Neural BC1 RNA as an evolutionary marker: guinea pig remains a rodent.

abstract：:Activated transcription of the bacteriophage T4 late genes, which is coupled to concurrent DNA replication, is accomplished by an initiation complex containing the host RNA polymerase associated with two phage-encoded proteins, gp55 (the basal promoter specificity factor) and gp33 (the coactivator), as well as the DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Twist KA,Campbell EA,Deighan P,Nechaev S,Jain V,Geiduschek EP,Hochschild A,Darst SA

更新日期：2011-12-13 00:00:00

abstract：:The challenging problem of ultra-high-energy-density, high-efficiency, and small-scale portable power generation is addressed here using a distinctive thermophotovoltaic energy conversion mechanism and chip-based system design, which we name the microthermophotovoltaic (μTPV) generator. The approach is predicted to be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan WR,Bermel P,Pilawa-Podgurski RC,Marton CH,Jensen KF,Senkevich JJ,Joannopoulos JD,Soljacic M,Celanovic I

更新日期：2013-04-02 00:00:00

abstract：:Helper-dependent adenoviral vectors deleted of all viral coding sequences have shown an excellent gene expression profile in a variety of animal models, as well as a reduced toxicity after systemic delivery. What is still unclear is whether long-term expression and therapeutic dosages of these vectors can be obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maione D,Della Rocca C,Giannetti P,D'Arrigo R,Liberatoscioli L,Franlin LL,Sandig V,Ciliberto G,La Monica N,Savino R

更新日期：2001-05-22 00:00:00

abstract：:Translational stop codon readthrough occurs in organisms ranging from viruses to mammals and is especially prevalent in decoding Drosophila and viral mRNAs. Recoding of UGA, UAG, or UAA to specify an amino acid allows a proportion of the protein encoded by a single gene to be C-terminally extended. The extended produc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hudson AM,Szabo NL,Loughran G,Wills NM,Atkins JF,Cooley L

更新日期：2021-02-02 00:00:00

abstract：:The receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) is composed of an alpha and beta subunit, which together form the high-affinity receptor. The alpha subunit by itself binds ligand at low affinity, whereas the isolated beta subunit does not bind GM-CSF. It is generally believed that the high-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding DX,Rivas CI,Heaney ML,Raines MA,Vera JC,Golde DW

更新日期：1994-03-29 00:00:00

abstract：:This work describes the rational design, synthesis, and study of a ligand that selectively complexes CUG repeats in RNA (and CTG repeats in DNA) with high nanomolar affinity. This sequence is considered a causative agent of myotonic dystrophy type 1 (DM1) because of its ability to sequester muscleblind-like (MBNL) pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arambula JF,Ramisetty SR,Baranger AM,Zimmerman SC

更新日期：2009-09-22 00:00:00

abstract：:Mucolipidosis type IV is an autosomal recessive lysosomal storage disease of unknown etiology that causes severe neurological and ophthalmological abnormalities. In an attempt to obtain insight into the nature of the metabolic abnormality in this disorder, we prospectively evaluated 15 consecutive patients, aged 2 to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiffmann R,Dwyer NK,Lubensky IA,Tsokos M,Sutliff VE,Latimer JS,Frei KP,Brady RO,Barton NW,Blanchette-Mackie EJ,Goldin E

更新日期：1998-02-03 00:00:00

abstract：:The uncatalyzed reactions of O(2) (S = 1) with organic substrates (S = 0) are thermodynamically favorable but kinetically slow because they are spin-forbidden and the one-electron reduction potential of O(2) is unfavorable. In nature, many of these important O(2) reactions are catalyzed by metalloenzymes. In the case ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pau MY,Lipscomb JD,Solomon EI

更新日期：2007-11-20 00:00:00

abstract：:Protein-based hydrogels have emerged as promising alternatives to synthetic hydrogels for biomedical applications, owing to the precise control of structure and function enabled by protein engineering. Nevertheless, strategies for assembling 3D molecular networks that carry the biological information encoded in full-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun F,Zhang WB,Mahdavi A,Arnold FH,Tirrell DA

