Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection.

abstract：:We have assessed whether retinoic acid (RA) comes from local sources or is available widely to activate gene expression in embryos. We used an RA-responsive indicator cell line, L-C2A5, to localize RA sources. In these cells, an RA-sensitive promoter/lacZ reporter construct used previously by us to produce indicator t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colbert MC,Linney E,LaMantia AS

更新日期：1993-07-15 00:00:00

abstract：:Using [3H]quinuclidinyl benzilate as a specific cholinergic muscarinic ligand, it has been demonstrated that lymphocytes have muscarinic binding sites. There are approximately 200 sites per cell and the dissociation constant for quinuclidinyl benzilate is approximately 1 X 10(-9) M. Quinuclidinyl benzilate receptor bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon MA,Cohen JJ,Wilson IB

更新日期：1978-06-01 00:00:00

abstract：:Transgenic mice have provided invaluable information about gene function and regulation. However, because of marked differences between rodents and primates, some areas of human biology such as early embryonic development, aging, and maternal-fetal interactions would be best studied in a nonhuman primate model. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolfgang MJ,Eisele SG,Browne MA,Schotzko ML,Garthwaite MA,Durning M,Ramezani A,Hawley RG,Thomson JA,Golos TG

更新日期：2001-09-11 00:00:00

abstract：:Morphine is one of the most prescribed and effective drugs used for the treatment of acute and chronic pain conditions. In addition to its central effects, morphine can also produce peripheral analgesia. However, the mechanisms underlying this peripheral action of morphine have not yet been fully elucidated. Here, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cunha TM,Roman-Campos D,Lotufo CM,Duarte HL,Souza GR,Verri WA Jr,Funez MI,Dias QM,Schivo IR,Domingues AC,Sachs D,Chiavegatto S,Teixeira MM,Hothersall JS,Cruz JS,Cunha FQ,Ferreira SH

更新日期：2010-03-02 00:00:00

abstract：:ErbB2 interacting protein (Erbin) is a widely expressed protein and participates in inhibition of several intracellular signaling pathways. Its mRNA has been found to be present in relatively high levels in the heart. However, its physiological role in the heart has not been explored. In the present work, we elucidate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rachmin I,Tshori S,Smith Y,Oppenheim A,Marchetto S,Kay G,Foo RS,Dagan N,Golomb E,Gilon D,Borg JP,Razin E

更新日期：2014-04-22 00:00:00

abstract：:The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

更新日期：2017-01-10 00:00:00

abstract：:Protein carboxymethylase, an enzyme capable of methylating proteins and polypeptides, was purified from bovine pituitary. The anterior pituitary hormones, luteinizing hormone, follicle-stimulating hormone, adrenocorticotropic hormone, growth hormone, thyroid-stimulating hormone, and prolactin, were found to be substra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diliberto EJ Jr,Axelrod J

更新日期：1974-05-01 00:00:00

abstract：:The E2F1 transcription factor has a well-characterized activation domain at its C terminus and the E1A protein has a recently defined activation domain at its N terminus. Here we show that these activation domains are highly related in sequence. The sequence homology reflects, at least partly, the conservation of comm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trouche D,Kouzarides T

更新日期：1996-02-20 00:00:00

abstract：:Axonal guidance is key to the formation of neuronal circuitry. Semaphorin 3A (Sema 3A; previously known as semaphorin III, semaphorin D, and collapsin-1), a secreted subtype of the semaphorin family, is an important axonal guidance molecule in vitro and in vivo. The molecular mechanisms of the repellent activity of se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Behar O,Mizuno K,Badminton M,Woolf CJ

更新日期：1999-11-09 00:00:00

abstract：:A complementary DNA (cDNA) clone from a human placenta cDNA library encoding extracellular superoxide dismutase (EC-SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) has been isolated and the nucleotide sequence determined. The cDNA has a very high G+C content. EC-SOD is synthesized with a putative 18-amino acid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hjalmarsson K,Marklund SL,Engström A,Edlund T

