Allosteric modulation of alternatively spliced Ca2+-activated Cl- channels TMEM16A by PI(4,5)P2 and CaMKII.

abstract：:Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) has been implicated in Parkinson's disease (PD) and is present in neurofibrillary tangles or Lewy bodies. However, the molecular basis for UCH-L1s involvement in proteinacious fibril formation is still elusive, especially in regard to the pathogenicity of the I93M muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koharudin LM,Liu H,Di Maio R,Kodali RB,Graham SH,Gronenborn AM

更新日期：2010-04-13 00:00:00

abstract：:The enterotoxigenic Escherichia coli (ETEC) are among the most common causes of diarrheal illness and death due to diarrhea among young children in low-/middle-income countries (LMICs). ETEC have also been associated with important sequelae including malnutrition and stunting, placing children at further risk of death...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheikh A,Tumala B,Vickers TJ,Alvarado D,Ciorba MA,Bhuiyan TR,Qadri F,Singer BB,Fleckenstein JM

更新日期：2020-11-17 00:00:00

abstract：:Quantitative studies of protein abundance rarely span more than a small number of experimental conditions and replicates. In contrast, quantitative studies of transcript abundance often span hundreds of experimental conditions and replicates. This situation exists, in part, because extracting quantitative data from la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan Z,Bloom JS,Garcia BA,Singh M,Kruglyak L

更新日期：2009-09-15 00:00:00

abstract：:In the retinae of many vertebrates, there are classes of horizontal cell that probably utilize gamma-aminobutyric acid (GABA) as a neurotransmitter. As with other amino acid transmitter agents, the postsynaptic action of GABA is thought to be terminated by uptake into neurons and glia surrounding the release site. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malchow RP,Ripps H

更新日期：1990-11-01 00:00:00

abstract：:The crown gall teratoma tumor line BT37, incited by Agrobacterium tumefaciens strain T37, has been found to contain part of the tumor-inducing plasmid, pTi T37, of the inciting strain. This foreign DNA segment, called T-DNA, is maintained at several copies per diploid tumor cell. We have examined subcellular DNA fract...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chilton MD,Saiki RK,Yadav N,Gordon MP,Quetier F

更新日期：1980-07-01 00:00:00

abstract：:The flux of solvent water coupled to the transit of ions through protein pores is considerable. The effect of this electroosmotic solvent flow on the binding of a neutral molecule [beta-cyclodextrin (betaCD)] to sites within the staphylococcal alpha-hemolysin pore was investigated. Mutant alpha-hemolysin pores were us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu LQ,Cheley S,Bayley H

更新日期：2003-12-23 00:00:00

abstract：:In Caenorhabditis elegans, the small nuclear ribonucleoprotein (snRNP)-associated proteins U1A and U2B'' are approximately 50% identical to each other, and neither bears signature characteristics of mammalian U1A or U2B'' or the single Drosophila homolog, SNF. We show here that the genes that encode these proteins (rn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saldi T,Wilusz C,MacMorris M,Blumenthal T

更新日期：2007-06-05 00:00:00

abstract：:Optimal infectivity of HIV-1 virions requires synthesis of the HIV-1 regulatory protein Nef in some producer cells but not others. A survey of 18 lymphoid cell lines found that Nef was dispensable in three, each of which harbored gammaretroviruses. Nef-dependent cell lines were rendered Nef-independent by a cell-free ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pizzato M

更新日期：2010-05-18 00:00:00

abstract：:Transcription termination is a critical step in the control of gene expression. One of the major termination mechanisms is mediated by Rho factor that dissociates the complex mRNA-DNA-RNA polymerase upon binding with RNA polymerase. Rho promotes termination at the end of operons, but it can also terminate transcriptio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva IJ,Barahona S,Eyraud A,Lalaouna D,Figueroa-Bossi N,Massé E,Arraiano CM

更新日期：2019-02-19 00:00:00

abstract：:Thioredoxins are small multifunctional redox active proteins widely if not universally distributed among living organisms. In chloroplasts, two types of thioredoxins (f and m) coexist and play central roles in regulating enzyme activity. Reduction of thioredoxins in chloroplasts is catalyzed by an iron-sulfur disulfid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balmer Y,Koller A,del Val G,Manieri W,Schürmann P,Buchanan BB

