Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin.

abstract：:Fluoride activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] is significantly enhanced (2 to 5 times) by a protein factor isolated from rat brain. The fluoride-dependent adenylate cyclase stimulator (FCS) is nondialyzable, trypsin-labile, and stable at 90 degrees C for 10 min. FCS stimula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasenick MM,Bitensky MW

更新日期：1980-08-01 00:00:00

abstract：:Lesion of the sciatic nerve caused a rapid increase in c-fos and c-jun mRNA that was followed about 2 hr later by an increase in nerve growth factor (NGF) mRNA. To evaluate whether the initial increase in c-fos mRNA is causally related to the subsequent increase in NGF mRNA, we performed experiments with fibroblasts o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hengerer B,Lindholm D,Heumann R,Rüther U,Wagner EF,Thoenen H

更新日期：1990-05-01 00:00:00

abstract：:C-1027 is an enediyne antitumor antibiotic composed of four distinct moieties: an enediyne core, a deoxy aminosugar, a beta-amino acid, and a benzoxazolinate moiety. We now show that the benzoxazolinate moiety is derived from chorismate by the sequential action of two enzymes-SgcD, a 2-amino-2-deoxyisochorismate (ADIC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Lanen SG,Lin S,Shen B

更新日期：2008-01-15 00:00:00

abstract：:The major histocompatibility complex class-I (MHC-I) peptide-loading complex (PLC) is a cornerstone of the human adaptive immune system, being responsible for processing antigens that allow killer T cells to distinguish between healthy and compromised cells. Based on a recent low-resolution cryo-electron microscopy (c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisette O,Schröder GF,Schäfer LV

更新日期：2020-08-25 00:00:00

abstract：:The roles of glycosylation and protein synthesis in the maintenance of insulin receptor levels and turnover rates in 3T3-L1 adipocytes were investigated. The heavy isotope density-shift technique was employed to determine the effects of inhibitors of these processes on the rates of synthesis and degradation of cellula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed BC,Ronnett GV,Lane MD

更新日期：1981-05-01 00:00:00

abstract：:The Landau spectrum of bismuth is complex and includes many angle-dependent lines in the extreme quantum limit. The adequacy of single-particle theory to describe this spectrum in detail has been an open issue. Here, we present a study of angle-resolved Nernst effect in bismuth, which maps the angle-resolved Landau sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Z,Fauqué B,Malone L,Antunes AB,Fuseya Y,Behnia K

更新日期：2012-09-11 00:00:00

abstract：:The composition of biologic molecules isolated from biominerals suggests that control of mineral growth is linked to biochemical features. Here, we define a systematic relationship between the ability of biomolecules in solution to promote the growth of calcite (CaCO3) and their net negative molecular charge and hydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elhadj S,De Yoreo JJ,Hoyer JR,Dove PM

更新日期：2006-12-19 00:00:00

abstract：:Werner syndrome and Bloom syndrome result from defects in the RecQ helicases Werner (WRN) and Bloom (BLM), respectively, and display premature aging phenotypes. Similarly, XFE progeroid syndrome results from defects in the ERCC1-XPF DNA repair endonuclease. To gain insight into the origin of cellular senescence and hu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagelstrom RT,Blagoev KB,Niedernhofer LJ,Goodwin EH,Bailey SM

更新日期：2010-09-07 00:00:00

abstract：:The lactate racemase enzyme (LarA) of Lactobacillus plantarum harbors a (SCS)Ni(II) pincer complex derived from nicotinic acid. Synthesis of the enzyme-bound cofactor requires LarB, LarC, and LarE, which are widely distributed in microorganisms. The functions of the accessory proteins are unknown, but the LarB C termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desguin B,Soumillion P,Hols P,Hausinger RP

更新日期：2016-05-17 00:00:00

abstract：:There is a gap between how many scientists communicate and how most people understand and interpret messages. This article argues that the extensive science communications literature needs to be joined by the health literacy literature and anthropological work on cultural variations in hearing and understanding messag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scrimshaw SC