更新日期：2014-08-05 00:00:00

abstract：:Novel organismal structures in metazoans are often undergirded by complex gene regulatory networks; as such, understanding the emergence of new structures through evolution requires reconstructing the series of evolutionary steps leading to these underlying networks. Here, we reconstruct the step-by-step assembly of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Irimia M,Denuc A,Burguera D,Somorjai I,Martín-Durán JM,Genikhovich G,Jimenez-Delgado S,Technau U,Roy SW,Marfany G,Garcia-Fernàndez J

更新日期：2011-03-29 00:00:00

abstract：:Topographic sensory maps are a prominent feature of the adult primate brain. Here, we asked whether topographic representations of the body are present at birth. Using functional MRI (fMRI), we find that the newborn somatomotor system, spanning frontoparietal cortex and subcortex, comprises multiple topographic repres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arcaro MJ,Schade PF,Livingstone MS

更新日期：2019-12-03 00:00:00

abstract：:Glucose stimulates insulin secretion from β-cells by increasing intracellular Ca(2+). Ca(2+) then binds to synaptotagmin-7 as a major Ca(2+) sensor for exocytosis, triggering secretory granule fusion and insulin secretion. In type-2 diabetes, insulin secretion is impaired; this impairment is ameliorated by glucagon-li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu B,Wei S,Petersen N,Ali Y,Wang X,Bacaj T,Rorsman P,Hong W,Südhof TC,Han W

更新日期：2015-08-11 00:00:00

abstract：:Soon after the initiation of sporulation, Bacillus subtilis divides asymmetrically to produce sister cells that have very different developmental fates. Recently, it has been proposed that the differential gene expression which begins soon after this division is due to cell-specific activation of the transcription fac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis PJ,Partridge SR,Errington J

更新日期：1994-04-26 00:00:00

abstract：:The Notch signaling pathway defines an evolutionarily conserved cell-cell interaction mechanism that throughout development controls the ability of precursor cells to respond to developmental signals. Here we show that Notch signaling regulates the expression of the master control genes eyeless, vestigial, and Distal-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurata S,Go MJ,Artavanis-Tsakonas S,Gehring WJ

更新日期：2000-02-29 00:00:00

abstract：:Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for exter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosmans F,Milescu M,Swartz KJ

更新日期：2011-12-13 00:00:00

abstract：:Cellular wound healing or the repair of plasma membrane/cell wall damage (plasma membrane damage) occurs frequently in nature. Although various cellular perturbations, such as DNA damage, spindle misalignment, and impaired daughter cell formation, are monitored by cell cycle checkpoint mechanisms in budding yeast, whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kono K,Al-Zain A,Schroeder L,Nakanishi M,Ikui AE

更新日期：2016-06-21 00:00:00

abstract：:The brain continuously influences and perceives the physiological condition of the body. Related cortical representations have been proposed to shape emotional experience and guide behavior. Although previous studies have identified brain regions recruited during autonomic processing, neurological lesion studies have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo CC,Sturm VE,Zhou J,Gennatas ED,Trujillo AJ,Hua AY,Crawford R,Stables L,Kramer JH,Rankin K,Levenson RW,Rosen HJ,Miller BL,Seeley WW

更新日期：2016-04-26 00:00:00

abstract：:To date, numerous inhibitors of the human immunodeficiency virus type 1 protease have been reported, but few have been studied extensively in humans, primarily as a consequence of poor oral bioavailability in animal models. L-735,524 represents a class of human immunodeficiency virus type 1 protease inhibitors, termed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vacca JP,Dorsey BD,Schleif WA,Levin RB,McDaniel SL,Darke PL,Zugay J,Quintero JC,Blahy OM,Roth E

更新日期：1994-04-26 00:00:00

abstract：:TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53-/-) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. RALBP1 (RLIP76, Rlip) is a stress-protective, mercapturic acid pathway transporter protein that also functions as a Ral ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awasthi S,Tompkins J,Singhal J,Riggs AD,Yadav S,Wu X,Singh S,Warden C,Liu Z,Wang J,Slavin TP,Weitzel JN,Yuan YC,Awasthi M,Srivastava SK,Awasthi YC,Singhal SS

更新日期：2018-04-10 00:00:00

abstract：:Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually induced a youthful appe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cotzias GC,Miller ST,Nicholson AR Jr,Maston WH,Tang LC

