Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages.

abstract：:Photolyzed rhodopsin catalyzes the exchange of GTP for FDP bound to a protein in retinal rod outer segments. We previously proposed that the GTP complex of this protein regulates the cyclic GMP phosphodiesterase and that it may be the first amplified intermediate in visual excitation [Fung, B. K.-K. & Stryer, L. (1980...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fung BK,Hurley JB,Stryer L

更新日期：1981-01-01 00:00:00

abstract：:Translational initiation factor 2 (IF2) is a guanine nucleotide-binding protein that can bind guanosine 3',5'-(bis) diphosphate (ppGpp), an alarmone involved in stringent response in bacteria. In cells growing under optimal conditions, the GTP concentration is very high, and that of ppGpp very low. However, under stre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milon P,Tischenko E,Tomsic J,Caserta E,Folkers G,La Teana A,Rodnina MV,Pon CL,Boelens R,Gualerzi CO

更新日期：2006-09-19 00:00:00

abstract：:The fluorescent vital dye rhodamine 123 (Rh-123), which preferentially accumulates in mitochondrial membranes, can be used as a probe to indicate mitochondrial and hence cellular activity. In this study, mouse bone marrow hematopoietic stem cells were subdivided into Rh-123lo, Rh-123med, and Rh-123hi populations. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spangrude GJ,Johnson GR

更新日期：1990-10-01 00:00:00

abstract：:Large mandibular defects are clinically challenging to reconstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue for repair. We envision leveraging current advances in fabrication and biomaterials to create implantable devices that generate bone within the patients themselves...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatara AM,Koons GL,Watson E,Piepergerdes TC,Shah SR,Smith BT,Shum J,Melville JC,Hanna IA,Demian N,Ho T,Ratcliffe A,van den Beucken JJJP,Jansen JA,Wong ME,Mikos AG

更新日期：2019-04-02 00:00:00

abstract：:The requirement for protein synthesis in the mechanism of a circadian pacemaker was investigated by using inhibitors of protein synthesis. Continuous treatment of the ocular circadian pacemaker of the mollusc Bulla gouldiana with anisomycin or cycloheximide substantially lengthened (up to 39 and 52 hr, respectively) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khalsa SB,Whitmore D,Block GD

更新日期：1992-11-15 00:00:00

abstract：:Multiple cues, across multiple sensory modalities, are involved in mate choice in a wide range of animal taxa. This multiplicity leads to the prediction that, in adaptive radiations, sexual isolation results from divergence in multiple dimensions. However, difficulties in directly measuring preferences and detecting m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohenlohe PA,Arnold SJ

更新日期：2010-09-21 00:00:00

abstract：:Some dinosaurs reached masses that were approximately 8 times those of the largest, ecologically equivalent terrestrial mammals. The factors most responsible for setting the maximal body size of vertebrates are resource quality and quantity, as modified by the mobility of the consumer, and the vertebrate's rate of ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNab BK

更新日期：2009-07-21 00:00:00

abstract：:Sheep antibodies directed against an AMP-bovine serum albumin conjugate exhibit highly specific binding toward AMP. These antibodies bind to the AMP moiety of adenylylated glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] from Escherichia coli and to no other antigenic determinant on the prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohman RJ,Rhee SG,Stadtman ER

更新日期：1980-12-01 00:00:00

abstract：:Dopamine-beta-hydroxylase (EC 1.14.2.1), an enzyme localized in sympathetic synaptic vesicles, was released together with norepinephrine during in vitro stimulation of the hypogastric nerve that innervates the vas deferens of the guinea pig. Stimulation of the nerve in the presence of high concentrations of calcium (7...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson DG,Thoa NB,Weinshilboum R,Axelrod J,Kopin IJ

更新日期：1971-09-01 00:00:00

abstract：:Chicken erythrocyte nuclei have been labeled in the active regions of the chromosome by using the nick translation reaction. In this procedure, accessible areas of the genome are preferentially nicked by the action of pancreatic DNase I and subsequently labeled by using DNA polymerase I from Escherichia coli. These nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gazit B,Panet A,Cedar H