更新日期：2003-01-07 00:00:00

abstract：:The physiological effects of nitroglycerin as a potent vasodilator have long been documented. However, the molecular mechanisms by which nitroglycerin exerts its biological functions are still a matter of intense debate. Enzymatic pathways converting nitroglycerin to vasoactive compounds have been identified, but none...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonini MG,Stadler K,Silva SO,Corbett J,Dore M,Petranka J,Fernandes DC,Tanaka LY,Duma D,Laurindo FR,Mason RP

更新日期：2008-06-24 00:00:00

abstract：:Type I (IFN-alpha/beta) and type III (IFN-lambdas) IFNs are important components of the host antiviral response. Although type III IFNs possess intrinsic antiviral activity similar to that of type I IFNs, they signal through a specific unique receptor complex, and their functional importance for antiviral resistance i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang J,Smirnov SV,Lewis-Antes A,Balan M,Li W,Tang S,Silke GV,Pütz MM,Smith GL,Kotenko SV

更新日期：2007-06-05 00:00:00

abstract：:Transfection of cells with the H-2Kk gene lacking the transmembrane and cytoplasmic segments resulted in secretion of the H-2Kk protein, as determined by immunoprecipitation with monoclonal anti-H-2Kk antibodies. Transgenic (H-2b X H-2d)F1 mice were established carrying integrated copies of the modified H-2Kk gene. Ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold B,Dill O,Küblbeck G,Jatsch L,Simon MM,Tucker J,Hämmerling GJ

更新日期：1988-04-01 00:00:00

abstract：:We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egerton M,Scollay R,Shortman K

更新日期：1990-04-01 00:00:00

abstract：:Eukaryotic translation initiation factor eIF-4E plays a central role in the recognition of the 7-methylguanosine-containing cap structure of mRNA and the formation of initiation complexes during protein synthesis. eIF-4E exists in both phosphorylated and nonphosphorylated forms, and the primary site of phosphorylation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minich WB,Balasta ML,Goss DJ,Rhoads RE

更新日期：1994-08-02 00:00:00

abstract：:In many plant species only a small proportion of buds yield branches. Both the timing and extent of bud activation are tightly regulated to produce specific branching architectures. For example, the primary shoot apex can inhibit the activation of lateral buds. This process is termed apical dominance and is dependent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prusinkiewicz P,Crawford S,Smith RS,Ljung K,Bennett T,Ongaro V,Leyser O

更新日期：2009-10-13 00:00:00

abstract：:Protein kinase P (PK-P) activated by histones or certain other basic compounds has been purified previously from yeast [Yanagita, Y., Abdel-Ghany, M., Raden, D., Nelson, N. & Racker, E. (1987) Proc. Natl. Acad. Sci. USA 84, 925-929]. It is shown here that PK-P is present in solubilized membranes of A-431 carcinoma cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abdel-Ghany M,Kole HK,Racker E

更新日期：1987-12-01 00:00:00

abstract：:High-resolution examination of pulse sequences generated by single visual cortex cells of the rhesus monkey in response to precisely controlled visual stimuli has disclosed (i) that the outputs of such neurons contain highly improbable (P less than 10(-7) numbers of identical triplets of precisely repeating pulse patt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strehler BL,Lestienne R

更新日期：1986-12-01 00:00:00

abstract：:Extracellular stimuli regulate neuronal differentiation and subtype specification during brain development, although the intracellular signaling pathways that mediate these processes remain largely unclear. We now show that the PDK1-Akt pathway regulates differentiation of telencephalic neural precursor cells (NPCs). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oishi K,Watatani K,Itoh Y,Okano H,Guillemot F,Nakajima K,Gotoh Y

更新日期：2009-08-04 00:00:00

abstract：:The clinical efficacy of local anesthetic and antiarrhythmic drugs is due to their voltage- and frequency-dependent block of Na+ channels. Quaternary local anesthetic analogs such as QX-314, which are permanently charged and membrane-impermeant, effectively block cardiac Na+ channels when applied from either side of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qu Y,Rogers J,Tanada T,Scheuer T,Catterall WA

