Modeling the status, trends, and impacts of wild bee abundance in the United States.

abstract：:Engaging mammalian Toll-like receptors (TLRs) activate both the NF-kappaB and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1(-/-) cells, is required for extracellular signal-regulated kinase (ERK) activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee A,Gugasyan R,McMahon M,Gerondakis S

更新日期：2006-02-28 00:00:00

abstract：:Organic agriculture promotes sustainability compared to conventional agriculture. However, the multifunctional sustainability benefits of organic farms might be mediated by landscape context. Assessing how landscape context affects sustainability may aid in targeting organic production to landscapes that promote high ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith OM,Cohen AL,Reganold JP,Jones MS,Orpet RJ,Taylor JM,Thurman JH,Cornell KA,Olsson RL,Ge Y,Kennedy CM,Crowder DW

更新日期：2020-02-11 00:00:00

abstract：:Previous studies have shown that the effect of language on categorical perception of color is stronger when stimuli are presented in the right visual field than in the left. To examine whether this lateralized effect occurs preattentively at an early stage of processing, we monitored the visual mismatch negativity, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mo L,Xu G,Kay P,Tan LH

更新日期：2011-08-23 00:00:00

abstract：:The latency-associated nuclear antigen (LANA) of Kaposi sarcoma herpesvirus (KSHV) is mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role in the replication and maintenance of latent viral episomal DNA. In addition, N-terminally truncated cytoplasmic isoforms of LANA, resul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang G,Chan B,Samarina N,Abere B,Weidner-Glunde M,Buch A,Pich A,Brinkmann MM,Schulz TF

更新日期：2016-02-23 00:00:00

abstract：:Rhythmic, spontaneously pulsating cardiac cells cultured from newborn rats are immediately stimulated to beat faster by addition of a number of tubulin-binding agents but not by their non-tubulin-binding analogues. The tubulin-binding agents tested include vinblastine, vincristine, navelbine, two analogs of vinblastin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampidis TJ,Kolonias D,Savaraj N,Rubin RW

更新日期：1992-02-15 00:00:00

abstract：:A leading hypothesis explaining Phanerozoic mass extinctions and associated carbon isotopic anomalies is the emission of greenhouse, other gases, and aerosols caused by eruptions of continental flood basalt provinces. However, the necessary serial relationship between these eruptions, isotopic excursions, and extincti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whiteside JH,Olsen PE,Eglinton T,Brookfield ME,Sambrotto RN

更新日期：2010-04-13 00:00:00

abstract：:The spatiotemporal regulation of neurotransmitter transporters involves proteins that interact with their intracellular domains. Using a proteomic approach, we identified several proteins that interact with the C terminus of the serotonin transporter (SERT). These included neuronal nitric oxide synthase (nNOS), a PSD-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chanrion B,Mannoury la Cour C,Bertaso F,Lerner-Natoli M,Freissmuth M,Millan MJ,Bockaert J,Marin P

更新日期：2007-05-08 00:00:00

abstract：:The sloppy paired (slp) locus consists of two genes, slp1 and slp2, both of which encode proteins containing a forkhead domain (a DNA-binding motif). Previous work has shown that a severe segmentation phenotype is obtained only when both slp genes are deleted. Here we examine the functional redundancy of the locus in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cadigan KM,Grossniklaus U,Gehring WJ

更新日期：1994-07-05 00:00:00

abstract：:Insulin binding to insulin receptors, on skin fibroblasts established in culture from an infant with insulin resistance and clinical features of leprechaunism was markedly decreased in comparison with cultures from an age-matched control. By contrast, the binding of epidermal growth factor, a polypeptide growth factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schilling EE,Rechler MM,Grunfeld C,Rosenberg AM

更新日期：1979-11-01 00:00:00

abstract：:Exocytosis allows the release of secretory products and the delivery of new membrane material to the plasma membrane. So far, little is known about the underlying molecular mechanism and its control in plant cells. We have used the whole-cell patch-clamp technique to monitor changes in membrane capacitance to study ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Homann U,Tester M

