Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1.

abstract：:Humans shift their gaze to a new location several times per second. It is still unclear what determines where they look next. Fixation behavior is influenced by the low-level salience of the visual stimulus, such as luminance, contrast, and color, but also by high-level task demands and prior knowledge. Under natural ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schütz AC,Trommershäuser J,Gegenfurtner KR

更新日期：2012-05-08 00:00:00

abstract：:Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success of such vaccines in mice has not translated readily to effective malaria vaccines in humans. Thus, mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt NW,Podyminogin RL,Butler NS,Badovinac VP,Tucker BJ,Bahjat KS,Lauer P,Reyes-Sandoval A,Hutchings CL,Moore AC,Gilbert SC,Hill AV,Bartholomay LC,Harty JT

更新日期：2008-09-16 00:00:00

abstract：:The repair of DNA double-strand breaks (DSBs) requires open, flexible chromatin domains. The NuA4-Tip60 complex creates these flexible chromatin structures by exchanging histone H2A.Z onto nucleosomes and promoting acetylation of histone H4. Here, we demonstrate that the accumulation of H2A.Z on nucleosomes at DSBs is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gursoy-Yuzugullu O,Ayrapetov MK,Price BD

更新日期：2015-06-16 00:00:00

abstract：:Variation is the raw material for natural selection, but the factors shaping variation are still poorly understood. Genetic and developmental interactions can direct variation, but there has been little synthesis of these effects with the extrinsic factors that can shape biodiversity over large scales. The study of ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goswami A,Binder WJ,Meachen J,O'Keefe FR

更新日期：2015-04-21 00:00:00

abstract：:A murine monoclonal antibody (OKT9) raised against human leukemic cells binds to a wide variety of leukemia and tumor cell lines and to a minority of leukemia cells taken directly from patients. Fetal thymus and liver are strongly reactive as are some normal, immature hemopoietic cells and activated lymphocytes. React...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sutherland R,Delia D,Schneider C,Newman R,Kemshead J,Greaves M

更新日期：1981-07-01 00:00:00

abstract：:The serological properties of the gag gene products p15 and p12 of N- and B-tropic viruses of C57BL mice have been examined. Although these viruses were serologically identical by competition assays for proteins gp71 and p30, they were readily distinguishable in competition assays for proteins p15 and p12. Two isolate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benade LE,Ihle JN,Declève A

更新日期：1978-09-01 00:00:00

abstract：:Bacterial populations are subject to complex processes of diversification that involve mutation and horizontal DNA transfer mediated by transformation, transduction, or conjugation. Tracing the evolutionary events leading to genetic changes allows us to infer the history of a microbe. Here, we combine experimental and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brochet M,Rusniok C,Couvé E,Dramsi S,Poyart C,Trieu-Cuot P,Kunst F,Glaser P

更新日期：2008-10-14 00:00:00

abstract：:In yeasts and mammals, PEX10 encodes an integral membrane protein with a C3HC4 RING finger motif in its C-terminal domain and is required for peroxisome biogenesis and matrix protein import. In humans, its dysfunction in peroxisome biogenesis leads to severe Zellweger Syndrome and infantile Refsum disease. Here we sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schumann U,Wanner G,Veenhuis M,Schmid M,Gietl C

更新日期：2003-08-05 00:00:00

abstract：:To study the mechanism of arrest of DNA synthesis at d(TC)n and d(GA)n sequences, single-stranded DNA molecules including d(TC)27 or d(TC)31 tracts or a d(GA)27 tract were used as templates for in vitro assays of complementary DNA synthesis performed by extension of a primer with the Klenow polymerase or the Taq polym...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baran N,Lapidot A,Manor H

更新日期：1991-01-15 00:00:00

abstract：:A three-dimensional map of the positions of four idiotypic determinants (idiotopes or Ids) and an isotypic determinant was derived by transmission electron microscopy of negatively stained immune complexes. Each complex was composed of a monoclonal Id-expressing IgG and one or two varieties of monoclonal anti-Id (or a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roux KH,Monafo WJ,Davie JM,Greenspan NS

