Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.

abstract：:After five decades of largely serendipitous (albeit formidable) progress, catalyst design in Ziegler-Natta olefin polymerization, i.e., the rational implementation of new active species to target predetermined polyolefin architectures, has ultimately become a realistic ambition, thanks to a much deeper fundamental und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busico V,Cipullo R,Pellecchia R,Ronca S,Roviello G,Talarico G

更新日期：2006-10-17 00:00:00

abstract：:When mouse spleen cells were stimulated with irradiated xenogeneic, allogeneic, or trinitrophenyl-modified syngeneic lymphoid cells, the strongest cytolytic response was induced by alloantigens. Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing rat strain, but ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burakoff SJ,Ratnofsky SE,Benacerraf B

更新日期：1977-10-01 00:00:00

abstract：:Duplexes constituted by closed or open RNA circles paired to single-stranded oligonucleotides terminating with 3'-CCAOH form resected pseudoknots that are substrates of yeast histidyl-tRNA synthetase. Design of this RNA fold is linked to the mimicry of the pseudoknotted amino acid accepting branch of the tRNA-like dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felden B,Giegé R

更新日期：1998-09-01 00:00:00

abstract：:Lewis base catalyzed bromo- and iodolactonization reactions have been developed and the effects of catalyst structure on rate and cyclization selectivity have been systematically explored. The effects of substrate structure on halolactonization reactions and the interaction of those effects with the effects of catalys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denmark SE,Burk MT

更新日期：2010-11-30 00:00:00

abstract：:Learning the properties of an image associated with human gaze placement is important both for understanding how biological systems explore the environment and for computer vision applications. There is a large literature on quantitative eye movement models that seeks to predict fixations from images (sometimes termed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kümmerer M,Wallis TS,Bethge M

更新日期：2015-12-29 00:00:00

abstract：:The grand partition function for a long linear system of alternating alpha and beta sequences with the restraint of a fixed number, N(alphabeta), of alphabeta boundaries depends in an extremely simple way on the alpha-sequence and beta-sequence grand partition functions, xi(alpha) and xi(beta). When the restraint is r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL

更新日期：1972-05-01 00:00:00

abstract：:A methylcholanthrene-induced glioblastoma of the C57BL/6 inbred mouse strain was used to raise antibodies in C57BL/6 and C57BL/10 inbred mice and in (C57BL/6 x DBA/2) and (C57BL/6 x Balb/c) F(1) hybrids. When examined by the cytotoxicity test, these antibodies define a cell-surface component (or components) found excl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schachner M

更新日期：1974-05-01 00:00:00

abstract：:The results of electron-nuclear double resonance and electron paramagnetic resonance (EPR) studies on the hydrogen peroxide compound of yeast cytochrome c peroxidase are inconsistent with previous proposals for the source of the EPR signal in this compound, in particular with its identification with an aromatic amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman BM,Roberts JE,Brown TG,Kang CH,Margoliash E

更新日期：1979-12-01 00:00:00

abstract：:Numerous biomolecular studies from the past 20 years have indicated that the large African monkeys Papio, Theropithecus, and Mandrillus have a diphyletic relationship with different species groups of mangabeys. According to the results of these studies, mandrills and drills (Mandrillus) are most closely related to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleagle JG,McGraw WS

更新日期：1999-02-02 00:00:00

abstract：:To reduce greenhouse gas emissions from deforestation, Indonesia instituted a nationwide moratorium on new license areas ("concessions") for oil palm plantations, timber plantations, and logging activity on primary forests and peat lands after May 2011. Here we indirectly evaluate the effectiveness of this policy usin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busch J,Ferretti-Gallon K,Engelmann J,Wright M,Austin KG,Stolle F,Turubanova S,Potapov PV,Margono B,Hansen MC,Baccini A

更新日期：2015-02-03 00:00:00

abstract：:Development of type 1 diabetes in the nonobese diabetic (NOD) mouse is preceded by an immune cell infiltrate in the pancreatic islets. The exact role of the attracted cells is still poorly understood. Chemokine CCL2/MCP-1 is known to attract CCR2(+) monocytes and dendritic cells (DCs). We have previously shown that tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriegel MA,Rathinam C,Flavell RA

更新日期：2012-02-28 00:00:00

abstract：:The concept of gametic isolation has its origins in the 1937 edition of T. Dobzhansky's Genetics and the Origin of Species. Involving either positive assortative fertilization (as opposed to self-incompatibility) or negative assortative fertilization, it occurs after mating but prior to fertilization. Gametic isolatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markow TA

更新日期：1997-07-22 00:00:00

abstract：:The improvement of motor behavior, based on experience, is a form of learning that is critically dependent on the cerebellum. A well studied example of cerebellar motor learning is short-term saccadic adaptation (STSA). In STSA, information on saccadic errors is used to improve future saccades. The information optimiz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catz N,Dicke PW,Thier P

更新日期：2008-05-20 00:00:00

abstract：:Here the first reproductive sterility system for the tephritid fruit fly pest, Anastrepha suspensa, is presented, based on lethality primarily limited to embryos heterozygous for a conditional lethal transgene combination. This tetracycline (Tet)-suppressible system uses a driver construct having the promoter from the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schetelig MF,Handler AM

更新日期：2012-06-12 00:00:00

abstract：:We have developed an efficient, versatile, and user-friendly viral engineering and expression system that is based on in planta assembly of functional viral vectors from separate pro-vector modules. With this new system, instead of supplying a plant cell with a complete viral vector as a mature viral particle, an RNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marillonnet S,Giritch A,Gils M,Kandzia R,Klimyuk V,Gleba Y

