • Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.

    abstract::Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive state. It was recently reported that Mos, an integral component of CSF, acts in part by promoting the Rsk-mediated phosphorylation of the APC inhibitor Emi2/Erp1....

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0707537104

    authors: Wu JQ,Hansen DV,Guo Y,Wang MZ,Tang W,Freel CD,Tung JJ,Jackson PK,Kornbluth S

    更新日期:2007-10-16 00:00:00

  • The dynamins: redundant or distinct functions for an expanding family of related GTPases?

    abstract::In the 7 years since dynamin was first isolated from bovine brain in search of novel microtubule-based motors, our understanding of this enzyme has expanded significantly. We now know that brain dynamin belongs to a family of large GTPases, which mediate vesicle trafficking. Furthermore, this enzymatic activity is mar...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,评审

    doi:10.1073/pnas.94.2.377

    authors: Urrutia R,Henley JR,Cook T,McNiven MA

    更新日期:1997-01-21 00:00:00

  • The specific direct interaction of helper T cells and antigen-presenting B cells.

    abstract::Cell couples have been formed by mixing an antigen- and Ia-specific cloned helper T-cell line with a B-cell hybridoma presenting the antigen. By immunofluorescence observations, we have shown that the microtubule-organizing center (MTOC) inside the helper T cell, but not in the bound antigen-presenting cell, becomes o...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.83.16.6080

    authors: Kupfer A,Swain SL,Janeway CA Jr,Singer SJ

    更新日期:1986-08-01 00:00:00

  • Improved probability of detection of ecological "surprises".

    abstract::Ecological "surprises" are defined as unexpected findings about the natural environment. They are critically important in ecology because they are catalysts for questioning and reformulating views of the natural world, help shape assessments of the veracity of a priori predictions about ecological trends and phenomena...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,评审

    doi:10.1073/pnas.1015696107

    authors: Lindenmayer DB,Likens GE,Krebs CJ,Hobbs RJ

    更新日期:2010-12-21 00:00:00

  • Tropical amphibian populations experience higher disease risk in natural habitats.

    abstract::Habitat loss and disease are main drivers of global amphibian declines, yet the interaction between them remains largely unexplored. Here we show that paradoxically, habitat loss is negatively associated with occurrence, prevalence, and infection intensity of the chytrid fungus Batrachochytrium dendrobatidis (Bd) in a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1014497108

    authors: Becker CG,Zamudio KR

    更新日期:2011-06-14 00:00:00

  • Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.

    abstract::The Taq DNA polymerase is the most commonly used enzyme in DNA sequencing. However, all versions of Taq polymerase are deficient in two respects: (i) these enzymes incorporate each of the four dideoxynucleoside 5' triphosphates (ddNTPs) at widely different rates during sequencing (ddGTP, for example, is incorporated 1...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.17.9491

    authors: Li Y,Mitaxov V,Waksman G

    更新日期:1999-08-17 00:00:00

  • Haplotype structure strongly affects recombination in a maize genetic interval polymorphic for Helitron and retrotransposon insertions.

    abstract::We have asked here how the remarkable variation in maize haplotype structure affects recombination. We compared recombination across a genetic interval of 9S in 2 highly dissimilar heterozygotes that shared 1 parent. The genetic interval in the common haplotype is approximately 100 kb long and contains 6 genes intersp...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0902972106

    authors: He L,Dooner HK

    更新日期:2009-05-26 00:00:00

  • Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval.

    abstract::The rationale for genome-wide association study (GWAS) results is sequence variation in cis-regulatory elements (CREs) modulating a target gene's expression as the major cause of trait variation. To understand the complete molecular landscape of one of these GWAS loci, we performed in vitro reporter screens in cardiom...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1808734116

    authors: Kapoor A,Lee D,Zhu L,Soliman EZ,Grove ML,Boerwinkle E,Arking DE,Chakravarti A

    更新日期:2019-05-28 00:00:00

  • Editing the stereochemical elements in an iridium catalyst for enantioselective allylic amination.

    abstract::Individual diastereomeric phosphoramidites and mixtures of diastereomeric phosphoramidites were evaluated in the iridium-catalyzed amination of allylic carbonates. The original process was conducted with a phosphoramidite ligand containing a resolved 2,2-dihydroxy-1,1-binaphthyl (BINOL) group and a diastereomerically ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0307967101

    authors: Leitner A,Shu C,Hartwig JF

    更新日期:2004-04-20 00:00:00

  • In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers.