更新日期：1997-06-10 00:00:00

abstract：:The enormous complexity of biological networks has led to the suggestion that networks are built of modules that perform particular functions and are "reused" in evolution in a manner similar to reusable domains in protein structures or modules of electronic circuits. Analysis of known biological networks has revealed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spirin V,Gelfand MS,Mironov AA,Mirny LA

更新日期：2006-06-06 00:00:00

abstract：:Adenosine deaminases that act on RNA (ADARs) constitute a family of RNA-editing enzymes that convert adenosine to inosine within double-stranded regions of RNA. We previously developed a method to identify inosine-containing RNAs and used it to identify five ADAR substrates in Caenorhabditis elegans. Here we use the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morse DP,Aruscavage PJ,Bass BL

更新日期：2002-06-11 00:00:00

abstract：:By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evidence supporting this notion is based on several findings: (i) a high...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van der Ploeg LH,Martin WJ,Howard AD,Nargund RP,Austin CP,Guan X,Drisko J,Cashen D,Sebhat I,Patchett AA,Figueroa DJ,DiLella AG,Connolly BM,Weinberg DH,Tan CP,Palyha OC,Pong SS,MacNeil T,Rosenblum C,Vongs A,Tang R

更新日期：2002-08-20 00:00:00

abstract：:The effects of pyrophosphate on RNA binding and ATPase activities of Escherichia coli transcription termination factor rho have been studied. Mutant rho-115 protein has a temperature-sensitive RNA-dependent ATPase activity due to the thermolability of binding to RNA [Kent, R.B. & Guterman, S.K. (1981) Fed. Proc. Fed. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kent RB,Guterman SK

更新日期：1982-07-01 00:00:00

abstract：:Caseinolytic proteases (ClpPs) are large oligomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bacteria. Although most organisms possess a single ClpP protein, some organisms encode two or more ClpP isoforms. Here, we elucidated the crystal structures of ClpP1 and ClpP2 fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeiler E,List A,Alte F,Gersch M,Wachtel R,Poreba M,Drag M,Groll M,Sieber SA

更新日期：2013-07-09 00:00:00

abstract：:Synthetic oligonucleotide probes can be easily obtained and used, in contrast to cDNA cloning to develop probes, and thus the present study was carried out to determine whether such probes could also be useful for in situ hybridization. A 24-base synthetic oligonucleotide complementary to part of the alpha-melanocyte-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis ME,Sherman TG,Burke S,Akil H,Davis LG,Arentzen R,Watson SJ

更新日期：1986-08-01 00:00:00

abstract：:The complete primary structure of the purple membrane protein bacteriorhodopsin, which contains 248 amino acid residues, has been determined. Methods used for separation of the hydrophobic fragments included gel permeation and reverse-phase high-pressure liquid chromatography in organic solvents. The amino acid sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khorana HG,Gerber GE,Herlihy WC,Gray CP,Anderegg RJ,Nihei K,Biemann K

更新日期：1979-10-01 00:00:00

abstract：:The availability of gene-targeted mice deficient in the urokinase-type plasminogen activator (uPA), urokinase receptor (uPAR), tissue-type plasminogen activator (tPA), and plasminogen permits a critical, genetic-based analysis of the physiological and pathological roles of the two mammalian plasminogen activators. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bugge TH,Flick MJ,Danton MJ,Daugherty CC,Romer J,Dano K,Carmeliet P,Collen D,Degen JL

更新日期：1996-06-11 00:00:00

abstract：:A study has been made of Cauchy's problem for a class of abstract parabolic differential equations. Our study is based upon a transformation that maps solutions of second-order abstract Cauchy problems into solutions of first-order. This is a preliminary report on some of the results obtained. These results include (1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson JA

更新日期：1971-09-01 00:00:00

abstract：:Methyl groups placed on varphiXsB1 replicative form DNA by the Escherichia coli B modification enzyme are located in the overlap between fragments Mbo II-3 and Alu I-2, a 61-base-pair DNA segment. Mutations that led to loss of susceptibility to restriction by E. coli B occurred within this segment at three positions s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lautenberger JA,Kan NC,Lackey D,Linn S,Edgell MH,Hutchison CA 3rd