更新日期：1987-09-01 00:00:00

abstract：:Resonance Raman and optical absorption spectra of ligand-free (deoxy) myoglobin and CO-bound myoglobin (MbCO) at pH 2.6 have been measured by using continuous-flow/rapid-mixing techniques. The spectra of deoxy myoglobin at low pH within 6 ms of the pH drop demonstrate that the iron-histidine bond has been ruptured but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han S,Rousseau DL,Giacometti G,Brunori M

更新日期：1990-01-01 00:00:00

abstract：:Cytochrome c oxidase (ferrocytochrome c: oxygen oxidoreductase, EC 1.9.3.1) has been resolved into a pair of complexes of unequal molecular weight. The larger complex (electron transfer complex) contains exclusively the oxidation-reduction proteins characteristic of cytochrome oxidase; the smaller complex (ion transfe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fry M,Vande Zande H,Green DE

更新日期：1978-12-01 00:00:00

abstract：:The bacterial hibernating 100S ribosome is a poorly understood form of the dimeric 70S particle that has been linked to pathogenesis, translational repression, starvation responses, and ribosome turnover. In the opportunistic pathogen Staphylococcus aureus and most other bacteria, hibernation-promoting factor (HPF) ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu A,Yap MN

更新日期：2017-09-26 00:00:00

abstract：:CCAAT enhancer-binding protein-alpha (C/EBPalpha) functions as a pleiotropic transcriptional activator of adipocyte genes during adipogenesis. Nuclear factor C/EBP undifferentiated protein (CUP), an isoform of activator protein-2alpha (AP-2alpha), binds to repressive elements in the C/EBPalpha gene promoter, silencing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang MS,Lane MD

更新日期：2000-11-07 00:00:00

abstract：:NK cells use surface NK receptors to discriminate self from non-self. The NK receptor ligand-binding domain (NKD) has been considered the sole regulator of ligand binding. Using a prototypic murine NK receptor, Ly49A, we show that the membrane proximal nonligand binding ecto-domain (the stalk region) is critical to li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito D,Iizuka YM,Katepalli MP,Iizuka K

更新日期：2009-07-07 00:00:00

abstract：:In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated. Expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin Z,Barthel LK,Raymond PA

更新日期：2009-06-09 00:00:00

abstract：:Several nonclassical major histocompatibilty antigens (class Ib molecules) have emerged as key players in the early immune response to pathogens or stress. Class Ib molecules activate subsets of T cells that mount effector responses before the adaptive immune system, and thus are called innate T cells. MR1 is a novel ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang S,Martin E,Kim S,Yu L,Soudais C,Fremont DH,Lantz O,Hansen TH

更新日期：2009-05-19 00:00:00

abstract：:Significant inhibition of spermatogenesis and appearance of antibodies against spermatogenic cells identified by cytotoxicity and immunofluorescence reactions were observed in mice of inbred strains 129/Sv and BALB/c and in albino guinea pigs after syngeneic, allogeneic, and xenogeneic immunization with mouse F9 embry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vojtiskova M,Pokorna Z,Draber P

更新日期：1983-01-01 00:00:00

abstract：:We report substantially improved performance of high-power quantum cascade lasers (QCLs) by using epitaxial-side-down mounting that provides superior heat dissipation properties. We used aluminum nitride as the heatsink material and gold-tin eutectic solder. We have obtained continuous wave power output of 450 mW at 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsekoun A,Go R,Pushkarsky M,Razeghi M,Patel CK

更新日期：2006-03-28 00:00:00

abstract：:Contractile forces are essential for many developmental processes involving cell shape change and tissue deformation. Recent experiments on reconstituted actomyosin networks, the major component of the contractile machinery, have shown that active contractility occurs above a threshold motor concentration and within a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Wolynes PG

更新日期：2012-04-24 00:00:00

abstract：:Spin-polarized charge currents induce magnetic tunnel junction (MTJ) switching by virtue of spin-transfer torque (STT). Recently, by taking advantage of the spin-dependent thermoelectric properties of magnetic materials, novel means of generating spin currents from temperature gradients, and their associated thermal-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pushp A,Phung T,Rettner C,Hughes BP,Yang SH,Parkin SS

