Abstract:
:Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5' and the 3' untranslated regions and affecting the stability and translation efficiency of the p53 mRNA. Here, we provide evidence of a feedback loop between p53 and the poly(A)-specific ribonuclease (PARN), in which PARN deadenylase keeps p53 levels low in nonstress conditions by destabilizing p53 mRNA, and the UV-induced increase in p53 activates PARN deadenylase, regulating gene expression during DNA damage response in a transactivation-independent manner. This model is innovative because it provides insights into p53 function and the mechanisms behind the regulation of mRNA 3' end processing in different cellular conditions.
journal_name
Proc Natl Acad Sci U S Aauthors
Devany E,Zhang X,Park JY,Tian B,Kleiman FEdoi
10.1073/pnas.1212533110subject
Has Abstractpub_date
2013-02-26 00:00:00pages
3351-6issue
9eissn
0027-8424issn
1091-6490pii
1212533110journal_volume
110pub_type
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