    abstract::Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Hox@C82 (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Hox@C82(OH)y. This metallofullerol was then neutron-activated (165Ho[n,g...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.9.5182

    authors: Cagle DW,Kennel SJ,Mirzadeh S,Alford JM,Wilson LJ

    更新日期:1999-04-27 00:00:00

  • Protein tyrosine phosphorylation in synaptic vesicles.

    abstract::Protein tyrosine phosphorylation in purified synaptic vesicles from rat forebrain has been studied in the presence of Mn2+ and orthovanadate. High levels of endogenous protein tyrosine phosphorylation were observed. Four major phosphoproteins, with apparent molecular masses of 105, 94, 38, and 30 kDa, were shown to co...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.3.762

    authors: Pang DT,Wang JK,Valtorta F,Benfenati F,Greengard P

    更新日期:1988-02-01 00:00:00

  • Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex.

    abstract::Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. Here, we found that isolation of neonatal rats induced glucocorticoid-dependent social dominance ove...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1606351113

    authors: Tada H,Miyazaki T,Takemoto K,Takase K,Jitsuki S,Nakajima W,Koide M,Yamamoto N,Komiya K,Suyama K,Sano A,Taguchi A,Takahashi T

    更新日期:2016-11-08 00:00:00

  • The evolution of coloration and toxicity in the poison frog family (Dendrobatidae).

    abstract::The poison frogs (family Dendrobatidae) are terrestrial anuran amphibians displaying a wide range of coloration and toxicity. These frogs generally have been considered to be aposematic, but relatively little research has been carried out to test the predictions of this hypothesis. Here we use a comparative approach t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.101134898

    authors: Summers K,Clough ME

    更新日期:2001-05-22 00:00:00

  • Mechanically-driven phase separation in a growing bacterial colony.

    abstract::Secretion of extracellular polymeric substances (EPSs) by growing bacteria is an integral part of forming biofilm-like structures. In such dense systems, mechanical interactions among the structural components can be expected to significantly contribute to morphological properties. Here, we use a particle-based modeli...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1504948112

    authors: Ghosh P,Mondal J,Ben-Jacob E,Levine H

    更新日期:2015-04-28 00:00:00

  • The peptide-catalyzed stereospecific synthesis of tetroses: a possible model for prebiotic molecular evolution.

    abstract::Using a water-based prebiotic model of sugar synthesis involving glycolaldehyde self-condensation, we demonstrate that homochiral L-dipeptide catalysts lead to the stereospecific syntheses of tetroses. The asymmetric effect is largest for erythrose, which may reach a D-enantiomeric excess of >80% with L-Val-L-Val cata...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0602320103

    authors: Weber AL,Pizzarello S

    更新日期:2006-08-22 00:00:00

  • Cell-surface heparan sulfate: an intercalated membrane proteoglycan.

    abstract::Two pools of heparan sulfate proteoglycans have been selectively solubilized from rat liver plasma membranes by successive incubations with heparin and detergent. The two populations of proteoglycans have similar polyanionic properties as indicated by identical elution positions on ion-exchange chromatography on DEAE-...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.78.9.5371

    authors: Kjellén L,Pettersson I,Höök M

    更新日期:1981-09-01 00:00:00

  • A coherent framework for multiresolution analysis of biological networks with "memory": Ras pathway, cell cycle, and immune system.

    abstract::Various biological processes exhibit characteristics that vary dramatically in response to different input conditions or changes in the history of the process itself. One of the examples studied here, the Ras-PKC-mitogen-activated protein kinase (MAPK) bistable pathway, follows two distinct dynamics (modes) depending ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0500554102

    authors: Barbano PE,Spivak M,Feng J,Antoniotti M,Mishra B

    更新日期:2005-05-03 00:00:00

  • Direct and indirect punishment among strangers in the field.

    abstract::Many interactions in modern human societies are among strangers. Explaining cooperation in such interactions is challenging. The two most prominent explanations critically depend on individuals' willingness to punish defectors: In models of direct punishment, individuals punish antisocial behavior at a personal cost, ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1413170111

    authors: Balafoutas L,Nikiforakis N,Rockenbach B

    更新日期:2014-11-11 00:00:00

  • SDS capillary gel electrophoresis of proteins in microfabricated channels.

    abstract::Analysis of variations in the concentrations or structures of biomolecules (e.g., mRNAs, proteins, peptides, natural products) that occur either naturally or in response to environmental or genetic perturbations can provide important insight into complex biological processes. Many biological samples are mixtures that ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.10.5372

    authors: Yao S,Anex DS,Caldwell WB,Arnold DW,Smith KB,Schultz PG

    更新日期:1999-05-11 00:00:00

  • Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry.