更新日期：2004-05-04 00:00:00

abstract：:Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo-Pastor C,Rubio-Moscardo F,Vogel-González M,Serra SA,Afthinos A,Mrkonjic S,Destaing O,Abenza JF,Fernández-Fernández JM,Trepat X,Albiges-Rizo C,Konstantopoulos K,Valverde MA

更新日期：2018-02-20 00:00:00

abstract：:Epithelia in animals are colonized by complex communities of microbes. Although a topic of long-standing interest, understanding the evolution of the microbial communities and their role in triggering innate immune responses has resisted analysis. Cnidaria are among the simplest animals at the tissue grade of organiza...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraune S,Bosch TC

更新日期：2007-08-07 00:00:00

abstract：:Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes are targets of Polycomb proteins and form local 3D clusters cent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieux-Rochas M,Fabre PJ,Leleu M,Duboule D,Noordermeer D

更新日期：2015-04-14 00:00:00

abstract：:As an electron transfer-driven proton pump, cytochrome c oxidase (ferrocytochrome-c:oxygen oxidoreductase, EC 1.9.3.1) must alternate between two conformations in each valence state of the redox element associated with ion translocation. Using second derivative absorption spectroscopy, the conformation of the cytochro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Copeland RA

更新日期：1991-08-15 00:00:00

abstract：:Neuronal dynamics display a complex spatiotemporal structure involving the precise, context-dependent coordination of activation patterns across a large number of spatially distributed regions. Functional magnetic resonance imaging (fMRI) has played a central role in demonstrating the nontrivial spatial and topologica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalesky A,Fornito A,Cocchi L,Gollo LL,Breakspear M

更新日期：2014-07-15 00:00:00

abstract：:The AAA-ATPase thyroid hormone receptor interacting protein 13 (TRIP13), jointly with the Mad2-binding protein p31(comet), promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitotic checkpoint complex (MCC). This checkpoint system ensures the accuracy of chromosome segregation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miniowitz-Shemtov S,Eytan E,Kaisari S,Sitry-Shevah D,Hershko A

更新日期：2015-09-15 00:00:00

abstract：:Mutational processes of simple sequence repeats (SSRs) in complex genomes are poorly understood. We examined these processes by introducing a two-phase mutation model. In this model, most mutations are single-step changes, but infrequent large jumps in repeat number also occur. We used computer simulations to determin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Rienzo A,Peterson AC,Garza JC,Valdes AM,Slatkin M,Freimer NB

更新日期：1994-04-12 00:00:00

abstract：:The active conformation of native peroxisomal 3-ketoacyl-CoA thiolases (EC 2.3.1.16) is homodimeric. We have previously shown that a truncated Saccharomyces cerevisiae thiolase lacking its first 16 N-terminal amino acids fails to be translocated into peroxisomes but assembles into an enzymatically active form in the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glover JR,Andrews DW,Rachubinski RA

更新日期：1994-10-25 00:00:00

abstract：:An enhancer specific to erythroid cells was identified previously in the 3' flanking sequence of the chicken adult beta-globin gene and shown to act on the beta-globin promoter. This enhancer lies between the adult beta-globin gene and the embryonic epsilon-globin gene, about equidistant from the two promoters. To det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nickol JM,Felsenfeld G

更新日期：1988-04-01 00:00:00

abstract：:Adenosine deaminase (ADA; adenosine aminohydrolase, EC 3.5.4.4) deficiency is one cause of the genetic disease severe combined immunodeficiency. To identify mutations responsible for ADA deficiency, we synthesized cDNAs to ADA mRNAs from two cell lines, GM2756 and GM2825A, derived from ADA-deficient immunodeficient pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akeson AL,Wiginton DA,States JC,Perme CM,Dusing MR,Hutton JJ

更新日期：1987-08-01 00:00:00

abstract：:The high-potential iron-sulfur center associated with the g = 1.89-1.90 electron paramagnetic resonance signal in spinach chloroplasts is fully reduced in the dark. It is photooxidized in the presence of 3-(3,4-dichlorophenyl)-1,1-dimethylurea and reduced after illumination with red actinic light in the absence of inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitmarsh J,Cramer WA

更新日期：1979-09-01 00:00:00

abstract：:We report the cloning and characterization of a cancer-associated cell membrane glycoprotein recognized by mAb NCC-3G10. The antibody showed strong reactivity to a wide variety of cancer cells, but only to a limited number of normal cells including lymphocytes, endothelial cells, and basal cells of stratified squamous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ino Y,Gotoh M,Sakamoto M,Tsukagoshi K,Hirohashi S

更新日期：2002-01-08 00:00:00

abstract：:Members of the platelet-derived growth factor (PDGF) ligand family are known to play important roles in wound healing and fibrotic disease. We show that both transient and stable expression of PDGF-C results in the development of liver fibrosis consisting of the deposition of collagen in a pericellular and perivenular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell JS,Hughes SD,Gilbertson DG,Palmer TE,Holdren MS,Haran AC,Odell MM,Bauer RL,Ren HP,Haugen HS,Yeh MM,Fausto N

更新日期：2005-03-01 00:00:00

abstract：:Studies have shown that hemophilia B (Christmas disease; factor IX deficiency) results from many different mutations in the factor IX gene, of which greater than 95% are single nucleotide substitutions. This study has identified a previously unreported form of hemophilia B in a patient who was a somatic mosaic for a g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor SA,Deugau KV,Lillicrap DP

更新日期：1991-01-01 00:00:00

abstract：:The retroviral integrase protein (IN) is responsible for catalyzing a concerted integration reaction in which the two termini of linear viral DNA are joined to host DNA. To probe the potential for IN to form protein multimers, we used the yeast two-hybrid system. The coexpression of a GAL4 DNA binding domain-IN fusion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalpana GV,Goff SP

更新日期：1993-11-15 00:00:00