Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses.

abstract：:Differences between early and late passage cell cultures on the organelle and macromolecular levels have been attributed to cellular "aging". However, concern has been expressed over whether changes in diploid cell populations after serial passage in vitro accurately reflect human cellular aging in vivo. Studies were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider EL,Mitsui Y

更新日期：1976-10-01 00:00:00

abstract：:Shewanella species are renowned for their respiratory versatility, including their ability to respire poorly soluble substrates by using enzymatic machinery that is localized to the outside of the cell. The ability to engage in "extracellular respiration" to date has focused primarily on respiration of minerals. Here,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gralnick JA,Vali H,Lies DP,Newman DK

更新日期：2006-03-21 00:00:00

abstract：:Gene delivery to the central nervous system is central to the development of gene therapy for neurological diseases. We developed a baculovirus-derived vector, the Bac-CMV-GFP vector, containing a reporter gene encoding for the green fluorescent protein (GFP) under the control of the cytomegalovirus (CMV) promoter. Tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkis C,Serguera C,Petres S,Buchet D,Ridet JL,Edelman L,Mallet J

更新日期：2000-12-19 00:00:00

abstract：:Xenopus oocytes express a gene encoding bovine rhodopsin as well as its SP6 RNA polymerase-derived transcripts and total retinal mRNA. The opsin produced is in unglycosylated (30 kDa) and two glycosylated (35 kDa and 41 kDa) forms. Incubation of the cells expressing the above proteins with 11-cis-retinal generates rho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khorana HG,Knox BE,Nasi E,Swanson R,Thompson DA

更新日期：1988-11-01 00:00:00

abstract：:Previous studies have shown that Delta-mediated Notch signaling regulates the number of early differentiating neurons. However, the role of Notch activation and Jagged-mediated signaling during late neurogenesis remains poorly defined. In the developing spinal cord of zebrafish, GABAergic Kolmer-Agduhr (KA'') cells an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeo SY,Chitnis AB

更新日期：2007-04-03 00:00:00

abstract：:Enhancing immune responses with immune-modulatory monoclonal antibodies directed to inhibitory immune receptors is a promising modality in cancer therapy. Clinical efficacy has been demonstrated with antibodies blocking inhibitory immune checkpoints such as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) or PD-1/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romano E,Kusio-Kobialka M,Foukas PG,Baumgaertner P,Meyer C,Ballabeni P,Michielin O,Weide B,Romero P,Speiser DE

更新日期：2015-05-12 00:00:00

abstract：:Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal disorders, causes photoreceptor loss and subsequent vision decline. Although caspase-dependent apoptotic pathways are activated after retinal det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trichonas G,Murakami Y,Thanos A,Morizane Y,Kayama M,Debouck CM,Hisatomi T,Miller JW,Vavvas DG

更新日期：2010-12-14 00:00:00

abstract：:Genome editing with engineered site-specific endonucleases involves nonhomologous end-joining, leading to reading frame disruption. The approach is applicable to dominant negative disorders, which can be treated simply by knocking out the mutant allele, while leaving the normal allele intact. We applied this strategy ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinkuma S,Guo Z,Christiano AM

更新日期：2016-05-17 00:00:00

abstract：:Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons JP,Al-Shawi R,Ellmerich S,Speck I,Aslam S,Hutchinson WL,Mangione PP,Disterer P,Gilbertson JA,Hunt T,Millar DJ,Minogue S,Bodin K,Pepys MB,Hawkins PN

更新日期：2013-10-01 00:00:00

abstract：:We present here a shorter version of the proof of our earlier work, showing that the von Neumann factor associated with the group Z(2)SL(2,Z) has trivial fundamental group. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popa S

更新日期：2004-01-20 00:00:00

abstract：:Photolyzed rhodopsin catalyzes the exchange of GTP for FDP bound to a protein in retinal rod outer segments. We previously proposed that the GTP complex of this protein regulates the cyclic GMP phosphodiesterase and that it may be the first amplified intermediate in visual excitation [Fung, B. K.-K. & Stryer, L. (1980...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fung BK,Hurley JB,Stryer L