更新日期：1978-05-01 00:00:00

abstract：:Biological polymers such as nucleic acids and proteins are constructed of only one-the d or l-of the two possible nonsuperimposable mirror images (enantiomers) of selected organic compounds. However, before the advent of life, it is generally assumed that chemical reactions produced 50:50 (racemic) mixtures of enantio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper G,Rios AC

更新日期：2016-06-14 00:00:00

abstract：:3-(4'-Benzoylphenyl)propionyl[3H] Phe-tRNA bound to the peptidyl site of the ribosome is photo-crosslinked exclusively to 23S RNA on irradiation at 320 nm. The site of reaction has been identified both by hybridization and primer-extension experiments as uridine-2584 and uridine-2585, located within the central loop o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barta A,Steiner G,Brosius J,Noller HF,Kuechler E

更新日期：1984-06-01 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae, mutations in either of two unlinked genes, RAM1 or RAM2, abolish the farnesyltransferase activity responsible for prenylation of Ras proteins and the a-factor mating pheromone. Here we report that the function of RAM1 and RAM2 genes is required for the membrane localization of Ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He B,Chen P,Chen SY,Vancura KL,Michaelis S,Powers S

更新日期：1991-12-15 00:00:00

abstract：:The 72-kDa spleen tyrosine kinase (Syk) and Src-family kinase p53/56Lyn (Lyn) contribute to signaling via the B-cell antigen receptor complex. Here we show that Syk and Lyn from human B lymphocytes can interact directly. Syk and Lyn coimmunoprecipitated from mature and activated B-cell lines, and gel-purified Syk and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidorenko SP,Law CL,Chandran KA,Clark EA

更新日期：1995-01-17 00:00:00

abstract：:Vertebrates can modulate the sound levels entering their inner ears in the face of intense external sound or during their own vocalizations. Middle ear muscle contractions restrain the motion of the middle ear ossicles, attenuating the transmission of low-frequency sound and thereby protecting the hair cells in the in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gridi-Papp M,Feng AS,Shen JX,Yu ZL,Rosowski JJ,Narins PM

更新日期：2008-08-05 00:00:00

abstract：:The murine paired box-containing gene Pax1 is required for normal development of the vertebral column, the sternum, and the scapula. Previous studies have shown that three natural Pax1 mouse mutants, the undulated alleles, exhibit phenotypes of different severity in these skeletal elements. Nevertheless, these analyse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilm B,Dahl E,Peters H,Balling R,Imai K

更新日期：1998-07-21 00:00:00

abstract：:Endogenous circadian rhythms have been described in a wide range of organisms from prokaryotes to man. Although basic circadian mechanisms at the molecular level are genetically fixed, certain properties of circadian rhythms at the organismic level can be modified by environmental conditions and subsequently retained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandstätter R,Kumar V,Abraham U,Gwinner E

更新日期：2000-10-24 00:00:00

abstract：:The excess proton in water, H(+)(aq), plays a fundamental role in aqueous solution chemistry. Its solution thermodynamic properties are essential to molecular descriptions of that chemistry and for validation of dynamical calculations. Within the quasichemical theory of solutions those thermodynamic properties are con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asthagiri D,Pratt LR,Kress JD

更新日期：2005-05-10 00:00:00

abstract：:Explanations for biogeographic disjunctions involving South America and Africa typically invoke vicariance of western Gondwanan biotas or long distance dispersal. These hypotheses are problematical because many groups originated and diversified well after the last known connection between Africa and South America (app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis CC,Bell CD,Mathews S,Donoghue MJ

更新日期：2002-05-14 00:00:00

abstract：:Gene regulation is a process with many steps allowing for stochastic biochemical reactions, which leads to expression noise-i.e., the cell-to-cell stochastic fluctuation in protein abundance. Such expression noise can give rise to drastically diverse phenotypes, even within isogenic cell populations. Although numerous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Min R,Vizeacoumar FJ,Jin K,Xin X,Zhang Z

更新日期：2010-06-08 00:00:00