更新日期：1974-06-01 00:00:00

abstract：:Smooth muscle cells (SMCs) have been shown to migrate in response to insulin-like growth factor I (IGF-I). However, the mechanism mediating this response has not been determined. The migration rates of porcine and human vascular SMCs were assessed in a monolayer wounding assay. IGF-I and IGF-II induced increases of 14...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones JI,Prevette T,Gockerman A,Clemmons DR

更新日期：1996-03-19 00:00:00

abstract：:Dendrite morphogenesis is regulated by neuronal activity or neurotrophins, which may function by activating intrinsic signaling proteins, including Rho family GTPases. Here we report that activity- and brain-derived neurotrophic factor (BDNF)-dependent dendritic morphogenesis requires activation of geranylgeranyltrans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou XP,Wu KY,Liang B,Fu XQ,Luo ZG

更新日期：2008-11-04 00:00:00

abstract：:Hookworms are hematophagous nematodes that infect a wide range of mammalian hosts, including humans. There has been speculation for nearly a century as to the identity of the anticoagulant substances) used by these organisms to subvert host hemostasis. Using molecular cloning, we describe a family of potent small prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stassens P,Bergum PW,Gansemans Y,Jespers L,Laroche Y,Huang S,Maki S,Messens J,Lauwereys M,Cappello M,Hotez PJ,Lasters I,Vlasuk GP

更新日期：1996-03-05 00:00:00

abstract：:The c-Raf-1 protein kinase plays a central role in the mitogenic response of cells to growth factors, cytokines, and many oncogenes. Despite the critical importance of this enzyme, very little is known of its biochemical properties or mechanisms of regulation. In these experiments, we used the only candidate physiolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Force T,Bonventre JV,Heidecker G,Rapp U,Avruch J,Kyriakis JM

更新日期：1994-02-15 00:00:00

abstract：:Recent laboratory studies have demonstrated that isoprene oxidation products can partition to atmospheric aerosols by reacting with condensed phase sulfuric acid, forming low-volatility organosulfate compounds. We have identified organosulfate compounds in free tropospheric aerosols by single particle mass spectrometr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Froyd KD,Murphy SM,Murphy DM,de Gouw JA,Eddingsaas NC,Wennberg PO

更新日期：2010-12-14 00:00:00

abstract：:Structural symmetry is a hallmark of homomeric ion channels. Nonobligatory regulatory proteins can also critically define the precise functional role of such channels. For instance, the pore-forming subunit of the large conductance voltage and calcium-activated potassium (BK, Slo1, or KCa1.1) channels encoded by a sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Perez V,Ben Johny M,Xia XM,Lingle CJ

更新日期：2018-10-02 00:00:00

abstract：:MyoD is a master regulatory gene for myogenesis. Its product, the MyoD protein, appears to act by binding to muscle-specific enhancer sequences. We show that MyoD binds cooperatively to two sites in the muscle-specific creatine kinase enhancer; this is dramatically reflected in dissociation-rate measurements. A deleti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weintraub H,Davis R,Lockshon D,Lassar A

更新日期：1990-08-01 00:00:00

abstract：:Trypanosoma brucei parasites successfully evade the host immune system by periodically switching the dense coat of variant surface glycoprotein (VSG) at the cell surface. Each parasite expresses VSGs in a monoallelic fashion that is tightly regulated. The consequences of exposing multiple VSGs during an infection, in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aresta-Branco F,Sanches-Vaz M,Bento F,Rodrigues JA,Figueiredo LM

更新日期：2019-10-08 00:00:00

abstract：:Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The popul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trivedi U,Madsen JS,Everett J,Fell C,Russel J,Haaber J,Crosby HA,Horswill AR,Burmølle M,Rumbaugh KP,Sørensen SJ

更新日期：2018-12-11 00:00:00

abstract：:The actin cytoskeleton is an essential intracellular filamentous structure that underpins cellular transport and cytoplasmic streaming in plant cells. However, the system-level properties of actin-based cellular trafficking remain tenuous, largely due to the inability to quantify key features of the actin cytoskeleton...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breuer D,Nowak J,Ivakov A,Somssich M,Persson S,Nikoloski Z

更新日期：2017-07-11 00:00:00