Solidification and superlubricity with molecular alkane films.

abstract：:Developmental genetic studies of evolved differences in morphology have led to the hypothesis that cis-regulatory changes often underlie morphological evolution. However, because most of these studies focus on evolved loss of traits, the genetic architecture and possible association with cis-regulatory changes of gain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleves PA,Ellis NA,Jimenez MT,Nunez SM,Schluter D,Kingsley DM,Miller CT

更新日期：2014-09-23 00:00:00

abstract：:Three-dimensional topological insulators (3D TIs) represent states of quantum matters in which surface states are protected by time-reversal symmetry and an inversion occurs between bulk conduction and valence bands. However, the bulk-band inversion, which is intimately tied to the topologically nontrivial nature of 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ZG,Chen RY,Zhong RD,Schneeloch J,Zhang C,Huang Y,Qu F,Yu R,Li Q,Gu GD,Wang NL

更新日期：2017-01-31 00:00:00

abstract：:High-affinity nuclear binding sites for 17 beta-estradiol (17 beta E2) were recently found in bone cells; however, the mechanism by which estrogen exerts its effect on bone in vivo is still unknown. To study if estrogen acts on bone directly, we used an experimental model in which test substances are infused locally i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takano-Yamamoto T,Rodan GA

更新日期：1990-03-01 00:00:00

abstract：:Tandem gene duplication is an important mutational process in evolutionary adaptation and human disease. Hypothetically, two tandem gene copies should produce twice the output of a single gene, but this expectation has not been rigorously investigated. Here, we show that tandem duplication often results in more than d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loehlin DW,Carroll SB

更新日期：2016-05-24 00:00:00

abstract：:Phosphatidylinositol 3-kinases (PI 3-kinases) have been implicated in membrane trafficking in the secretory and endocytic pathways of yeast and mammalian cells, but the molecular mechanisms by which these lipid kinases operate are not known. Here we identify a protein of 170 kDa that is rapidly released from cell memb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patki V,Virbasius J,Lane WS,Toh BH,Shpetner HS,Corvera S

更新日期：1997-07-08 00:00:00

abstract：:Antibodies to electrolectin, a lectin endogenous to embryonic skeletal muscle, have been used to study the distribution of electrolectin during myogenesis in L6 cells and rat primary muscle cultures. Antibody binding is highest to mononucleated cells and is low to myotubes in both systems. Binding is much lower to fib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Podleski TR,Greenberg I

更新日期：1980-02-01 00:00:00

abstract：:The fluorescent vital dye rhodamine 123 (Rh-123), which preferentially accumulates in mitochondrial membranes, can be used as a probe to indicate mitochondrial and hence cellular activity. In this study, mouse bone marrow hematopoietic stem cells were subdivided into Rh-123lo, Rh-123med, and Rh-123hi populations. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spangrude GJ,Johnson GR

更新日期：1990-10-01 00:00:00

abstract：:The x-ray crystal structures of the sulfide oxidase antibody 28B4 and of antibody 28B4 complexed with hapten have been solved at 2.2-angstrom and 1.9-angstrom resolution, respectively. To our knowledge, these structures are the highest resolution catalytic antibody structures to date and provide insight into the molec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsieh-Wilson LC,Schultz PG,Stevens RC

更新日期：1996-05-28 00:00:00

abstract：:The periaqueductal gray (PAG) and amygdala are known to be important for defensive responses, and many contemporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropriate behavior (i.e., freezing or fleeing). However, empirical studies of this circuitry are inconsistent and w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim EJ,Horovitz O,Pellman BA,Tan LM,Li Q,Richter-Levin G,Kim JJ

更新日期：2013-09-03 00:00:00

abstract：:We have studied the expression of simian virus 40 (SV40) specific tumor antigen (T-antigen) and viral RNA in SV40-transformed mouse 3T3 cells that are temperature-sensitive for the expression of the transformed phenotype (ts SV3T3). Although transformed by wild-type SV40, ts SV3T3 cells at 32 degrees behave like stand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basilico C,Zouzias D

