Transient inositol 1,4,5-trisphosphate-induced Ca2+ release: a model based on regulatory Ca(2+)-binding sites along the permeation pathway.

abstract：:The mechanism of phosphosylation and dephosphorylation of spectrin from human erythrocyte membranes has been examined under closely physiological conditions. The results support the hypothesis that spectrin is an autophosphorylating and dephosphorylating system. (i) Extraction from ghosts of up to 85% of the kinase (c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imhof BA,Acha-Orbea HJ,Libermann TA,Reber BF,Lanz JH,Winterhalter KH,Birchmeier W

更新日期：1980-06-01 00:00:00

abstract：:Alkylation of DNA by 7r,8t-dihydroxy,9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) forms mainly trans adducts (with respect to the C-9/10 positions). We recently described a halide-catalyzed pathway that preferentially generates cis adducts and now report that the trans chlorohydrin of anti-BPDE (trans-BP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meehan T,Wolfe AR,Negrete GR,Song Q

更新日期：1997-03-04 00:00:00

abstract：:The colony-stimulating factors (CSFs) greatly influence mature macrophage function in vitro: macrophage (M)-CSF induces maturation of monocytes and enhances differentiated cell function; granulocyte-macrophage (GM)-CSF stimulates a variety of antimicrobial functions. In vivo M-CSF is thought to promote differentiation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Nichilo MO,Burns GF

更新日期：1993-03-15 00:00:00

abstract：:To examine the hypothesis that bone marrow consists of discrete stem cell regulatory volumes or domains, we studied spleen colony-forming unit (CFU-S) population growth kinetics in unirradiated WBB6F1-W/Wv mice receiving various doses of +/+ bone marrow cells. Assay of femoral marrow CFU-S content in the eight recipie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maloney MA,Lamela RA,Banda MJ,Patt HM

更新日期：1982-02-01 00:00:00

abstract：:Soluble extracts of adenovirus-infected HeLa cell nuclei support DNA replication on exogenous adenovirus DNA templates. Conditions of synthesis using both wild-type and temperature-sensitive extracts have been defined. Nuclear extracts prepared from cells permissively infected with the adenovirus mutant H5ts125 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan LM,Ariga H,Hurwitz J,Horwitz MS

更新日期：1979-11-01 00:00:00

abstract：:Age-related degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive decline in Alzheimer's disease and Down's syndrome. With aging, the partial trisomy 16 (Ts65Dn) mouse model of Down's syndrome exhibited reductions in BFCN size and number and regressive changes in the hippocampal terminal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper JD,Salehi A,Delcroix JD,Howe CL,Belichenko PV,Chua-Couzens J,Kilbridge JF,Carlson EJ,Epstein CJ,Mobley WC

更新日期：2001-08-28 00:00:00

abstract：:A central tenet in understanding the biological effects of ionizing radiation has been that the initially affected cells were directly damaged by the radiation. By contrast, evidence has emerged concerning "bystander" responses involving damage to nearby cells that were not themselves directly traversed by the radiati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belyakov OV,Mitchell SA,Parikh D,Randers-Pehrson G,Marino SA,Amundson SA,Geard CR,Brenner DJ

更新日期：2005-10-04 00:00:00

abstract：:This presentation reviews Chandra's major contribution to the understanding of nearby galaxies. After a brief summary on significant advances in characterizing various types of discrete x-ray sources, the presentation focuses on the global hot gas in and around galaxies, especially normal ones like our own. The hot ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang QD

更新日期：2010-04-20 00:00:00

abstract：:The fatty acids associated with phospholipids of cell membranes, and particularly their degree of unsaturation, contribute to the fluidity of their structure and hance determine many of their biological properties. We describe a technique for modulating membrane fluidity which consists of hydrogenating the unsaturated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chapman D,Quinn PJ

更新日期：1976-11-01 00:00:00

abstract：:Using tunicamycin, we have investigated the role of glycoproteins in membrane transport. Tunicamycin is a glucosamine-containing antibiotic that specifically inhibits dolichol pyrophosphate-mediated glycosylation of asparaginyl residues of glycoproteins. Inhibition of protein glycosylation in chick embryo fibroblasts ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olden K,Pratt RM,Jaworski C,Yamada KM