更新日期：1981-01-01 00:00:00

abstract：:We examined the contributions of the human pulvinar to goal directed selection of visual targets in 3 patients with chronic, unilateral lesions involving topographic maps in the ventral pulvinar. Observers completed 2 psychophysical tasks in which they discriminated the orientation of a lateralized target grating in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snow JC,Allen HA,Rafal RD,Humphreys GW

更新日期：2009-03-10 00:00:00

abstract：:Membraneless organelles contain a wide spectrum of molecular chaperones, indicating their important roles in modulating the metastable conformation and biological function of membraneless organelles. Here we report that class I and II Hsp40 (DNAJ) proteins possess a high ability of phase separation rendered by the fle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu J,Liu Z,Zhang S,Li Y,Xia W,Wang C,Xiang H,Liu Z,Tan L,Fang Y,Liu C,Li D

更新日期：2020-12-08 00:00:00

abstract：:In a classic model of mammalian brain formation, precursors of principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precursors migrate tangentially. These migration modes have significant implications for brain function. Here we used clonal lineage tracing of active r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun GJ,Zhou Y,Stadel RP,Moss J,Yong JH,Ito S,Kawasaki NK,Phan AT,Oh JH,Modak N,Reed RR,Toni N,Song H,Ming GL

更新日期：2015-07-28 00:00:00

abstract：:By harnessing the oxidative power of microorganisms, energy can be recovered from reservoirs of less-concentrated organic matter, such as marine sediment, wastewater, and waste biomass. Left unmanaged, these reservoirs can become eutrophic dead zones and sites of greenhouse gas generation. Here, we introduce a unique ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie X,Ye M,Hsu PC,Liu N,Criddle CS,Cui Y

更新日期：2013-10-01 00:00:00

abstract：:Apomixis is a naturally occurring mode of reproduction that results in embryo formation without the involvement of meiosis or fertilization of the egg. Seed-derived progeny of an apomictic plant are genetically identical to the maternal parent. We are studying a form of apomixis called apospory that occurs in the genu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozias-Akins P,Roche D,Hanna WW

更新日期：1998-04-28 00:00:00

abstract：:Susceptibility of activated T cells to apoptosis must be tightly regulated to ensure sufficient T cell progeny for an effective response, while allowing a rapid depletion of them at the end of the immune response. We show here that a previously isolated, NF-kappa B/rel target gene IEX-1 (Immediate Early response gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Schlossman SF,Edwards RA,Ou CN,Gu J,Wu MX

更新日期：2002-01-22 00:00:00

abstract：:New Zealand Black (NZB) mice develop after 16 weeks of age an autoimmune and lymphoproliferative disease which is a model for systemic lupus erythematosus and lymphoid malignancy in humans. At this age, the mice manifest a progressive decline in T lymphocyte (thymus-derived lymphocyte) functions and serum thymosin lev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dauphinee MJ,Talal N,Goldstein AL,White A

更新日期：1974-07-01 00:00:00

abstract：:Intracellular Ca(2+) release in many types of cells is mediated by ryanodine receptor Ca(2+) release channels (RyRCs) that are assembled into two-dimensional paracrystalline arrays in the endoplasmic/sarcoplasmic reticulum. However, the in situ operating mechanism of the RyRC array is unknown. Here, we found that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang SQ,Stern MD,Ríos E,Cheng H

更新日期：2004-03-16 00:00:00

abstract：:Locomotion of the nematode Caenorhabditis elegans is a key observable used in investigations ranging from behavior to neuroscience to aging. However, while the natural environment of this model organism is 3D, quantitative investigations of its locomotion have been mostly limited to 2D motion. Here, we present a quant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bilbao A,Patel AK,Rahman M,Vanapalli SA,Blawzdziewicz J

更新日期：2018-04-17 00:00:00

abstract：:Fast neurotransmission requires that docked synaptic vesicles be located near the presynaptic N-type or P/Q-type calcium channels. Specific protein-protein interactions between a synaptic protein interaction (synprint) site on N-type and P/Q-type channels and the presynaptic SNARE proteins syntaxin, SNAP-25, and synap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DK,Catterall WA