更新日期：1980-04-01 00:00:00

abstract：:The study of the metabolome presents numerous challenges, first among them being the cataloging of its constituents. A step in this direction will be the development of tools to identify metabolites that share common structural features. The importance of sulfated molecules in cell-cell communication motivated us to d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mougous JD,Leavell MD,Senaratne RH,Leigh CD,Williams SJ,Riley LW,Leary JA,Bertozzi CR

更新日期：2002-12-24 00:00:00

abstract：:Given a collection L of n points on a sphere [Formula: see text] of surface area n, a fair allocation is a partition of the sphere into n parts each of area 1, and each is associated with a distinct point of L. We show that, if the n points are chosen uniformly at random and if the partition is defined by a certain "g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holden N,Peres Y,Zhai A

更新日期：2018-09-25 00:00:00

abstract：:In enzyme catalysis, where exquisitely positioned functionality is the sine qua non, atomic coordinates for a Michaelis complex can provide powerful insights into activation of the substrate. We focus here on the initial proton transfer of the isomerization reaction catalyzed by triosephosphate isomerase and present t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jogl G,Rozovsky S,McDermott AE,Tong L

更新日期：2003-01-07 00:00:00

abstract：:Activation of JAK2 by chromosomal translocation or point mutation is a recurrent event in hematopoietic malignancies, including acute leukemias and myeloproliferative disorders. Although the effects of activated JAK2 signaling have been examined in cell lines and murine models, the functional consequences of deregulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kennedy JA,Barabé F,Patterson BJ,Bayani J,Squire JA,Barber DL,Dick JE

更新日期：2006-11-07 00:00:00

abstract：:Human skin and lung mast cells and rodent peritoneal mast cells contain a carboxypeptidase in their secretory granules. We have screened human lung cDNA libraries with a mouse mast cell carboxypeptidase A (MC-CPA) cDNA probe to isolate a near-full-length cDNA that encodes human MC-CPA. The 5' end of the human MC-CPA t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds DS,Gurley DS,Stevens RL,Sugarbaker DJ,Austen KF,Serafin WE

更新日期：1989-12-01 00:00:00

abstract：:Increases in cytoplasmic free calcium ([Ca2+]i) can be induced in resting B cells either by a low molecular weight (12-kDa) B-cell growth factor (LMW-BCGF) or by crosslinking the B-cell antigen CD19 with monoclonal antibody (mAb). LMW-BCGF causes a slow [Ca2+]i increase in peripheral blood and tonsillar B cells but ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ledbetter JA,Rabinovitch PS,June CH,Song CW,Clark EA,Uckun FM

更新日期：1988-03-01 00:00:00

abstract：:Microarrays have enabled the determination of how thousands of genes are expressed to coordinate function within single organisms. Yet applications to natural or engineered communities where different organisms interact to produce complex properties are hampered by theoretical and technological limitations. Here we de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marcelino LA,Backman V,Donaldson A,Steadman C,Thompson JR,Preheim SP,Lien C,Lim E,Veneziano D,Polz MF

更新日期：2006-09-12 00:00:00

abstract：:Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5' and the 3' untranslated regions and affecting the stability and translation efficiency of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devany E,Zhang X,Park JY,Tian B,Kleiman FE

更新日期：2013-02-26 00:00:00

abstract：:Compositeness of the electron may show up in a very small deviation of the measured electron g factor from one calculated for a point electron by quantum electrodynamics. The precision of our g measurements is currently limited by an interaction of the cyclotron motion with standing waves in the trap cavity containing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dehmelt H,Van Dyck R Jr,Palmer F

更新日期：1992-03-01 00:00:00

abstract：:The phenotype of several erythromycin-resistant mutants of Chlamydomonas reinhardi was further characterized in terms of the electrophoretic properties of their chloroplast ribosomal proteins. In mutant ery-M2d a single protein of the large (52 S) subunit has altered properties, which probably result from a change in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mets L,Bogorad L