更新日期：1979-02-01 00:00:00

abstract：:TGF-β activated kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK families and include ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin RS,Hertz NT,Burlingame AL,Shokat KM,Mukherjee S

更新日期：2016-08-16 00:00:00

abstract：:The Tap protein mediates the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element (CTE). Previously, the structures of individual Tap subdomains, including ribonucleoprotein and leucine-rich repeat domains, have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho DN,Coburn GA,Kang Y,Cullen BR,Georgiadis MM

更新日期：2002-02-19 00:00:00

abstract：:Elongin is a heterotrimeric transcription elongation factor composed of subunits A, B, and C in mammals. Elongin A and C are F-box-containing and SKP1 homologue proteins, respectively, and are therefore of interest for their potential roles in cell cycle-dependent proteolysis. Mammalian elongin C interacts with both e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Botuyan MV,Koth CM,Mer G,Chakrabartty A,Conaway JW,Conaway RC,Edwards AM,Arrowsmith CH,Chazin WJ

更新日期：1999-08-03 00:00:00

abstract：:Direct conversion of carbon dioxide to multicarbon products remains as a grand challenge in electrochemical CO2 reduction. Various forms of oxidized copper have been demonstrated as electrocatalysts that still require large overpotentials. Here, we show that an ensemble of Cu nanoparticles (NPs) enables selective form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim D,Kley CS,Li Y,Yang P

更新日期：2017-10-03 00:00:00

abstract：:Long interspersed nuclear elements 1 (L1) are active retrotransposons that reside in many species, including humans and rodents. L1 elements produce an RNA intermediate that is reverse transcribed to DNA and inserted in a new genomic location. We have tagged an active human L1 element (L1(RP)) with a gene encoding enh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prak ET,Dodson AW,Farkash EA,Kazazian HH Jr

更新日期：2003-02-18 00:00:00

abstract：:We deal with the issue of quantifying and optimizing the rotation dynamics of synthetic molecular motors. For this purpose, the continuous four-stage rotation behavior of a typical light-activated molecular motor was measured in detail. All reaction constants were determined empirically. Next, we developed a Markov mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geertsema EM,van der Molen SJ,Martens M,Feringa BL

更新日期：2009-10-06 00:00:00

abstract：:Developing tissues contain motile populations of cells that can self-organize into spatially ordered tissues based on differences in their interfacial surface energies. However, it is unclear how self-organization by this mechanism remains robust when interfacial energies become heterogeneous in either time or space. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerchiari AE,Garbe JC,Jee NY,Todhunter ME,Broaders KE,Peehl DM,Desai TA,LaBarge MA,Thomson M,Gartner ZJ

更新日期：2015-02-17 00:00:00

abstract：:The brain continuously influences and perceives the physiological condition of the body. Related cortical representations have been proposed to shape emotional experience and guide behavior. Although previous studies have identified brain regions recruited during autonomic processing, neurological lesion studies have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo CC,Sturm VE,Zhou J,Gennatas ED,Trujillo AJ,Hua AY,Crawford R,Stables L,Kramer JH,Rankin K,Levenson RW,Rosen HJ,Miller BL,Seeley WW

更新日期：2016-04-26 00:00:00

abstract：:Endogenous retroviruses (ERVs) are the remnants of ancient retroviral infections of germ cells and have been maintained in whole or part as heritable genomic elements. The last known endogenization events occurred several million years ago, and therefore stepwise analysis of retroviral endogenization has not been poss...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliveira NM,Satija H,Kouwenhoven IA,Eiden MV

更新日期：2007-10-30 00:00:00

abstract：:Paired oxygen-isotopic analyses of abiotic carbonate and benthic-ostracode shells from lake sediments provide a continuous quantitative record of growing-season temperature for the past 2000 years in the northwestern foothills of the Alaska Range. This record reveals three time intervals of comparable warmth: anno Dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu FS,Ito E,Brown TA,Curry BB,Engstrom DR