更新日期：2019-04-16 00:00:00

abstract：:When various wild strains of Penicillium lanosum and Aspergillus niger were placed in the same mild laboratory environment, their frequencies of new spontaneous mutations were clearly related to whether they had been isolated from a region of high or low microclimatic stress. In the mild environment, the total frequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamb BC,Mandaokar S,Bahsoun B,Grishkan I,Nevo E

更新日期：2008-04-15 00:00:00

abstract：:The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). Two systems are of particular interest in this respect, synthesizing alpha-melanocyte-stimulating hormone (alp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fetissov SO,Hallman J,Oreland L,Af Klinteberg B,Grenbäck E,Hulting AL,Hökfelt T

更新日期：2002-12-24 00:00:00

abstract：:We have generated a hybridoma cell line secreting a monoclonal antibody that specifically binds to the surfaces of oligodendrocytes and Schwann cells, the cells involved in myelin formation in the central and peripheral nervous systems, respectively. Binding studies using purified sphingolipids showed that this antibo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranscht B,Clapshaw PA,Price J,Noble M,Seifert W

更新日期：1982-04-01 00:00:00

abstract：:Radiation dose rates were evaluated in three areas neighboring a restricted area within a 20- to 50-km radius of the Fukushima Daiichi Nuclear Power Plant in August-September 2012 and projected to 2022 and 2062. Study participants wore personal dosimeters measuring external dose equivalents, almost entirely from depos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada KH,Niisoe T,Imanaka M,Takahashi T,Amako K,Fujii Y,Kanameishi M,Ohse K,Nakai Y,Nishikawa T,Saito Y,Sakamoto H,Ueyama K,Hisaki K,Ohara E,Inoue T,Yamamoto K,Matsuoka Y,Ohata H,Toshima K,Okada A,Sato H,Kuwa

更新日期：2014-03-11 00:00:00

abstract：:Activation of androgen receptor (AR) via androgen in muscle cells has been closely linked to their growth and differentiation. Here, we report the cloning and characterization of supervillin (SV), a 205-kDa actin-binding protein, as an AR coregulator from the skeletal muscle cDNA library. Mammalian two-hybrid and glut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ting HJ,Yeh S,Nishimura K,Chang C

更新日期：2002-01-22 00:00:00

abstract：:Far-red radiation (FR) reflected by green tissues is a key signal that plants use to detect the proximity of future competitors. Perception of increased levels of FR elicits a suite of responses collectively known as the shade-avoidance syndrome, which includes increased stem elongation, production of erect leaves, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Izaguirre MM,Mazza CA,Biondini M,Baldwin IT,Ballaré CL

更新日期：2006-05-02 00:00:00

abstract：:The bactericidal effects of antibiotics are undoubtedly triggered by target-specific interactions, but there is growing evidence that an important aspect of cytotoxicity results from treatment-induced metabolic perturbations. In this study, we characterized molecular mechanisms whereby trimethoprim treatment results i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giroux X,Su WL,Bredeche MF,Matic I

更新日期：2017-10-24 00:00:00

abstract：:The Fbw7 (F-box/WD repeat-containing protein 7) ubiquitin ligase targets multiple oncoproteins for degradation and is commonly mutated in cancers. Like other pleiotropic tumor suppressors, Fbw7's complex biology has impeded our understanding of how Fbw7 mutations promote tumorigenesis and hindered the development of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis RJ,Gönen M,Margineantu DH,Handeli S,Swanger J,Hoellerbauer P,Paddison PJ,Gu H,Raftery D,Grim JE,Hockenbery DM,Margolin AA,Clurman BE

更新日期：2018-05-22 00:00:00

abstract：:Three naturally occurring dermorphin-like peptides from the skin of the frog Phyllomedusa bicolor, the related carboxyl-terminal amides, and some substituted analogs were synthesized, their binding profiles to opioid receptors were determined, and their biological activities were studied in isolated organ preparations...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negri L,Erspamer GF,Severini C,Potenza RL,Melchiorri P,Erspamer V