更新日期：1997-12-23 00:00:00

abstract：:To study the multistep process of cervical cancer development, we analyzed 128 frozen cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia (CIN1- CIN3), and cervical cancer (CxCa) from multiple perspectives, revealing a cascade of progressive changes. Compared with normal tissue, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： den Boon JA,Pyeon D,Wang SS,Horswill M,Schiffman M,Sherman M,Zuna RE,Wang Z,Hewitt SM,Pearson R,Schott M,Chung L,He Q,Lambert P,Walker J,Newton MA,Wentzensen N,Ahlquist P

更新日期：2015-06-23 00:00:00

abstract：:The intracellular pathogen Salmonella enterica serovar Typhimurium requires the mgtC gene to cause disease. The mgtC transcript includes a long leader region that harbors a short proline codon-rich ORF--termed mgtP--the translation of which is predicted to favor formation of one of two alternative stem-loop structures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee EJ,Choi J,Groisman EA

更新日期：2014-02-25 00:00:00

abstract：:Biological invasions contribute to global environmental change, but the dynamics and consequences of most invasions are difficult to assess at regional scales. We deployed an airborne remote sensing system that mapped the location and impacts of five highly invasive plant species across 221,875 ha of Hawaiian ecosyste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asner GP,Hughes RF,Vitousek PM,Knapp DE,Kennedy-Bowdoin T,Boardman J,Martin RE,Eastwood M,Green RO

更新日期：2008-03-18 00:00:00

abstract：:An explicitly polarizable force field based exclusively on quantum data is applied to calculations of relative binding affinities of ligands to proteins. Five ligands, differing by replacement of an atom or functional group, in complexes with three serine proteases-trypsin, thrombin, and urokinase-type plasminogen act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khoruzhii O,Donchev AG,Galkin N,Illarionov A,Olevanov M,Ozrin V,Queen C,Tarasov V

更新日期：2008-07-29 00:00:00

abstract：:Congenital malformations now represent the largest single cause of mortality in the infant of the diabetic mother. The mechanism by which diabetes exerts its teratogenic effects is not known. This study evaluated whether arachidonic acid might be involved, a possibility raised by the role of arachidonic acid in palata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldman AS,Baker L,Piddington R,Marx B,Herold R,Egler J

更新日期：1985-12-01 00:00:00

abstract：:Hypothesis directed proteomics offers higher throughput over global analyses. We show that immunoprecipitation (IP)-tandem mass spectrometry (LC-MS/MS) in H929 multiple myeloma (MM) cancer cells led to the discovery of a rare and unexpected BCR-ABL fusion, informing a therapeutic intervention using imatinib (Gleevec)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breitkopf SB,Yuan M,Pihan GA,Asara JM

更新日期：2012-10-02 00:00:00

abstract：:A 165-kilodalton (kDal) surface glycoprotein encoded by human chromosome 7 (SA-7) had been characterized by using antisera raised against human chromosome 7-containing somatic cell hybrids. We now present evidence that SA-7 is the human receptor for epidermal growth factor (EGF) and that these antisera recognize human...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carlin CR,Knowles BB

更新日期：1982-08-01 00:00:00

abstract：:The insulin and glucagon responses to 10 mM glucose and 10 mM arginine were studied in pancreata isolated from nondiabetic diabetes-prone and diabetes-resistant BB/W rats at 60, 80, and 140 days of age and in diabetic BB/W rats on the 1st and 14th days of their diabetes. In the former group the insulin response to glu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tominaga M,Komiya I,Johnson JH,Inman L,Alam T,Moltz J,Crider B,Stefan Y,Baetens D,McCorkle K

更新日期：1986-12-01 00:00:00

abstract：:Accurate calculations of force generated and of ATP flux, in steady isotonic contractions, are made on a simple, two-state muscle model of the sliding filament type. The objective is to illustrate the proper formulation and use of a complete and self-consistent molecular model of muscle. Otherwise, the model is not me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1974-05-01 00:00:00