更新日期：1976-06-01 00:00:00

abstract：:A critique is presented of the Lumsden-Wilson theory [Lumsden, C. J. & Wilson, E. O. (1980) Proc. Natl. Acad. Sci. USA 77, 4382-4386] of the transmission of cultural traits. An analysis of the underlying assumptions and the mathematical nature of the theory clarifies its essentially reductionist and determinist qualit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alper JS,Lange RV

更新日期：1981-06-01 00:00:00

abstract：:The breast and ovarian cancer suppressor BRCA2 controls the enzyme RAD51 during homologous DNA recombination (HDR) to preserve genome stability. BRCA2 binds to RAD51 through 8 conserved BRC repeat motifs dispersed in an 1127-residue region (BRCA2([BRC1-8])). Here, we show that BRCA2([BRC1-8]) exerts opposing effects o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shivji MK,Mukund SR,Rajendra E,Chen S,Short JM,Savill J,Klenerman D,Venkitaraman AR

更新日期：2009-08-11 00:00:00

abstract：:Tooth decay (dental caries) is a widespread human disease caused by microbial biofilms. Streptococcus mutans, a biofilm-former, has been consistently associated with severe childhood caries; however, how this bacterium is spatially organized with other microorganisms in the oral cavity to promote disease remains unkno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim D,Barraza JP,Arthur RA,Hara A,Lewis K,Liu Y,Scisci EL,Hajishengallis E,Whiteley M,Koo H

更新日期：2020-06-02 00:00:00

abstract：:Exposure of Chinese hamster cells to reduced oxygen partial pressure results in a marked enhancement in the frequency of methotrexate resistance and dihydrofolate reductase gene amplification. The frequency of enhanced resistance is a function of the length of exposure to hypoxic conditions and the time after recovery...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice GC,Hoy C,Schimke RT

更新日期：1986-08-01 00:00:00

abstract：:In this model gravitation results from the emission and absorption of quanta (gravitons) that are scattered a few times in crossing a typical galaxy. Many features of the universe can be explained in terms of this model, although theoretical justification for the scattering of gravitons is lacking. Gravitons follow a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Britten RJ

更新日期：1992-05-01 00:00:00

abstract：:Inferring causal effects from observational and interventional data is a highly desirable but ambitious goal. Many of the computational and statistical methods are plagued by fundamental identifiability issues, instability, and unreliable performance, especially for large-scale systems with many measured variables. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meinshausen N,Hauser A,Mooij JM,Peters J,Versteeg P,Bühlmann P

更新日期：2016-07-05 00:00:00

abstract：:Oxidative stress is known to cause tumorigenesis through induction of DNA and lipid damage. It also promotes cancer progression through a largely unknown mechanism. Sulfiredoxin (Srx) is a novel oxidative stress-induced antioxidant protein whose function in tumorigenesis and cancer progression has not been well studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Q,Jiang H,Xiao Z,Baker A,Young MR,Veenstra TD,Colburn NH

更新日期：2011-04-26 00:00:00

abstract：:After exposure of segments of rabbit taenia coli to the nonionic detergent Triton X-100, tension could be induced by increasing the [Ca2+] in the micromolar range. In the presence of a saturating [Ca2+], this preparation developed nearly 100% of the control tetanus tension recorded from the intact muscle prior to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon AR

更新日期：1978-07-01 00:00:00

abstract：:Fluorescence in situ hybridization (FISH) is a powerful tool for physical mapping in human and other mammalian species. However, application of the FISH technique has been limited in plant species, especially for mapping single- or low-copy DNA sequences, due to inconsistent signal production in plant chromosome prepa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang J,Gill BS,Wang GL,Ronald PC,Ward DC

更新日期：1995-05-09 00:00:00

abstract：:We have studied the involvement of the 5' cap structure in the splicing of precursor mRNAs in a HeLa nuclear extract. We show that precursor mRNAs are spliced efficiently only when they possess a cap structure and that preincubation of a HeLa nuclear extract rendered the splicing reaction highly sensitive to inhibitio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edery I,Sonenberg N