更新日期：1995-12-05 00:00:00

abstract：:Transgenic (Tg) mouse lines that express chimeric mouse-human prion protein (PrP), designated MHu2M, are susceptible to prions from patients with sporadic Creutzfeldt-Jakob disease (sCJD). With the aim of decreasing the incubation time to fewer than 200 days, we constructed transgenes in which one or more of the nine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korth C,Kaneko K,Groth D,Heye N,Telling G,Mastrianni J,Parchi P,Gambetti P,Will R,Ironside J,Heinrich C,Tremblay P,DeArmond SJ,Prusiner SB

更新日期：2003-04-15 00:00:00

abstract：:Functionally differentiated chicken macrophages were derived by in vitro differentiation of embryonic yolk sac cells and were characterized by several macrophage-specific cell markers. Uniform, infected, virus-producing cultures were obtained after exposure of these macrophages to avian myoblastosis virus (AMV), avian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Durban EM,Boettiger D

更新日期：1981-06-01 00:00:00

abstract：:A controversial topic in the recent climate modeling literature is the fashion in which metastable low-frequency regimes in the atmosphere occur despite nearly Gaussian statistics for these planetary waves. Here a simple 57-mode paradigm model for such metastable atmospheric regime behavior is introduced and analyzed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ,Franzke CL,Fischer A,Crommelin DT

更新日期：2006-05-30 00:00:00

abstract：:Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. In addition, they are secreted by activated cells and act in a cytokine-like manner, presumably via signaling through a cell surface cyclophilin receptor. More recently, host-derived cyclophili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sherry B,Zybarth G,Alfano M,Dubrovsky L,Mitchell R,Rich D,Ulrich P,Bucala R,Cerami A,Bukrinsky M

更新日期：1998-02-17 00:00:00

abstract：:Our laboratory has previously developed cell lines derived from mouse NIH 3T3 fibroblasts and C127 mammary tumor cells that stably express mouse mammary tumor virus (MMTV) long terminal repeat fusion genes in bovine papillomavirus-based episomes. Glucocorticoid hormone strongly activates transcription from episomes an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bresnick EH,John S,Berard DS,LeFebvre P,Hager GL

更新日期：1990-05-01 00:00:00

abstract：:The unique specificity of monoclonal antibodies (Ab) was combined with the cell-killing function of the cytolytic alternative pathway of complement. The functionally C3b-like glycoprotein of cobra venom was linked to a murine monoclonal Ab directed to a human melanoma-associated antigen by a disulfide bond, by using a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogel CW,Müller-Eberhard HJ

更新日期：1981-12-01 00:00:00

abstract：:Developmental genetic studies of evolved differences in morphology have led to the hypothesis that cis-regulatory changes often underlie morphological evolution. However, because most of these studies focus on evolved loss of traits, the genetic architecture and possible association with cis-regulatory changes of gain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleves PA,Ellis NA,Jimenez MT,Nunez SM,Schluter D,Kingsley DM,Miller CT

更新日期：2014-09-23 00:00:00

abstract：:A parathyroid hormone-like peptide (PTH-LP) has recently been identified in human tumors associated with the syndrome of humoral hypercalcemia of malignancy. The peptide appears to be encoded by a single-copy gene that gives rise to multiple mRNAs that are heterogeneous at both their 5' and their 3' ends. Alternative ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangin M,Ikeda K,Dreyer BE,Broadus AE

更新日期：1989-04-01 00:00:00

abstract：:We extend and apply theories of filled foam elasticity and failure to recently available data on foods. The predictions of elastic modulus and failure mode dependence on internal pressure and on wall integrity are borne out by photographic evidence of distortion and failure under compressive loading and under the loca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner M,Thiel BL,Donald AM

更新日期：2000-02-15 00:00:00

abstract：:Protein synthesis initiation in reticulocyte lysates is inhibited by heme deficiency, low levels of double-stranded RNA (dsRNA), oxidized glutathione (GSSG), or the purified kinase (HRI) that acts on the alpha polypeptide of eukaryotic initiation factor 2 (eIF-2alpha). The phosphoprotein profiles produced in lysates i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ernst V,Levin DH,London IM

更新日期：1979-05-01 00:00:00