更新日期：1972-12-01 00:00:00

abstract：:The sessile plants have evolved a large number of receptor-like kinases (RLKs) and receptor-like cytoplasmic kinases (RLCKs) to modulate diverse biological processes, including plant innate immunity. Phosphorylation of the RLK/RLCK complex constitutes an essential step to initiate immune signaling. Two Arabidopsis pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin W,Li B,Lu D,Chen S,Zhu N,He P,Shan L

更新日期：2014-03-04 00:00:00

abstract：:The bacterial pathogen Streptococcus pneumoniae is a major public health concern, being responsible for more than 1.5 million deaths annually through pneumonia, meningitis, and septicemia. Available vaccines target only a subset of serotypes, so vaccination is often accompanied by a rise in the frequency of nonvaccine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Obolski U,Lourenço J,Thompson C,Thompson R,Gori A,Gupta S

更新日期：2018-03-20 00:00:00

abstract：:Ca(2+) is essential for physiological depolarization-evoked synchronous neurotransmitter release. But, whether Ca(2+) influx or another factor controls release initiation is still under debate. The time course of ACh release is controlled by a presynaptic inhibitory G protein-coupled autoreceptor (GPCR), whose agonist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kupchik YM,Rashkovan G,Ohana L,Keren-Raifman T,Dascal N,Parnas H,Parnas I

更新日期：2008-03-18 00:00:00

abstract：:A de novo mutation in the KCND2 gene, which encodes the Kv4.2 K+ channel, was identified in twin boys with intractable, infant-onset epilepsy and autism. Kv4.2 channels undergo closed-state inactivation (CSI), a mechanism by which channels inactivate without opening during subthreshold depolarizations. CSI dynamically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin MA,Cannon SC,Papazian DM

更新日期：2018-04-10 00:00:00

abstract：:A23187 is a carboxylic antibiotic that selectively transfers calcium, magnesium, and other divalent cations across biologic membranes. This ionophore was found to produce morphologic blast transformation, DNA synthesis, and mitosis in human lymphocytes. Several hours of ionophore-cell contact were necessary to produce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luckasen JR,White JG,Kersey JH

更新日期：1974-12-01 00:00:00

abstract：:Are animals conscious? If so, when did consciousness evolve? We address these long-standing and essential questions using a modern neuroscientific approach that draws on diverse fields such as consciousness studies, evolutionary neurobiology, animal psychology, and anesthesiology. We propose that the stepwise emergenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mashour GA,Alkire MT

更新日期：2013-06-18 00:00:00

abstract：:Active coping underlies a healthy stress response, but neural processes supporting such resilient coping are not well-known. Using a brief, sustained exposure paradigm contrasting highly stressful, threatening, and violent stimuli versus nonaversive neutral visual stimuli in a functional magnetic resonance imaging (fM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinha R,Lacadie CM,Constable RT,Seo D

更新日期：2016-08-02 00:00:00

abstract：:The recently evolved Hawaiian species Drosophila silvestris has a subdivided population structure and shows great spatial heterogeneity in chromosome inversion distributions and frequencies within its extremely limited geographic range. Pattern analysis of the 11 chromosomal polymorphisms in the context of the recentl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Craddock EM,Carson HL

更新日期：1989-06-01 00:00:00

abstract：:DNA polymerases from Xenopus laevis oocytes, unfertilized eggs, and kidney cells grown in culture have been characterized. The same three major DNA polymerase activities are present in all cell types examined. We attempt to relate the characteristics of amphibian enzymes to those of mammalian polymerases. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatò F,Gandini DA,Tocchini-Valentini GP

更新日期：1974-09-01 00:00:00

abstract：:Scholander and his coworkers have described in These Proceedings several experiments in which the osmotic pressure exerted by colloidal particles appears to be altered when the particles are subject to an external force; they interpret the experiments as showing that the traditional explanation of osmotic pressure is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie RK

更新日期：1974-08-01 00:00:00