    abstract::Protein-based hydrogels have emerged as promising alternatives to synthetic hydrogels for biomedical applications, owing to the precise control of structure and function enabled by protein engineering. Nevertheless, strategies for assembling 3D molecular networks that carry the biological information encoded in full-l...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1401291111

    authors: Sun F,Zhang WB,Mahdavi A,Arnold FH,Tirrell DA

    更新日期:2014-08-05 00:00:00

  • Conversion of Bacillus subtilis RNA polymerase activity in vitro by a protein induced by phage SP01.

    abstract::A protein fraction from B. subtilis infected with phage SP01 (fraction LGG) stimulates the activity of RNA polymerase (EC 2.7.7.6; nucleosidetriphosphate:RNA nucleotidyltransferase) core from uninfected bacteria. Fraction LGG contains a protein (P-28, molecular weight 28,000) that is labeled after phage infection and ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.72.6.2366

    authors: Duffy JJ,Petrusek RL,Geiduschek EP

    更新日期:1975-06-01 00:00:00

  • Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm.

    abstract::The endosperm of cereal grains is one of the most valuable products of modern agriculture. Cereal endosperm development comprises different phases characterized by mitotic cell proliferation, endoreduplication, the accumulation of storage compounds, and programmed cell death. Although manipulation of these processes c...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1304903110

    authors: Sabelli PA,Liu Y,Dante RA,Lizarraga LE,Nguyen HN,Brown SW,Klingler JP,Yu J,LaBrant E,Layton TM,Feldman M,Larkins BA

    更新日期:2013-05-07 00:00:00

  • Neuromolecular responses to social challenge: common mechanisms across mouse, stickleback fish, and honey bee.

    abstract::Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1420369111

    authors: Rittschof CC,Bukhari SA,Sloofman LG,Troy JM,Caetano-Anollés D,Cash-Ahmed A,Kent M,Lu X,Sanogo YO,Weisner PA,Zhang H,Bell AM,Ma J,Sinha S,Robinson GE,Stubbs L

    更新日期:2014-12-16 00:00:00

  • MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

    abstract::Chronic inflammation is a major risk factor for colorectal cancer. The p38/MAPKAP Kinase 2 (MK2) kinase axis controls the synthesis of proinflammatory cytokines that mediate both chronic inflammation and tumor progression. Blockade of this pathway has been previously reported to suppress inflammation and to prevent co...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1722020115

    authors: Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB

    更新日期:2018-05-01 00:00:00

  • Intermolecular complementation between two defective mutant signal-transducing receptors of Escherichia coli.

    abstract::Taz1 is a hybrid signal-transducing membrane receptor between Tar, an aspartate chemoreceptor, and EnvZ, an osmosensor of Escherichia coli that is able to induce ompC expression by phosphorylating OmpR (a transcriptional activator) in response to aspartate. When the Taz1 His-277, the proposed autophosphorylation site ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.24.11057

    authors: Yang Y,Inouye M

    更新日期:1991-12-15 00:00:00

  • Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

    abstract::The phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin on liver. Here, we show that mice with a liver-specific deletion of the p85alpha regulatory subunit of PI3K (L-Pik3r1KO) exhibit a paradoxical improvement of hepatic and peripheral insulin sensitivity. Although PI3K enzymatic a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0604628103

    authors: Taniguchi CM,Tran TT,Kondo T,Luo J,Ueki K,Cantley LC,Kahn CR

    更新日期:2006-08-08 00:00:00

  • Comparative study of optical absorption and circular dichroism of bacteriochlorophyll oligomers in Triton X-100, the antenna pigment B850, and the primary donor P-860 of photosynthetic bacteria indicates that all are similar dimers of bacteriochlorophyll

    abstract::Dimers of bacteriochlorophyll a (Bchla) with optical absorption maximum at 853 nm and a nonconservative circular dichroism spectrum are formed in a solution of formamide/water that contains micelles of Triton X-100. The apparent equilibrium constant and the corresponding Gibbs energy change for the Bchl self-organizat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.86.5.1505

    authors: Scherz A,Rosenbach-Belkin V

    更新日期:1989-03-01 00:00:00

  • Investigations into the relationship between structure and function of diphtheria toxin.

    abstract::Studies on the structure-function relationship of diphtheria toxin are reported. New methods are described for the preparation of pure intact ("unnicked") toxin and for the preparation of the individual A and B chains. A biological assay method for the B chain is also presented, as well as a method for the labelling o...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.74.2.472

    authors: Everse J,Lappi DA,Beglau JM,Lee CL,Kaplan NO

    更新日期:1977-02-01 00:00:00