更新日期：2001-09-11 00:00:00

abstract：:Embryonic stem cells (ESCs) represent an important research tool and a potential resource for regenerative medicine. Generally, ESCs are cocultured with a supportive feeder cell layer of murine embryonic fibroblasts, which maintain the ESCs' capacity for self-renewal and block spontaneous differentiation. These cumber...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyabayashi T,Teo JL,Yamamoto M,McMillan M,Nguyen C,Kahn M

更新日期：2007-03-27 00:00:00

abstract：:Learning and memory rely on dopamine and downstream cAMP-dependent plasticity across diverse organisms. Despite the central role of cAMP signaling, it is not known how cAMP-dependent plasticity drives coherent changes in neuronal physiology that encode the memory trace, or engram. In Drosophila, the mushroom body (MB)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Louis T,Stahl A,Boto T,Tomchik SM

更新日期：2018-01-16 00:00:00

abstract：:AB5 bacterial toxins and polyomaviruses induce membrane curvature as a mechanism to facilitate their entry into host cells. How membrane bending is accomplished is not yet fully understood but has been linked to the simultaneous binding of the pentameric B subunit to multiple copies of glycosphingolipid receptors. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kabbani AM,Raghunathan K,Lencer WI,Kenworthy AK,Kelly CV

更新日期：2020-06-30 00:00:00

abstract：:Fragility is an empirical property that describes how abruptly a glass-forming material solidifies upon supercooling. The degree of fragility carries important implications for the functionality and processability of a material, as well as for our fundamental understanding of the glass transition. However, the microst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ciarella S,Biezemans RA,Janssen LMC

更新日期：2019-12-10 00:00:00

abstract：:The amino acid sequences of a number of closely related proteins ("napin") isolated from Brassica napus were determined by mass spectrometry without prior separation into individual components. Some of these proteins correspond to those previously deduced (napA, BngNAP1, and gNa), chiefly from DNA sequences. Others we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gehrig PM,Krzyzaniak A,Barciszewski J,Biemann K

更新日期：1996-04-16 00:00:00

abstract：:The x-ray structure of rubredoxin has been refined by energy minimization. The computed structure is constrained to have standard bond lengths, bond angles, and planar trans peptide groups. Also, since most of the steric overlaps have been relieved, it has a very low energy. As judged by the root mean square (RMS) dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasse D,Warme PK,Scheraga HA

更新日期：1974-09-01 00:00:00

abstract：:Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. Accordingly, reversal of structural remodelin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czéh B,Michaelis T,Watanabe T,Frahm J,de Biurrun G,van Kampen M,Bartolomucci A,Fuchs E

更新日期：2001-10-23 00:00:00

abstract：:Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death from cardiac arrhythmias. We recently discovered that mutations in HERG, a K+-channel gene, cause chromosome 7-linked LQT. Heterologous expression of HERG in Xenopus oocytes revealed that HERG current was similar to a well-characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanguinetti MC,Curran ME,Spector PS,Keating MT

更新日期：1996-03-05 00:00:00

abstract：:The voltage-gated proton channel Hv1 plays a critical role in the fast proton translocation that underlies a wide range of physiological functions, including the phagocytic respiratory burst, sperm motility, apoptosis, and metastatic cancer. Both voltage activation and proton conduction are carried out by a voltage-se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Q,Shen R,Treger JS,Wanderling SS,Milewski W,Siwowska K,Bezanilla F,Perozo E

更新日期：2015-11-03 00:00:00

abstract：:Social ties are crucial for physical and mental health. However, psychiatric patients frequently encounter social rejection. Moreover, an increased reactivity to social exclusion influences the development, progression, and treatment of various psychiatric disorders. Nevertheless, the neuromodulatory substrates of rej...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preller KH,Pokorny T,Hock A,Kraehenmann R,Stämpfli P,Seifritz E,Scheidegger M,Vollenweider FX

更新日期：2016-05-03 00:00:00