更新日期：1987-07-01 00:00:00

abstract：:During latent infection of humans with Mycobacterium tuberculosis, bacteria persist in the asymptomatic host within granulomas, organized collections of differentiated macrophages, and other immune cells. The mechanisms for persistence remain poorly understood, as is the metabolic and replicative state of the microbes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan K,Knaak T,Satkamp L,Humbert O,Falkow S,Ramakrishnan L

更新日期：2002-03-19 00:00:00

abstract：:On April 20, 2010, the Deepwater Horizon (DWH) blowout occurred, releasing more oil than any accidental spill in history. Oil release continued for 87 d and much of the oil and gas remained in, or returned to, the deep sea. A coral community significantly impacted by the spill was discovered in late 2010 at 1,370 m de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisher CR,Hsing PY,Kaiser CL,Yoerger DR,Roberts HH,Shedd WW,Cordes EE,Shank TM,Berlet SP,Saunders MG,Larcom EA,Brooks JM

更新日期：2014-08-12 00:00:00

abstract：:The osteopontin (Opn) glycoprotein has been implicated in diverse physiological processes, including vascularization, bone formation, and inflammatory responses. Studies of its role in immune responses has suggested that Opn can set the early stage of type-1 immune (cell-mediated) responses through differential regula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinohara ML,Jansson M,Hwang ES,Werneck MB,Glimcher LH,Cantor H

更新日期：2005-11-22 00:00:00

abstract：:Sr-bearing marine barite [(Ba x , Sr1-x )SO4] cycling has been widely used to reconstruct geochemical evolutions of paleoenvironments. However, an understanding of barite precipitation in the ocean, which is globally undersaturated with respect to barite, is missing. Moreo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deng N,Stack AG,Weber J,Cao B,De Yoreo JJ,Hu Y

更新日期：2019-07-02 00:00:00

abstract：:Stepwise, synthetic alteration of oxytocin, guided by conformational and enzymological considerations, has led to analogs with specifically modified activity profiles and resistance to enzymatic inactivation. General requirements for the design of peptides with therapeutic value are discussed. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Yamanaka T,Sakakibara S

更新日期：1974-05-01 00:00:00

abstract：:A three-step purification procedure for the isolation of heart muscle chalones is described. The method uses ultrafiltration followed by concanavalin A-Sepharose affinity chromatography and subsequent sucrose density gradient centrifugation. Analytical ultracentrifugation of the highly purified chalone fraction indica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriek JA,van der Walt BJ,Bester AJ

更新日期：1981-07-01 00:00:00

abstract：:Paired oxygen-isotopic analyses of abiotic carbonate and benthic-ostracode shells from lake sediments provide a continuous quantitative record of growing-season temperature for the past 2000 years in the northwestern foothills of the Alaska Range. This record reveals three time intervals of comparable warmth: anno Dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu FS,Ito E,Brown TA,Curry BB,Engstrom DR

更新日期：2001-09-11 00:00:00

abstract：:A Mr 35,000 calmodulin-binding protein, which also possesses the ability to interact with a number of cytoskeletal elements, was purified from bovine synaptosomal membranes, using hydroxylapatite and phosphocellulose column chromatography. We call this protein "cytosynalin," which is derived from a combination of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sobue K,Okabe T,Kadowaki K,Itoh K,Tanaka T,Fujio Y

更新日期：1987-04-01 00:00:00

abstract：:We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egerton M,Scollay R,Shortman K

更新日期：1990-04-01 00:00:00

abstract：:The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larner AC,Jonak G,Cheng YS,Korant B,Knight E,Darnell JE Jr