更新日期：2015-05-26 00:00:00

abstract：:Proteins of ribosomes from various stages of development in Dictyostelium discoideum were analyzed by two-dimensional polyacrylamide gel electrophoresis. Significant changes in protein composition were observed; the data demonstrate that cell differentiation in a eukaryotic system is accompanied by ribosome heterogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramagopal S,Ennis HL

更新日期：1981-05-01 00:00:00

abstract：:Hydrocarbon films confined between smooth mica surfaces have long provided an experimental playground for model studies of structure and dynamics of confined liquids. However, fundamental questions regarding the phase behavior and shear properties in this simple system remain unsolved. With ultrasensitive resolution i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith AM,Hallett JE,Perkin S

更新日期：2019-12-17 00:00:00

abstract：:Electrophysiological mapping of chronic atrial fibrillation (AF) at high throughput and high resolution is critical for understanding its underlying mechanism and guiding definitive treatment such as cardiac ablation, but current electrophysiological tools are limited by either low spatial resolution or electromechani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Zhang X,Liu Y,Rodrigo M,Loftus PD,Aparicio-Valenzuela J,Zheng J,Pong T,Cyr KJ,Babakhanian M,Hasi J,Li J,Jiang Y,Kenney CJ,Wang PJ,Lee AM,Bao Z

更新日期：2020-06-30 00:00:00

abstract：:P-glycoprotein is an ATP-binding cassette multidrug transporter that actively transports chemically diverse substrates across the lipid bilayer. The precise molecular mechanism underlying transport is not fully understood. Here, we present crystal structures of a eukaryotic P-glycoprotein homolog, CmABCB1 from Cyanidi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kodan A,Yamaguchi T,Nakatsu T,Sakiyama K,Hipolito CJ,Fujioka A,Hirokane R,Ikeguchi K,Watanabe B,Hiratake J,Kimura Y,Suga H,Ueda K,Kato H

更新日期：2014-03-18 00:00:00

abstract：:GB virus B (GBV-B), which infects tamarins, is the virus most closely related to hepatitis C virus (HCV). HCV has a protein (p7) that is believed to form an ion channel. It is critical for viability. In vitro studies suggest that GBV-B has an analogous but larger protein (p13). We found that substitutions of the -1 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takikawa S,Engle RE,Emerson SU,Purcell RH,St Claire M,Bukh J

更新日期：2006-02-28 00:00:00

abstract：:Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success of such vaccines in mice has not translated readily to effective malaria vaccines in humans. Thus, mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt NW,Podyminogin RL,Butler NS,Badovinac VP,Tucker BJ,Bahjat KS,Lauer P,Reyes-Sandoval A,Hutchings CL,Moore AC,Gilbert SC,Hill AV,Bartholomay LC,Harty JT

更新日期：2008-09-16 00:00:00

abstract：:Reactive oxygen species (ROS) mediate apoptosis in many different cell types. We have previously shown that the antioxidant Mn(III) tetrakis(5,10,15,20-benzoic acid)porphyrin (MnTBAP) decreased intracellular ROS and prevented the apoptosis of activated T cells in vitro. To determine the mechanism(s) by which MnTBAP af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hildeman DA,Mitchell T,Aronow B,Wojciechowski S,Kappler J,Marrack P

更新日期：2003-12-09 00:00:00

abstract：:Use-dependent long-term changes of neuronal response properties must be gated to prevent irrelevant activity from inducing inappropriate modifications. Here we test the hypothesis that local network dynamics contribute to such gating. As synaptic modifications depend on temporal contiguity between presynaptic and post...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galuske RAW,Munk MHJ,Singer W

更新日期：2019-11-12 00:00:00

abstract：:There is increasing evidence for an important role of adverse early experience on the development of major psychiatric disorders in adulthood. Corticotropin-releasing factor (CRF), an endogenous neuropeptide, is the primary physiological regulator of the mammalian stress response. Grown nonhuman primates who were expo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coplan JD,Andrews MW,Rosenblum LA,Owens MJ,Friedman S,Gorman JM,Nemeroff CB

更新日期：1996-02-20 00:00:00