更新日期：1985-11-01 00:00:00

abstract：:Spectrin is an important structural component of the plasma membrane skeleton. Heretofore-unidentified isoforms of spectrin also associate with Golgi and other organelles. We have discovered another member of the beta-spectrin gene family by homology searches of the GenBank databases and by 5' rapid amplification of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stankewich MC,Tse WT,Peters LL,Ch'ng Y,John KM,Stabach PR,Devarajan P,Morrow JS,Lux SE

更新日期：1998-11-24 00:00:00

abstract：:Recent studies have shown that orthotopic (transurethral) transplantation of human bladder cancer cell lines into nude mice permits tumor growth that accurately reflects their clinical malignant status in the original host. Thus, such a system allows a unique opportunity to analyze the genetic events involved in the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Theodorescu D,Cornil I,Fernandez BJ,Kerbel RS

更新日期：1990-11-01 00:00:00

abstract：:Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Crowther RA,Jakes R,Hasegawa M,Goedert M

更新日期：1998-05-26 00:00:00

abstract：:Gating currents of the cloned delayed-rectifier K+ channel DRK1 expressed in Xenopus oocytes were measured with the open-oocyte Vaseline-gap voltage-clamp technique. DRK1 gating charge had the following salient properties: (i) gating-charge amplitude correlated positively with size of the expressed ionic K+ currents; ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taglialatela M,Stefani E

更新日期：1993-05-15 00:00:00

abstract：:Bacteria have evolved the ability to produce a wide range of structurally complex natural products historically called "secondary" metabolites. Although some of these compounds have been identified as bacterial communication cues, more frequently natural products are scrutinized for antibiotic activities that are rele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bleich R,Watrous JD,Dorrestein PC,Bowers AA,Shank EA

更新日期：2015-03-10 00:00:00

abstract：:Erickson [Erickson CL (2000) Nature 408 (6809):190-193] interpreted features in seasonal floodplains in Bolivia's Beni savannas as vestiges of pre-European earthen fish weirs, postulating that they supported a productive, sustainable fishery that warranted cooperation in the construction and maintenance of perennial s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKey DB,Durécu M,Pouilly M,Béarez P,Ovando A,Kalebe M,Huchzermeyer CF

更新日期：2016-12-27 00:00:00

abstract：:The pleiotropic effect of the sickle gene suggests that factors in addition to polymerization of the mutant gene product might be involved in sickle disease pathobiology. We have examined rates of heme transfer to hemopexin from hemoglobin in dilute aqueous solution (0.5 mg of Hb per ml) at 37 degrees C. HbO2 S loses ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hebbel RP,Morgan WT,Eaton JW,Hedlund BE

更新日期：1988-01-01 00:00:00

abstract：:Gene III protein of bacteriophage f1 is inserted into the host cell membrane where it is assembled into phage particles. A truncated form of gene III protein, encoded by a recombinant plasmid and lacking the carboxyl terminus, does not remain in the membrane but instead appears to slip through it. Fusion of a hydropho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boeke JD,Model P

更新日期：1982-09-01 00:00:00

abstract：:To elucidate the means by which metabolic inhibition depolarizes cardiac cells, spontaneously beating chicken embryonic myocardial cell aggregates were voltage clamped during superfusion with 2,4-dinitrophenol and iodoacetic acid. In aggregates continuously clamped in the pacemaker potential range, abrupt exposure to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clusin WT

更新日期：1983-06-01 00:00:00

abstract：:Some realistic galaxy models have been found to support discrete unstable spiral modes. Here, through the study of the relevant physical mechanisms and an extensive numerical investigation of the properties of the dominant modes in a wide class of galactic equilibria, we show how spiral structures are excited with dif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haass J,Bertin G,Lin CC

更新日期：1982-06-01 00:00:00