更新日期：1992-08-01 00:00:00

abstract：:Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. The paracellular pathway in the collecting duct of the kidney is a predominant route for transepithelial chloride reabsorption that determines the extracellular NaCl content and the blood pressure. However, the molecular me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou J,Renigunta A,Yang J,Waldegger S

更新日期：2010-10-19 00:00:00

abstract：:The rat anterior pituitary gland (AP) receives all of its blood supply via the hypophyseal portal circulation. We now report, in rats with estradiol (E2)-induced prolactin-secreting tumors, that newly formed arteries directly supply the AP and that this arteriogenesis is closely correlated with the sensitivity of two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elias KA,Weiner RI

更新日期：1984-07-01 00:00:00

abstract：:DNA replication intermediates in human melanoma cells have been investigated by using the drug aphidicolin, which inhibits DNA polymerase alpha. In untreated cells, Okazaki fragments and 10-kilobase (kb) DNA intermediates are formed. In aphidicolin-treated cells, the replication fork is stopped and there is no formati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lönn U,Lönn S

更新日期：1983-07-01 00:00:00

abstract：:The accuracy of the 3'-end processing by cleavage and polyadenylation is essential for mRNA biogenesis and transcription termination. In yeast, two poorly conserved neighboring elements upstream of cleavage sites are important for accuracy and efficiency of this process. These two RNA sequences are recognized by the R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnwal RP,Lee SD,Moore C,Varani G

更新日期：2012-12-26 00:00:00

abstract：:This study demonstrates the presence of an N-acetyl-D-galactosaminyltransferase in human serum and in erythrocyte membranes. This enzyme catalyzes the transfer of N-acetyl-D-galactosamine from UDP-N-acetyl-D-galactosamine to a mucin receptor and 2'-fucosyllactose that have blood group H activity and may be responsible...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YS,Perdomo J,Bella A Jr,Nordberg J

更新日期：1971-08-01 00:00:00

abstract：:An inwardly rectifying, ATP-regulated K+ channel with a distinctive molecular architecture, ROMK1, was recently cloned from rat kidney. Using patch clamp techniques, we have investigated the regulation of ROMK1 with particular emphasis on phosphorylation/dephosphorylation processes. Spontaneous channel rundown occurre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNicholas CM,Wang W,Ho K,Hebert SC,Giebisch G

更新日期：1994-08-16 00:00:00

abstract：:Rat beta-lipotropin was isolated from 40 anterior pituitaries using high efficiency chromatography columns and sensitive fluorometric methods. The beta-lipotropin was characterized as to molecular weight, amino acid composition, and generation of opioid activity by trypsinization. Other opioid peptides, as well as a p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubinstein M,Stein S,Gerber LD,Udenfriend S

更新日期：1977-07-01 00:00:00

abstract：:A generic modeling framework to infer the failure-spreading process based on failure times of individual nodes is proposed and tested in four simulation studies: one for cascading failures in interdependent power and transportation networks, one for influenza epidemics, one benchmark test case for congestion cascade i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan X,Chen C

更新日期：2018-08-28 00:00:00

abstract：:Climate change and resource exploitation have been shown to modify the importance of bottom-up and top-down forces in ecosystems. However, the resulting pattern of trophic control in complex food webs is an emergent property of the system and thus unintuitive. We develop a statistical nondeterministic model, capable o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynam CP,Llope M,Möllmann C,Helaouët P,Bayliss-Brown GA,Stenseth NC

更新日期：2017-02-21 00:00:00

abstract：:Natural ecosystems contain many individuals and species interacting with each other and with their abiotic environment. Such systems can be expected to exhibit complex dynamics in which small perturbations can be amplified to cause large changes. Here, we document the reorganization of an arid ecosystem that has occur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JH,Valone TJ,Curtin CG

更新日期：1997-09-02 00:00:00

abstract：:Dendritic spines receive most synaptic inputs in the forebrain. Their morphology, with a spine head isolated from the dendrite by a slender neck, indicates a potential role in isolating inputs. Indeed, biochemical compartmentalization occurs at spine heads because of the diffusional bottleneck created by the spine nec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araya R,Jiang J,Eisenthal KB,Yuste R

更新日期：2006-11-21 00:00:00