更新日期：1984-11-01 00:00:00

abstract：:Wild bees are highly valuable pollinators. Along with managed honey bees, they provide a critical ecosystem service by ensuring stable pollination to agriculture and wild plant communities. Increasing concern about the welfare of both wild and managed pollinators, however, has prompted recent calls for national evalua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koh I,Lonsdorf EV,Williams NM,Brittain C,Isaacs R,Gibbs J,Ricketts TH

更新日期：2016-01-05 00:00:00

abstract：:Diffuse celestial sources of relatively low surface brightness such as the Milky Way, zodiacal light, and gegenschein (or contre lumière) can be studied most reliably from above the earth's atmosphere with equipment flown in artificial satellites. We review the techniques used and some of the difficulties encountered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roach FE,Carroll B,Aller LH,Smith L

更新日期：1972-03-01 00:00:00

abstract：:Eukaryotic transcriptional activators may function by stimulating formation of RNA polymerase II preinitiation complexes at the core promoter of genes. In this case, their mode of action will intrinsically depend on how these complexes assemble on promoters in living cells, an issue that remains largely unexplored. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Couto E,Klages N,Strubin M

更新日期：1997-07-22 00:00:00

abstract：:Whether the mate sampling and choice performed by females in nature influences offspring performance is a controversial issue in theory and an open empirical question. Pronghorn (Antilocapra americana) females engage in an obvious and energetically expensive mate sampling process to identify vigorous males. Although i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Byers JA,Waits L

更新日期：2006-10-31 00:00:00

abstract：:Previous studies have demonstrated that mutation in the forkhead domain of the forkhead box P2 (FOXP2) protein (R553H) causes speech-language disorders. To further analyze FOXP2 function in speech learning, we generated a knockin (KI) mouse for Foxp2 (R552H) [Foxp2 (R552H)-KI], corresponding to the human FOXP2 (R553H)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujita E,Tanabe Y,Shiota A,Ueda M,Suwa K,Momoi MY,Momoi T

更新日期：2008-02-26 00:00:00

abstract：:Observations with the image tube scanner at the Shane 3-m telescope are combined with data obtained with the International Ultraviolet Explorer to assess the spectrum of the remarkable high-excitation planetary nebula NGC 6537. We have analyzed the spectrum of this nitrogen-rich object with the aid of the theoretical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feibelman W,Aller LH,Keyes CD,Czyzak SJ

更新日期：1985-04-01 00:00:00

abstract：:Striking taste disturbances are reported in cancer patients treated with Hedgehog (HH)-pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector Smoothened (SMO). We tested the potential for molecular, cellular, and functional recovery in mice from the severe disruption of taste-organ ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumari A,Ermilov AN,Grachtchouk M,Dlugosz AA,Allen BL,Bradley RM,Mistretta CM

更新日期：2017-11-28 00:00:00

abstract：:The Madden-Julian oscillation (MJO) is the dominant mode of variability in the tropical atmosphere on intraseasonal timescales and planetary spatial scales. Despite the primary importance of the MJO and the decades of research progress since its original discovery, a generally accepted theory for its essential mechani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ,Stechmann SN

更新日期：2009-05-26 00:00:00

abstract：:Glutathione, an essential cellular antioxidant required for mitochondrial function, is not synthesized by mitochondria but is imported from the cytosol. Rat liver mitochondria have a multicomponent system that underlies the remarkable ability of mitochondria to take up and retain glutathione. At external glutathione l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mårtensson J,Lai JC,Meister A

更新日期：1990-09-01 00:00:00

abstract：:Transmembrane 16A (TMEM16A, anoctamin1), 1 of 10 TMEM16 family proteins, is a Cl- channel activated by intracellular Ca2+ and membrane voltage. This channel is also regulated by the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. We find that two splice variants of TMEM16A show different sensi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ko W,Jung SR,Kim KW,Yeon JH,Park CG,Nam JH,Hille B,Suh BC

更新日期：2020-12-01 00:00:00